Abstract:
BACKGROUND:Implantation site is an important factor affecting the effect of islet transplantation. In the literature, the gastric subserous space (GSS) is rarely used as the implantation site of islets. Our present study reports the initial results with a limited numbers of islets transplanted into the GSS in Lewis rats and compares the outcomes between the GSS and the liver. MATERIAL AND METHODS:STZ was used to induce diabetes in Lewis rats, using a limited numbers of islets from the donors of the same species transplanted into the GSS and also into the portal vein (PV). Fasting blood glucose levels were measured and the transplanted insulin-positive islets were detected using immunohistochemical method. RESULTS:The fasting blood glucose levels were significantly reduced compared with that in the pre-transplantation period in rats of the GSS group. Oral glucose tolerance testing (OGTT) on day 28 after transplantation revealed an excellent functional capacity. Insulin-positive islets were identified in the stomach throughout the study. However, we found no difference in fasting blood glucose between pre- and post-transplantation and no insulin-positive islets were discovered in rats of the PV group. CONCLUSIONS:Under the treatment of a limited numbers of islets, the gastric subserous space reveals a preferable capacity for glycometabolism of STZ-induced Lewis diabetic rats compared with the portal vein.
journal_name
Ann Transplantjournal_title
Annals of transplantationauthors
Liu X,Zhang J,Li Y,Hu S,Zhang G,Wang Ldoi
10.12659/AOT.890744subject
Has Abstractpub_date
2014-07-11 00:00:00pages
331-6eissn
1425-9524issn
2329-0358pii
890744journal_volume
19pub_type
杂志文章abstract:BACKGROUND:Lung transplant recipients are at great risk for developing various infectious complications. These infections portend a significant morbidity and mortality throughout their lifetime following transplantation. At times, cutaneous manifestations are the only clues to systemic infection. CASE REPORT:A 62 year...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/AOT.883846
更新日期:2013-03-14 00:00:00
abstract:BACKGROUND:Transplant renal artery stenosis (TRAS) is a serious vascular complication due to non-specific clinical manifestations, causing serious diagnostic difficulties. Contrast-enhanced ultrasound (CE-US) can complement standard sonographic examination in evaluation of TRAS. MATERIAL AND METHODS:Standard ultrasoun...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/AOT.883896
更新日期:2013-04-26 00:00:00
abstract::BACKGROUND Numerically, nurses represent the largest healthcare profession, thus setting norms for the quality and safety of direct patient care. Evidence of a global shortage of nurses in all clinical practice settings across different healthcare systems and countries has been documented. The aims of the present stud...
journal_title:Annals of transplantation
pub_type: 杂志文章,多中心研究
doi:10.12659/aot.898305
更新日期:2016-09-01 00:00:00
abstract::Applications of allogenic amnion grafts range from wound dressing of severe burns, dermabrasions and lower extremity ulcer treatments to plastic surgery, laryngology and ophthalmology. The aim of the present study was to elaborate the method of processing, preservation and sterilization of human amnion allografts prep...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract::BACKGROUND Chronic allograft nephropathy (CAN) remains a major problem for long-term graft survival and different pathways participate in its development. CXC chemokine receptor 4 (CXCR4) is significantly upregulated following renal injury and fibrotic response. We investigated the effect of AMD3100, a CXCR4 antagonis...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/AOT.899492
更新日期:2016-11-25 00:00:00
abstract::BACKGROUND In kidney transplantation, the association of cold ischemia time (CIT), anastomosis time (AT), and delayed graft function (DGF) is particularly detrimental in grafts from marginal donors; however, actual cut-off criteria are still debated. MATERIAL AND METHODS Data from patients >65 years (n=193) and patien...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/aot.896672
更新日期:2016-05-31 00:00:00
abstract:BACKGROUND:This study evaluated the effect of liver transplantation (LTX) and STACE on overall survival in palliative patients with HCC exceeding Milan criteria. MATERIAL AND METHODS:At a single center 63 HCC patients exceeding Milan criteria were retrospectively analyzed. Forty patients underwent STACE as palliative ...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/AOT.884018
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:As newer immunosuppressive regimens have steadily reduced in the incidence of acute rejection and have extended the life expectancy of allograft recipients, posttransplant de novo malignancies have become an important cause of death in cadaveric donor transplantation. Also, according with the recent accumula...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/aot.883230
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:Fulminant liver failure (FLF) is a severe clinical condition usually accompanied by a coagulopathy, which is one of the key selection criteria for liver transplantation. Prolongation of prothrombin time can vary between etiologies of FHF, being one of the worst in fulminant presentation of Wilson's disease. ...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:2010-07-01 00:00:00
abstract::The number of liver grafts obtained from a cadaver can be greatly increased with the application of split liver transplantation. In the last 10 years, pediatric waiting list mortality has been reduced significantly with the use of this form of liver transplantation, which has 2 major forms. In its most commonly used f...
