Abstract：
:Calcium plays a crucial role in physiological process in liver cells however in high concentrations these ions can be pathogenic and lead to cell death. Mechanisms responsible for maintaining calcium ion concentration gradient in physiological conditions include transmembrane transport, storage in intracellular organelles and binding to cytoplasmatic proteins. Ischemia, sepsis, anoxia and action of toxins are responsible for uncontrolled influx of calcium and consequently cell damage. Liver damage during its preservation for transplantation is connected with dysfunction of many enzymes, damage of cell membrane and cytoskeleton proteins. During reperfusion Kupffer cells are activated, reactive oxygen species are produced and microcirculation is disordered by calcium--dependent processes. Calcium channel blocking (CCB) drugs exhibit immunomodulatory impact and positive interaction with cyclosporine or tacrolismus. They also have cytoprotective properties during preservation end reperfusion time. They seem to improve liver function, decrease liver cell damage, elevate bile production, decrease lipid peroxydation and free radicals production. But in some experiments CCB do not modify calcium concentration. More research on preservation conditions is needed to increase the probability of a successful liver transplantation.
journal_name
Ann Transplantjournal_title
Annals of transplantationauthors
Trocha M,Szelag Akeywords:
subject
Has Abstractpub_date
2004-01-01 00:00:00pages
5-11issue
3eissn
1425-9524issn
2329-0358journal_volume
9pub_type
杂志文章,评审abstract：BACKGROUND:Transplant renal artery stenosis (TRAS) is a serious vascular complication due to non-specific clinical manifestations, causing serious diagnostic difficulties. Contrast-enhanced ultrasound (CE-US) can complement standard sonographic examination in evaluation of TRAS. MATERIAL AND METHODS:Standard ultrasoun...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/AOT.883896
更新日期：2013-04-26 00:00:00
abstract：BACKGROUND:Institut Georges Lopez-1 (IGL-1) is a new preservation solution with lower potassium and lower viscosity than University Wisconsin solution (UW). These characteristics which improve liver preservation lead us to evaluate clinical effects of IGL-1 in a randomized controlled study with UW. MATERIAL/METHODS:Fr...
journal_title：Annals of transplantation
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2010-10-01 00:00:00
abstract：:BACKGROUND Intrahepatic cholangiocarcinoma (ICC) can be incidentally diagnosed after liver transplantation (LT). We investigated the clinicopathological features of LT recipients with ICC and compared prognosis with that of the control group. MATERIAL AND METHODS We identified 16 recipients with ICC in our institution...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/aot.901504
更新日期：2017-01-26 00:00:00
abstract：BACKGROUND:Xenotransplantation from pig to humans may be associated with the risk of transmission of porcine endogenous retroviruses (PERVs) that are present in the genome of all pigs and that infect human cells in vitro. However, it remains unclear whether PERVs infect transplant recipients in vivo and, if so, whether...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
abstract：:The liver immune function is associated with specific lymphocyte population transiently marginated in the liver sinusoids. These cells are of blood origin, however they are phenotypically and functionally different from peripheral blood lymphocytes. The question arises whether tumor proliferating in the liver can modi...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：OBJECTIVE:Hormonal alterations caused by chronic liver disease are well described. In contrast, the reversibility of peripheral hormonal changes after orthotopic liver transplantation (OLT) has only partially been analyzed since the establishment of OLT as treatment of chronic hepatic failure. In addition it is not fin...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：:Stem cell research seems now to reach important progress in biomedicine, giving promising perspective for clinical implementation. The review of stem cell research is presented including origin, content in various organs, harvesting, preservation and storage. Some examples of results achieved in stem cell research inc...
