当前位置： SCI文献检索 > ACS Combinatorial Science期刊下所有文献 > Solid-Phase Synthesis of Oligopeptides Containing Sterically Hindered Amino Acids on Nonswellable Resin Using 3-Nitro-1,2,4-triazol-1-yl-tris(pyrrolidin-1-yl)phosphonium Hexafluorophosphate (PyNTP) as the Condensing Reagent.

Solid-Phase Synthesis of Oligopeptides Containing Sterically Hindered Amino Acids on Nonswellable Resin Using 3-Nitro-1,2,4-triazol-1-yl-tris(pyrrolidin-1-yl)phosphonium Hexafluorophosphate (PyNTP) as the Condensing Reagent.

Abstract：

:Peptides are still difficult to synthesize when they contain sterically hindered amino acids, such as α,α-disubstituted amino acids and N-substituted amino acids. In this study, solid-phase syntheses of oligopeptides containing multiple α-aminoisobutyric acid (Aib) residues were performed in high yields by using a nonswellable resin as the solid-support and 3-nitro-1,2,4-triazol-1-yl-tris(pyrrolidin-1-yl)phosphonium hexafluorophosphate (PyNTP) as the condensing reagent.

journal_name

ACS Comb Sci

journal_title

ACS combinatorial science

authors

Hara RI,Mitsuhashi Y,Saito K,Maeda Y,Wada T

doi

10.1021/acscombsci.7b00184

subject

Has Abstract

pub_date

2018-03-12 00:00:00

pages

132-136

issue

3

eissn

2156-8952

issn

2156-8944

journal_volume

20

pub_type

杂志文章

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