Abstract:
BACKGROUND:Metabolic abnormalities have been reported in patients undergoing hematopoietic stem cell transplantation (HSCT). Potential causes, risk factors and outcomes of electrolyte imbalances have thoroughly been investigated. On HSCT recipients, multiple pathophysiologic contributors are inflicting electrolyte abnormalities, with special attention being paid to engraftment per se as an important contributor. Engraftment contribution to electrolyte imbalances has been reported for hypophosphatemia and for other electrolyte abnormalities in autologous setting. However in the allogeneic setting serum electrolyte level changes and the timing of any probable abnormality are unknown. MATERIAL AND METHODS:We performed a retrospective study in order to evaluate the pattern of phosphorous, magnesium, potassium and uric acid serum changes, timing of any probable abnormality and their possible association with WBC and platelet engraftment in 65 allogeneic HCT recipients from day -9 to +32 after transplantation. Besides we assessed frequency and severity of the abnormalities. RESULTS:We observed a declining pattern of electrolyte concentrations with nadirs antedating WBC and platelet engrafments. Phosphorous and potassium serum changes were correlated with natural logarithm of WBC and platelet level changes. Observed overall incidence of hypophosphatemia (9.2%) and hypomagnesemia (3%) was lower than those previously reported. CONCLUSION:Abnormalities found reflect a combination of pathophysiologic mechanisms. Occurrence of electrolyte nadirs antedating engraftment confirms increased consumption by rapidly replicating cells as a contributor in allogeneic setting and specifies a susceptible period requiring intensive monitoring. Considering high risk patients and managing various organ system complications lower incidence of some electrolyte abnormalities may be observed.
journal_name
Ann Transplantjournal_title
Annals of transplantationauthors
Faghihi T,Iravani M,Shamshiri AR,Hadjibabaie M,Mousavi SA,Alimoghaddam K,Ghavamzadeh Asubject
Has Abstractpub_date
2009-07-01 00:00:00pages
51-7issue
3eissn
1425-9524issn
2329-0358pii
891822journal_volume
14pub_type
杂志文章abstract::Recovery of the patients after transplantation of non-renal organs may be complicated by multi-faceted chronic renal failure (CKD) which is regarded as an independent risk factor of graft dysfunction and mortality. The occurrence of CKD in non-renal transplant recipients depends mainly on a type of transplanted organ,...
journal_title:Annals of transplantation
pub_type: 杂志文章,评审
doi:
更新日期:2005-01-01 00:00:00
abstract::Advances in molecular biology techniques allowed for introduction of PCR-based methods for HLA typing. In routine HLA typing for organ transplantation serological method is still being used as a standard, although molecular techniques are applied more and more often. The aim of our study was to compare HLA-DR typing u...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::BACKGROUND The incidence of surgical complications after kidney transplantation ranges from 10-25%. The purpose of this study was to evaluate if the application of fibrin glue as a preventive agent reduces surgical morbidity after a living-related-donor kidney transplantation. MATERIAL AND METHODS A controlled clinica...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/aot.899821
更新日期:2016-09-20 00:00:00
abstract:OBJECTIVE:The Czech Bone Marrow Donor Registry (CBMD)--established 9 years ago, operates within the National HLA Centre, a constituent part of the Department of Immunology at the Institute for Clinical and Experimental Medicine. The Czech Cord Blood Register (CSCB) was recently established (in 1996) and started its act...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
abstract::BACKGROUND Perioperative monitoring and hemodynamic management after heterotopic thoracic cardiac xenotransplantation is challenging due to 2 independently beating hearts. Telemetry allows continuous monitoring of hemodynamic parameters of both the donor and recipient hearts. We describe our experience and report on t...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/AOT.909522
更新日期:2018-07-20 00:00:00
abstract:BACKGROUND:To investigate whether the retroperitoneal or transperitoneal approach is preferable for right-sided laparoscopic donor nephrectomy (R-LDN). MATERIAL/METHODS:We retrospectively compared the donor and recipient outcomes of R-LDNs performed with a standard transperitoneal approach (n=21) or a semi-open retrop...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:Autologous peripheral blood stem cell transplantation (PBSCT) is commonly used in the treatment of lymphoma patients. G-CSF is widely used to boost white blood cell recovery. However, there are no clear data indicating which strategy of using G-CSF provides the most benefit. The aim of our study was to compa...
