Biological variation in musculoskeletal injuries: current knowledge, future research and practical implications.


:Evidence from familial and genetic association studies have reported that DNA sequence variants play an important role, together with non-genetic factors, in the aetiology of both exercise-associated and occupational-associated acute and chronic musculoskeletal soft tissue injuries. The associated variants, which have been identified to date, may contribute to the interindividual variation in the structure and, by implication, mechanical properties of the collagen fibril and surrounding matrix within musculoskeletal soft tissues, as well as their response to mechanical loading and other stimuli. Future work should focus on the establishment of multidisciplinary international consortia for the identification of biologically relevant variants involved in modulating injury risk. These consortia will improve the limitations of the published hypothesis-driven genetic association studies, since they will allow resources to be pooled in recruiting large well-characterised cohorts required for whole-genome screening. Finally, clinicians and coaches need to be aware that many direct-to-consumer companies are currently marketing genetic tests directly to athletes without it being requested by an appropriately qualified healthcare professional, and without interpretation alongside other clinical indicators or lifestyle factors. These specific genetic tests are premature and are not necessarily required to evaluate susceptibility to musculoskeletal soft tissue injury. Current practice should rather consider susceptibility through known risk factors such as a positive family history of a specific injury, a history of other tendon and/or ligament injuries and participation in activities associated with the specific musculoskeletal injuries. Potential susceptible athletes may then be individually managed to reduce their risk profile.


Br J Sports Med


Collins M,September AV,Posthumus M




Has Abstract


2015-12-01 00:00:00














  • Excellent reliability for MRI grading and prognostic parameters in acute hamstring injuries.

    abstract:BACKGROUND:Categorical grading and other measurable MRI parameters are frequently utilised for predicting the outcome of hamstring injuries. However, the reliability and smallest detectable difference (SDD) have not been previously evaluated. It therefore remains unclear if the variability in previously reported result...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Hamilton B,Whiteley R,Almusa E,Roger B,Geertsema C,Tol JL

    更新日期:2014-09-01 00:00:00

  • Clinical assessment of the scapula: a review of the literature.

    abstract::Scientific evidence supporting a role for faulty scapular positioning in patients with various shoulder disorders is cumulating. Clinicians who manage patients with shoulder pain and athletes at risk of developing shoulder pain need to have the skills to assess static and dynamic scapular positioning and dynamic contr...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章,评审


    authors: Struyf F,Nijs J,Mottram S,Roussel NA,Cools AM,Meeusen R

    更新日期:2014-06-01 00:00:00

  • Salbutamol exhibits androgenic activity in vitro.

    abstract:BACKGROUND:Salbutamol has been shown to mediate anabolic effects after intravenous administration. However, the mechanism responsible for the anabolic actions of salbutamol remains unknown. AIM:To investigate the potential mechanism by which salbutamol mediates anabolic effects in vitro. METHODS:The potential androge...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章


    authors: von Bueren AO,Ma R,Schlumpf M,Lichtensteiger W

    更新日期:2007-12-01 00:00:00

  • New method to identify athletes at high risk of ACL injury using clinic-based measurements and freeware computer analysis.

    abstract:BACKGROUND:High knee abduction moment (KAM) landing mechanics, measured in the biomechanics laboratory, can successfully identify female athletes at increased risk for anterior cruciate ligament (ACL) injury. METHODS:The authors validated a simpler, clinic-based ACL injury prediction algorithm to identify female athle...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章


    authors: Myer GD,Ford KR,Hewett TE

    更新日期:2011-04-01 00:00:00

  • Significance of deep T-wave inversions in asymptomatic athletes with normal cardiovascular examinations: practical solutions for managing the diagnostic conundrum.

