Attitudes to xenotransplantation: scientific enthusiasm, assumptions and evidence.

Abstract:

:The use of xenografts could relieve the chronically inadequate supply of human organs for transplantation, but doubts have been expressed about the general acceptability of transplanting animal organs into human. Some researchers and clinicians have chosen to ignore negative attitudes towards clinical xenotransplantation, assuming that people will automatically embrace this new technology when it becomes available. A review of eight studies of attitudes to xenotransplantation did not reveal overwhelming support for it. Particularly negative views were expressed by acute care nurses. Primates have been the donors of choice in clinical xenotransplantation to date, but their continued use is a highly contentious option; the preferred animal donor is now clearly the pig. Animal farming for xenotransplantation is generally regarded as acceptable since animals provide food for man and are an accepted source of items for human use such as heart valves and insulin. Open debate about xenotransplantation must now take place, and present attitudes may change as a result of this. However, it remains to be seen whether xenografts will be widely accepted and used, and the extent to which the chronic shortage of organs for transplantation will thereby be alleviated.

journal_name

Ann Transplant

authors

Mohacsi PJ,Thompson JF,Quine S

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

38-45

issue

2

eissn

1425-9524

issn

2329-0358

journal_volume

3

pub_type

杂志文章
  • Day 1 post-operative fasting hyperglycemia may affect graft survival in kidney transplantation.

    abstract:BACKGROUND:Early post-operative hyperglycemia is commonly encountered in patients without pre-existing diabetes mellitus who are undergoing kidney transplantation. The aim of this study was to determine the effect of early post-operative hyperglycemia on graft and patient survival after kidney transplantation in our ce...

    journal_title:Annals of transplantation

    pub_type: 杂志文章

    doi:10.12659/AOT.883937

    authors: Kek PC,Tan HC,Kee TY,Goh SY,Bee YM

    更新日期:2013-06-07 00:00:00

  • Assessment of the willingness of potential live related kidney donors.

    abstract::Even in the case of live related kidney donation, coercion within families is applied on the most vulnerable amongst them. This vulnerability could be financial, social or psychological In this paper we discuss how to assess the willingness or unwillingness of a kidney donor and discover if any coercion has been appli...

    journal_title:Annals of transplantation

    pub_type: 杂志文章

    doi:

    authors: Al-Khader A,Jondeby M,Ghamdi G,Flaiw A,Hejaili F,Querishi J

    更新日期:2005-01-01 00:00:00

  • Prevention of hepatitis B recurrence after liver transplantation.

    abstract::Over the last decade significant improvement in patient and graft survival has been observed after liver transplantation for hepatitis B virus (HBV)-related liver disease, mostly because of efficient prophylaxis against hepatitis B reinfection. This review discusses different approches in prevention of hepatitis B rec...

    journal_title:Annals of transplantation

    pub_type: 杂志文章,评审

    doi:

    authors: Polak WG,Gładysz A,Rotter K

    更新日期:2005-01-01 00:00:00

  • Serum electrolyte changes at engraftment time in patients undergoing allogeneichematopoietic stem cell transplantation.

    abstract:BACKGROUND:Metabolic abnormalities have been reported in patients undergoing hematopoietic stem cell transplantation (HSCT). Potential causes, risk factors and outcomes of electrolyte imbalances have thoroughly been investigated. On HSCT recipients, multiple pathophysiologic contributors are inflicting electrolyte abno...

    journal_title:Annals of transplantation

    pub_type: 杂志文章

    doi:

    authors: Faghihi T,Iravani M,Shamshiri AR,Hadjibabaie M,Mousavi SA,Alimoghaddam K,Ghavamzadeh A

    更新日期:2009-07-01 00:00:00

  • Expression pattern of extracellular matrix proteins in the pancreas of various domestic pig breeds, the Goettingen Minipig and the Wild Boar.

    abstract:UNLABELLED:In spite of progress in biotechnology, isolation of porcine pancreatic islets remains a difficult task with unpredictable results. One reason could be the lack of knowledge as to the expression of extracellular matrix proteins in porcine exocrine and endocrine tissues, particularly in "islet capsules". Such ...