journal_title：Annals of transplantation
pub_type： 杂志文章,评审
doi：
更新日期：2003-01-01 00:00:00
abstract：:Solid organ transplantation program in Poland is very limited. The main reason of this is organ shortage. All the organs procured are transplanted. It is a general feeling that recently issued legal regulations will favorably influence organ donation, however the improvement may be expected within a few years and will...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：BACKGROUND:Lung transplant recipients are at great risk for developing various infectious complications. These infections portend a significant morbidity and mortality throughout their lifetime following transplantation. At times, cutaneous manifestations are the only clues to systemic infection. CASE REPORT:A 62 year...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/AOT.883846
更新日期：2013-03-14 00:00:00
abstract：BACKGROUND:Sirolimus is a potent immunosuppressive drug that has been shown to decrease the incidence of rejection post renal transplantation. Dyslipidemia is a well recognized side effect of sirolimus therapy, which may have an impact on patient survival and post-transplant cardiac morbidity and mortality. It is unkno...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND:Data in kidney transplant recipients regarding elimination of calcineurin inhibitor (CNI) therapy from a de novo regimen based on low CNI exposure and an mTOR inhibitor are sparse, and restricted to CNI elimination within the first six months post-transplant. MATERIAL/METHODS:In a 12-month, randomized, mult...
journal_title：Annals of transplantation
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.12659/aot.882637
更新日期：2012-01-01 00:00:00
abstract：:BACKGROUND Left ventricular assist devices (LVAD) are used to treat heart failure. Preoperative prediction of RV function after LVAD implantation is crucial. Correlations were found between preoperative echo and RV function after LVAD implantation. MATERIAL AND METHODS We retrospectively reviewed 23 male patients (8 i...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/aot.899054
更新日期：2016-08-11 00:00:00
abstract：:BACKGROUND Percutaneous liver biopsy is an established diagnostic procedure for the assessment of liver pathologies. Limited data are available on the clinical impact of liver biopsies in liver transplant recipients. MATERIAL AND METHODS Liver transplant recipients undergoing liver biopsy between 2000 and 2013 were an...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/aot.901487
更新日期：2017-02-24 00:00:00
abstract：:For each individual, there is a limit to the capacity to perform exercise. The limitation, however, depends on the nature of the task and is also influenced by a number of other factors. Muscle strength is determined largely by muscle mass, specifically muscle cross-sectional area, but is also influenced by neural dri...
journal_title：Annals of transplantation
pub_type： 杂志文章,评审
doi：
更新日期：2005-01-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to characterize patient antibodies before and after cadaver and/or living-donor kidney transplantation and to correlate these data with the clinical course after transplantation. METHODS:Sera from 69 cadaver, 9 living-related and 2 patients waiting for living-donor kidney transplant...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
abstract：:BACKGROUND Chronic allograft nephropathy (CAN) remains a major problem for long-term graft survival and different pathways participate in its development. CXC chemokine receptor 4 (CXCR4) is significantly upregulated following renal injury and fibrotic response. We investigated the effect of AMD3100, a CXCR4 antagonis...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/AOT.899492
更新日期：2016-11-25 00:00:00
abstract：BACKGROUND:Anti-CMV prophylaxis is currently a routine management in patients after organ transplantation. One of the clinical symptoms of CMV infection may be lesions in the oral cavity.The aim of this study was to determine the relationship between CMV infection, occurrence of Candida species and presence of oral muc...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND:The impact of treated preoperative bacterial infections on the outcome of living-donor liver transplantation (LDLT) is not well defined. The aim of this study was to determine the frequency of pre-transplant bacterial infections within one month before LDLT and their impact on the post-transplant morbidity a...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/AOT.892095
更新日期：2014-12-23 00:00:00
abstract：:Rat pancreatic islets were immunoisolated within alginate capsules with additional polyethyleneimine-protamine-heparin highly biocompatible membrane. Perifusion study in vitro demonstrated satisfactory similarities between the insulin release profiles of encapsulated and free islets. Concordant xenotransplantation of ...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:A short review of legal aspects of organ transplantation. The influence of type of consent and the family attitude on organ donation rate in all European countries. A special attention is given to the legal and ethical aspects of living organ and tissue transplantation. ...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：:BACKGROUND Long-term real-world data are relatively sparse regarding recurrence of chronic hepatitis B virus (HBV) infection after liver transplantation using hepatitis B immunoglobulin (HBIg) and nucleos(t)ide analogue (NUC) prophylaxis. MATERIAL AND METHODS Data from 371 adults transplanted for HBV-related disease a...
