Biological variation in musculoskeletal injuries: current knowledge, future research and practical implications.


:Evidence from familial and genetic association studies have reported that DNA sequence variants play an important role, together with non-genetic factors, in the aetiology of both exercise-associated and occupational-associated acute and chronic musculoskeletal soft tissue injuries. The associated variants, which have been identified to date, may contribute to the interindividual variation in the structure and, by implication, mechanical properties of the collagen fibril and surrounding matrix within musculoskeletal soft tissues, as well as their response to mechanical loading and other stimuli. Future work should focus on the establishment of multidisciplinary international consortia for the identification of biologically relevant variants involved in modulating injury risk. These consortia will improve the limitations of the published hypothesis-driven genetic association studies, since they will allow resources to be pooled in recruiting large well-characterised cohorts required for whole-genome screening. Finally, clinicians and coaches need to be aware that many direct-to-consumer companies are currently marketing genetic tests directly to athletes without it being requested by an appropriately qualified healthcare professional, and without interpretation alongside other clinical indicators or lifestyle factors. These specific genetic tests are premature and are not necessarily required to evaluate susceptibility to musculoskeletal soft tissue injury. Current practice should rather consider susceptibility through known risk factors such as a positive family history of a specific injury, a history of other tendon and/or ligament injuries and participation in activities associated with the specific musculoskeletal injuries. Potential susceptible athletes may then be individually managed to reduce their risk profile.


Br J Sports Med


Collins M,September AV,Posthumus M




Has Abstract


2015-12-01 00:00:00














  • Imaging services at the Paralympic Games London 2012: analysis of demand and distribution of workload.

    abstract:BACKGROUND:Very little data have been published on medical imaging services at disability games. 7.9 million euros (£6.6 million, US$11 million) were invested in setting up radiology facilities within purpose built polyclinics at the London 2012 Olympic and Paralympic games. This paper details imaging services at the 2...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章


    authors: Bethapudi S,Campbell RS,Budgett R,Willick SE,Van de Vliet P

    更新日期:2015-01-01 00:00:00

  • Effects of hyperbaric exposures on cardiac pacemakers.

    abstract::Data on tolerance of cardiac pacemakers during diving are very scarce. The aim of this study was to test electronic and mechanical tolerances of pacemakers exposed to experimental reproductions of pressures encountered during diving. Two samples each of 20 different models of cardiac pacemakers were exposed to compres...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章


    authors: Lafay V,Trigano JA,Gardette B,Micoli C,Carre F

    更新日期:2008-03-01 00:00:00

  • Influence of rugby injuries on players' subsequent health and lifestyle: beginning a long term follow up.

    abstract:OBJECTIVES:To describe the current rugby playing status of a cohort of 1,169 men who had previously participated in an epidemiological survey of rugby injuries during the 1993-1994 season, and assess the consequences of rugby injuries sustained. METHODS:In May 1998, 911 (78%) men completed a questionnaire reporting th...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章


    authors: Lee AJ,Garraway WM,Hepburn W,Laidlaw R

    更新日期:2001-02-01 00:00:00

  • Interseason variability of a functional movement test, the 9+ screening battery, in professional male football players.

    abstract:BACKGROUND:The Nine Plus screening battery test (9+) is a functional movement test intended to identify limitations in fundamental movement patterns predisposing athletes to injury. However, the interseason variability is unknown. AIM:To examine the variability of the 9+ test between 2 consecutive seasons in professio...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章


    authors: Bakken A,Targett S,Bere T,Eirale C,Farooq A,Tol JL,Whiteley R,Witvrouw E,Khan KM,Bahr R

    更新日期:2017-07-01 00:00:00

  • Outcomes of hip arthroscopy. A prospective analysis and comparison between patients under 25 and over 25 years of age.

    abstract:OBJECTIVE:To compare the results of hip arthroscopy in patients under the age of 25 with those over 25 years. DESIGN:From March 2006 until May 2010, data were collected on all patients who underwent hip arthroscopy for symptomatic intra-articular hip pathology. The patients were divided into two groups based on age (l...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章


    authors: Cooper AP,Basheer SZ,Maheshwari R,Regan L,Madan SS

    更新日期:2013-03-01 00:00:00

  • Alterations to cell metabolism in connective tissues of the knee after ovariohysterectomy in a rabbit model: are there implications for the postmenopausal athlete?

    abstract:BACKGROUND:Participation in regular exercise and athletic activities across the lifespan is encouraged to maintain the cardiovascular and musculoskeletal systems and general wellbeing. Before the menopause there is an increased risk of anterior cruciate ligament (ACL) injuries in female athletes, whereas there is an in...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章


    authors: Hart DA,Achari Y

    更新日期:2010-09-01 00:00:00

  • Solid organ transplant recipients: clinical considerations in the application of exercise.

    abstract::Over 100 000 solid organ transplants are performed worldwide each year and this has a significant impact on physical function and quality of life. However, the capacity for exercise in solid-organ recipients is reduced. Regular physical activity improves most of the indices of fitness in these patients but, with few e...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章,评审


    authors: McKenzie KJ,McKenzie DC,Yoshida EM

    更新日期:2015-01-01 00:00:00

  • Classification and grading of muscle injuries: a narrative review.