    journal_title:Annals of transplantation

    pub_type: 杂志文章

    doi:

    authors: Meyer T,Czub S,Chodnewska I,Beutner U,Hamelmann W,Klöck G,Zimmermann U,Thiede A,Ulrichs K

    更新日期:1997-01-01 00:00:00

  • An overview of legal aspects in organ transplantation--what are the family rights?

    abstract::A short review of legal aspects of organ transplantation. The influence of type of consent and the family attitude on organ donation rate in all European countries. A special attention is given to the legal and ethical aspects of living organ and tissue transplantation. ...

    journal_title:Annals of transplantation

    pub_type: 杂志文章

    doi:

    authors: Aigner G

    更新日期:2004-01-01 00:00:00

  • No transmission of porcine endogenous retroviruses (PERVs) in a long-term pig to rat xenotransplantation model and no infection of immunosuppressed rats.

    abstract:BACKGROUND:Xenotransplantation from pig to humans may be associated with the risk of transmission of porcine endogenous retroviruses (PERVs) that are present in the genome of all pigs and that infect human cells in vitro. However, it remains unclear whether PERVs infect transplant recipients in vivo and, if so, whether...

    journal_title:Annals of transplantation

    pub_type: 杂志文章

    doi:

    authors: Denner J,Specke V,Karlas A,Chodnevskaja I,Meyer T,Moskalenko V,Kurth R,Ulrichs K

    更新日期:2008-01-01 00:00:00

  • Reduction of Cold Ischemia Time and Anastomosis Time Correlates with Lower Delayed Graft Function Rates Following Transplantation of Marginal Kidneys.

    abstract::BACKGROUND In kidney transplantation, the association of cold ischemia time (CIT), anastomosis time (AT), and delayed graft function (DGF) is particularly detrimental in grafts from marginal donors; however, actual cut-off criteria are still debated. MATERIAL AND METHODS Data from patients >65 years (n=193) and patien...

    journal_title:Annals of transplantation

    pub_type: 杂志文章

    doi:10.12659/aot.896672

    authors: Denecke C,Biebl M,Fritz J,Brandl A,Weiss S,Dziodzio T,Aigner F,Sucher R,Bösmüller C,Pratschke J,Öllinger R

    更新日期:2016-05-31 00:00:00

  • Living Donor Liver Transplantation in Acute Liver Failure Patients with Grade IV Encephalopathy: Is Deep Hepatic Coma Still an Absolute Contraindication? A Successful Single-Center Experience.

    abstract::BACKGROUND The prognosis of the patients of acute liver failure (ALF) with onset of hepatic coma is often dismal. ALF is a well-accepted indication for liver transplantation (LT) and has markedly improved the prognosis of these patients. However, its role in ALF patients with onset of hepatic coma has never been eluci...

    journal_title:Annals of transplantation

    pub_type: 杂志文章

    doi:

    authors: Yang HR,Thorat A,Jeng LB,Hsu SC,Li PC,Yeh CC,Chen TH,Poon KS

    更新日期:2018-03-13 00:00:00

  • Costs of Long-Term Post-Transplantation Care in Kidney Transplant Recipients.

    abstract::BACKGROUND Solid organ transplantations lead to improvements in patient survival and patient quality of life, as well as health care system economic benefits. However, over time, health problems can accumulate post-transplantation. Therefore, we hypothesized that in the late post-transplantation period, the costs of p...

    journal_title:Annals of transplantation

    pub_type: 杂志文章

    doi:10.12659/AOT.914661

    authors: Łabuś A,Niemczyk M,Czyżewski Ł,Fliszkiewicz M,Kulesza A,Mucha K,Pączek L

    更新日期:2019-05-07 00:00:00

  • The effect of The World Transplant Games on transplant rates in five continents.

    abstract::This paper outlines the effect that the Transplant Games have had in influencing public opinion and the translation of that effect resulting in increased organ donation and transplantation in the global venues in which this activity took place. A brief account of the history of the Transplant Games now 25 years after ...

    journal_title:Annals of transplantation

    pub_type: 杂志文章

    doi:

    authors: Slapak M

    更新日期:2004-01-01 00:00:00

  • Split liver transplantation (SLT).

