Abstract：
BACKGROUND:Fulminant liver failure (FLF) is a severe clinical condition usually accompanied by a coagulopathy, which is one of the key selection criteria for liver transplantation. Prolongation of prothrombin time can vary between etiologies of FHF, being one of the worst in fulminant presentation of Wilson's disease. Although INR value is not predictive for hemorrhage, it is commonly accepted that INR >1.9 carries a substantial risk of intraoperative bleeding. We tested the hypothesis that preemptive administration of recombinant factor VII (rFVIIa) is a safe and efficacious approach allowing performance of urgent liver transplantation without significant bleeding and thrombotic complications. MATERIAL/METHODS:In 14 analyzed cases of fulminant Wilson's disease subjected for orthotopic liver transplantation (OLT), a single bolus of rFVIIa 10 minutes before skin incision was given routinely in a median dose of 55.9 microg/kg. RESULTS:Median value of INR dropped from 3.1 to 1.2 30 minutes after rFVIIa administration. Transfusion requirements in those cases did not differ from standard transfusion requirements of PRBCs observed in elective OLTx in our center (6 units v. 5, respectively). Recurrent bleeding was noted in 1 patient with the rupture of aorta. One-year survival rate in the studied group was 85.7%. Thrombotic complications were noted in none of the patients. CONCLUSIONS:We conclude that preemptive use of rFVIIa allows performance of a broad surgical procedure without hemorrhagic complications and without increased risk of thromboembolic events in patients with severe coagulopathy.
journal_name
Ann Transplantjournal_title
Annals of transplantationauthors
Czuprynska MM,Wawrzynowicz-Syczewska M,Jureczko L,Andrzejewska J,Jarosz K,Trzebicki J,Pacholczyk M,Chmura A,Wojcicki Msubject
Has Abstractpub_date
2010-07-01 00:00:00pages
7-10issue
3eissn
1425-9524issn
2329-0358pii
881163journal_volume
15pub_type
杂志文章abstract：BACKGROUND:Markers currently used to detect kidney damage are effective in both early (KIM-1, NGAL) and late (MCP-1, MMP, TIMP) stages of renal tubular damage, indicating the progression of chronic kidney disease. Immunosuppressive drugs may damage the transplanted organ through their direct toxic effects and by contri...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/aot.895275
更新日期：2016-03-03 00:00:00
abstract：:Solid organ transplantation program in Poland is very limited. The main reason of this is organ shortage. All the organs procured are transplanted. It is a general feeling that recently issued legal regulations will favorably influence organ donation, however the improvement may be expected within a few years and will...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：UNLABELLED:In spite of progress in biotechnology, isolation of porcine pancreatic islets remains a difficult task with unpredictable results. One reason could be the lack of knowledge as to the expression of extracellular matrix proteins in porcine exocrine and endocrine tissues, particularly in "islet capsules". Such ...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：BACKGROUND:Xenotransplantation from pig to humans may be associated with the risk of transmission of porcine endogenous retroviruses (PERVs) that are present in the genome of all pigs and that infect human cells in vitro. However, it remains unclear whether PERVs infect transplant recipients in vivo and, if so, whether...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND:This study evaluated the effect of liver transplantation (LTX) and STACE on overall survival in palliative patients with HCC exceeding Milan criteria. MATERIAL AND METHODS:At a single center 63 HCC patients exceeding Milan criteria were retrospectively analyzed. Forty patients underwent STACE as palliative ...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/AOT.884018
更新日期：2013-10-01 00:00:00
abstract：:Over the last decade significant improvement in patient and graft survival has been observed after liver transplantation for hepatitis B virus (HBV)-related liver disease, mostly because of efficient prophylaxis against hepatitis B reinfection. This review discusses different approches in prevention of hepatitis B rec...