    abstract::Preparticipation screening programmes for underlying cardiac pathologies are now commonplace for many international sporting organisations. However, providing medical clearance for an asymptomatic athlete without a family history of sudden cardiac death (SCD) is especially challenging when the athlete demonstrates par...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章,评审


    authors: Wilson MG,Sharma S,Carré F,Charron P,Richard P,O'Hanlon R,Prasad SK,Heidbuchel H,Brugada J,Salah O,Sheppard M,George KP,Whyte G,Hamilton B,Chalabi H

    更新日期:2012-11-01 00:00:00

  • Exercise interventions for cognitive function in adults older than 50: a systematic review with meta-analysis.

    abstract:BACKGROUND:Physical exercise is seen as a promising intervention to prevent or delay cognitive decline in individuals aged 50 years and older, yet the evidence from reviews is not conclusive. OBJECTIVES:To determine if physical exercise is effective in improving cognitive function in this population. DESIGN:Systemati...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章,meta分析,评审


    authors: Northey JM,Cherbuin N,Pumpa KL,Smee DJ,Rattray B

    更新日期:2018-02-01 00:00:00

  • Visual or computer-based measurements: important for interpretation of athletes' ECG.

    abstract:BACKGROUND:ECG is recommended for preparticipation health examination in athletes. Owing to a lack of consensus on how to read and interpret athletes' ECGs, different criteria for abnormality are used. AIMS:To compare the prevalence of abnormal ECGs and test the correlation between visual and computer-based measuremen...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章


    authors: Berge HM,Steine K,Andersen TE,Solberg EE,Gjesdal K

    更新日期:2014-05-01 00:00:00

  • Ultrasound guided dry needling and autologous blood injection for patellar tendinosis.

    abstract:OBJECTIVE:To evaluate the efficacy of ultrasound guided dry needling and autologous blood injection for the treatment of patellar tendinosis. DESIGN:Prospective cohort study. SETTING:Hospital/clinic based. PATIENTS:47 knees in 44 patients (40 men, 7 women, mean age 34.5 years, age range 17 to 54 years) with refracto...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章


    authors: James SL,Ali K,Pocock C,Robertson C,Walter J,Bell J,Connell D

    更新日期:2007-08-01 00:00:00

  • Half pipe snowboarding: an (un)forgettable experience or an increasing risk for head injury?

    abstract::The case is presented of a professional half pipe snowboarder with a large post-traumatic subdural haematoma, which allowed close to normal functioning and socialisation. It is an example of a potentially life threatening sports injury in an increasingly commercialised and popular winter sport. It highlights that a kn...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章


    authors: Rajan GP,Zellweger R

    更新日期:2004-12-01 00:00:00

  • Health and ergogenic effects of caffeine.

    abstract::The indiscriminate use of caffeine by people of all ages may present health hazards. The public at large needs to be more informed of the presence of caffeine in commonly consumed foods and beverages, particularly by infants, children and pregnant women. It is the responsibility of all consumers to investigate the caf...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章,评审


    authors: Jacobson BH,Kulling FA

    更新日期:1989-03-01 00:00:00

  • Injury risk factors, screening tests and preventative strategies: a systematic review of the evidence that underpins the perceptions and practices of 44 football (soccer) teams from various premier leagues.

    abstract:PURPOSE:To systematically review the scientific level of evidence for the 'Top 3' risk factors, screening tests and preventative exercises identified by a previously published survey of 44 premier league football (soccer) teams. Also, to provide an overall scientific level of evidence and graded recommendation based on...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章,评审


    authors: McCall A,Carling C,Davison M,Nedelec M,Le Gall F,Berthoin S,Dupont G

    更新日期:2015-05-01 00:00:00

  • Physiological characteristics of junior and senior rugby league players.

    abstract:OBJECTIVES:To investigate the physiological characteristics of subelite junior and senior rugby league players and establish performance standards for these athletes. METHODS:A total of 159 junior (under 16, 15, 14, and 13, n = 88) and senior (first grade, second grade, and under 19, n = 71) rugby league players (forw...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章


    authors: Gabbett TJ

    更新日期:2002-10-01 00:00:00

  • Protective capability of bicycle helmets.