    abstract:OBJECTIVES:In the last three decades liver transplantation (LT) has become a standard procedure for terminal liver failure. Anyway the procedure is highly limited by the availability of donor organs. The use of segmental liver grafts from living or cadaver donors are an attractive way to increase the donor pool for LT ...

    journal_title:Annals of transplantation

    pub_type: 杂志文章,评审

    doi:

    authors: Gundlach M,Topp S,Bröring D,Rogiers X

    更新日期:2000-01-01 00:00:00

  • Ano-genital neoplasia in renal transplant patients.

    abstract::Ano-genital neoplasia is about 20 x more common in renal transplant patients than the general population. Neoplasms in the immunosuppressed are more morbid and mortal because: patients are younger; tumors are more undifferentiated; they have more and larger foci; more sites are involved; neoplasms tend to persist, rec...

    journal_title:Annals of transplantation

    pub_type: 杂志文章,评审

    doi:

    authors: Sillman FH,Sentovich S,Shaffer D

    更新日期:1997-01-01 00:00:00

  • Gastric subserous space islet transplantation: techniques and initial results in diabetic inbred Lewis rats.

    abstract:BACKGROUND:Implantation site is an important factor affecting the effect of islet transplantation. In the literature, the gastric subserous space (GSS) is rarely used as the implantation site of islets. Our present study reports the initial results with a limited numbers of islets transplanted into the GSS in Lewis rat...

    journal_title:Annals of transplantation

    pub_type: 杂志文章

    doi:10.12659/AOT.890744

    authors: Liu X,Zhang J,Li Y,Hu S,Zhang G,Wang L

    更新日期:2014-07-11 00:00:00

  • Cobalt 60 versus 15 MeV photons during total body irradiation: doses in the critical organs and complexicity of the procedure.

    abstract:OBJECTIVES:The aim of this work was to compare the doses in critical organs, treatment duration, patient comfort and personnel workload during total body irradiation carried out alternatively with a Cobalt 60 and with 15 MeV photons at linear accelerator. PATIENTS AND METHODS:Twenty consecutive patients irradiated wit...

    journal_title:Annals of transplantation

    pub_type: 临床试验,杂志文章

    doi:

    authors: Malicki J,Kosicka G,Stryczyńska G,Wachowiak J

    更新日期:2001-01-01 00:00:00

  • New Perspectives on Treatment of Hepatitis B Before and After Liver Transplantation.

    abstract::The hepatitis B virus (HBV) infects more than 260 million people globally, with increasing incidence, especially in developing countries. Despite antiviral therapies, HBV-related end-stage liver disease remains one of the most important indications for liver transplantation worldwide. Although new available treatments...

    journal_title:Annals of transplantation

    pub_type: 杂志文章,评审

    doi:10.12659/aot.900216

    authors: Zanetto A,Ferrarese A,Bortoluzzi I,Burra P,Russo FP

    更新日期:2016-10-14 00:00:00

  • Physical activity long-term after liver transplantation yields better quality of life.

    abstract:BACKGROUND:Transplantation is the only effective method of treatment for end-stage and acute liver failure. Increased average survival time has been observed, and results from improved surgical technique and amended immunosuppression protocols. However, longer survival of patients after orthotopic liver transplantation...

    journal_title:Annals of transplantation

    pub_type: 杂志文章

    doi:10.12659/aot.882005

    authors: Rongies W,Stepniewska S,Lewandowska M,Smolis-Bak E,Dolecki W,Sierdzinski J,Trzepla E,Cholewinska G,Stankiewicz W

    更新日期:2011-07-01 00:00:00

  • Excellent outcome of renal transplantation using single old kidneys in old recipients.

    abstract::Aim of this monocentric study is to compare the outcome of 101 renal transplants performed in patients older than 55 years with single kidney retrieved from donors older than 50 years, with 263 transplants performed in patients younger than 55 years transplanted with young kidneys. Delayed graft function (DGF) had sim...

    journal_title:Annals of transplantation

    pub_type: 杂志文章

    doi:

    authors: Bertoni E,Rosati A,Zanazzi M,Di Maria L,Becherelli P,Gallo M,Salvadori M

    更新日期:2004-01-01 00:00:00

  • Malignant diverticulitis of the left colon complicating heart transplantation.

