Abstract：
:BACKGROUND Correction of hypovitaminosis D is simple, but it is unclear whether it is associated with an accelerated decline of renal allograft function in pediatric renal transplantation patients. This retrospective single center cohort study aimed at analyzing the effect of vitamin D and covariates on the slope of 1/creatinine after the first year. MATERIAL AND METHODS After ethics committee approval, 37 (14 male) pediatric renal transplant recipients on mycophenolate mofetil, who were followed between 2006 and 2014, were included in this study. We analyzed the slope of 1/creatinine, length of follow-up, average vitamin D levels, calcium, phosphate, alkaline phosphatase levels, intact parathyroid hormone (PTH) levels, and therapeutic drug monitoring parameters. RESULTS Median slope of 1/creatinine was -2.587e-006 L/µmol. We divided the 37 patients into two groups based on slope: 18 patients with a poorer slope and 19 patients with a good slope, with the median slope of 1/creatinine being significantly different between the two groups. Creatinine and cystatin C at one-year post-transplantation did not differ between the two groups. Average vitamin D levels were 71.4±31.01 pmol/L and identical in each group (averages 71.67 and 69.23 pmol/L, respectively). Only the mycophenolic acid coefficient of variation (MPA CV), which may promote formation of donor-specific antibodies, and PTH levels were significantly associated with 1/creatinine slope. CONCLUSIONS Our data suggest that the impact of mild and moderate decreased levels of vitamin D can have a mild impact on the progression of allograft dysfunction in transplant recipients. However, given the medication burden and adherence challenges in adolescents, correction of mildly decreased vitamin D levels may not be necessary.
journal_name
Ann Transplantjournal_title
Annals of transplantationauthors
Wile B,Yoo E,Alvarez Elias AC,Subramanian L,Eager K,Sharma AP,Filler Gsubject
Has Abstractpub_date
2018-04-17 00:00:00pages
252-257eissn
1425-9524issn
2329-0358pii
907170journal_volume
23pub_type
杂志文章abstract：:BACKGROUND The aim of this study was to investigate the clinical features and treatment strategies of transplant renal artery stenosis (TRAS) with kidneys from donation after cardiac death (DCD). MATERIAL AND METHODS We collected the clinical data of donors and recipients of single-center DCD-induced TRAS from January...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/AOT.918076
更新日期：2020-02-04 00:00:00
abstract：BACKGROUND:Induction of the hepatic and intestinal cytochrome P450-3A4 system and intestinal P-glycoprotein is an unavoidable consequence of rifampin administration which requires substantial increase in tacrolimus dose when given concurrently. Chronic diarrhea is known to precipitate tacrolimus toxicity irrespective o...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：2010-01-01 00:00:00
abstract：:Calcium plays a crucial role in physiological process in liver cells however in high concentrations these ions can be pathogenic and lead to cell death. Mechanisms responsible for maintaining calcium ion concentration gradient in physiological conditions include transmembrane transport, storage in intracellular organe...
journal_title：Annals of transplantation
pub_type： 杂志文章,评审
doi：
更新日期：2004-01-01 00:00:00
abstract：:BACKGROUND Minimally invasive surgery (MIS) has rapidly advanced, but its use in transplant patients has lagged. We share our experience of MIS for patients after kidney and liver transplantation and compare our results with similar studies in the literature. MATERIAL AND METHODS This study included 14 MIS (12 laparos...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/AOT.922602
更新日期：2020-06-16 00:00:00
abstract：BACKGROUND:Significant geographic disparities exist in access to liver transplantation and consequently the current liver allocation system is being challenged. We sought to describe our unique experience with using organs with long cold ischemia times from the largest donation service area. MATERIAL AND METHODS:From ...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/aot.896190
更新日期：2016-03-08 00:00:00
abstract：BACKGROUND:Renal dysfunction often occurs in liver transplant (LT) recipients receiving calcineurin inhibitor (CNI)-based immunosuppressive regimens, increasing morbidity and mortality rates. Replacement of CNIs by mTOR inhibitor-based immunosuppressive protocols may prevent renal impairment in LT recipients. MATERIAL...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/aot.895320
更新日期：2015-11-26 00:00:00
abstract：BACKGROUND:Intraoperative circulatory risk factors are associated with unfavorable outcomes after living donor liver transplantation (LDLT). We investigated whether the preoperative neutrophil-to-lymphocyte ratio (NLR) can predict intraoperative circulatory risks. MATERIAL AND METHODS:The perioperative data of 276 pat...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/AOT.894048
更新日期：2015-07-21 00:00:00
abstract：:Ano-genital neoplasia is about 20 x more common in renal transplant patients than the general population. Neoplasms in the immunosuppressed are more morbid and mortal because: patients are younger; tumors are more undifferentiated; they have more and larger foci; more sites are involved; neoplasms tend to persist, rec...
