Synthesis of Aminofuran-Linked Benzimidazoles and Cyanopyrrole-Fused Benzimidazoles by Condition-Based Skeletal Divergence.


:A condition-based skeletal divergent synthesis was explored to achieve skeletal diversity in two component condensation reaction. Cyanomethyl benzimidazole was reacted with α-bromoketone under thermal conditions to furnish 2-aminofuranyl-benzimidazoles, while the same reaction afforded 3-cyano-benzopyrrolo-imidazoles under microwave irradiation. Two nonequivalent nucleophilic centers on benzimidazole moiety were manipulated elegantly by different reaction conditions to achieve the skeletal diversity.


ACS Comb Sci


Hsu WS,Tsai MH,Barve IJ,Yellol GS,Sun CM




Has Abstract


2017-07-10 00:00:00












  • Parallel and combinatorial liquid-phase synthesis of alkylbiphenyls using pentaerythritol support.

    abstract::Unfunctionalized alkylbiphenyls were fabricated by a parallel and combinatorial synthesis using pentaerythritol as a tetrapodal soluble support for a sulfonate-based traceless multifunctional linker system. Nickel N-heterocyclic carbene-catalyzed reactions of pentaerythritol tetrakis(biphenylsulfonate)s with primary a...

    journal_title:ACS combinatorial science

    pub_type: 杂志文章


    authors: Kim WK,Jang JH,Jo H,Park K

    更新日期:2014-05-12 00:00:00

  • Facile Synthesis of Azaarene-Substituted Hydroxycoumarins Possessing High Biological Activities via Three-Component C(sp(3))-H Functionalization.

    abstract::An unprecedented three-component C(sp(3))-H functionalization of 2-alkylazaarenes with aryl aldehydes and 4-hydroxycoumarins was realized, providing azaarene-substituted 3-benzyl-4-hydroxycoumarins in good to excellent yields. These new target compounds displayed broad-spectrum antibacterial activities, providing a ne...

    journal_title:ACS combinatorial science

    pub_type: 杂志文章


    authors: Dong H,Xu L,Li SS,Wang L,Shao CL,Xiao J

    更新日期:2016-09-12 00:00:00

  • Machine Learning Prediction of the Energy Gap of Graphene Nanoflakes Using Topological Autocorrelation Vectors.

    abstract::The possibility of band gap engineering in graphene opens countless new opportunities for application in nanoelectronics. In this work, the energy gaps of 622 computationally optimized graphene nanoflakes were mapped to topological autocorrelation vectors using machine learning techniques. Machine learning modeling re...

    journal_title:ACS combinatorial science

    pub_type: 杂志文章


    authors: Fernandez M,Abreu JI,Shi H,Barnard AS

    更新日期:2016-11-14 00:00:00

  • An Engineered Sso7d Variant Enables Efficient Magnetization of Yeast Cells.

    abstract::Magnetization using cheap and minimally toxic materials, such as iron oxide nanoparticles can enable easy separation of cells from culture medium and is relevant to several industrial applications. Here, we show that cell surface expression of a mutant protein that binds iron oxide can enable efficient magnetization o...

    journal_title:ACS combinatorial science

    pub_type: 杂志文章


    authors: Cruz-Teran CA,Bacon K,McArthur N,Rao BM

    更新日期:2018-10-08 00:00:00

  • Regio- and stereoselective synthesis of a library of bioactive dispiro-oxindolo/acenaphthoquino andrographolides via 1,3-dipolar cycloaddition reaction under microwave irradiation.

    abstract::Dispiro-pyrrolidino/pyrrolizidino fused oxindoles/acenaphthoquinones have been derived from andrographolide via azomethine ylide cycloaddition to the conjugated double-bond under microwave (MW) irradiation. The reactions are chemo-, stereo-, and regioselective in nature. Change in amino acid from sarcosine/N-benzyl gl...

    journal_title:ACS combinatorial science

    pub_type: 杂志文章


    authors: Hazra A,Bharitkar YP,Chakraborty D,Mondal SK,Singal N,Mondal S,Maity A,Paira R,Banerjee S,Mondal NB