    abstract:BACKGROUND:Colonic diverticular disease is rare in developing nations but common in Western and industrialized societies. Many studies show that heart and lung transplantation increase the risk of having severe diverticulitis, although the exact magnitude of this risk remain unclear because many of these studies have b...

    journal_title:Annals of transplantation

    pub_type: 杂志文章

    doi:

    authors: Pagano D,Cintorino D,Gruttadauria S,Spada M,Echeverri G,Botrugno I,di Francesco F,Li Petri S,Gridelli B

    更新日期:2010-07-01 00:00:00

  • The APACHE III score as preoperative indicator of patient outcome in liver transplantation after fulminant hepatic failure.

    abstract:BACKGROUND:Given the current organ shortage, an accurate assessment of the patient's outcome after orthotopic liver transplantation (OLTX) for fulminant hepatic failure (FHF) is crucial in order to determine the suitability for transplantation. The purpose of this study was to assess whether APACHE II and III scores wo...

    journal_title:Annals of transplantation

    pub_type: 杂志文章

    doi:

    authors: Fikatas P,Ulrich F,Lee JE,Sauer IM,Chopra S,Schmidt SC,Pascher A,Pratschke J

    更新日期:2011-01-01 00:00:00

  • Transplant Nurses' Work Environment: A Cross-Sectional Multi-Center Study.

    abstract::BACKGROUND Numerically, nurses represent the largest healthcare profession, thus setting norms for the quality and safety of direct patient care. Evidence of a global shortage of nurses in all clinical practice settings across different healthcare systems and countries has been documented. The aims of the present stud...

    journal_title:Annals of transplantation

    pub_type: 杂志文章,多中心研究

    doi:10.12659/aot.898305

    authors: Kugler C,Akca S,Einhorn I,Rebafka A,Russell CL

    更新日期:2016-09-01 00:00:00

  • Comparision of benefits of early, delayed, and no administration of G-CSF after autologous peripheral blood stem cell transplantation in lymphoma patients.

    abstract:BACKGROUND:Autologous peripheral blood stem cell transplantation (PBSCT) is commonly used in the treatment of lymphoma patients. G-CSF is widely used to boost white blood cell recovery. However, there are no clear data indicating which strategy of using G-CSF provides the most benefit. The aim of our study was to compa...

    journal_title:Annals of transplantation

    pub_type: 杂志文章,多中心研究

    doi:10.12659/AOT.883965

    authors: Wyleżoł I,Snarski E,Markiewicz M,Kyrcz-Krzemień S,Jędrzejczak WW,Walewski J

    更新日期:2013-07-02 00:00:00

  • A case of gastric cancer after living donor liver transplantation.

    abstract:BACKGROUND:As newer immunosuppressive regimens have steadily reduced in the incidence of acute rejection and have extended the life expectancy of allograft recipients, posttransplant de novo malignancies have become an important cause of death in cadaveric donor transplantation. Also, according with the recent accumula...

    journal_title:Annals of transplantation

    pub_type: 杂志文章

    doi:10.12659/aot.883230

    authors: Shimizu T,Hayashi M,Inoue Y,Komeda K,Asakuma M,Hirokawa F,Miyamoto Y,Tanigawa N,Uchiyama K

    更新日期:2012-04-01 00:00:00

  • ABO-Incompatible Living Donor Liver Transplantation with Reduced Rituximab Dose: A Retrospective Analysis of 65 Patients - Can We Fast-Track Liver Transplant Surgery and Improve Long-Term Survival?

    abstract::BACKGROUND ABO-incompatible (ABO-i) living donor liver transplantation (LDLT) is a feasible alternative for donor liver allograft in emergency situations, especially in Asia, where deceased-donor organs remain scarce. The reported outcomes of ABO-i LDLT after optimal desensitization are comparable to those of ABO-comp...

    journal_title:Annals of transplantation

    pub_type: 杂志文章

    doi:10.12659/AOT.923502

    authors: Hsu SC,Thorat A,Jeng LB,Li PC,Chen TH,Yang HR,Poon KS

    更新日期:2020-09-18 00:00:00

  • Transplantation in adults with primary hyperoxaluria: single unit experience and treatment algorithm.

