Ethical and societal problems in organ transplantation.

Abstract:

:Transplantation medicine, like no other medical specialty, is connected with a wide range of very difficult ethical issues. Among those are: availability of the treatment, consent for cadaveric donation, allocation of available organs, new categories of living unrelated donors and economic aspects of this method of treatment. Authors discuss sensitive aspects in societal perception of the Polish Transplantation Act, ethical issues of living donor kidney transplantation, the role of mass media and economic aspects of transplantation.

journal_name

Ann Transplant

authors

Rowiński W,Wałaszewski J

keywords:

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

7-9

issue

4

eissn

1425-9524

issn

2329-0358

journal_volume

7

pub_type

杂志文章
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    doi:10.12659/aot.883230

    authors: Shimizu T,Hayashi M,Inoue Y,Komeda K,Asakuma M,Hirokawa F,Miyamoto Y,Tanigawa N,Uchiyama K

    更新日期:2012-04-01 00:00:00

  • Comparision of benefits of early, delayed, and no administration of G-CSF after autologous peripheral blood stem cell transplantation in lymphoma patients.

    abstract:BACKGROUND:Autologous peripheral blood stem cell transplantation (PBSCT) is commonly used in the treatment of lymphoma patients. G-CSF is widely used to boost white blood cell recovery. However, there are no clear data indicating which strategy of using G-CSF provides the most benefit. The aim of our study was to compa...

    journal_title:Annals of transplantation

    pub_type: 杂志文章,多中心研究

    doi:10.12659/AOT.883965

    authors: Wyleżoł I,Snarski E,Markiewicz M,Kyrcz-Krzemień S,Jędrzejczak WW,Walewski J

    更新日期:2013-07-02 00:00:00

  • Impact of Cold Ischemia Time on Outcomes of Liver Transplantation: A Single Center Experience.

    abstract:BACKGROUND:Significant geographic disparities exist in access to liver transplantation and consequently the current liver allocation system is being challenged. We sought to describe our unique experience with using organs with long cold ischemia times from the largest donation service area. MATERIAL AND METHODS:From ...

    journal_title:Annals of transplantation

    pub_type: 杂志文章

    doi:10.12659/aot.896190

    authors: Sibulesky L,Li M,Hansen RN,Dick AA,Montenovo MI,Rayhill SC,Bakthavatsalam R,Reyes JD

    更新日期:2016-03-08 00:00:00

  • Reversal of hyperglycemia in streptozotocin diabetic mice by xenotransplantation of microencapsulated rat islets.

    abstract::Rat pancreatic islets were immunoisolated within alginate capsules with additional polyethyleneimine-protamine-heparin highly biocompatible membrane. Perifusion study in vitro demonstrated satisfactory similarities between the insulin release profiles of encapsulated and free islets. Concordant xenotransplantation of ...

    journal_title:Annals of transplantation

    pub_type: 杂志文章

    doi:

    authors: Tatarkiewicz K,Sitarek E,Sabat M,Orłowski T

    更新日期:1997-01-01 00:00:00

  • Living Donor Liver Transplantation in Acute Liver Failure Patients with Grade IV Encephalopathy: Is Deep Hepatic Coma Still an Absolute Contraindication? A Successful Single-Center Experience.

    abstract::BACKGROUND The prognosis of the patients of acute liver failure (ALF) with onset of hepatic coma is often dismal. ALF is a well-accepted indication for liver transplantation (LT) and has markedly improved the prognosis of these patients. However, its role in ALF patients with onset of hepatic coma has never been eluci...

    journal_title:Annals of transplantation

    pub_type: 杂志文章

    doi:

    authors: Yang HR,Thorat A,Jeng LB,Hsu SC,Li PC,Yeh CC,Chen TH,Poon KS

    更新日期:2018-03-13 00:00:00

  • Conversion from cyclosporine-based immunosuppression to tacrolimus/mycophenolate mofetil in patients with refractory and ongoing acute renal allograft rejection.

