Abstract:
BACKGROUND:Transarterial chemoembolization (TACE) induces ischemic tumor necrosis, which is intensified by regional chemotherapy. By reducing the active tumor tissue, it can be assumed that patients on the waiting list for liver transplantation may benefit from this locoregional treatment. The aim of this study was to assess the relevance of TACE in hepatocellular carcinoma (HCC) patients before liver transplantation. MATERIAL AND METHODS:A retrospective analysis was performed on data of 229 patients who were transplanted for HCC. A group of 75 patients were treated with TACE prior to liver transplantation. Tumor necrosis related to pretransplantation locoregional treatment was assessed in an explanted liver and classified into extensive (51-100%), moderate (26-50%) and limited (<25%) grades. Five-year recurrence-free survival was estimated using the Kaplan-Meier method and compared using the log-rank test. RESULTS:In total, 143 HCC lesions were treated with TACE. Extensive necrosis was found in 63 (44.0%) tumors. Moderate and limited necrosis were observed in 42 (29.4%) and 38 (26.6%) tumors, respectively. In 36 (58.1%) explanted livers, every tumor was classified as extensively necrotic. The 5-year recurrence-free survival was estimated as 81.6% in the group not treated with TACE prior to liver transplantation (TACE-) and as 73.1% in the TACE+ group (p=0.169). Among patients not fulfilling the Milan criteria, 5-year recurrence-free survival was 63.1% in TACE- and 65.1% in TACE+ (p=0.656). CONCLUSIONS:In conclusion, TACE prior to liver transplantation is effective in inducing tumor necrosis. However, evidence of benefits in long-term results after liver transplantation requires further confirmation.
journal_name
Ann Transplantjournal_title
Annals of transplantationauthors
Hołówko W,Wróblewski T,Wojtaszek M,Grąt M,Kobryń K,Ziarkiewicz-Wróblewska B,Krawczyk Mdoi
10.12659/aot.896778subject
Has Abstractpub_date
2015-12-29 00:00:00pages
764-8eissn
1425-9524issn
2329-0358pii
896778journal_volume
20pub_type
杂志文章abstract::BACKGROUND Correction of hypovitaminosis D is simple, but it is unclear whether it is associated with an accelerated decline of renal allograft function in pediatric renal transplantation patients. This retrospective single center cohort study aimed at analyzing the effect of vitamin D and covariates on the slope of 1...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:2018-04-17 00:00:00
abstract::BACKGROUND Laparoscopic donor nephrectomy (LDN) has evolved and has been established as a surgical standard of care for kidney transplantation. MATERIAL AND METHODS This study retrospectively reviews 1132 patients who underwent 4 different laparoscopic living-donor nephrectomies: hand-assisted laparoscopic nephrectomy...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/AOT.918189
更新日期:2020-02-11 00:00:00
abstract:OBJECTIVES:In the last three decades liver transplantation (LT) has become a standard procedure for terminal liver failure. Anyway the procedure is highly limited by the availability of donor organs. The use of segmental liver grafts from living or cadaver donors are an attractive way to increase the donor pool for LT ...
journal_title:Annals of transplantation
pub_type: 杂志文章,评审
doi:
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:Expansion of the donor pool by the use of grafts with extended donor criteria reduces waiting list mortality with an increased risk for graft and patient survival after liver transplantation. This study investigates the ability of the Donor-Risk-Index (DRI), the Extended-Criteria-Donor-Score (ECD-score) and ...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/aot.883452
更新日期:2012-07-01 00:00:00
abstract::BACKGROUND Minimally invasive surgery (MIS) has rapidly advanced, but its use in transplant patients has lagged. We share our experience of MIS for patients after kidney and liver transplantation and compare our results with similar studies in the literature. MATERIAL AND METHODS This study included 14 MIS (12 laparos...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/AOT.922602
更新日期:2020-06-16 00:00:00
abstract::BACKGROUND TruGraf is a blood-based biomarker test that measures differential expression of a collection of genes that have been shown to correlate with surveillance biopsy results. However, in the majority of U.S. transplant centers, surveillance biopsies are not performed. The objectives of this study were to evalua...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/AOT.920839
更新日期:2020-04-28 00:00:00
abstract::Advances in molecular biology techniques allowed for introduction of PCR-based methods for HLA typing. In routine HLA typing for organ transplantation serological method is still being used as a standard, although molecular techniques are applied more and more often. The aim of our study was to compare HLA-DR typing u...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::For each individual, there is a limit to the capacity to perform exercise. The limitation, however, depends on the nature of the task and is also influenced by a number of other factors. Muscle strength is determined largely by muscle mass, specifically muscle cross-sectional area, but is also influenced by neural dri...