journal_title:Annals of transplantation
pub_type: 杂志文章,评审
doi:10.12659/aot.896351
更新日期:2016-07-01 00:00:00
abstract::BACKGROUND Perioperative monitoring and hemodynamic management after heterotopic thoracic cardiac xenotransplantation is challenging due to 2 independently beating hearts. Telemetry allows continuous monitoring of hemodynamic parameters of both the donor and recipient hearts. We describe our experience and report on t...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/AOT.909522
更新日期:2018-07-20 00:00:00
abstract::Solid organ transplantation program in Poland is very limited. The main reason of this is organ shortage. All the organs procured are transplanted. It is a general feeling that recently issued legal regulations will favorably influence organ donation, however the improvement may be expected within a few years and will...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:The impact of treated preoperative bacterial infections on the outcome of living-donor liver transplantation (LDLT) is not well defined. The aim of this study was to determine the frequency of pre-transplant bacterial infections within one month before LDLT and their impact on the post-transplant morbidity a...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/AOT.892095
更新日期:2014-12-23 00:00:00
abstract:OBJECTIVES:The goal of this study was to examine the impact of various immunosuppressive regimens on an early NK cell recovery following haematopoietic cell transplantation (alloHCT). METHODS:The number of peripheral blood NK cells was analysed with the use of flow cytometry on day +30 (+/-2) after alloHCT from an HLA...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract::The hepatitis B virus (HBV) infects more than 260 million people globally, with increasing incidence, especially in developing countries. Despite antiviral therapies, HBV-related end-stage liver disease remains one of the most important indications for liver transplantation worldwide. Although new available treatments...
journal_title:Annals of transplantation
pub_type: 杂志文章,评审
doi:10.12659/aot.900216
更新日期:2016-10-14 00:00:00
abstract:BACKGROUND:Post kidney transplantation Re-admissions are focused because they are costly and cause morbidity, or may end with unsatisfactory endpoints namely graft loss or death. We compared the pattern, outcome and cost of re-admissions in different post-kidney transplantation periods. MATERIAL/METHODS:In a retrospec...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND:Early initiation of enteral nutrition is recommended after some surgical procedures. This study retrospectively analyzed the effects of addition of early enteral nutrition (EEN) support during the postoperative phase in patients after living-donor liver transplantation (LDLT). MATERIAL AND METHODS:The subje...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/AOT.893421
更新日期:2015-06-25 00:00:00
abstract::BACKGROUND Normothermic machine perfusion (NMP) preservation is superior to cold preservation during reduced-size liver transplantation (RSLT) in pigs. However, the mechanism of this protective effect has not been explained. We aimed to compare the effects of NMP preservation with that of cold preservation (CS) in pro...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/AOT.910774
更新日期:2019-01-04 00:00:00
abstract:BACKGROUND:Animal models to investigate pathophysiology and xenotransplantation require complex techniques and significant animal utilization. The aim of the study was to develop a reliable ex-vivo technique to test xenotransplant interventions. MATERIAL/METHODS:Miniature Swine being utilized for a nonsurvival study a...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:2011-01-01 00:00:00
abstract::BACKGROUND The aim of this study was to investigate the clinical features and treatment strategies of transplant renal artery stenosis (TRAS) with kidneys from donation after cardiac death (DCD). MATERIAL AND METHODS We collected the clinical data of donors and recipients of single-center DCD-induced TRAS from January...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/AOT.918076
更新日期:2020-02-04 00:00:00
