Identification of an Escherichia coli gene homologous to virR, a regulator of Shigella virulence.

Abstract:

:Virulence in Shigella spp., as well as in strains of enteroinvasive Escherichia coli, is regulated by growth temperature. Previously, virR had been identified as the gene controlling the temperature-regulated expression of Shigella virulence. Since Shigella spp. and E. coli are also known to share greater than 90% DNA sequence homology, we sought to determine if nonpathogenic E. coli K-12 C600 contains a gene homologous to the Shigella flexneri 2a gene virR. Through the use of transduction and molecular cloning of strain C600 chromosomal DNA we have shown that E. coli K-12 does indeed contain a gene functionally homologous to the virR of S. flexneri.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Hromockyj AE,Maurelli AT

doi

10.1128/jb.171.5.2879-2881.1989

subject

Has Abstract

pub_date

1989-05-01 00:00:00

pages

2879-81

issue

5

eissn

0021-9193

issn

1098-5530

journal_volume

171

pub_type

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