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Efficient domino strategy for the synthesis of polyfunctionalized benzofuran-4(5H)-ones and cinnoline-4-carboxamides.

Abstract：

:An efficient, three-component strategy for the improved synthesis of multifunctionalized 6,7-dihydrobenzofuran-4(5H)-ones under microwave irradiation in ethyl alcohol within short periods has been established. The synthesized benzofuran-4(5H)-ones have been readily converted into polyfunctionalized cinnoline-4-carboxamides by treating with hydrazine hydratein in the same solvent through a regioselective ring-opening of the furan. Tedious workup procedures can be avoided because of the direct precipitation of products from the reaction solution by water addition, thus rendering the two-steps process ecofriendly.

journal_name

ACS Comb Sci

journal_title

ACS combinatorial science

authors

Ma GH,Tu XJ,Ning Y,Jiang B,Tu SJ

doi

10.1021/co5000097

subject

Has Abstract

pub_date

2014-06-09 00:00:00

pages

281-6

issue

6

eissn

2156-8952

issn

2156-8944

journal_volume

16

pub_type

杂志文章

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