Abstract：
BACKGROUND:Given the current organ shortage, an accurate assessment of the patient's outcome after orthotopic liver transplantation (OLTX) for fulminant hepatic failure (FHF) is crucial in order to determine the suitability for transplantation. The purpose of this study was to assess whether APACHE II and III scores would provide prognosis of posttransplant mortality. MATERIAL/METHODS:The study included 129 patients with FHF who underwent OLTX between 1988 and 2008. APACHE II and III scores were calculated one day before transplantation and correlated with postoperative mortality. The cohort consisted of 42 males and 87 females with a mean age of 32 ± 17 years. RESULTS:Gender, age and etiology of FHF did not correlate with posttransplant survival (p=NS). The APACHE II score was not significantly higher amongst 30-day non-survivors (p = NS). Both patients who died during this period had a significantly higher APACHE III score compared to survivors (82 ± 19.4 vs. 62 ± 18, p<0.01). Patients with an APACHE III score > 68 had a significantly higher mortality rate (p<0.01). Cox regression analysis revealed the APACHE III score as a significant predictor of death (p<0.001). Each additional point in the APACHE III system raises the postoperative mortality by 3.1%. CONCLUSIONS:The major advantage of the APACHE III score is that its application and prognostic ability is independent from etiology of FHF. This accurate and reproducible evaluation system could be useful to identify patients with poor outcome.
journal_name
Ann Transplantjournal_title
Annals of transplantationauthors
Fikatas P,Ulrich F,Lee JE,Sauer IM,Chopra S,Schmidt SC,Pascher A,Pratschke Jsubject
Has Abstractpub_date
2011-01-01 00:00:00pages
18-25issue
1eissn
1425-9524issn
2329-0358pii
881634journal_volume
16pub_type
杂志文章abstract：:Transplantation of liver has been remarkably effective in the treatment of liver failure and liver-based inherited metabolic diseases and has revolutionized the care of patients with end-stage liver disease. Unfortunately demand for transplantable livers is progressively outpacing the supply of donated cadaver organs,...
journal_title：Annals of transplantation
pub_type： 杂志文章,评审
doi：
更新日期：2007-01-01 00:00:00
abstract：:BACKGROUND Acute graft-versus-host disease (aGVHD) remains the most common and challenging complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). An important obstacle to the therapeutic effect of aGVHD is the inability to identify risk factors for an individual patient at the onset of symp...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/aot.901495
更新日期：2017-02-03 00:00:00
abstract：BACKGROUND:Markers currently used to detect kidney damage are effective in both early (KIM-1, NGAL) and late (MCP-1, MMP, TIMP) stages of renal tubular damage, indicating the progression of chronic kidney disease. Immunosuppressive drugs may damage the transplanted organ through their direct toxic effects and by contri...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/aot.895275
更新日期：2016-03-03 00:00:00
abstract：:Successful kidney transplantation (KT) improves significantly the quality of life as compared with hemodialysis. Vocational rehabilitation and professional activity are the vital part of general rehabilitation and play an important role in determining the quality of life. The aim of this study was to evaluate the degr...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：:Human BK polyomavirus (BKV) infection is poorly documented in heart and lung transplant patients. BK viruria and viremia have been estimated to affect 19% and 5% of heart transplant recipients, respectively. Data are limited, especially for lung transplantation, but the proportion of patients progressing from BK virur...
