Abstract:
OBJECTIVES:Aim of the study was to assess frequency and risk factors of steroid resistant cellular rejection (SRR) in heart transplant recipients, to determine methods of its treatment, and to evaluate influence of steroid resistant rejection and method of its treatment on short- and long-term results. METHODS:All pts. received cyclosporine-A, azathioprine and prednisone. Biopsy results > or = 3A (ISHLT) were considered a significant rejection, requiring treatment with 1 g i.v. methylprednizolone for 3 days followed by oral prednisone. SRR was recognized in case of biopsy-proven progression of rejection, lack of improvement in 2 consecutive biopsies, or increasing hemodynamic compromise despite treatment of biopsy-proven rejection. 146 pts. eligible for the study were divided into: study group--15 pts. with SRR (10%), and control group--131 pts. SRR was treated with: cytolytic therapy--ATG (10 pts.), mycophenolate mofetil (3 pts.) or steroids (2 pts.). Number of biopsies > or = 3A, cumulative biopsy score, average biopsy result, effectiveness of SRR treatment, side effects of therapy, and survival were analysed. RESULTS:All parameters characterizing rejection were significantly higher in the study group. No risk factors of SRR were found. In 6 pts. with SRR and hemodynamic compromise (all treated with ATG) improvement was observed in 4 pts, while death occurred in 2 pts. There were no deaths in pts. without hemodynamic compromise--none of 3 methods of treatment was superior, however ATG increased the infection risk. Survival in the 1st year was significantly lower in the study group (67% vs. 89% in the control group). CONCLUSIONS:SRR is recognized in about 10% of heart transplant recipients, increasing risk of death in the 1st year after surgery. Cytolytic therapy increases risk of infection, and should be avoided in pts. without hemodynamic compromise.
journal_name
Ann Transplantjournal_title
Annals of transplantationauthors
Zakliczyński M,Nozyński J,Zakliczyńska H,Kozłowska K,Trzcińska I,Szewczyk M,Konecka-Mrówka D,Foremny J,Swierad M,Przybylski R,Pisarska H,Wojarski J,Durmała J,Zembala Mkeywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
25-36issue
1eissn
1425-9524issn
2329-0358journal_volume
8pub_type
杂志文章abstract:BACKGROUND:Insufficiency of blood vessels supplying a limb allograft may lead to loss of the extremity. Thus, a regular evaluation of perfusion of transplants seems a reasonable approach. The purpose of the present study was assessment of allograft perfusion by means of non-invasive methods. MATERIAL/METHODS:Six hand ...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/AOT.892422
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:Morbid obesity is associated with liver pathology, most commonly non-alcoholic steatohepatitis (NASH) leading to cirrhosis. However, the morbid obesity impedes qualification for organ transplantation. CASE REPORT:We present a case report of a 56-year-old woman who underwent bariatric procedure followed by l...
journal_title:Annals of transplantation
pub_type: 杂志文章,评审
doi:10.12659/AOT.893797
更新日期:2015-02-25 00:00:00
abstract::BACKGROUND Prospective evidence is lacking regarding the association between renal dysfunction and cardiovascular events after liver transplantation. MATERIAL AND METHODS Data were analyzed post hoc regarding renal function and major adverse cardiac events in a two-year prospective trial of de novo liver transplant re...
