Solid-supported cross-metathesis and a formal alkane metathesis for the generation of biologically relevant molecules.

Abstract:

:Solid-phase synthetic strategies toward the generation of libraries of biologically relevant molecules were developed using olefin cross-metathesis as a key step. It is remarkably the formal alkane metathesis based on a one-pot, microwave-assisted, ruthenium-catalyzed cross-metathesis and reduction to obtain Csp3-Csp3 linkages.

journal_name

ACS Comb Sci

authors

Méndez L,Mata EG

doi

10.1021/co500176b

subject

Has Abstract

pub_date

2015-02-09 00:00:00

pages

81-6

issue

2

eissn

2156-8952

issn

2156-8944

journal_volume

17

pub_type

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