Abstract:
:A condition-based skeletal divergent synthesis was explored to achieve skeletal diversity in two component condensation reaction. Cyanomethyl benzimidazole was reacted with α-bromoketone under thermal conditions to furnish 2-aminofuranyl-benzimidazoles, while the same reaction afforded 3-cyano-benzopyrrolo-imidazoles under microwave irradiation. Two nonequivalent nucleophilic centers on benzimidazole moiety were manipulated elegantly by different reaction conditions to achieve the skeletal diversity.
journal_name
ACS Comb Scijournal_title
ACS combinatorial scienceauthors
Hsu WS,Tsai MH,Barve IJ,Yellol GS,Sun CMdoi
10.1021/acscombsci.7b00052subject
Has Abstractpub_date
2017-07-10 00:00:00pages
492-499issue
7eissn
2156-8952issn
2156-8944journal_volume
19pub_type
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journal_title:ACS combinatorial science
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