Abstract：
BACKGROUND:Fungal infections have a significant impact on patient survival after liver transplantation, mostly caused by Candida and Aspergillus. The clinical manifestations vary, and range from colonization, active local infection, to severe invasive form. A high degree of suspicion is required for the early diagnosis and, accordingly, the optimal management of these infections. This study aimed to evaluate fungal infection in the Intensive care Unit (ICU) in admitted liver transplant patients, focussing of etiologic agent, clinical/laboratory presentation (including mortality), and risk factors. MATERIAL AND METHODS:This retrospective study included living related liver transplanted patients admitted to the ICU. Clinical data was collected, thorough clinical evaluation was done, and laboratory tests were performed. Microbiological examination detecting the presence of fungus in various samples, using cultures and serology, and imaging investigations were carried out in all patients. RESULTS:This study included 23 cases of ICU-admitted liver transplant patients who were diagnosed with fungal infection. Candida was the most common fungal infection and occurred at a mean of 2 months after transplantation; while Aspergillus was less common and occurred later with worse laboratory findings. Invasive fungal infection constituted 43% of the diagnosed cases. Difference in mortality between Aspergillus and Candida was insignificant, as was difference between patients with and without fungal infection. CONCLUSIONS:Fungal infection among LT patients was common, including the invasive forms.
journal_name
Ann Transplantjournal_title
Annals of transplantationauthors
Marzaban R,Salah M,Mukhtar AM,Dwedar RA,Abdel-Latif W,Mahmoud Idoi
10.12659/AOT.892132subject
Has Abstractpub_date
2014-12-22 00:00:00pages
667-73eissn
1425-9524issn
2329-0358pii
892132journal_volume
19pub_type
杂志文章abstract：:Liver graft function after transplantation is dependent on ischemia-reperfusion injury, toxicity of drugs (immunosuppression, antibiotics and other) and transplant rejection. Although routinely monitored with enzymatic tests (AST, ALT, GGT, ALP), bilirubin and coagulation parameters, differentiation between these path...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：:Recognition of mismatched (foreign) alloantigens on the graft by the recipients T cells initiates allograft rejection. This process is mediated by two mayor mechanisms--direct and indirect allorecognition. Both process are being discussed. ...
journal_title：Annals of transplantation
pub_type： 杂志文章,评审
doi：
更新日期：2001-01-01 00:00:00
abstract：BACKGROUND:Pseudoaneurysm is a very rare and unusual form of myocardial rupture, with complications such as chest trauma, inflammation, acute myocardial infarction, and infection. Although this rare complication has already been reported, it has never been found in a transplanted patient. CASE REPORT:We present the ca...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/AOT.890417
更新日期：2014-06-26 00:00:00
abstract：:Transplantation of liver has been remarkably effective in the treatment of liver failure and liver-based inherited metabolic diseases and has revolutionized the care of patients with end-stage liver disease. Unfortunately demand for transplantable livers is progressively outpacing the supply of donated cadaver organs,...