journal_title:Annals of transplantation
pub_type: 杂志文章,评审
doi:
更新日期:2005-01-01 00:00:00
abstract::BACKGROUND Diffuse thrombosis of iliac veins and IVC has been considered a significant technical obstacle in pediatric kidney transplantation (KT). MATERIAL AND METHODS Between 1984 and 2018, 951 KTs were performed in our institution. In 4 children qualified for KT, diffuse thrombosis of iliac veins or IVC was found. T...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/AOT.912657
更新日期:2019-01-11 00:00:00
abstract:BACKGROUND:We report, for the first time, the data on the outcome of kidney transplantation activities in the Afghan population from Iran. MATERIAL/METHOD:We extracted the demographic, clinical and the outcome related data of all Afghan kidney transplanted patients, from 1998 to April 2006, from the United Nations Hig...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:2010-04-01 00:00:00
abstract::The hepatitis B virus (HBV) infects more than 260 million people globally, with increasing incidence, especially in developing countries. Despite antiviral therapies, HBV-related end-stage liver disease remains one of the most important indications for liver transplantation worldwide. Although new available treatments...
journal_title:Annals of transplantation
pub_type: 杂志文章,评审
doi:10.12659/aot.900216
更新日期:2016-10-14 00:00:00
abstract:BACKGROUND:Fungal infections have a significant impact on patient survival after liver transplantation, mostly caused by Candida and Aspergillus. The clinical manifestations vary, and range from colonization, active local infection, to severe invasive form. A high degree of suspicion is required for the early diagnosis...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/AOT.892132
更新日期:2014-12-22 00:00:00
abstract:BACKGROUND:Antibody-mediated rejection (AMR), associated with the presence of C4d deposits, is well-defined in kidney transplantation but much less documented in liver transplantation (LTx). The aim of our study was to retrospectively analyze a group of pediatric liver transplant recipients who experienced episodes of ...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/AOT.889921
更新日期:2014-03-04 00:00:00
abstract::The ability of kidney transplantation to improve quality of life has made this therapeutic modality the treatment of choice among renal replacement therapies; however, the continuing organ shortage has forced the use of marginal kidneys as a supplementary source of allografts. It has been repeatedly suggested that fai...
