Abstract：
:A novel immobilized N-chlorosuccinimide resin was developed for peptide disulfide bond formation in combinatorial libraries. The resin is prepared in a simple two-step process from commercial starting materials. Disulfide formation is initiated by adding a peptide solution to the resin, and excess reagent is removed by a convenient filtration upon completion of disulfide formation. Completion of disulfide formation is rapid and clean, as demonstrated by the oxidation of a small nonapeptide library. This immobilized reagent allows a wider scope for the use of N-chlorosuccinimide-based disulfide formation in combinatorial chemistry.
journal_name
ACS Comb Scijournal_title
ACS combinatorial scienceauthors
Postma TM,Albericio Fdoi
10.1021/co500003psubject
Has Abstractpub_date
2014-04-14 00:00:00pages
160-3issue
4eissn
2156-8952issn
2156-8944journal_volume
16pub_type
杂志文章abstract：:Unfunctionalized alkylbiphenyls were fabricated by a parallel and combinatorial synthesis using pentaerythritol as a tetrapodal soluble support for a sulfonate-based traceless multifunctional linker system. Nickel N-heterocyclic carbene-catalyzed reactions of pentaerythritol tetrakis(biphenylsulfonate)s with primary a...
journal_title：ACS combinatorial science
pub_type： 杂志文章
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journal_title：ACS combinatorial science
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journal_title：ACS combinatorial science
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journal_title：ACS combinatorial science
pub_type： 杂志文章
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journal_title：ACS combinatorial science
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journal_title：ACS combinatorial science
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journal_title：ACS combinatorial science
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journal_title：ACS combinatorial science
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journal_title：ACS combinatorial science
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journal_title：ACS combinatorial science
pub_type： 杂志文章
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journal_title：ACS combinatorial science
pub_type： 杂志文章
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更新日期：2014-10-13 00:00:00
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journal_title：ACS combinatorial science
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journal_title：ACS combinatorial science
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journal_title：ACS combinatorial science
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journal_title：ACS combinatorial science
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journal_title：ACS combinatorial science
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journal_title：ACS combinatorial science
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journal_title：ACS combinatorial science
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journal_title：ACS combinatorial science
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journal_title：ACS combinatorial science
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journal_title：ACS combinatorial science
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journal_title：ACS combinatorial science
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