journal_title：Annals of transplantation
pub_type： 杂志文章,评审
doi：
更新日期：2007-01-01 00:00:00
abstract：:BACKGROUND Minimally invasive surgery (MIS) has rapidly advanced, but its use in transplant patients has lagged. We share our experience of MIS for patients after kidney and liver transplantation and compare our results with similar studies in the literature. MATERIAL AND METHODS This study included 14 MIS (12 laparos...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/AOT.922602
更新日期：2020-06-16 00:00:00
abstract：OBJECTIVE:Hormonal alterations caused by chronic liver disease are well described. In contrast, the reversibility of peripheral hormonal changes after orthotopic liver transplantation (OLT) has only partially been analyzed since the establishment of OLT as treatment of chronic hepatic failure. In addition it is not fin...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：BACKGROUND:Metabolic abnormalities have been reported in patients undergoing hematopoietic stem cell transplantation (HSCT). Potential causes, risk factors and outcomes of electrolyte imbalances have thoroughly been investigated. On HSCT recipients, multiple pathophysiologic contributors are inflicting electrolyte abno...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：2009-07-01 00:00:00
abstract：:BACKGROUND Dual kidney transplantation (DKT) of expanded-criteria donors is a cost-intensive procedure that aims to increase the pool of available deceased organ donors and has demonstrated equivalent outcomes to expanded-criteria single kidney transplantation (eSKT). The objective of this study was to develop an allo...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/aot.898328
更新日期：2016-09-08 00:00:00
abstract：:BACKGROUND Solid organ transplantations lead to improvements in patient survival and patient quality of life, as well as health care system economic benefits. However, over time, health problems can accumulate post-transplantation. Therefore, we hypothesized that in the late post-transplantation period, the costs of p...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/AOT.914661
更新日期：2019-05-07 00:00:00
abstract：BACKGROUND:Colonic diverticular disease is rare in developing nations but common in Western and industrialized societies. Many studies show that heart and lung transplantation increase the risk of having severe diverticulitis, although the exact magnitude of this risk remain unclear because many of these studies have b...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：2010-07-01 00:00:00
abstract：:BACKGROUND Diffuse thrombosis of iliac veins and IVC has been considered a significant technical obstacle in pediatric kidney transplantation (KT). MATERIAL AND METHODS Between 1984 and 2018, 951 KTs were performed in our institution. In 4 children qualified for KT, diffuse thrombosis of iliac veins or IVC was found. T...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/AOT.912657
更新日期：2019-01-11 00:00:00
abstract：BACKGROUND:The early phase of MPA exposure has rarely been investigated after solid organ transplantation, especially in heart transplantation patients. We evaluated the association between exposure to mycophenolic acid (MPA), a main metabolite of mycophenolate mofetil (MMF), and clinical events within 3 months after h...
journal_title：Annals of transplantation
pub_type： 临床试验,杂志文章
doi：10.12659/AOT.883812
更新日期：2013-02-05 00:00:00
abstract：:BACKGROUND Left ventricular assist devices (LVAD) are used to treat heart failure. Preoperative prediction of RV function after LVAD implantation is crucial. Correlations were found between preoperative echo and RV function after LVAD implantation. MATERIAL AND METHODS We retrospectively reviewed 23 male patients (8 i...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/aot.899054
更新日期：2016-08-11 00:00:00
abstract：BACKGROUND:Data in kidney transplant recipients regarding elimination of calcineurin inhibitor (CNI) therapy from a de novo regimen based on low CNI exposure and an mTOR inhibitor are sparse, and restricted to CNI elimination within the first six months post-transplant. MATERIAL/METHODS:In a 12-month, randomized, mult...
journal_title：Annals of transplantation
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.12659/aot.882637
更新日期：2012-01-01 00:00:00
abstract：:BACKGROUND Prognostic models for 3-year mortality after kidney transplantation based on pre-transplant donor and recipient variables may avoid futility and thus improve donor organ allocation. MATERIAL AND METHODS There were 1546 consecutive deceased-donor kidney transplants in adults (January 1, 2000 to December 31, ...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/AOT.913217
更新日期：2019-05-17 00:00:00
abstract：BACKGROUND:Transarterial chemoembolization (TACE) induces ischemic tumor necrosis, which is intensified by regional chemotherapy. By reducing the active tumor tissue, it can be assumed that patients on the waiting list for liver transplantation may benefit from this locoregional treatment. The aim of this study was to ...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/aot.896778
更新日期：2015-12-29 00:00:00
abstract：BACKGROUND:Sirolimus is a potent immunosuppressive drug that has been shown to decrease the incidence of rejection post renal transplantation. Dyslipidemia is a well recognized side effect of sirolimus therapy, which may have an impact on patient survival and post-transplant cardiac morbidity and mortality. It is unkno...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND:Morbid obesity is associated with liver pathology, most commonly non-alcoholic steatohepatitis (NASH) leading to cirrhosis. However, the morbid obesity impedes qualification for organ transplantation. CASE REPORT:We present a case report of a 56-year-old woman who underwent bariatric procedure followed by l...