journal_title:Annals of transplantation
pub_type: 杂志文章,评审
doi:10.12659/aot.898405
更新日期:2016-07-26 00:00:00
abstract:BACKGROUND:Insufficiency of blood vessels supplying a limb allograft may lead to loss of the extremity. Thus, a regular evaluation of perfusion of transplants seems a reasonable approach. The purpose of the present study was assessment of allograft perfusion by means of non-invasive methods. MATERIAL/METHODS:Six hand ...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/AOT.892422
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:Extensive stricture of ureter still poses a difficult challenge for urologic surgons, especially when its middle part is affected. We present a reconstructive method of long ureteral strictures with use of xenogenic collagen membranes as a scaffolding to promote new tissue growth in the area of extensive uret...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:The impact of treated preoperative bacterial infections on the outcome of living-donor liver transplantation (LDLT) is not well defined. The aim of this study was to determine the frequency of pre-transplant bacterial infections within one month before LDLT and their impact on the post-transplant morbidity a...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/AOT.892095
更新日期:2014-12-23 00:00:00
abstract::Transplantation medicine, like no other medical specialty, is connected with a wide range of very difficult ethical issues. Among those are: availability of the treatment, consent for cadaveric donation, allocation of available organs, new categories of living unrelated donors and economic aspects of this method of tr...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Implantation site is an important factor affecting the effect of islet transplantation. In the literature, the gastric subserous space (GSS) is rarely used as the implantation site of islets. Our present study reports the initial results with a limited numbers of islets transplanted into the GSS in Lewis rat...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/AOT.890744
更新日期:2014-07-11 00:00:00
abstract:BACKGROUND:The calcineurin inhibitor (CNI) tacrolimus (Tac) is an effective immunosuppressant used after liver transplantation (LTx), but is often associated with CNI nephrotoxicity. Currently, there is no simple clinical predictor for CNI nephrotoxicity after LTx. We hypothesized that the Tac metabolism rate - defined...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/aot.895898
更新日期:2016-03-22 00:00:00
abstract:OBJECTIVES:Aim of the study was to assess frequency and risk factors of steroid resistant cellular rejection (SRR) in heart transplant recipients, to determine methods of its treatment, and to evaluate influence of steroid resistant rejection and method of its treatment on short- and long-term results. METHODS:All pts...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract::BACKGROUND Hypothermic machine perfusion (HMP) appears to exert a reconditioning effect on the ischemic damage of kidney grafts. However, some concerns still remain about its real effectiveness when it is delayed after a preliminary period of static cold storage (SCS) or with prolonged overall cold ischemia time (CIT)...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/AOT.918997
更新日期:2020-02-25 00:00:00
abstract::HIV infection has been traditionally considered to be an absolute contraindication for solid organ transplantation. Recent advances in HIV treatment, as highly active antiretroviral therapy (HAART), significantly reduced HIV-related mortality and morbidity. At the same time the number of HIV-infected patients with end...
journal_title:Annals of transplantation
pub_type: 杂志文章,评审
doi:
更新日期:2003-01-01 00:00:00
abstract::Transplantation of hands in humans has become an accepted therapeutic modality. A hand transplant is composed of various tissues of different degree of immunogenicity. In addition, skin contains own resident bacterial flora that may become virulent in the ischemic and rejecting graft. Discrimination between skin rejec...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00
abstract::The number of liver grafts obtained from a cadaver can be greatly increased with the application of split liver transplantation. In the last 10 years, pediatric waiting list mortality has been reduced significantly with the use of this form of liver transplantation, which has 2 major forms. In its most commonly used f...
journal_title:Annals of transplantation
pub_type: 杂志文章,评审
doi:10.12659/aot.896351
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:Early initiation of enteral nutrition is recommended after some surgical procedures. This study retrospectively analyzed the effects of addition of early enteral nutrition (EEN) support during the postoperative phase in patients after living-donor liver transplantation (LDLT). MATERIAL AND METHODS:The subje...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/AOT.893421
更新日期:2015-06-25 00:00:00
abstract:BACKGROUND:Metabolic abnormalities have been reported in patients undergoing hematopoietic stem cell transplantation (HSCT). Potential causes, risk factors and outcomes of electrolyte imbalances have thoroughly been investigated. On HSCT recipients, multiple pathophysiologic contributors are inflicting electrolyte abno...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:2009-07-01 00:00:00
abstract::Year by year the actual number of transplanted organs has been growing in Poland. In the event of the Województwo Zachodniopomorskie (Western Pomeranian Province) the primary activities were focused on informing medical personnel at hospital departments about approaching donors through trainings for such medical perso...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract::Rejecting tissue and organ grafts shed cellular debris from damaged cells. Cellular debris contains fragments of nuclei with their genetic material. The question arises what is the fate of donor DNA in recipient fluids and tissues. Is it enzymatically disintegrated and becomes a waste product or it is utilized by reci...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:As newer immunosuppressive regimens have steadily reduced in the incidence of acute rejection and have extended the life expectancy of allograft recipients, posttransplant de novo malignancies have become an important cause of death in cadaveric donor transplantation. Also, according with the recent accumula...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/aot.883230
更新日期:2012-04-01 00:00:00