当前位置： SCI文献检索 > Annals of Transplantation期刊下所有文献 > Malignancy after renal transplantation in the new era of immunosuppression.

Malignancy after renal transplantation in the new era of immunosuppression.

Abstract：

BACKGROUND:This retrospective single-center study was undertaken to assess the occurrence of de novo neoplasms in renal transplant recipients according to the immunosuppressive regimen and time after transplantation. MATERIAL/METHODS:Observation encompassed 1028 patients transplanted between the years 1983-2006 and followed for 0.5-23 years. Patients with skin cancer other than melanoma were excluded due to incomplete data collection. RESULTS:Malignancy appeared in 4.8% (49) of the patients after the period of 5.8 ± 4.7 years at the age of 54 ± 13 years. The most common malignancies were urinary tract tumors (22%) and non-Hodgkin lymphoma with post-transplant lymphoproliferative disease (PTLD) (16%). Malignancy occurred in 5.2% of patients on cyclosporine (CSA), azathioprine (AZA) and prednisone (P); in 3.4% of patients on mofetil mycophenolate (MMF) with CSA and P; in 3.3% of patients on MMF with tacrolimus (TAC) and P; and in 2 of 20 patients (10%) receiving AZA with P 15 years after transplantation. The regimen consisting of CSA, AZA with P could be distinguished by the higher risk of malignancy occurrence. The occurrence of malignancy was significantly earlier on MMF+TAC+P compared to other regimens (p<0.05). The highest incidence of malignancy on AZA with P could be attributed to the longer observation period. CONCLUSIONS:In the new era of immunosuppression, despite lower occurrence, malignancy tends to appear earlier after the transplantation.

journal_name

Ann Transplant

journal_title

Annals of transplantation

authors

Watorek E,Boratynska M,Smolska D,Patrzalek D,Klinger M

subject

Has Abstract

pub_date

2011-04-01 00:00:00

pages

14-8

issue

2

eissn

1425-9524

issn

2329-0358

pii

881859

journal_volume

16

pub_type

杂志文章

相关文献

Annals of Transplantation文献大全
  • Fusion of spine in children scoliosis with frozen & radiation--sterilized bone allograft.

    abstract：:102 children have been treated at the Institute of Traumatology, Orthopaedics & Neurosurgery a result of scoliosis. In all of these multi-step treatment has been applied. Initially a telescopic rod was implanted into the spine. Allografts were introduced around the rod hook, after 6 or 8 months, when angle of scoliosi...

    journal_title：Annals of transplantation

    pub_type： 杂志文章

    doi：

    authors： Marczyński W,Komender J,Stepién K,Barański M

    更新日期：1999-01-01 00:00:00

  • Long term medical and economical benefit of machine perfusion (MP) kidney storage in comparison to cold storage (CS).

    abstract：BACKGROUND:Despite documented positive effect of MachinePerfusion (MP) on long-term kidneys-graft function its wide use is restricted due to higher costs. The aim of this study was to analyze the difference in costs of kidney transplantation in patients who received organ stored in ColdStorage (CS) vs those who receive...

    journal_title：Annals of transplantation

    pub_type： 杂志文章

    doi：

    authors： Wszola M,Kwiatkowski A,Latek M,Ostrowski K,Domagala P,Ciszek M,Trzebicki J,Durlik M,Chmura A,Rowinski W

    更新日期：2009-04-01 00:00:00

  • Effects of Delayed Hypothermic Machine Perfusion on Kidney Grafts with a Preliminary Period of Static Cold Storage and a Total Cold Ischemia Time of Over 24 Hours.

    abstract：:BACKGROUND Hypothermic machine perfusion (HMP) appears to exert a reconditioning effect on the ischemic damage of kidney grafts. However, some concerns still remain about its real effectiveness when it is delayed after a preliminary period of static cold storage (SCS) or with prolonged overall cold ischemia time (CIT)...

    journal_title：Annals of transplantation

    pub_type： 杂志文章

    doi：10.12659/AOT.918997

    authors： Adani GL,Pravisani R,Crestale S,Baccarani U,Scott CA,D'Alì L,DeMaglio G,Tulissi P,Vallone C,Isola M,Righi E,Pizzolito S,Di Loreto C,Risaliti A

    更新日期：2020-02-25 00:00:00

  • The limits of human athletic performance.

    abstract：:For each individual, there is a limit to the capacity to perform exercise. The limitation, however, depends on the nature of the task and is also influenced by a number of other factors. Muscle strength is determined largely by muscle mass, specifically muscle cross-sectional area, but is also influenced by neural dri...