journal_title:Annals of transplantation
pub_type: 杂志文章,多中心研究
doi:10.12659/AOT.883965
更新日期:2013-07-02 00:00:00
abstract::Over the last decade significant improvement in patient and graft survival has been observed after liver transplantation for hepatitis B virus (HBV)-related liver disease, mostly because of efficient prophylaxis against hepatitis B reinfection. This review discusses different approches in prevention of hepatitis B rec...
journal_title:Annals of transplantation
pub_type: 杂志文章,评审
doi:
更新日期:2005-01-01 00:00:00
abstract::The Kidney Donor Risk Index (KDRI) and Kidney Donor Profile Index (KDPI) assist clinicians with the selection of deceased donor kidneys. This scoring system is based on 10 donor factors including Hepatitis C virus (HCV) status from serological or NAT testing. The donor HCV status (i.e., having either a positive hepati...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/aot.905428
更新日期:2017-11-06 00:00:00
abstract:BACKGROUND:Anti-CMV prophylaxis is currently a routine management in patients after organ transplantation. One of the clinical symptoms of CMV infection may be lesions in the oral cavity.The aim of this study was to determine the relationship between CMV infection, occurrence of Candida species and presence of oral muc...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
abstract::BACKGROUND Diffuse thrombosis of iliac veins and IVC has been considered a significant technical obstacle in pediatric kidney transplantation (KT). MATERIAL AND METHODS Between 1984 and 2018, 951 KTs were performed in our institution. In 4 children qualified for KT, diffuse thrombosis of iliac veins or IVC was found. T...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/AOT.912657
更新日期:2019-01-11 00:00:00
abstract:BACKGROUND:We report our contemporary experiences with renal autotransplantation in patients with complicated renal vascular diseases and/or complex ureteral injuries. Since its first performance, renal autotransplantation has been steadily improved and become a safe and effective procedure. MATERIAL/METHODS:Between 1...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/aot.883690
更新日期:2012-12-31 00:00:00
abstract:BACKGROUND:Significant geographic disparities exist in access to liver transplantation and consequently the current liver allocation system is being challenged. We sought to describe our unique experience with using organs with long cold ischemia times from the largest donation service area. MATERIAL AND METHODS:From ...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/aot.896190
更新日期:2016-03-08 00:00:00
abstract:BACKGROUND:Graft-versus-host disease (GvHD) is the most important complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT) responsible for increased mortality. Recent studies have discussed the use of oral GvHD screening tests in the diagnosis of systemic GvHD. This is the first study of the si...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/aot.883462
更新日期:2012-07-01 00:00:00
abstract:OBJECTIVES:Aim of the study was to assess frequency and risk factors of steroid resistant cellular rejection (SRR) in heart transplant recipients, to determine methods of its treatment, and to evaluate influence of steroid resistant rejection and method of its treatment on short- and long-term results. METHODS:All pts...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract::Irrespectively of universal shortage of donor organs there is a tendency of increasing the number of transplantations from living and deceased donors. Each of these two methods has positive and negative features. The main obstacles using living donors are health hazard, necessity to solve certain donor's social and ps...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract::BACKGROUND The purpose of this study was to assess the effect of an organ transplantation scandal on the rate of corneal donations and organ donors at the University Hospital Tübingen. MATERIAL AND METHODS Data from all hospital deaths from January 2012 to December 2013 were analyzed retrospectively. Each deceased pat...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/aot.901385
更新日期:2017-07-11 00:00:00
abstract::Stem cell research seems now to reach important progress in biomedicine, giving promising perspective for clinical implementation. The review of stem cell research is presented including origin, content in various organs, harvesting, preservation and storage. Some examples of results achieved in stem cell research inc...