journal_title:Annals of transplantation
pub_type: 杂志文章,随机对照试验
doi:10.12659/AOT.911030
更新日期:2018-10-26 00:00:00
abstract::This paper outlines the effect that the Transplant Games have had in influencing public opinion and the translation of that effect resulting in increased organ donation and transplantation in the global venues in which this activity took place. A brief account of the history of the Transplant Games now 25 years after ...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Expansion of the donor pool by the use of grafts with extended donor criteria reduces waiting list mortality with an increased risk for graft and patient survival after liver transplantation. This study investigates the ability of the Donor-Risk-Index (DRI), the Extended-Criteria-Donor-Score (ECD-score) and ...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/aot.883452
更新日期:2012-07-01 00:00:00
abstract::BACKGROUND Sleep disturbance is a common problem in liver transplant recipients, but few studies have confirmed the psychosocial factors associated with sleep quality in patients after liver transplantation. This study aimed to identify the psychosocial factors related to sleep quality among liver transplant patients ...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/AOT.920984
更新日期:2020-02-18 00:00:00
abstract::BACKGROUND Dual kidney transplantation (DKT) of expanded-criteria donors is a cost-intensive procedure that aims to increase the pool of available deceased organ donors and has demonstrated equivalent outcomes to expanded-criteria single kidney transplantation (eSKT). The objective of this study was to develop an allo...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/aot.898328
更新日期:2016-09-08 00:00:00
abstract:BACKGROUND:Studies have documented deficits of pneumococcal and other vaccinations in kidney and lung transplant patients, but the vaccination status of liver transplant (LT) recipients is unknown. This cross-sectional study investigated the prevalence of immunizations among LT patients at a large university medical ce...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/aot.896436
更新日期:2016-04-07 00:00:00
abstract:OBJECTIVES:The aim of this work was to compare the doses in critical organs, treatment duration, patient comfort and personnel workload during total body irradiation carried out alternatively with a Cobalt 60 and with 15 MeV photons at linear accelerator. PATIENTS AND METHODS:Twenty consecutive patients irradiated wit...
journal_title:Annals of transplantation
pub_type: 临床试验,杂志文章
doi:
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:Extensive stricture of ureter still poses a difficult challenge for urologic surgons, especially when its middle part is affected. We present a reconstructive method of long ureteral strictures with use of xenogenic collagen membranes as a scaffolding to promote new tissue growth in the area of extensive uret...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Fulminant liver failure (FLF) is a severe clinical condition usually accompanied by a coagulopathy, which is one of the key selection criteria for liver transplantation. Prolongation of prothrombin time can vary between etiologies of FHF, being one of the worst in fulminant presentation of Wilson's disease. ...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:2010-07-01 00:00:00
abstract::Organ transplantation program has been slowly developing over last 30 years. The number of DD (deceased donors) stabilized on the level of approximately 13/million of population. Multiorgan donation has been 45%, due to some problems with donor management. Polish Transplant Coordinating Center POLTRANSPLANT which is r...
journal_title:Annals of transplantation
pub_type: 社论
doi:
更新日期:2007-01-01 00:00:00
abstract::The ability of kidney transplantation to improve quality of life has made this therapeutic modality the treatment of choice among renal replacement therapies; however, the continuing organ shortage has forced the use of marginal kidneys as a supplementary source of allografts. It has been repeatedly suggested that fai...
journal_title:Annals of transplantation
pub_type: 杂志文章,评审
doi:10.12659/aot.898405
更新日期:2016-07-26 00:00:00
abstract:BACKGROUND:Lung transplant recipients are at great risk for developing various infectious complications. These infections portend a significant morbidity and mortality throughout their lifetime following transplantation. At times, cutaneous manifestations are the only clues to systemic infection. CASE REPORT:A 62 year...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/AOT.883846
更新日期:2013-03-14 00:00:00
abstract::102 children have been treated at the Institute of Traumatology, Orthopaedics & Neurosurgery a result of scoliosis. In all of these multi-step treatment has been applied. Initially a telescopic rod was implanted into the spine. Allografts were introduced around the rod hook, after 6 or 8 months, when angle of scoliosi...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:Data in kidney transplant recipients regarding elimination of calcineurin inhibitor (CNI) therapy from a de novo regimen based on low CNI exposure and an mTOR inhibitor are sparse, and restricted to CNI elimination within the first six months post-transplant. MATERIAL/METHODS:In a 12-month, randomized, mult...
journal_title:Annals of transplantation
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.12659/aot.882637
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Autologous peripheral blood stem cell transplantation (PBSCT) is commonly used in the treatment of lymphoma patients. G-CSF is widely used to boost white blood cell recovery. However, there are no clear data indicating which strategy of using G-CSF provides the most benefit. The aim of our study was to compa...