    abstract:AIM OF THE STUDY:was to examine the influence of conversion from cyclosporine-based therapy to tacrolimus/mycophenolate mofetil (MMF) on renal graft survival in patients with refractory rejection and on the recurrence of rejection in patients converted at the time of the first episode of rejection. PATIENTS AND METHOD...

    journal_title:Annals of transplantation

    pub_type: 杂志文章,评审

    doi:

    authors: Boratyńska M,Banasik M,Patrzałek D,Klinger M

    更新日期:2006-01-01 00:00:00

  • Mechanisms of allorecognition and organ transplant rejection.

    abstract::Recognition of mismatched (foreign) alloantigens on the graft by the recipients T cells initiates allograft rejection. This process is mediated by two mayor mechanisms--direct and indirect allorecognition. Both process are being discussed. ...

    journal_title:Annals of transplantation

    pub_type: 杂志文章,评审

    doi:

    authors: Slavcev A

    更新日期:2001-01-01 00:00:00

  • Experience with pancreas islets separation, immunoisolation and cryopreservation.

    abstract::Experience of Warsaw Pancreas Laboratory is presented. Some improvement in the methods of rat, human and pig pancreases digestion, and in identification of Langerhans islets by means of intravenous injection of I-DTZ was achieved. For immunoisolation of islets, 2 methods were elaborated: capsules containing alginate/p...

    journal_title:Annals of transplantation

    pub_type: 杂志文章

    doi:

    authors: Orłowski T,Tatarkiewicz K,Sitarek E,Sabat M,Fiedor P,Samsel R

    更新日期:1996-01-01 00:00:00

  • Diagnosis and treatment of steroid resistant cellular rejection in heart transplant recipients--single center experience.

    abstract:OBJECTIVES:Aim of the study was to assess frequency and risk factors of steroid resistant cellular rejection (SRR) in heart transplant recipients, to determine methods of its treatment, and to evaluate influence of steroid resistant rejection and method of its treatment on short- and long-term results. METHODS:All pts...

    journal_title:Annals of transplantation

    pub_type: 杂志文章

    doi:

    authors: Zakliczyński M,Nozyński J,Zakliczyńska H,Kozłowska K,Trzcińska I,Szewczyk M,Konecka-Mrówka D,Foremny J,Swierad M,Przybylski R,Pisarska H,Wojarski J,Durmała J,Zembala M

    更新日期:2003-01-01 00:00:00

  • The role of calcium and calcium channel blocking drugs in damage to the liver preserved for transplantation.

    abstract::Calcium plays a crucial role in physiological process in liver cells however in high concentrations these ions can be pathogenic and lead to cell death. Mechanisms responsible for maintaining calcium ion concentration gradient in physiological conditions include transmembrane transport, storage in intracellular organe...

    journal_title:Annals of transplantation

    pub_type: 杂志文章,评审

    doi:

    authors: Trocha M,Szelag A

    更新日期:2004-01-01 00:00:00

  • Simultaneous Clostridium difficile-associated colitis and late-onset intestinal cytomegalovirus disease in a renal transplant recipient.

    abstract:BACKGROUND:Infection remains the most common complication following renal transplantation (RT). Cytomegalovirus (CMV) is one of the most important pathogens in this patient population and Clostridium difficile-associated colitis (CDAC) has emerged as one of the most frequent gastrointestinal complications. Only few cas...

    journal_title:Annals of transplantation

    pub_type: 杂志文章

    doi:

    authors: Dahman M,Krell R,Brayman K,Sawyer RG,Cathro HP,Hagspiel KD,Sifri CD,Bonatti HJ

    更新日期:2010-10-01 00:00:00

  • Effect of Fibrin Glue on the Incidence of Surgical Complications After Living-Related-Donor Kidney Transplantation: Results of a Randomized Clinical Trial.

    abstract::BACKGROUND The incidence of surgical complications after kidney transplantation ranges from 10-25%. The purpose of this study was to evaluate if the application of fibrin glue as a preventive agent reduces surgical morbidity after a living-related-donor kidney transplantation. MATERIAL AND METHODS A controlled clinica...