    journal_title：Annals of transplantation

    pub_type： 杂志文章,评审

    doi：

    authors： Maughan RJ

    更新日期：2005-01-01 00:00:00

  • The first Polish liver transplantation after Roux-en-Y gastric bypass surgery for morbid obesity: a case report and literature review.

    abstract：BACKGROUND:Morbid obesity is associated with liver pathology, most commonly non-alcoholic steatohepatitis (NASH) leading to cirrhosis. However, the morbid obesity impedes qualification for organ transplantation. CASE REPORT:We present a case report of a 56-year-old woman who underwent bariatric procedure followed by l...

    journal_title：Annals of transplantation

    pub_type： 杂志文章,评审

    doi：10.12659/AOT.893797

    authors： Marszałek R,Ziemiański P,Łągiewska B,Pacholczyk M,Domienik-Karłowicz J,Trzebicki J,Wierzbicki Z,Jankowski K,Kosieradzki M,Wasiak D,Jonas M,Pruszczyk P,Durlik M,Lisik W,Chmura A

    更新日期：2015-02-25 00:00:00

  • Structure of Post-Transplant Care in a Single Transplant Center.

    abstract：BACKGROUND:The number of transplant surgeries across the globe has markedly increased in recent decades and is associated with improvement in outcomes. Factors that could improve the organization of post-transplant care are sought. The aim of our study was to evaluate the changes in post-transplant care in the largest ...

    journal_title：Annals of transplantation

    pub_type： 杂志文章

    doi：10.12659/aot.895981

    authors： Szymańska A,Pączek L,Mucha K,Krajewska M,Florczak M,Ciszek M,Sańko-Resmer J,Chmura A,Nazarewski S,Górski A,Durlik M,Krawczyk M,Foroncewicz B

    更新日期：2016-04-05 00:00:00

  • Myocardial performance after brain death: studies in isolated hearts.

    abstract：OBJECTIVES AND METHODS:Brain death related hemodynamic instability and/or cardiac dysfunction is frequently described in the potential organ donor which may lead to exclusion of the heart from transplantation. The underlying mechanisms are controversely discussed. Therefore, in the present study, potential brain death ...

    journal_title：Annals of transplantation

    pub_type： 杂志文章

    doi：

    authors： Szabó G,Hackert T,Buhmann V,Sebening C,Vahl CF,Hagl S

    更新日期：2000-01-01 00:00:00

  • Graft-versus-Host Disease after Liver Transplantation: A Single-Center Case Series.

    abstract：BACKGROUND:Graft versus host disease (GVHD) is a rare complication following liver transplantation (LT) and has high mortality. We describe our single-center experience with 6 cases of GVHD diagnosed over a period of 14 years in a total of 604 liver transplant recipients--283 deceased donor liver transplants (DDLT) and...

    journal_title：Annals of transplantation

    pub_type： 杂志文章

    doi：10.12659/AOT.893616

    authors： Elsiesy H,Ibrahim A,Selim K,Al Sebayel M,Broering D,Al Hamoudi W,Al Arieh R,Abaalkhail F

    更新日期：2015-07-14 00:00:00

  • Long-Term Renal Function in Liver Transplant Recipients After Conversion From Calcineurin Inhibitors to mTOR Inhibitors.

    abstract：BACKGROUND:Renal dysfunction often occurs in liver transplant (LT) recipients receiving calcineurin inhibitor (CNI)-based immunosuppressive regimens, increasing morbidity and mortality rates. Replacement of CNIs by mTOR inhibitor-based immunosuppressive protocols may prevent renal impairment in LT recipients. MATERIAL...

    journal_title：Annals of transplantation

    pub_type： 杂志文章

    doi：10.12659/aot.895320

    authors： Hüsing A,Schmidt M,Beckebaum S,Cicinnati VR,Koch R,Thölking G,Stella J,Heinzow H,Schmidt HH,Kabar I

    更新日期：2015-11-26 00:00:00

  • Laparoscopic live-donor nephrectomy with retroperitoneoscopic access - first case experience.

    abstract：BACKGROUND:Despite observed huge progress in understanding the immunological basis of transplantation and the development of new immunosuppressive agents that have significantly improved both -- the patient and graft survival, still the kidney donation from live volunteers remains the most consistent factor which affec...

    journal_title：Annals of transplantation

    pub_type： 杂志文章

    doi：

    authors： Słojewski M,Sluzar T,Gołab A,Chłodny J,Zeair S,Dziewanowski K,Umiński M,Sikorski A