journal_title：Annals of transplantation
pub_type： 杂志文章,评审
doi：10.12659/AOT.908429
更新日期：2018-05-11 00:00:00
abstract：BACKGROUND:We report, for the first time, the data on the outcome of kidney transplantation activities in the Afghan population from Iran. MATERIAL/METHOD:We extracted the demographic, clinical and the outcome related data of all Afghan kidney transplanted patients, from 1998 to April 2006, from the United Nations Hig...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：2010-04-01 00:00:00
abstract：:Irrespectively of universal shortage of donor organs there is a tendency of increasing the number of transplantations from living and deceased donors. Each of these two methods has positive and negative features. The main obstacles using living donors are health hazard, necessity to solve certain donor's social and ps...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：:BACKGROUND The incidence of surgical complications after kidney transplantation ranges from 10-25%. The purpose of this study was to evaluate if the application of fibrin glue as a preventive agent reduces surgical morbidity after a living-related-donor kidney transplantation. MATERIAL AND METHODS A controlled clinica...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/aot.899821
更新日期：2016-09-20 00:00:00
abstract：:BACKGROUND Solid organ transplantations lead to improvements in patient survival and patient quality of life, as well as health care system economic benefits. However, over time, health problems can accumulate post-transplantation. Therefore, we hypothesized that in the late post-transplantation period, the costs of p...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/AOT.914661
更新日期：2019-05-07 00:00:00
abstract：:Transplantation medicine, like no other medical specialty, is connected with a wide range of very difficult ethical issues. Among those are: availability of the treatment, consent for cadaveric donation, allocation of available organs, new categories of living unrelated donors and economic aspects of this method of tr...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：UNLABELLED:In spite of progress in biotechnology, isolation of porcine pancreatic islets remains a difficult task with unpredictable results. One reason could be the lack of knowledge as to the expression of extracellular matrix proteins in porcine exocrine and endocrine tissues, particularly in "islet capsules". Such ...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:The draft of the working group of experts for a Recommendation of the Committee of Ministers to Member States on Xenotransplantation was finalized in September 2001, ending a working period of two and a half years. This paper will briefly reflect upon the development of the recommendation up to this point in time. A s...
journal_title：Annals of transplantation
pub_type： 指南,杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：OBJECTIVES:The aim of this work was to compare the doses in critical organs, treatment duration, patient comfort and personnel workload during total body irradiation carried out alternatively with a Cobalt 60 and with 15 MeV photons at linear accelerator. PATIENTS AND METHODS:Twenty consecutive patients irradiated wit...
journal_title：Annals of transplantation
pub_type： 临床试验,杂志文章
doi：
更新日期：2001-01-01 00:00:00
abstract：BACKGROUND:To investigate whether the retroperitoneal or transperitoneal approach is preferable for right-sided laparoscopic donor nephrectomy (R-LDN). MATERIAL/METHODS:We retrospectively compared the donor and recipient outcomes of R-LDNs performed with a standard transperitoneal approach (n=21) or a semi-open retrop...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：2011-10-01 00:00:00
abstract：:The aim of the report is to present successful surgical treatment of aneurysm of common iliac artery (CIA) and internal iliac artery (IIA) in a kidney transplant patient. The aneurysm of CIA and IIA, causing arterial hypertension, was diagnosed and treated surgically in a 47-year-old male patient, who had received a c...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：BACKGROUND:Sulforaphane is a naturally occuring antioxidative and anti-inflammatory isothiocyanat. In this study, its impact on experimental kidney transplantation was evaluated. MATERIAL AND METHODS:Male Brown Norway rats (n=112) were used as experimental animals. Donor kidneys were harvested and stored for 12 hours ...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/AOT.884013
更新日期：2013-09-18 00:00:00
abstract：BACKGROUND:Intraoperative circulatory risk factors are associated with unfavorable outcomes after living donor liver transplantation (LDLT). We investigated whether the preoperative neutrophil-to-lymphocyte ratio (NLR) can predict intraoperative circulatory risks. MATERIAL AND METHODS:The perioperative data of 276 pat...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/AOT.894048
更新日期：2015-07-21 00:00:00
abstract：BACKGROUND:This study evaluated the effect of liver transplantation (LTX) and STACE on overall survival in palliative patients with HCC exceeding Milan criteria. MATERIAL AND METHODS:At a single center 63 HCC patients exceeding Milan criteria were retrospectively analyzed. Forty patients underwent STACE as palliative ...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/AOT.884018
更新日期：2013-10-01 00:00:00
abstract：:Advances in molecular biology techniques allowed for introduction of PCR-based methods for HLA typing. In routine HLA typing for organ transplantation serological method is still being used as a standard, although molecular techniques are applied more and more often. The aim of our study was to compare HLA-DR typing u...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:Ischemic reperfusion injury is a complex pathophysiological event associated with significant impairment of multiple vascular and cellular responses. Oxidative damage due to the presence of radical oxygen species is the essential step that initiates a wide range of intracellular stress signaling processes that culmina...