    abstract::Cycle helmets that meet UK and US standards have been tested. The mechanisms of energy absorption for frontal and side impacts have been analysed. A good helmet should protect the wearer for impacts up to 15 mph into a rigid flat surface. ...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章


    authors: Mills NJ

    更新日期:1990-03-01 00:00:00

  • Higher fasting plasma glucose levels within the normoglycaemic range and rotator cuff tears.

    abstract:OBJECTIVE:To determine the plasma glucose levels in non-diabetic patients with rotator cuff tear. DESIGN:Frequency-matched case-control study. SETTING:University Teaching Hospital. PARTICIPANTS:The study included 194 subjects who were operated on at our institution. Group 1 included 97 consecutive patients (36 men a...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章


    authors: Longo UG,Franceschi F,Ruzzini L,Spiezia F,Maffulli N,Denaro V

    更新日期:2009-04-01 00:00:00

  • Do team gymnasts compete in spite of symptoms from an injury?

    abstract:BACKGROUND:Gymnasts practise many hours a week, and symptoms from injuries do not seem to stop them from continuing with practice. They may even compete with symptoms from injuries, which could increase the risk of reinjury, or of the occurrence of a more severe injury. OBJECTIVES:To investigate whether team gymnasts ...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章


    authors: Harringe ML,Lindblad S,Werner S

    更新日期:2004-08-01 00:00:00

  • Response of bone metabolism related hormones to a single session of strenuous exercise in active elderly subjects.

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    journal_title:British journal of sports medicine

    pub_type: 杂志文章


    authors: Maïmoun L,Simar D,Malatesta D,Caillaud C,Peruchon E,Couret I,Rossi M,Mariano-Goulart D

    更新日期:2005-08-01 00:00:00

  • Power output for wheelchair driving on a treadmill compared with arm crank ergometry.

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    journal_title:British journal of sports medicine

    pub_type: 杂志文章


    authors: Tropp H,Samuelsson K,Jorfeldt L

    更新日期:1997-03-01 00:00:00

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    abstract::In Part II of the study, the British Olympic track (sprint) squad cyclists demonstrated reductions in body fat index, % body fat and endomorphy (p greater than .05), increased Hb and PCV % (p greater than .05), and lowered HR at rest and in warm-up exercise (p greater than .05), but no change in leg power. Repeated in...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章


    authors: White JA,Quinn G,Al-Dawalibi M,Mulhall J

    更新日期:1982-03-01 00:00:00

  • Eccentric/concentric ratios at selected velocities for the invertor and evertor muscles of the chronically unstable ankle.

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    journal_title:British journal of sports medicine

    pub_type: 杂志文章


    authors: Hartsell HD,Spaulding SJ

    更新日期:1999-08-01 00:00:00

  • MRI of the knee in asymptomatic adolescent swimmers: a controlled study.

    abstract:BACKGROUND:Swimming is a widespread sporting activity generally regarded as an ideal form of exercise, which has little or no impact on the knees. However, overuse or repetitive microtrauma injuries may often affect the knee joint of young competitive swimmers. These early lesions are frequently asymptomatic for a cons...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章


    authors: Soder RB,Mizerkowski MD,Petkowicz R,Baldisserotto M

    更新日期:2012-03-01 00:00:00

  • Perceptions of retired professional soccer players about the provision of support services before and after retirement.

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    journal_title:British journal of sports medicine

    pub_type: 杂志文章


    authors: Drawer S,Fuller CW

    更新日期:2002-02-01 00:00:00

  • The validity and reliability of a novel activity monitor as a measure of walking.

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    journal_title:British journal of sports medicine

    pub_type: 杂志文章


    authors: Ryan CG,Grant PM,Tigbe WW,Granat MH

    更新日期:2006-09-01 00:00:00

  • The New Zealand rugby injury and performance project. IV. Anthropometric and physical performance comparisons between positional categories of senior A rugby players.