    journal_title:Annals of transplantation

    pub_type: 杂志文章

    doi:10.12659/aot.899821

    authors: Fuentes-Orozco C,González-Mercado S,Sandoval-Sandoval JM,Valdespino-Mejía C,González-González E,Ramírez-Robles JN,Gómez-Navarro B,Dávalos-Delgadillo BE,Marquez-Leaño L,Chávez-Tostado M,Ramírez-Arce A,Andalón-Dueñas E,Espinosa-Par

    更新日期:2016-09-20 00:00:00

  • Dose-normalization for exposure to mycophenolic acid and the early clinical outcome in patients taking tacrolimus after heart transplantation.

    abstract:BACKGROUND:The early phase of MPA exposure has rarely been investigated after solid organ transplantation, especially in heart transplantation patients. We evaluated the association between exposure to mycophenolic acid (MPA), a main metabolite of mycophenolate mofetil (MMF), and clinical events within 3 months after h...

    journal_title:Annals of transplantation

    pub_type: 临床试验,杂志文章

    doi:10.12659/AOT.883812

    authors: Roan JN,Chou CH,Hsu CH,Wu SY,Huang YC,Yang YJ,Luo CY

    更新日期:2013-02-05 00:00:00

  • The fate of the Council of Europe's recommendation on xenotransplantation.

    abstract::The draft of the working group of experts for a Recommendation of the Committee of Ministers to Member States on Xenotransplantation was finalized in September 2001, ending a working period of two and a half years. This paper will briefly reflect upon the development of the recommendation up to this point in time. A s...

    journal_title:Annals of transplantation

    pub_type: 指南,杂志文章

    doi:

    authors: Härtel I,Council of Europe.

    更新日期:2003-01-01 00:00:00

  • Causes and prognostic value of pre-transplant elevated kynurenine level in kidney allograft recipients.

    abstract:BACKGROUND:The activation of the tryptophane catabolizing enzyme Indoleamine 2,3-dioxygenase leads to the formation of kynurenine and other metabolites that counter-regulate immune activation resulting in restoration of immune homeostasis. But in chronic immune activation, as in hemodialysed patients, the immunosuppres...

    journal_title:Annals of transplantation

    pub_type: 杂志文章

    doi:10.12659/AOT.889764

    authors: Kaden J,Abendroth D,Völp A,Marzinzig M,Wesslau C

    更新日期:2014-01-27 00:00:00

  • Solid organ transplantation and HIV infection.

    abstract::HIV infection has been traditionally considered to be an absolute contraindication for solid organ transplantation. Recent advances in HIV treatment, as highly active antiretroviral therapy (HAART), significantly reduced HIV-related mortality and morbidity. At the same time the number of HIV-infected patients with end...

    journal_title:Annals of transplantation

    pub_type: 杂志文章,评审

    doi:

    authors: Polak WG,Gładysz A

    更新日期:2003-01-01 00:00:00

  • The effect of The World Transplant Games on transplant rates in five continents.

    abstract::This paper outlines the effect that the Transplant Games have had in influencing public opinion and the translation of that effect resulting in increased organ donation and transplantation in the global venues in which this activity took place. A brief account of the history of the Transplant Games now 25 years after ...

    journal_title:Annals of transplantation

    pub_type: 杂志文章

    doi:

    authors: Slapak M

    更新日期:2004-01-01 00:00:00

  • Stem cell research as a base for reconstructive medicine.

    abstract::Stem cell research seems now to reach important progress in biomedicine, giving promising perspective for clinical implementation. The review of stem cell research is presented including origin, content in various organs, harvesting, preservation and storage. Some examples of results achieved in stem cell research inc...

    journal_title:Annals of transplantation

    pub_type: 杂志文章,评审

    doi:

    authors: Komender J

    更新日期:2003-01-01 00:00:00

  • DNA from rejecting donor organs can be detected in recipient lymphoid and non-lymphoid tissues.