    abstract:BACKGROUND:Kidney transplantation alone in Primary Hyperoxaluria is associated with a high rate of recurrence and in many cases early graft loss. Liver transplantation offers the possibility of correcting the metabolic defect. MATERIAL/METHODS:A retrospective review of five cases of Primary Hyperoxaluria managed at a ...

    journal_title:Annals of transplantation

    pub_type: 杂志文章

    doi:10.12659/aot.882227

    authors: Malde DJ,Pararajasingam R,Tavakoli A,Campbell B,Riad H,Parrot N,Prasad KR,Augustine T

    更新日期:2011-10-01 00:00:00

  • Long term medical and economical benefit of machine perfusion (MP) kidney storage in comparison to cold storage (CS).

    abstract:BACKGROUND:Despite documented positive effect of MachinePerfusion (MP) on long-term kidneys-graft function its wide use is restricted due to higher costs. The aim of this study was to analyze the difference in costs of kidney transplantation in patients who received organ stored in ColdStorage (CS) vs those who receive...

    journal_title:Annals of transplantation

    pub_type: 杂志文章

    doi:

    authors: Wszola M,Kwiatkowski A,Latek M,Ostrowski K,Domagala P,Ciszek M,Trzebicki J,Durlik M,Chmura A,Rowinski W

    更新日期:2009-04-01 00:00:00

  • Pre transplant serum magnesium level predicts outcome after pediatric living donor liver transplantation.

    abstract:BACKGROUND:Hypomagnesaemia is a frequent complication after liver transplantation (LTx) however; magnesium is not routinely replaced in the perioperative period. MATERIAL/METHODS:The incidence of hypomagnesaemia before and after pediatric LTx was studied in 673 pediatric patients who underwent living-donor liver trans...

    journal_title:Annals of transplantation

    pub_type: 杂志文章

    doi:10.12659/aot.883220

    authors: Elgend HM,El Moghazy WM,Uemoto S,Fukuda K

    更新日期:2012-04-01 00:00:00

  • The Donor-Risk-Index, ECD-Score and D-MELD-Score all fail to predict short-term outcome after liver transplantation with acceptable sensitivity and specificity.

    abstract:BACKGROUND:Expansion of the donor pool by the use of grafts with extended donor criteria reduces waiting list mortality with an increased risk for graft and patient survival after liver transplantation. This study investigates the ability of the Donor-Risk-Index (DRI), the Extended-Criteria-Donor-Score (ECD-score) and ...

    journal_title:Annals of transplantation

    pub_type: 杂志文章

    doi:10.12659/aot.883452

    authors: Schrem H,Reichert B,Frühauf N,Becker T,Lehner F,Kleine M,Bektas H,Zachau L,Klempnauer J

    更新日期:2012-07-01 00:00:00

  • Outcomes of Non-Cryopreserved Versus Cryopreserved Peripheral Blood Stem Cells for Autologous Stem Cell Transplantation in Multiple Myeloma.

    abstract::BACKGROUND Autologous stem cell transplantation (ASCT) has become a standard procedure in multiple myeloma (MM) patients. Cryopreservation (CRYO) of stem cells may be associated with adverse reactions of dimethyl sulfoxide. Previous studies showed that stem cell storage at 4°C (non-cryopreserved [NC] method) may have ...

    journal_title:Annals of transplantation

    pub_type: 杂志文章

    doi:10.12659/AOT.927084

    authors: Piriyakhuntorn P,Tantiworawit A,Rattanathammethee T,Hantrakool S,Chai-Adisaksopha C,Rattarittamrong E,Norasetthada L

    更新日期:2020-12-11 00:00:00

  • Toxic tacrolimus blood levels with rifampin administration in a renal transplant recipient.

    abstract:BACKGROUND:Induction of the hepatic and intestinal cytochrome P450-3A4 system and intestinal P-glycoprotein is an unavoidable consequence of rifampin administration which requires substantial increase in tacrolimus dose when given concurrently. Chronic diarrhea is known to precipitate tacrolimus toxicity irrespective o...

    journal_title:Annals of transplantation

    pub_type: 杂志文章

    doi:

    authors: Abdel Halim M,Al-Otaibi T,Gheith O,El-Kholy O,Abdel Tawab K,Said T,Nair P,Nampoory MR

    更新日期:2010-01-01 00:00:00