    更新日期：2008-01-01 00:00:00

  • Activity of glutathione S-transferases in the urine of kidney transplant recipients during the first week after transplantation.

    abstract：UNLABELLED:Glutathione S-Tranferases (GST) are the enzymes which are strictly specific for epithelial cells of the proximal and distal tubules in the kidney. These enzymes are detected in the urine when some tubular damage process is found. In healthy people urine GST is hardly detected. The goal of this study was to e...

    journal_title：Annals of transplantation

    pub_type： 杂志文章

    doi：

    authors： Polak WP,Kosieradzki M,Kwiatkowski A,Danielewicz R,Lisik W,Michalak G,Paczek L,Lao M,Wałaszewski J,Rowiński WA

    更新日期：1999-01-01 00:00:00

  • Living Donor Liver Transplantation in Acute Liver Failure Patients with Grade IV Encephalopathy: Is Deep Hepatic Coma Still an Absolute Contraindication? A Successful Single-Center Experience.

    abstract：:BACKGROUND The prognosis of the patients of acute liver failure (ALF) with onset of hepatic coma is often dismal. ALF is a well-accepted indication for liver transplantation (LT) and has markedly improved the prognosis of these patients. However, its role in ALF patients with onset of hepatic coma has never been eluci...

    journal_title：Annals of transplantation

    pub_type： 杂志文章

    doi：

    authors： Yang HR,Thorat A,Jeng LB,Hsu SC,Li PC,Yeh CC,Chen TH,Poon KS

    更新日期：2018-03-13 00:00:00

  • Sleep Quality and Psychosocial Factors in Liver Transplant Recipients at an Outpatient Follow-Up Clinic in China.

    abstract：:BACKGROUND Sleep disturbance is a common problem in liver transplant recipients, but few studies have confirmed the psychosocial factors associated with sleep quality in patients after liver transplantation. This study aimed to identify the psychosocial factors related to sleep quality among liver transplant patients ...

    journal_title：Annals of transplantation

    pub_type： 杂志文章

    doi：10.12659/AOT.920984

    authors： Zhu X,Ming Y,Liu J,Liu L,Cheng K,Mao P

    更新日期：2020-02-18 00:00:00

  • Stem cell research as a base for reconstructive medicine.

    abstract：:Stem cell research seems now to reach important progress in biomedicine, giving promising perspective for clinical implementation. The review of stem cell research is presented including origin, content in various organs, harvesting, preservation and storage. Some examples of results achieved in stem cell research inc...

    journal_title：Annals of transplantation

    pub_type： 杂志文章,评审

    doi：

    authors： Komender J

    更新日期：2003-01-01 00:00:00

  • Causes of re-hospitalization in different post kidney transplantation periods.

    abstract：BACKGROUND:Post kidney transplantation Re-admissions are focused because they are costly and cause morbidity, or may end with unsatisfactory endpoints namely graft loss or death. We compared the pattern, outcome and cost of re-admissions in different post-kidney transplantation periods. MATERIAL/METHODS:In a retrospec...

    journal_title：Annals of transplantation

    pub_type： 杂志文章

    doi：

    authors： Moghani Lankarani M,Noorbala MH,Assari S

    更新日期：2009-10-01 00:00:00

  • Doses in critical organs during total body irradiation before bone marrow transplantation.

    abstract：OBJECTIVES:Modification of the total body irradiation technique before bone marrow transplantation has been implemented to improve uniformity of the dose inside the irradiated body and to obtain appropriate reduction in doses in critical organs. METHODS:The total dose of 12.6 Gy was delivered with the use of a combina...

    journal_title：Annals of transplantation

    pub_type： 杂志文章

    doi：

    authors： Malicki J

    更新日期：1998-01-01 00:00:00

  • Liver transplantation versus supraselective transarterial chemoembolization in palliative patients with hepatocellular carcinoma exceeding the Milan Criteria - is it time for a more individual approach?

    abstract：BACKGROUND:This study evaluated the effect of liver transplantation (LTX) and STACE on overall survival in palliative patients with HCC exceeding Milan criteria. MATERIAL AND METHODS:At a single center 63 HCC patients exceeding Milan criteria were retrospectively analyzed. Forty patients underwent STACE as palliative ...

    journal_title：Annals of transplantation

    pub_type： 杂志文章

    doi：10.12659/AOT.884018

    authors： Heinzow HS,Brockmann JG,Köhler M,Wolters HH,Senninger N,Schmidt H,Meister T

    更新日期：2013-10-01 00:00:00

  • Amnion allografts prepared in the Central Tissue Bank in Warsaw.