journal_title：Annals of transplantation
pub_type： 杂志文章,评审
doi：
更新日期：2005-01-01 00:00:00
abstract：BACKGROUND:Intraoperative circulatory risk factors are associated with unfavorable outcomes after living donor liver transplantation (LDLT). We investigated whether the preoperative neutrophil-to-lymphocyte ratio (NLR) can predict intraoperative circulatory risks. MATERIAL AND METHODS:The perioperative data of 276 pat...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/AOT.894048
更新日期：2015-07-21 00:00:00
abstract：:The aim of the report is to present successful surgical treatment of aneurysm of common iliac artery (CIA) and internal iliac artery (IIA) in a kidney transplant patient. The aneurysm of CIA and IIA, causing arterial hypertension, was diagnosed and treated surgically in a 47-year-old male patient, who had received a c...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：:Experience of Warsaw Pancreas Laboratory is presented. Some improvement in the methods of rat, human and pig pancreases digestion, and in identification of Langerhans islets by means of intravenous injection of I-DTZ was achieved. For immunoisolation of islets, 2 methods were elaborated: capsules containing alginate/p...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：BACKGROUND:As newer immunosuppressive regimens have steadily reduced in the incidence of acute rejection and have extended the life expectancy of allograft recipients, posttransplant de novo malignancies have become an important cause of death in cadaveric donor transplantation. Also, according with the recent accumula...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/aot.883230
更新日期：2012-04-01 00:00:00
abstract：BACKGROUND:Animal models to investigate pathophysiology and xenotransplantation require complex techniques and significant animal utilization. The aim of the study was to develop a reliable ex-vivo technique to test xenotransplant interventions. MATERIAL/METHODS:Miniature Swine being utilized for a nonsurvival study a...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：2011-01-01 00:00:00
abstract：BACKGROUND:To investigate whether the retroperitoneal or transperitoneal approach is preferable for right-sided laparoscopic donor nephrectomy (R-LDN). MATERIAL/METHODS:We retrospectively compared the donor and recipient outcomes of R-LDNs performed with a standard transperitoneal approach (n=21) or a semi-open retrop...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：2011-10-01 00:00:00
abstract：BACKGROUND:The early phase of MPA exposure has rarely been investigated after solid organ transplantation, especially in heart transplantation patients. We evaluated the association between exposure to mycophenolic acid (MPA), a main metabolite of mycophenolate mofetil (MMF), and clinical events within 3 months after h...
journal_title：Annals of transplantation
pub_type： 临床试验,杂志文章
doi：10.12659/AOT.883812
更新日期：2013-02-05 00:00:00
abstract：BACKGROUND:Fungal infections have a significant impact on patient survival after liver transplantation, mostly caused by Candida and Aspergillus. The clinical manifestations vary, and range from colonization, active local infection, to severe invasive form. A high degree of suspicion is required for the early diagnosis...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/AOT.892132
更新日期：2014-12-22 00:00:00
abstract：BACKGROUND:Despite observed huge progress in understanding the immunological basis of transplantation and the development of new immunosuppressive agents that have significantly improved both -- the patient and graft survival, still the kidney donation from live volunteers remains the most consistent factor which affec...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
abstract：OBJECTIVE:Extensive stricture of ureter still poses a difficult challenge for urologic surgons, especially when its middle part is affected. We present a reconstructive method of long ureteral strictures with use of xenogenic collagen membranes as a scaffolding to promote new tissue growth in the area of extensive uret...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：:Organ transplantation program has been slowly developing over last 30 years. The number of DD (deceased donors) stabilized on the level of approximately 13/million of population. Multiorgan donation has been 45%, due to some problems with donor management. Polish Transplant Coordinating Center POLTRANSPLANT which is r...
journal_title：Annals of transplantation
pub_type： 社论
doi：
更新日期：2007-01-01 00:00:00
abstract：:BACKGROUND The purpose of this study was to assess the effect of an organ transplantation scandal on the rate of corneal donations and organ donors at the University Hospital Tübingen. MATERIAL AND METHODS Data from all hospital deaths from January 2012 to December 2013 were analyzed retrospectively. Each deceased pat...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/aot.901385
更新日期：2017-07-11 00:00:00
abstract：:BACKGROUND Organ transplantation is one of the most critical topics in medical ethics that is commonplace in various countries. This study aimed to evaluate the knowledge and the ethical issues surrounding organ transplantation and organ donation among healthcare personnel in Tehran, Iran. MATERIAL AND METHODS In a cr...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/AOT.908615
更新日期：2018-05-04 00:00:00
abstract：:HIV infection has been traditionally considered to be an absolute contraindication for solid organ transplantation. Recent advances in HIV treatment, as highly active antiretroviral therapy (HAART), significantly reduced HIV-related mortality and morbidity. At the same time the number of HIV-infected patients with end...