    abstract::Rejecting tissue and organ grafts shed cellular debris from damaged cells. Cellular debris contains fragments of nuclei with their genetic material. The question arises what is the fate of donor DNA in recipient fluids and tissues. Is it enzymatically disintegrated and becomes a waste product or it is utilized by reci...

    journal_title:Annals of transplantation

    pub_type: 杂志文章

    doi:

    authors: Interewicz B,Olszewski WL,Maksymowicz M,Stanislawska J,Szyper E

    更新日期:2002-01-01 00:00:00

  • The Role of Medical Air Rescue Services in Medical Transport of Organ Recipients in Poland: Organizational Solutions Supporting Transplantation Medicine.

    abstract:BACKGROUND:The aim of this study was to analyze the use of fixed-wing air ambulance (FWAA) services in Poland during the period 2012-2013, with particular emphasis on air transport of organ recipients to transplantation centers. MATERIAL AND METHODS:This was a retrospective, cross-sectional analysis of data derived fr...

    journal_title:Annals of transplantation

    pub_type: 杂志文章

    doi:10.12659/aot.895321

    authors: Gałązkowski R,Pawlak A,Rabczenko D,Michalak G,Farkowski MM,Danielewicz R,Sterliński M

    更新日期:2015-10-20 00:00:00

  • Activity of glutathione S-transferases in the urine of kidney transplant recipients during the first week after transplantation.

    abstract:UNLABELLED:Glutathione S-Tranferases (GST) are the enzymes which are strictly specific for epithelial cells of the proximal and distal tubules in the kidney. These enzymes are detected in the urine when some tubular damage process is found. In healthy people urine GST is hardly detected. The goal of this study was to e...

    journal_title:Annals of transplantation

    pub_type: 杂志文章

    doi:

    authors: Polak WP,Kosieradzki M,Kwiatkowski A,Danielewicz R,Lisik W,Michalak G,Paczek L,Lao M,Wałaszewski J,Rowiński WA

    更新日期:1999-01-01 00:00:00

  • Malignancy after renal transplantation in the new era of immunosuppression.

    abstract:BACKGROUND:This retrospective single-center study was undertaken to assess the occurrence of de novo neoplasms in renal transplant recipients according to the immunosuppressive regimen and time after transplantation. MATERIAL/METHODS:Observation encompassed 1028 patients transplanted between the years 1983-2006 and fo...

    journal_title:Annals of transplantation

    pub_type: 杂志文章

    doi:

    authors: Watorek E,Boratynska M,Smolska D,Patrzalek D,Klinger M

    更新日期:2011-04-01 00:00:00

  • The APACHE III score as preoperative indicator of patient outcome in liver transplantation after fulminant hepatic failure.

    abstract:BACKGROUND:Given the current organ shortage, an accurate assessment of the patient's outcome after orthotopic liver transplantation (OLTX) for fulminant hepatic failure (FHF) is crucial in order to determine the suitability for transplantation. The purpose of this study was to assess whether APACHE II and III scores wo...

    journal_title:Annals of transplantation

    pub_type: 杂志文章

    doi:

    authors: Fikatas P,Ulrich F,Lee JE,Sauer IM,Chopra S,Schmidt SC,Pascher A,Pratschke J

    更新日期:2011-01-01 00:00:00

  • Does Immunosuppressive Therapy Affect Markers of Kidney Damage?

    abstract:BACKGROUND:Markers currently used to detect kidney damage are effective in both early (KIM-1, NGAL) and late (MCP-1, MMP, TIMP) stages of renal tubular damage, indicating the progression of chronic kidney disease. Immunosuppressive drugs may damage the transplanted organ through their direct toxic effects and by contri...

    journal_title:Annals of transplantation

    pub_type: 杂志文章

    doi:10.12659/aot.895275

    authors: Kędzierska K,Sindrewicz K,Sporniak-Tutak K,Gołembiewska E,Zair L,Sieńko J,Stańczyk-Dunaj M,Baranowska-Bosiacka I,Ciechanowski K