abstract:BACKGROUND:Sulforaphane is a naturally occuring antioxidative and anti-inflammatory isothiocyanat. In this study, its impact on experimental kidney transplantation was evaluated. MATERIAL AND METHODS:Male Brown Norway rats (n=112) were used as experimental animals. Donor kidneys were harvested and stored for 12 hours ...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/AOT.884013
更新日期:2013-09-18 00:00:00
abstract:BACKGROUND:The objective was to evaluate contrast enhanced ultrasound (CEUS) based cholangiography compared to conventional radiography as a reference method in patients after liver transplantation. MATERIAL/METHODS:Contrast agents were administered through T-tubes, which were placed during the operation. Twelve patie...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/aot.883700
更新日期:2012-12-31 00:00:00
abstract:BACKGROUND:Early post-operative hyperglycemia is commonly encountered in patients without pre-existing diabetes mellitus who are undergoing kidney transplantation. The aim of this study was to determine the effect of early post-operative hyperglycemia on graft and patient survival after kidney transplantation in our ce...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/AOT.883937
更新日期:2013-06-07 00:00:00
abstract:BACKGROUND:We report, for the first time, the data on the outcome of kidney transplantation activities in the Afghan population from Iran. MATERIAL/METHOD:We extracted the demographic, clinical and the outcome related data of all Afghan kidney transplanted patients, from 1998 to April 2006, from the United Nations Hig...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:2010-04-01 00:00:00
abstract::Recovery of the patients after transplantation of non-renal organs may be complicated by multi-faceted chronic renal failure (CKD) which is regarded as an independent risk factor of graft dysfunction and mortality. The occurrence of CKD in non-renal transplant recipients depends mainly on a type of transplanted organ,...
journal_title:Annals of transplantation
pub_type: 杂志文章,评审
doi:
更新日期:2005-01-01 00:00:00
abstract::The ability of kidney transplantation to improve quality of life has made this therapeutic modality the treatment of choice among renal replacement therapies; however, the continuing organ shortage has forced the use of marginal kidneys as a supplementary source of allografts. It has been repeatedly suggested that fai...
journal_title:Annals of transplantation
pub_type: 杂志文章,评审
doi:10.12659/aot.898405
更新日期:2016-07-26 00:00:00
abstract::Stem cell research seems now to reach important progress in biomedicine, giving promising perspective for clinical implementation. The review of stem cell research is presented including origin, content in various organs, harvesting, preservation and storage. Some examples of results achieved in stem cell research inc...
journal_title:Annals of transplantation
pub_type: 杂志文章,评审
doi:
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVES:Modification of the total body irradiation technique before bone marrow transplantation has been implemented to improve uniformity of the dose inside the irradiated body and to obtain appropriate reduction in doses in critical organs. METHODS:The total dose of 12.6 Gy was delivered with the use of a combina...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Organ transplantation increases the risk of cancer including lymphomas through various and insidious mechanisms. In this study, we aimed to gather and analyze data of 5 international studies on late onset lymphoproliferative disorders after renal and liver transplantation. MATERIAL/METHODS:We conducted a co...
journal_title:Annals of transplantation
pub_type: 杂志文章,评审
doi:
更新日期:2009-10-01 00:00:00
abstract::BACKGROUND Minimally invasive surgery (MIS) has rapidly advanced, but its use in transplant patients has lagged. We share our experience of MIS for patients after kidney and liver transplantation and compare our results with similar studies in the literature. MATERIAL AND METHODS This study included 14 MIS (12 laparos...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/AOT.922602
更新日期:2020-06-16 00:00:00