journal_title：Annals of transplantation
pub_type： 杂志文章,评审
doi：
更新日期：1997-01-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to characterize patient antibodies before and after cadaver and/or living-donor kidney transplantation and to correlate these data with the clinical course after transplantation. METHODS:Sera from 69 cadaver, 9 living-related and 2 patients waiting for living-donor kidney transplant...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
abstract：BACKGROUND:Abdominal complications are recognized as a common complication of solid organ transplantation. These complications can range from gastritis with minor morbidity to viscus perforation and death. This study addresses specifically colonic complications in lung transplant patients to highlight their high incide...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
abstract：:BACKGROUND Diffuse thrombosis of iliac veins and IVC has been considered a significant technical obstacle in pediatric kidney transplantation (KT). MATERIAL AND METHODS Between 1984 and 2018, 951 KTs were performed in our institution. In 4 children qualified for KT, diffuse thrombosis of iliac veins or IVC was found. T...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/AOT.912657
更新日期：2019-01-11 00:00:00
abstract：:BACKGROUND The incidence of surgical complications after kidney transplantation ranges from 10-25%. The purpose of this study was to evaluate if the application of fibrin glue as a preventive agent reduces surgical morbidity after a living-related-donor kidney transplantation. MATERIAL AND METHODS A controlled clinica...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/aot.899821
更新日期：2016-09-20 00:00:00
abstract：:Over the last decade significant improvement in patient and graft survival has been observed after liver transplantation for hepatitis B virus (HBV)-related liver disease, mostly because of efficient prophylaxis against hepatitis B reinfection. This review discusses different approches in prevention of hepatitis B rec...
journal_title：Annals of transplantation
pub_type： 杂志文章,评审
doi：
更新日期：2005-01-01 00:00:00
abstract：:BACKGROUND Graft rejection and graft versus host disease (GvHD) have impeded the success of hematopoietic cell transplantation for severe aplastic anemia (SAA) patients. There is no sufficient data to identify the outcomes of peripheral blood stem cell transplantation (PBSCT) in SAA patients, especially for adult SAA ...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/AOT.915696
更新日期：2019-08-09 00:00:00
abstract：BACKGROUND:The activation of the tryptophane catabolizing enzyme Indoleamine 2,3-dioxygenase leads to the formation of kynurenine and other metabolites that counter-regulate immune activation resulting in restoration of immune homeostasis. But in chronic immune activation, as in hemodialysed patients, the immunosuppres...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/AOT.889764
更新日期：2014-01-27 00:00:00
abstract：:The draft of the working group of experts for a Recommendation of the Committee of Ministers to Member States on Xenotransplantation was finalized in September 2001, ending a working period of two and a half years. This paper will briefly reflect upon the development of the recommendation up to this point in time. A s...