    更新日期:2016-03-03 00:00:00

  • Toxic tacrolimus blood levels with rifampin administration in a renal transplant recipient.

    abstract:BACKGROUND:Induction of the hepatic and intestinal cytochrome P450-3A4 system and intestinal P-glycoprotein is an unavoidable consequence of rifampin administration which requires substantial increase in tacrolimus dose when given concurrently. Chronic diarrhea is known to precipitate tacrolimus toxicity irrespective o...

    journal_title:Annals of transplantation

    pub_type: 杂志文章

    doi:

    authors: Abdel Halim M,Al-Otaibi T,Gheith O,El-Kholy O,Abdel Tawab K,Said T,Nair P,Nampoory MR

    更新日期:2010-01-01 00:00:00

  • Cobalt 60 versus 15 MeV photons during total body irradiation: doses in the critical organs and complexicity of the procedure.

    abstract:OBJECTIVES:The aim of this work was to compare the doses in critical organs, treatment duration, patient comfort and personnel workload during total body irradiation carried out alternatively with a Cobalt 60 and with 15 MeV photons at linear accelerator. PATIENTS AND METHODS:Twenty consecutive patients irradiated wit...

    journal_title:Annals of transplantation

    pub_type: 临床试验,杂志文章

    doi:

    authors: Malicki J,Kosicka G,Stryczyńska G,Wachowiak J

    更新日期:2001-01-01 00:00:00

  • Sleep Quality and Psychosocial Factors in Liver Transplant Recipients at an Outpatient Follow-Up Clinic in China.

    abstract::BACKGROUND Sleep disturbance is a common problem in liver transplant recipients, but few studies have confirmed the psychosocial factors associated with sleep quality in patients after liver transplantation. This study aimed to identify the psychosocial factors related to sleep quality among liver transplant patients ...

    journal_title:Annals of transplantation

    pub_type: 杂志文章

    doi:10.12659/AOT.920984

    authors: Zhu X,Ming Y,Liu J,Liu L,Cheng K,Mao P

    更新日期:2020-02-18 00:00:00

  • Preemptive administration of recombinant factor VII (rVIIa) in patients transplanted due to fulminant Wilson's disease.

    abstract:BACKGROUND:Fulminant liver failure (FLF) is a severe clinical condition usually accompanied by a coagulopathy, which is one of the key selection criteria for liver transplantation. Prolongation of prothrombin time can vary between etiologies of FHF, being one of the worst in fulminant presentation of Wilson's disease. ...

    journal_title:Annals of transplantation

    pub_type: 杂志文章

    doi:

    authors: Czuprynska MM,Wawrzynowicz-Syczewska M,Jureczko L,Andrzejewska J,Jarosz K,Trzebicki J,Pacholczyk M,Chmura A,Wojcicki M

    更新日期:2010-07-01 00:00:00

  • Organ donation in Poland 2006.

    abstract::Organ transplantation program has been slowly developing over last 30 years. The number of DD (deceased donors) stabilized on the level of approximately 13/million of population. Multiorgan donation has been 45%, due to some problems with donor management. Polish Transplant Coordinating Center POLTRANSPLANT which is r...

    journal_title:Annals of transplantation

    pub_type: 社论

    doi:

    authors: Czerwinski J,Antoszkiewicz K,Malanowski P,Durlik M,Kaliciński P,Lisik W,Wałaszewski J,Rowiński W

    更新日期:2007-01-01 00:00:00

  • Doses in critical organs during total body irradiation before bone marrow transplantation.

    abstract:OBJECTIVES:Modification of the total body irradiation technique before bone marrow transplantation has been implemented to improve uniformity of the dose inside the irradiated body and to obtain appropriate reduction in doses in critical organs. METHODS:The total dose of 12.6 Gy was delivered with the use of a combina...

    journal_title:Annals of transplantation

    pub_type: 杂志文章

    doi:

    authors: Malicki J

    更新日期:1998-01-01 00:00:00