journal_title:Annals of transplantation
pub_type: 杂志文章,多中心研究
doi:10.12659/AOT.883965
更新日期:2013-07-02 00:00:00
abstract:OBJECTIVES:Modification of the total body irradiation technique before bone marrow transplantation has been implemented to improve uniformity of the dose inside the irradiated body and to obtain appropriate reduction in doses in critical organs. METHODS:The total dose of 12.6 Gy was delivered with the use of a combina...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::The hepatitis B virus (HBV) infects more than 260 million people globally, with increasing incidence, especially in developing countries. Despite antiviral therapies, HBV-related end-stage liver disease remains one of the most important indications for liver transplantation worldwide. Although new available treatments...
journal_title:Annals of transplantation
pub_type: 杂志文章,评审
doi:10.12659/aot.900216
更新日期:2016-10-14 00:00:00
abstract::Irrespectively of universal shortage of donor organs there is a tendency of increasing the number of transplantations from living and deceased donors. Each of these two methods has positive and negative features. The main obstacles using living donors are health hazard, necessity to solve certain donor's social and ps...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Transarterial chemoembolization (TACE) induces ischemic tumor necrosis, which is intensified by regional chemotherapy. By reducing the active tumor tissue, it can be assumed that patients on the waiting list for liver transplantation may benefit from this locoregional treatment. The aim of this study was to ...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/aot.896778
更新日期:2015-12-29 00:00:00
abstract::BACKGROUND The aim of this study was to investigate the clinical features and treatment strategies of transplant renal artery stenosis (TRAS) with kidneys from donation after cardiac death (DCD). MATERIAL AND METHODS We collected the clinical data of donors and recipients of single-center DCD-induced TRAS from January...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/AOT.918076
更新日期:2020-02-04 00:00:00
abstract:BACKGROUND:Sirolimus is a potent immunosuppressive drug that has been shown to decrease the incidence of rejection post renal transplantation. Dyslipidemia is a well recognized side effect of sirolimus therapy, which may have an impact on patient survival and post-transplant cardiac morbidity and mortality. It is unkno...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Organ transplantation increases the risk of cancer including lymphomas through various and insidious mechanisms. In this study, we aimed to gather and analyze data of 5 international studies on late onset lymphoproliferative disorders after renal and liver transplantation. MATERIAL/METHODS:We conducted a co...
journal_title:Annals of transplantation
pub_type: 杂志文章,评审
doi:
更新日期:2009-10-01 00:00:00
abstract::The use of xenografts could relieve the chronically inadequate supply of human organs for transplantation, but doubts have been expressed about the general acceptability of transplanting animal organs into human. Some researchers and clinicians have chosen to ignore negative attitudes towards clinical xenotransplantat...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Abdominal complications are recognized as a common complication of solid organ transplantation. These complications can range from gastritis with minor morbidity to viscus perforation and death. This study addresses specifically colonic complications in lung transplant patients to highlight their high incide...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVE:The Czech Bone Marrow Donor Registry (CBMD)--established 9 years ago, operates within the National HLA Centre, a constituent part of the Department of Immunology at the Institute for Clinical and Experimental Medicine. The Czech Cord Blood Register (CSCB) was recently established (in 1996) and started its act...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Chronic nephrotoxic effects of calcineurin inhibitors may be responsible for late allograft dysfunction and reduced allograft half-life. Mammalian target of rapamycin inhibitors (mTOR-i's), a newer class of immunosuppressant, do not have the chronic nephrotoxic effects shown with calcineurin inhibitors (CNI)...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/aot.881869
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:The results of pancreas transplantation depend in a large degree on appropriate pancreas allograft donor selection. Several risk factors of early surgical complications or pancreas allograft loss following transplantation have been identified, but the final decision on pancreas harvesting for transplantation...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/aot.894464
更新日期:2015-11-03 00:00:00
abstract::Aim of this monocentric study is to compare the outcome of 101 renal transplants performed in patients older than 55 years with single kidney retrieved from donors older than 50 years, with 263 transplants performed in patients younger than 55 years transplanted with young kidneys. Delayed graft function (DGF) had sim...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00