    更新日期:2013-01-14 00:00:00

  • New diethylsilylacetylenic linker for parallel solid-phase synthesis of libraries of hydroxy acetylenic steroid derivatives with improved metabolic stability.

    abstract::Acetylenic tertiary alcohols are well-known to be compounds that are biologically more stable than their corresponding secondary alcohols. The linkage of an acetylenic compound to a polymer support and further introduction of molecular diversity was found to be an interesting way to generate libraries of hydroxy acety...

    journal_title:ACS combinatorial science

    pub_type: 杂志文章


    authors: Talbot A,Maltais R,Poirier D

    更新日期:2012-06-11 00:00:00

  • Synthesis of a 3-(α-styryl)benzo[b]-thiophene library via bromocyclization of alkynes and palladium-catalyzed to sylhydrazones cross-couplings: evaluation as antitubulin agents.

    abstract::A library of functionalized 3-(α-styryl)-benzo[b]thiophenes, endowed with a high level of molecular diversity, was efficiently synthesized by applying a synthetic sequence that allowed introduction of various substituents on aromatic A, B, and C-rings. The strategy developed involves the synthesis of 3-bromobenzo[b]th...

    journal_title:ACS combinatorial science

    pub_type: 杂志文章


    authors: Tréguier B,Lawson M,Bernadat G,Bignon J,Dubois J,Brion JD,Alami M,Hamze A

    更新日期:2014-12-08 00:00:00

  • Synthesis of a stereochemically diverse library of medium-sized lactams and sultams via S(N)Ar cycloetherification.

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    journal_title:ACS combinatorial science

    pub_type: 杂志文章


    authors: Gerard B,Duvall JR,Lowe JT,Murillo T,Wei J,Akella LB,Marcaurelle LA

    更新日期:2011-07-11 00:00:00

  • In Vitro Identification of the Hamiltonian Cycle Using a Circular Structure Assisted DNA Computer.

    abstract::Adleman's illustration of molecular computing using DNA paved the way toward an entirely new direction of computing (Adleman, L. M. Science 1994, 266, 1021). The exponential time complex combinatorial problem on a traditional computer turns out to be a separation problem involving a polynomial number of steps in DNA c...

    journal_title:ACS combinatorial science

    pub_type: 杂志文章


    authors: Sharma D,Ramteke M

    更新日期:2020-05-11 00:00:00

  • Efficient Synthesis of 1,9-Substituted Benzo[h][1,6]naphthyridin-2(1H)-ones and Evaluation of their Plasmodium falciparum Gametocytocidal Activities.

    abstract::A novel three-component, two-step, one-pot nucleophilic aromatic substitution (SNAr)-intramolecular cyclization-Suzuki coupling reaction was developed for the synthesis of benzo[h][1,6]naphthyridin-2(1H)-ones (Torins). On the basis of the new efficiently convergent synthetic route, a library of Torin analogs was synth...

    journal_title:ACS combinatorial science

    pub_type: 杂志文章


    authors: Li H,Sun W,Huang X,Lu X,Patel PR,Kim M,Orr MJ,Fisher RM,Tanaka TQ,McKew JC,Simeonov A,Sanderson PE,Zheng W,Williamson KC,Huang W

    更新日期:2017-12-11 00:00:00

  • Semiautomated Parallel RAFT Copolymerization of Isoprene with Glycidyl Methacrylate.

    abstract::Copolymerization of isoprene (IP) with glycidyl methacrylate (GMA) was performed under RAFT (reversible addition-fragmentation chain-transfer) polymerization conditions in a platform for high-output experimentation. Covering the range between 1 and 0.2 molar fraction of IP in the feed, four sets of reactions were carr...

    journal_title:ACS combinatorial science

    pub_type: 杂志文章


    authors: Rosales-Guzmán M,Pérez-Camacho O,Guerrero-Sánchez C,Harrisson S,Torres-Lubián R,Vitz J,Schubert US,Saldívar-Guerra E