journal_title：Annals of transplantation
pub_type： 杂志文章,多中心研究
doi：10.12659/AOT.910176
更新日期：2018-11-13 00:00:00
abstract：:The hepatitis B virus (HBV) infects more than 260 million people globally, with increasing incidence, especially in developing countries. Despite antiviral therapies, HBV-related end-stage liver disease remains one of the most important indications for liver transplantation worldwide. Although new available treatments...
journal_title：Annals of transplantation
pub_type： 杂志文章,评审
doi：10.12659/aot.900216
更新日期：2016-10-14 00:00:00
abstract：BACKGROUND:The activation of the tryptophane catabolizing enzyme Indoleamine 2,3-dioxygenase leads to the formation of kynurenine and other metabolites that counter-regulate immune activation resulting in restoration of immune homeostasis. But in chronic immune activation, as in hemodialysed patients, the immunosuppres...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/AOT.889764
更新日期：2014-01-27 00:00:00
abstract：:The aim of the report is to present successful surgical treatment of aneurysm of common iliac artery (CIA) and internal iliac artery (IIA) in a kidney transplant patient. The aneurysm of CIA and IIA, causing arterial hypertension, was diagnosed and treated surgically in a 47-year-old male patient, who had received a c...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：:BACKGROUND The prognosis of the patients of acute liver failure (ALF) with onset of hepatic coma is often dismal. ALF is a well-accepted indication for liver transplantation (LT) and has markedly improved the prognosis of these patients. However, its role in ALF patients with onset of hepatic coma has never been eluci...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：2018-03-13 00:00:00
abstract：OBJECTIVES:Modification of the total body irradiation technique before bone marrow transplantation has been implemented to improve uniformity of the dose inside the irradiated body and to obtain appropriate reduction in doses in critical organs. METHODS:The total dose of 12.6 Gy was delivered with the use of a combina...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:BACKGROUND The aim of this study was to investigate the clinical features and treatment strategies of transplant renal artery stenosis (TRAS) with kidneys from donation after cardiac death (DCD). MATERIAL AND METHODS We collected the clinical data of donors and recipients of single-center DCD-induced TRAS from January...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/AOT.918076
更新日期：2020-02-04 00:00:00
abstract：BACKGROUND:Autologous peripheral blood stem cell transplantation (PBSCT) is commonly used in the treatment of lymphoma patients. G-CSF is widely used to boost white blood cell recovery. However, there are no clear data indicating which strategy of using G-CSF provides the most benefit. The aim of our study was to compa...
journal_title：Annals of transplantation
pub_type： 杂志文章,多中心研究
doi：10.12659/AOT.883965
更新日期：2013-07-02 00:00:00
abstract：:The number of liver grafts obtained from a cadaver can be greatly increased with the application of split liver transplantation. In the last 10 years, pediatric waiting list mortality has been reduced significantly with the use of this form of liver transplantation, which has 2 major forms. In its most commonly used f...
journal_title：Annals of transplantation
pub_type： 杂志文章,评审
doi：10.12659/aot.896351
更新日期：2016-07-01 00:00:00
abstract：BACKGROUND:Induction of the hepatic and intestinal cytochrome P450-3A4 system and intestinal P-glycoprotein is an unavoidable consequence of rifampin administration which requires substantial increase in tacrolimus dose when given concurrently. Chronic diarrhea is known to precipitate tacrolimus toxicity irrespective o...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：2010-01-01 00:00:00