journal_title：Annals of transplantation
pub_type： 杂志文章,评审
doi：
更新日期：2004-01-01 00:00:00
abstract：BACKGROUND:Autologous peripheral blood stem cell transplantation (PBSCT) is commonly used in the treatment of lymphoma patients. G-CSF is widely used to boost white blood cell recovery. However, there are no clear data indicating which strategy of using G-CSF provides the most benefit. The aim of our study was to compa...
journal_title：Annals of transplantation
pub_type： 杂志文章,多中心研究
doi：10.12659/AOT.883965
更新日期：2013-07-02 00:00:00
abstract：BACKGROUND:Studies have documented deficits of pneumococcal and other vaccinations in kidney and lung transplant patients, but the vaccination status of liver transplant (LT) recipients is unknown. This cross-sectional study investigated the prevalence of immunizations among LT patients at a large university medical ce...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/aot.896436
更新日期：2016-04-07 00:00:00
abstract：BACKGROUND:Metabolic abnormalities have been reported in patients undergoing hematopoietic stem cell transplantation (HSCT). Potential causes, risk factors and outcomes of electrolyte imbalances have thoroughly been investigated. On HSCT recipients, multiple pathophysiologic contributors are inflicting electrolyte abno...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：2009-07-01 00:00:00
abstract：:BACKGROUND Diffuse thrombosis of iliac veins and IVC has been considered a significant technical obstacle in pediatric kidney transplantation (KT). MATERIAL AND METHODS Between 1984 and 2018, 951 KTs were performed in our institution. In 4 children qualified for KT, diffuse thrombosis of iliac veins or IVC was found. T...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/AOT.912657
更新日期：2019-01-11 00:00:00
abstract：:BACKGROUND Dual kidney transplantation (DKT) of expanded-criteria donors is a cost-intensive procedure that aims to increase the pool of available deceased organ donors and has demonstrated equivalent outcomes to expanded-criteria single kidney transplantation (eSKT). The objective of this study was to develop an allo...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/aot.898328
更新日期：2016-09-08 00:00:00
abstract：:BACKGROUND This study examined the attitude of patients' relatives in South Korea toward organ donation after brain death. MATERIAL AND METHODS A structured questionnaire was used to obtain the information on the attitude toward organ donation for relatives of patients who were admitted to the surgical intensive care ...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/aot.906485
更新日期：2017-10-27 00:00:00
abstract：BACKGROUND:Fulminant liver failure (FLF) is a severe clinical condition usually accompanied by a coagulopathy, which is one of the key selection criteria for liver transplantation. Prolongation of prothrombin time can vary between etiologies of FHF, being one of the worst in fulminant presentation of Wilson's disease. ...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：2010-07-01 00:00:00
abstract：BACKGROUND:Early post-operative hyperglycemia is commonly encountered in patients without pre-existing diabetes mellitus who are undergoing kidney transplantation. The aim of this study was to determine the effect of early post-operative hyperglycemia on graft and patient survival after kidney transplantation in our ce...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/AOT.883937
更新日期：2013-06-07 00:00:00
abstract：BACKGROUND:Sirolimus is a potent immunosuppressive drug that has been shown to decrease the incidence of rejection post renal transplantation. Dyslipidemia is a well recognized side effect of sirolimus therapy, which may have an impact on patient survival and post-transplant cardiac morbidity and mortality. It is unkno...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
abstract：:BACKGROUND ABO-incompatible (ABO-i) living donor liver transplantation (LDLT) is a feasible alternative for donor liver allograft in emergency situations, especially in Asia, where deceased-donor organs remain scarce. The reported outcomes of ABO-i LDLT after optimal desensitization are comparable to those of ABO-comp...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/AOT.923502
更新日期：2020-09-18 00:00:00