    更新日期:2019-12-09 00:00:00

  • First-Principles Computational Screening of Perovskite Hydrides for Hydrogen Release.

    abstract::This study investigates perovskite hydrides (ABH3) comprising alkali metals of A, where A is Li, Na, K, Rb, or Cs, and alkaline-earth metals of B, where B is Be, Mg, Ca, Sr, or Ba, to screen the highest potential hydrides for hydrogen release. Herein, we investigated the most favorable dehydrogenation pathway for each...

    journal_title:ACS combinatorial science

    pub_type: 杂志文章


    authors: Li Y,Chung JS,Kang SG

    更新日期:2019-11-11 00:00:00

  • Use of Target-Displaying Magnetized Yeast in Screening mRNA-Display Peptide Libraries to Identify Ligands.

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    journal_title:ACS combinatorial science

    pub_type: 杂志文章


    authors: Bacon K,Bowen J,Reese H,Rao BM,Menegatti S

    更新日期:2020-12-14 00:00:00

  • Discovery of Novel Tricyclic Thiazepine Derivatives as Anti-Drug-Resistant Cancer Agents by Combining Diversity-Oriented Synthesis and Converging Screening Approach.

    abstract::An efficient discovery strategy by combining diversity-oriented synthesis and converging cellular screening is described. By a three-round screening process, we identified novel tricyclic pyrido[2,3-b][1,4]benzothiazepines showing potent inhibitory activity against paclitaxel-resistant cell line H460TaxR (EC50 < 1.0 μ...

    journal_title:ACS combinatorial science

    pub_type: 杂志文章


    authors: Xiang J,Zhang Z,Mu Y,Xu X,Guo S,Liu Y,Russo DP,Zhu H,Yan B,Bai X

    更新日期:2016-05-09 00:00:00

  • Build/couple/pair strategy for the synthesis of stereochemically diverse macrolactams via head-to-tail cyclization.

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    journal_title:ACS combinatorial science

    pub_type: 杂志文章


    authors: Fitzgerald ME,Mulrooney CA,Duvall JR,Wei J,Suh BC,Akella LB,Vrcic A,Marcaurelle LA

    更新日期:2012-02-13 00:00:00

  • Calculating Resin Functionalization in Solid-Phase Peptide Synthesis Using a Standardized Method based on Fmoc Determination.

    abstract::Solid-phase synthesis is the method of choice for peptide preparation in both research and industrial settings. The whole synthetic process is governed by the initial functionalization of the resin. Although the literature provides several methods to determine such functionalization, the addition of an Fmoc-amino acid...

    journal_title:ACS combinatorial science

    pub_type: 杂志文章


    authors: Al Musaimi O,Basso A,de la Torre BG,Albericio F

    更新日期:2019-11-11 00:00:00

  • Structural and Functional Properties of the Thin Film System Ti-Ni-Si.

    abstract::The thin film system Ti-Ni-Si was investigated using methods of combinatorial materials science. A thin film composition spread library of the system was fabricated using combinatorial magnetron sputtering. The functional properties Seebeck coefficient, electrical resistivity, and luminance were determined using high-...

    journal_title:ACS combinatorial science

    pub_type: 杂志文章


    authors: Wambach M,Ziolkowski P,Müller E,Ludwig A

    更新日期:2019-05-13 00:00:00

  • (Hetero-)(arylidene)arylhydrazides as Multitarget-Directed Monoamine Oxidase Inhibitors.

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    journal_title:ACS combinatorial science

    pub_type: 杂志文章


    authors: Palakkathondi A,Oh JM,Dev S,Rangarajan TM,Kaipakasseri S,Kavully FS,Gambacorta N,Nicolotti O,Kim H,Mathew B

    更新日期:2020-11-09 00:00:00

  • Library synthesis and antibacterial investigation of cationic anthraquinone analogs.