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    journal_title:British journal of sports medicine

    pub_type: 杂志文章


    authors: Quarrie KL,Handcock P,Toomey MJ,Waller AE

    更新日期:1996-03-01 00:00:00

  • Lactic acid removal and heart rate frequencies during recovery after strenuous rowing exercise.

    abstract::Three tests were conducted to assess the effectiveness of three different intensities of exercise both in reducing blood lactic acid (LA) levels and in influencing subjects' heart rate (HR), following a 2000 m race in a rowing boat. In the first and second tests these variables were investigated during a 13 min recove...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章


    authors: Koutedakis Y,Sharp NC

    更新日期:1985-12-01 00:00:00

  • Models for the pathogenesis of stress fractures in athletes.

    abstract::It would seem that the development of a stress fracture results from unsuccessful adaptation of bone to a change in its mechanical environment caused by repetitive loading. It involves the physiological processes of microdamage production and remodelling. Whether the initiating factor is microdamage production or acti...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章,评审


    authors: Bennell KL,Malcolm SA,Wark JD,Brukner PD

    更新日期:1996-09-01 00:00:00

  • A quantifiable approach in the comparison of isokinetic assessment data--new correlation equations for the Johnson antishear device and standard shin pad in the isokinetic assessment of the knee.

    abstract::The rehabilitation of the knee with a deficient anterior cruciate ligament (ACL) always presents a great challenge. Isokinetic assessment allows muscle performance to be quantified. The antishear device, introduced by Johnson, has the distinct advantage of minimizing the anterior translation force during isokinetic ex...

    journal_title:British journal of sports medicine

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Li CK,Chan KM,Hsu YS,Chien P,Wong WN

    更新日期:1995-09-01 00:00:00

  • Limitations of serum values to estimate glomerular filtration rate during exercise.

    abstract:OBJECTIVE:Glomerular filtration rate (GFR) is part of routine medical practice for clinical assessment of kidney function in health and disease conditions, and is determined by measuring the clearance of creatinine (Cl-Crn) or estimated (eGFR) from equations using serum creatinine (Crn) or cystatin C (Cyst C). Crn and ...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章


    authors: Poortmans JR,Gulbis B,De Bruyn E,Baudry S,Carpentier A

    更新日期:2013-12-01 00:00:00

  • Mitochondrial haplogroups associated with elite Japanese athlete status.

    abstract:PURPOSE:It has been hypothesised that certain mitochondrial haplogroups, which are defined by the presence of a characteristic cluster of tightly linked mitochondrial DNA polymorphisms, would be associated with elite Japanese athlete status. To examine this hypothesis, the frequencies of mitochondrial haplogroups found...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章


    authors: Mikami E,Fuku N,Takahashi H,Ohiwa N,Scott RA,Pitsiladis YP,Higuchi M,Kawahara T,Tanaka M

    更新日期:2011-12-01 00:00:00

  • Ergometer training volume and previous injury predict back pain in rowing; strategies for injury prevention and rehabilitation.

    abstract::The most commonly reported injury site in rowers is the lower back. Research in recent years has focused on epidemiology and biomechanical analyses to try and understand mechanisms that contribute to this injury's onset. Injury surveillance mainly comprises retrospective questionnaires and reviews of medical records w...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章,评审


    authors: Wilson F,Gissane C,McGregor A

    更新日期:2014-11-01 00:00:00

  • Energy demands during a judo match and recovery.

    abstract:OBJECTIVE:To assess energy demand during a judo match and the kinetics of recovery by measuring the metabolites of the oxypurine cascade, lipolytic activity, and glycolytic pathway. METHODS:Venous blood samples were taken from 16 national judoists (mean (SEM) age 18.4 (1.6) years), before (T(1)) and three minutes (T(2...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章


    authors: Degoutte F,Jouanel P,Filaire E

    更新日期:2003-06-01 00:00:00