journal_title：Annals of transplantation
pub_type： 指南,杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：BACKGROUND:Markers currently used to detect kidney damage are effective in both early (KIM-1, NGAL) and late (MCP-1, MMP, TIMP) stages of renal tubular damage, indicating the progression of chronic kidney disease. Immunosuppressive drugs may damage the transplanted organ through their direct toxic effects and by contri...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/aot.895275
更新日期：2016-03-03 00:00:00
abstract：OBJECTIVES:Aim of the study was to assess frequency and risk factors of steroid resistant cellular rejection (SRR) in heart transplant recipients, to determine methods of its treatment, and to evaluate influence of steroid resistant rejection and method of its treatment on short- and long-term results. METHODS:All pts...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：BACKGROUND:The results of pancreas transplantation depend in a large degree on appropriate pancreas allograft donor selection. Several risk factors of early surgical complications or pancreas allograft loss following transplantation have been identified, but the final decision on pancreas harvesting for transplantation...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/aot.894464
更新日期：2015-11-03 00:00:00
abstract：BACKGROUND:Graft versus host disease (GVHD) is a rare complication following liver transplantation (LT) and has high mortality. We describe our single-center experience with 6 cases of GVHD diagnosed over a period of 14 years in a total of 604 liver transplant recipients--283 deceased donor liver transplants (DDLT) and...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/AOT.893616
更新日期：2015-07-14 00:00:00
abstract：:Solid organ transplantation program in Poland is very limited. The main reason of this is organ shortage. All the organs procured are transplanted. It is a general feeling that recently issued legal regulations will favorably influence organ donation, however the improvement may be expected within a few years and will...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：BACKGROUND:As newer immunosuppressive regimens have steadily reduced in the incidence of acute rejection and have extended the life expectancy of allograft recipients, posttransplant de novo malignancies have become an important cause of death in cadaveric donor transplantation. Also, according with the recent accumula...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/aot.883230
更新日期：2012-04-01 00:00:00
abstract：:The patient is a 28 year old woman who received a heart transplant in 1992 secondary to hypertrophic cardiomyopathy with unremarkable post-operative course. In the period immediately post transplantation the patient was on a four-drug immunosuppressive regimen which was subsequently changed to standard three-agent the...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:Transplantation medicine, like no other medical specialty, is connected with a wide range of very difficult ethical issues. Among those are: availability of the treatment, consent for cadaveric donation, allocation of available organs, new categories of living unrelated donors and economic aspects of this method of tr...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：BACKGROUND:Transplantation is the only effective method of treatment for end-stage and acute liver failure. Increased average survival time has been observed, and results from improved surgical technique and amended immunosuppression protocols. However, longer survival of patients after orthotopic liver transplantation...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/aot.882005
更新日期：2011-07-01 00:00:00
abstract：:For each individual, there is a limit to the capacity to perform exercise. The limitation, however, depends on the nature of the task and is also influenced by a number of other factors. Muscle strength is determined largely by muscle mass, specifically muscle cross-sectional area, but is also influenced by neural dri...
journal_title：Annals of transplantation
pub_type： 杂志文章,评审
doi：
更新日期：2005-01-01 00:00:00
abstract：BACKGROUND:Kidney transplantation alone in Primary Hyperoxaluria is associated with a high rate of recurrence and in many cases early graft loss. Liver transplantation offers the possibility of correcting the metabolic defect. MATERIAL/METHODS:A retrospective review of five cases of Primary Hyperoxaluria managed at a ...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/aot.882227
更新日期：2011-10-01 00:00:00
abstract：:BACKGROUND Prospective evidence is lacking regarding the association between renal dysfunction and cardiovascular events after liver transplantation. MATERIAL AND METHODS Data were analyzed post hoc regarding renal function and major adverse cardiac events in a two-year prospective trial of de novo liver transplant re...
journal_title：Annals of transplantation
pub_type： 杂志文章,随机对照试验
doi：10.12659/AOT.911030
更新日期：2018-10-26 00:00:00
abstract：UNLABELLED:Glutathione S-Tranferases (GST) are the enzymes which are strictly specific for epithelial cells of the proximal and distal tubules in the kidney. These enzymes are detected in the urine when some tubular damage process is found. In healthy people urine GST is hardly detected. The goal of this study was to e...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：:HIV infection has been traditionally considered to be an absolute contraindication for solid organ transplantation. Recent advances in HIV treatment, as highly active antiretroviral therapy (HAART), significantly reduced HIV-related mortality and morbidity. At the same time the number of HIV-infected patients with end...
journal_title：Annals of transplantation
pub_type： 杂志文章,评审
doi：
更新日期：2003-01-01 00:00:00
