Reversal of hyperglycemia in streptozotocin diabetic mice by xenotransplantation of microencapsulated rat islets.

Abstract:

:Rat pancreatic islets were immunoisolated within alginate capsules with additional polyethyleneimine-protamine-heparin highly biocompatible membrane. Perifusion study in vitro demonstrated satisfactory similarities between the insulin release profiles of encapsulated and free islets. Concordant xenotransplantation of microencapsulated rat islets significantly prolonged mean time of restored normoglycemia (46 +/- 15 days) in streptozotocin-diabetic BALB/c mice recipients comparing to uncoated grafts (7 +/- 2 days).

journal_name

Ann Transplant

authors

Tatarkiewicz K,Sitarek E,Sabat M,Orłowski T

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

20-3

issue

2

eissn

1425-9524

issn

2329-0358

journal_volume

2

pub_type

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