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    journal_title:ACS combinatorial science

    pub_type: 杂志文章


    authors: Fosso MY,Chan KY,Gregory R,Chang CW

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  • Combinatorial Strategies for Synthesis and Characterization of Alloy Microstructures over Large Compositional Ranges.

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    journal_title:ACS combinatorial science

    pub_type: 杂志文章


    authors: Li Y,Jensen KE,Liu Y,Liu J,Gong P,Scanley BE,Broadbridge CC,Schroers J

    更新日期:2016-10-10 00:00:00

  • Design, synthesis, and diversification of 3,5-substituted enone library.

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    journal_title:ACS combinatorial science

    pub_type: 信件


    authors: Khalaf J,Estrella-Jimenez ME,Shashack MJ,Phatak SS,Zhang S,Gilbertson SR

    更新日期:2011-07-11 00:00:00

  • Early Years of High-Throughput Experimentation and Combinatorial Approaches in Catalysis and Materials Science.

    abstract::This is a report on the early years of combinatorial materials science and technology. High-throughput technologies (HTTs) are found in life- and materials-science laboratories. Although HTTs have long been the standard in life sciences in academia as well as in industry, HTTs in materials science have become the stan...

    journal_title:ACS combinatorial science

    pub_type: 历史文章,杂志文章,评审


    authors: Maier WF

    更新日期:2019-06-10 00:00:00

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    journal_title:ACS combinatorial science

    pub_type: 杂志文章


    authors: Banko L,Ries S,Grochla D,Arghavani M,Salomon S,Pfetzing-Micklich J,Kostka A,Rogalla D,Schulze J,Awakowicz P,Ludwig A

    更新日期:2019-12-09 00:00:00

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    journal_title:ACS combinatorial science

    pub_type: 杂志文章


    authors: Zhuang QY,Wang X,Gao Y,Shi F,Jiang B,Tu SJ

    更新日期:2011-01-10 00:00:00

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    journal_title:ACS combinatorial science

    pub_type: 杂志文章


    authors: Burlingame MA,Tom CT,Renslo AR

    更新日期:2011-05-09 00:00:00

  • Right-first-time isocratic preparative liquid chromatography-mass spectrometry purification.

    abstract::Preparative RP-LCMS is widely used to purify compounds from crude reaction mixtures in drug discovery today. Method development for preparative Liquid Chromatography-Mass Spectrometry (LCMS) consists of finding the right balance between speed and quality, often leading to the use of fast generic gradients (5-95% organ...

    journal_title:ACS combinatorial science

    pub_type: 杂志文章


    authors: Koza P,Gonnot V,Pelleter J

    更新日期:2012-04-09 00:00:00

  • Modeling and Optimization of NLDH/PVDF Ultrafiltration Nanocomposite Membrane Using Artificial Neural Network-Genetic Algorithm Hybrid.

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    journal_title:ACS combinatorial science

    pub_type: 杂志文章


    authors: Arefi-Oskoui S,Khataee A,Vatanpour V

    更新日期:2017-07-10 00:00:00

  • High Throughput Light Absorber Discovery, Part 1: An Algorithm for Automated Tauc Analysis.

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    journal_title:ACS combinatorial science

    pub_type: 杂志文章


    authors: Suram SK,Newhouse PF,Gregoire JM

    更新日期:2016-11-14 00:00:00

  • Application of Silica-Supported Alkylating Reagents in a One-Pot, Sequential Protocol to Diverse Benzoxathiazepine 1,1-Dioxides.

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    journal_title:ACS combinatorial science

    pub_type: 杂志文章


    authors: Faisal S,Maity PK,Zang Q,Samarakoon TB,Sourk RL,Hanson PR

    更新日期:2016-07-11 00:00:00

  • Combinatorial Investigations of High Temperature CuNb Oxide Phases for Photoelectrochemical Water Splitting.

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    journal_title:ACS combinatorial science

    pub_type: 杂志文章


    authors: Skorupska K,Maggard PA,Eichberger R,Schwarzburg K,Shahbazi P,Zoellner B,Parkinson BA

    更新日期:2015-12-14 00:00:00