journal_title:Annals of transplantation
pub_type: 杂志文章,评审
doi:
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Sirolimus is a potent immunosuppressive drug that has been shown to decrease the incidence of rejection post renal transplantation. Dyslipidemia is a well recognized side effect of sirolimus therapy, which may have an impact on patient survival and post-transplant cardiac morbidity and mortality. It is unkno...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
abstract::Between August 2006 and August 2009, 34 ethnic Mongolians were the recipients of a kidney transplant at the Central Clinical Hospital in Ulaanbaatar, Mongolia. In 31 of the operations the donor was either a sibling or parent. In 4 recipients the donors were 2 recently deceased accident victims following controlled car...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/aot.882647
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:This retrospective single-center study was undertaken to assess the occurrence of de novo neoplasms in renal transplant recipients according to the immunosuppressive regimen and time after transplantation. MATERIAL/METHODS:Observation encompassed 1028 patients transplanted between the years 1983-2006 and fo...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:2011-04-01 00:00:00
abstract::Experience of Warsaw Pancreas Laboratory is presented. Some improvement in the methods of rat, human and pig pancreases digestion, and in identification of Langerhans islets by means of intravenous injection of I-DTZ was achieved. For immunoisolation of islets, 2 methods were elaborated: capsules containing alginate/p...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract::Transplantation of liver has been remarkably effective in the treatment of liver failure and liver-based inherited metabolic diseases and has revolutionized the care of patients with end-stage liver disease. Unfortunately demand for transplantable livers is progressively outpacing the supply of donated cadaver organs,...
journal_title:Annals of transplantation
pub_type: 杂志文章,评审
doi:
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Expansion of the donor pool by the use of grafts with extended donor criteria reduces waiting list mortality with an increased risk for graft and patient survival after liver transplantation. This study investigates the ability of the Donor-Risk-Index (DRI), the Extended-Criteria-Donor-Score (ECD-score) and ...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/aot.883452
更新日期:2012-07-01 00:00:00
abstract:AIM OF THE STUDY:was to examine the influence of conversion from cyclosporine-based therapy to tacrolimus/mycophenolate mofetil (MMF) on renal graft survival in patients with refractory rejection and on the recurrence of rejection in patients converted at the time of the first episode of rejection. PATIENTS AND METHOD...
journal_title:Annals of transplantation
pub_type: 杂志文章,评审
doi:
更新日期:2006-01-01 00:00:00
abstract::BACKGROUND Acute graft-versus-host disease (aGVHD) remains the most common and challenging complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). An important obstacle to the therapeutic effect of aGVHD is the inability to identify risk factors for an individual patient at the onset of symp...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/aot.901495
更新日期:2017-02-03 00:00:00
abstract:BACKGROUND:Morbid obesity is associated with liver pathology, most commonly non-alcoholic steatohepatitis (NASH) leading to cirrhosis. However, the morbid obesity impedes qualification for organ transplantation. CASE REPORT:We present a case report of a 56-year-old woman who underwent bariatric procedure followed by l...
journal_title:Annals of transplantation
pub_type: 杂志文章,评审
doi:10.12659/AOT.893797
更新日期:2015-02-25 00:00:00
abstract::The liver immune function is associated with specific lymphocyte population transiently marginated in the liver sinusoids. These cells are of blood origin, however they are phenotypically and functionally different from peripheral blood lymphocytes. The question arises whether tumor proliferating in the liver can modi...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::Solid organ transplantation program in Poland is very limited. The main reason of this is organ shortage. All the organs procured are transplanted. It is a general feeling that recently issued legal regulations will favorably influence organ donation, however the improvement may be expected within a few years and will...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract::BACKGROUND ABO-incompatible (ABO-i) living donor liver transplantation (LDLT) is a feasible alternative for donor liver allograft in emergency situations, especially in Asia, where deceased-donor organs remain scarce. The reported outcomes of ABO-i LDLT after optimal desensitization are comparable to those of ABO-comp...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/AOT.923502
更新日期:2020-09-18 00:00:00