    abstract：:Applications of allogenic amnion grafts range from wound dressing of severe burns, dermabrasions and lower extremity ulcer treatments to plastic surgery, laryngology and ophthalmology. The aim of the present study was to elaborate the method of processing, preservation and sterilization of human amnion allografts prep...

    journal_title：Annals of transplantation

    pub_type： 杂志文章

    doi：

    authors： Tyszkiewicz JT,Uhrynowska-Tyszkiewicz IA,Kaminski A,Dziedzic-Goclawska A

    更新日期：1999-01-01 00:00:00

  • Evolution of Laparoscopic Donor Nephrectomy Techniques and Outcomes: A Single-Center Experience with More than 1000 Cases.

    abstract：:BACKGROUND Laparoscopic donor nephrectomy (LDN) has evolved and has been established as a surgical standard of care for kidney transplantation. MATERIAL AND METHODS This study retrospectively reviews 1132 patients who underwent 4 different laparoscopic living-donor nephrectomies: hand-assisted laparoscopic nephrectomy...

    journal_title：Annals of transplantation

    pub_type： 杂志文章

    doi：10.12659/AOT.918189

    authors： Cho SJ,Moon HW,Kang SM,Choi SW,Kim KS,Choi YS,Hong SH,Ha US,Lee JY,Kim SW,Kim JC,Cho HJ

    更新日期：2020-02-11 00:00:00

  • Effect of Organ Scandal on Corneal Donation Rate and Organ Donors at a German University Hospital.

    abstract：:BACKGROUND The purpose of this study was to assess the effect of an organ transplantation scandal on the rate of corneal donations and organ donors at the University Hospital Tübingen. MATERIAL AND METHODS Data from all hospital deaths from January 2012 to December 2013 were analyzed retrospectively. Each deceased pat...

    journal_title：Annals of transplantation

    pub_type： 杂志文章

    doi：10.12659/aot.901385

    authors： Röck D,Petersen P,Yoeruek E,Thaler S,Bartz-Schmidt KU,Röck T

    更新日期：2017-07-11 00:00:00

  • Expression pattern of extracellular matrix proteins in the pancreas of various domestic pig breeds, the Goettingen Minipig and the Wild Boar.

    abstract：UNLABELLED:In spite of progress in biotechnology, isolation of porcine pancreatic islets remains a difficult task with unpredictable results. One reason could be the lack of knowledge as to the expression of extracellular matrix proteins in porcine exocrine and endocrine tissues, particularly in "islet capsules". Such ...

    journal_title：Annals of transplantation

    pub_type： 杂志文章

    doi：

    authors： Meyer T,Czub S,Chodnewska I,Beutner U,Hamelmann W,Klöck G,Zimmermann U,Thiede A,Ulrichs K

    更新日期：1997-01-01 00:00:00

  • Pituitary function test and endocrine status in patient with cirrhosis of the liver before and after hepatic transplantation.

    abstract：OBJECTIVE:Hormonal alterations caused by chronic liver disease are well described. In contrast, the reversibility of peripheral hormonal changes after orthotopic liver transplantation (OLT) has only partially been analyzed since the establishment of OLT as treatment of chronic hepatic failure. In addition it is not fin...

    journal_title：Annals of transplantation

    pub_type： 杂志文章

    doi：

    authors： Seehofer D,Steinmueller T,Graef KJ,Rayes N,Wiegand W,Tullius SG,Settmacher U,Neuhaus P

    更新日期：2002-01-01 00:00:00

  • Clinicopathological Features and Prognosis of Intrahepatic Cholangiocarcinoma After Liver Transplantation and Resection.

    abstract：:BACKGROUND Intrahepatic cholangiocarcinoma (ICC) can be incidentally diagnosed after liver transplantation (LT). We investigated the clinicopathological features of LT recipients with ICC and compared prognosis with that of the control group. MATERIAL AND METHODS We identified 16 recipients with ICC in our institution...

    journal_title：Annals of transplantation

    pub_type： 杂志文章

    doi：10.12659/aot.901504

    authors： Jung DH,Hwang S,Song GW,Ahn CS,Moon DB,Kim KH,Ha TY,Park GC,Hong SM,Kim WJ,Kang WH,Kim SH,Yu ES,Lee SG

    更新日期：2017-01-26 00:00:00

  • Contrast enhanced ultrasound cholangiography via T-tube following liver transplantation.