journal_title：Annals of transplantation
pub_type： 杂志文章,评审
doi：
更新日期：2003-01-01 00:00:00
abstract：BACKGROUND:Living liver donation is associated with size-dependent complications. The resectable size and its safety margin should be defined for the safety of donors. The purpose of the present study was to determine if the current partial hepatectomies are done under the safety margin of the resectable size, by measu...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/AOT.892490
更新日期：2015-01-26 00:00:00
abstract：:The use of xenografts could relieve the chronically inadequate supply of human organs for transplantation, but doubts have been expressed about the general acceptability of transplanting animal organs into human. Some researchers and clinicians have chosen to ignore negative attitudes towards clinical xenotransplantat...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:BACKGROUND Perioperative monitoring and hemodynamic management after heterotopic thoracic cardiac xenotransplantation is challenging due to 2 independently beating hearts. Telemetry allows continuous monitoring of hemodynamic parameters of both the donor and recipient hearts. We describe our experience and report on t...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/AOT.909522
更新日期：2018-07-20 00:00:00
abstract：:BACKGROUND TruGraf is a blood-based biomarker test that measures differential expression of a collection of genes that have been shown to correlate with surveillance biopsy results. However, in the majority of U.S. transplant centers, surveillance biopsies are not performed. The objectives of this study were to evalua...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/AOT.920839
更新日期：2020-04-28 00:00:00
abstract：BACKGROUND:The results of pancreas transplantation depend in a large degree on appropriate pancreas allograft donor selection. Several risk factors of early surgical complications or pancreas allograft loss following transplantation have been identified, but the final decision on pancreas harvesting for transplantation...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/aot.894464
更新日期：2015-11-03 00:00:00
abstract：BACKGROUND:Morbid obesity is associated with liver pathology, most commonly non-alcoholic steatohepatitis (NASH) leading to cirrhosis. However, the morbid obesity impedes qualification for organ transplantation. CASE REPORT:We present a case report of a 56-year-old woman who underwent bariatric procedure followed by l...
journal_title：Annals of transplantation
pub_type： 杂志文章,评审
doi：10.12659/AOT.893797
更新日期：2015-02-25 00:00:00
abstract：:BACKGROUND Autologous stem cell transplantation (ASCT) has become a standard procedure in multiple myeloma (MM) patients. Cryopreservation (CRYO) of stem cells may be associated with adverse reactions of dimethyl sulfoxide. Previous studies showed that stem cell storage at 4°C (non-cryopreserved [NC] method) may have ...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/AOT.927084
更新日期：2020-12-11 00:00:00
abstract：BACKGROUND:Antibody-mediated rejection (AMR), associated with the presence of C4d deposits, is well-defined in kidney transplantation but much less documented in liver transplantation (LTx). The aim of our study was to retrospectively analyze a group of pediatric liver transplant recipients who experienced episodes of ...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/AOT.889921
更新日期：2014-03-04 00:00:00
abstract：:The draft of the working group of experts for a Recommendation of the Committee of Ministers to Member States on Xenotransplantation was finalized in September 2001, ending a working period of two and a half years. This paper will briefly reflect upon the development of the recommendation up to this point in time. A s...
journal_title：Annals of transplantation
pub_type： 指南,杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：:BACKGROUND Laparoscopic donor nephrectomy (LDN) has evolved and has been established as a surgical standard of care for kidney transplantation. MATERIAL AND METHODS This study retrospectively reviews 1132 patients who underwent 4 different laparoscopic living-donor nephrectomies: hand-assisted laparoscopic nephrectomy...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/AOT.918189
更新日期：2020-02-11 00:00:00