journal_title：Annals of transplantation
pub_type： 杂志文章,评审
doi：10.12659/AOT.893797
更新日期：2015-02-25 00:00:00
abstract：:Recovery of the patients after transplantation of non-renal organs may be complicated by multi-faceted chronic renal failure (CKD) which is regarded as an independent risk factor of graft dysfunction and mortality. The occurrence of CKD in non-renal transplant recipients depends mainly on a type of transplanted organ,...
journal_title：Annals of transplantation
pub_type： 杂志文章,评审
doi：
更新日期：2005-01-01 00:00:00
abstract：BACKGROUND:The aim of this study was to analyze the use of fixed-wing air ambulance (FWAA) services in Poland during the period 2012-2013, with particular emphasis on air transport of organ recipients to transplantation centers. MATERIAL AND METHODS:This was a retrospective, cross-sectional analysis of data derived fr...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/aot.895321
更新日期：2015-10-20 00:00:00
abstract：:BACKGROUND Normothermic machine perfusion (NMP) preservation is superior to cold preservation during reduced-size liver transplantation (RSLT) in pigs. However, the mechanism of this protective effect has not been explained. We aimed to compare the effects of NMP preservation with that of cold preservation (CS) in pro...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/AOT.910774
更新日期：2019-01-04 00:00:00
abstract：:Transplantation medicine, like no other medical specialty, is connected with a wide range of very difficult ethical issues. Among those are: availability of the treatment, consent for cadaveric donation, allocation of available organs, new categories of living unrelated donors and economic aspects of this method of tr...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：:BACKGROUND Perioperative monitoring and hemodynamic management after heterotopic thoracic cardiac xenotransplantation is challenging due to 2 independently beating hearts. Telemetry allows continuous monitoring of hemodynamic parameters of both the donor and recipient hearts. We describe our experience and report on t...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/AOT.909522
更新日期：2018-07-20 00:00:00
abstract：:The patient is a 28 year old woman who received a heart transplant in 1992 secondary to hypertrophic cardiomyopathy with unremarkable post-operative course. In the period immediately post transplantation the patient was on a four-drug immunosuppressive regimen which was subsequently changed to standard three-agent the...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:BACKGROUND In kidney transplantation, the association of cold ischemia time (CIT), anastomosis time (AT), and delayed graft function (DGF) is particularly detrimental in grafts from marginal donors; however, actual cut-off criteria are still debated. MATERIAL AND METHODS Data from patients >65 years (n=193) and patien...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/aot.896672
更新日期：2016-05-31 00:00:00
abstract：BACKGROUND:Lung transplant recipients are at great risk for developing various infectious complications. These infections portend a significant morbidity and mortality throughout their lifetime following transplantation. At times, cutaneous manifestations are the only clues to systemic infection. CASE REPORT:A 62 year...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/AOT.883846
更新日期：2013-03-14 00:00:00
abstract：:BACKGROUND Intrahepatic cholangiocarcinoma (ICC) can be incidentally diagnosed after liver transplantation (LT). We investigated the clinicopathological features of LT recipients with ICC and compared prognosis with that of the control group. MATERIAL AND METHODS We identified 16 recipients with ICC in our institution...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：10.12659/aot.901504
更新日期：2017-01-26 00:00:00
abstract：:Complete situs inversus (SI) is a very rare anomaly characterized by the total inversion of all abdominal and thoracic organs. SI has been traditionally considered an absolute contraindication for liver and heart transplantation. We report a case of a donor with complete SI diagnosed at the time of organ recovery and ...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：:The ability of kidney transplantation to improve quality of life has made this therapeutic modality the treatment of choice among renal replacement therapies; however, the continuing organ shortage has forced the use of marginal kidneys as a supplementary source of allografts. It has been repeatedly suggested that fai...
journal_title：Annals of transplantation
pub_type： 杂志文章,评审
doi：10.12659/aot.898405
更新日期：2016-07-26 00:00:00
abstract：BACKGROUND:Fulminant liver failure (FLF) is a severe clinical condition usually accompanied by a coagulopathy, which is one of the key selection criteria for liver transplantation. Prolongation of prothrombin time can vary between etiologies of FHF, being one of the worst in fulminant presentation of Wilson's disease. ...
journal_title：Annals of transplantation
pub_type： 杂志文章
doi：
更新日期：2010-07-01 00:00:00