    abstract：BACKGROUND:The objective was to evaluate contrast enhanced ultrasound (CEUS) based cholangiography compared to conventional radiography as a reference method in patients after liver transplantation. MATERIAL/METHODS:Contrast agents were administered through T-tubes, which were placed during the operation. Twelve patie...

    journal_title：Annals of transplantation

    pub_type： 杂志文章

    doi：10.12659/aot.883700

    authors： Chopra SS,Eisele R,Stelter L,Seehofer D,Grieser C,Warnick P,Denecke T

    更新日期：2012-12-31 00:00:00

  • Histopathological Examination may be Useful for Assessment of Fibrosis and Lipomatosis of Pancreas Allograft Prior to Solid Organ Transplantation.

    abstract：BACKGROUND:The results of pancreas transplantation depend in a large degree on appropriate pancreas allograft donor selection. Several risk factors of early surgical complications or pancreas allograft loss following transplantation have been identified, but the final decision on pancreas harvesting for transplantation...

    journal_title：Annals of transplantation

    pub_type： 杂志文章

    doi：10.12659/aot.894464

    authors： Kajor M,Ziaja J,Liszka Ł,Kostrząb-Zdebel A,Właszczuk P,Karkoszka H,Sekta S,Król R,Cierpka L

    更新日期：2015-11-03 00:00:00

  • An overview of legal aspects in organ transplantation--what are the family rights?

    abstract：:A short review of legal aspects of organ transplantation. The influence of type of consent and the family attitude on organ donation rate in all European countries. A special attention is given to the legal and ethical aspects of living organ and tissue transplantation. ...

    journal_title：Annals of transplantation

    pub_type： 杂志文章

    doi：

    authors： Aigner G

    更新日期：2004-01-01 00:00:00

  • Does Vitamin D Affect Chronic Renal Allograft Function in Pediatric Transplant Patients?

    abstract：:BACKGROUND Correction of hypovitaminosis D is simple, but it is unclear whether it is associated with an accelerated decline of renal allograft function in pediatric renal transplantation patients. This retrospective single center cohort study aimed at analyzing the effect of vitamin D and covariates on the slope of 1...

    journal_title：Annals of transplantation

    pub_type： 杂志文章

    doi：

    authors： Wile B,Yoo E,Alvarez Elias AC,Subramanian L,Eager K,Sharma AP,Filler G

    更新日期：2018-04-17 00:00:00

  • Successful full-term pregnancy in a patient three and a half years after a heart transplant.

    abstract：:The patient is a 28 year old woman who received a heart transplant in 1992 secondary to hypertrophic cardiomyopathy with unremarkable post-operative course. In the period immediately post transplantation the patient was on a four-drug immunosuppressive regimen which was subsequently changed to standard three-agent the...

    journal_title：Annals of transplantation

    pub_type： 杂志文章

    doi：

    authors： Dziatkowiak A,Zdebski Z,Tracz W,Piwowarska W,Garlicki M,Kapelak B,Tomaszczyk T,Migdał M,Wysocka T,Sadowski J,Pfitzner R,Nessler J,Pietrzyk E,Wójcik S,Rudziński P,Lesniak A

    更新日期：1996-01-01 00:00:00

  • Pregnancy Outcomes Following Pediatric Liver Transplantation: A Single-Center Experience in Japan.

    abstract：:BACKGROUND The number of pregnancies after liver transplantation (LT) is increasing; however, the safety and incidence of complications associated with these pregnancies are still unclear. In this report, we retrospectively assessed the influences and problems associated with post-transplant pregnancy on allografts, r...

    journal_title：Annals of transplantation

    pub_type： 杂志文章

    doi：10.12659/AOT.921193

    authors： Naya I,Sanada Y,Katano T,Miyahara G,Hirata Y,Yamada N,Okada N,Onishi Y,Sakuma Y,Sata N

    更新日期：2020-06-09 00:00:00

  • Preemptive administration of recombinant factor VII (rVIIa) in patients transplanted due to fulminant Wilson's disease.

    abstract：BACKGROUND:Fulminant liver failure (FLF) is a severe clinical condition usually accompanied by a coagulopathy, which is one of the key selection criteria for liver transplantation. Prolongation of prothrombin time can vary between etiologies of FHF, being one of the worst in fulminant presentation of Wilson's disease. ...

    journal_title：Annals of transplantation

    pub_type： 杂志文章

    doi：

    authors： Czuprynska MM,Wawrzynowicz-Syczewska M,Jureczko L,Andrzejewska J,Jarosz K,Trzebicki J,Pacholczyk M,Chmura A,Wojcicki M

    更新日期：2010-07-01 00:00:00