    abstract::A limitation to the accurate study of muscle injuries and their management has been the lack of a uniform approach to the categorisation and grading of muscle injuries. The goal of this narrative review was to provide a framework from which to understand the historical progression of the classification and grading of ...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章,评审


    authors: Hamilton B,Valle X,Rodas G,Til L,Grive RP,Rincon JA,Tol JL

    更新日期:2015-03-01 00:00:00

  • Mental health symptoms and disorders in elite athletes: a systematic review on cultural influencers and barriers to athletes seeking treatment.

    abstract:OBJECTIVE:To summarise the literature on the barriers to athletes seeking mental health treatment and cultural influencers of mental health in elite athletes. DESIGN:Systematic review DATA SOURCES: PubMed, Cochrane, Scopus, SportDiscus (Ebsco), and PsycINFO (ProQuest) up to November 2018. ELIGIBILITY CRITERIA FOR SEL...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章


    authors: Castaldelli-Maia JM,Gallinaro JGME,Falcão RS,Gouttebarge V,Hitchcock ME,Hainline B,Reardon CL,Stull T

    更新日期:2019-06-01 00:00:00

  • β-2 agonists in sport: are the anti-doping rules meeting the needs of asthmatic athletes?

    abstract:OBJECTIVES:(a) To review the methacholine tests performed in our laboratory up until 2008; (b) to compare them with previously reported data in 2006 and (c) to examine if the anti-doping rules are meeting the needs of asthmatic athletes who really need bronchodilator treatment. METHODS:Between April 2004 and September...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章


    authors: Orellana JN,Márquez MD

    更新日期:2011-08-01 00:00:00

  • Methods for injury surveillance in international cricket.

    abstract:BACKGROUND:The varying methods of cricket injury surveillance have made direct comparison of published studies in this field impossible. METHODS:A consensus regarding definitions and methods to calculate injury rates in cricket was sought between researchers in this field. This was arrived at through a variety of face...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章


    authors: Orchard JW,Newman D,Stretch R,Frost W,Mansingh A,Leipus A

    更新日期:2005-04-01 00:00:00

  • Do the associations of sedentary behaviour with cardiovascular disease mortality and cancer mortality differ by physical activity level? A systematic review and harmonised meta-analysis of data from 850 060 participants.

    abstract:OBJECTIVE:To examine whether the associations between sedentary behaviours (ie, daily sitting/TV-viewing time) and mortality from cardiovascular disease (CVD) and cancer differ by different levels of physical activity (PA). DESIGN:Harmonised meta-analysis of prospective cohort studies. Data on exposure variables were ...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章,meta分析


    authors: Ekelund U,Brown WJ,Steene-Johannessen J,Fagerland MW,Owen N,Powell KE,Bauman AE,Lee IM

    更新日期:2019-07-01 00:00:00

  • Comparison of the '11+ Kids' injury prevention programme and a regular warmup in children's football (soccer): a cost effectiveness analysis.

    abstract:OBJECTIVE:To evaluate a potential reduction in injury related healthcare costs when using the '11+ Kids' injury prevention programme compared with a usual warmup in children's football. METHODS:This cost effectiveness analysis was based on data collected in a cluster randomised controlled trial over one season from fo...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章,随机对照试验


    authors: Rössler R,Verhagen E,Rommers N,Dvorak J,Junge A,Lichtenstein E,Donath L,Faude O

    更新日期:2019-03-01 00:00:00

  • Anxiety, depression and perceived sporting performance among professional cricket players.

    abstract:BACKGROUND:Mental health in sport is a hard-hitting topic that is frequently the subject of news coverage and increasingly a theme for avid research. Some suggest that cricketers, participating in a game unique in its statistical analysis of individual performance, prolonged periods of play away from home and extended ...

    journal_title:British journal of sports medicine

    pub_type: 信件


    authors: Sahni M,Bhogal G

    更新日期:2017-05-10 00:00:00

  • Multicentre, randomised clinical trial of paediatric concussion assessment of rest and exertion (PedCARE): a study to determine when to resume physical activities following concussion in children.

    abstract:INTRODUCTION:Rest until symptom-free, followed by a progressive stepwise return to activities, is often prescribed in the management of paediatric concussions. Recent evidence suggests prolonged rest may hinder recovery, and early resumption of physical activity may be associated with more rapid recovery postconcussion...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Ledoux AA,Barrowman NJ,Boutis K,Davis A,Reid S,Sangha G,Farion KJ,Belanger K,Tremblay MS,Yeates KO,DeMatteo C,Reed N,Zemek R,Pediatric Emergency Research Canada PedCARE team.

    更新日期:2019-02-01 00:00:00

  • Effect of marathon training on the plasma lactate response to submaximal exercise in middle-aged men.

    abstract::Twenty-one previously sedentary male volunteers (aged 35-50 years) undertook a defined marathon training programme lasting 30 weeks. At weeks 0 (T1), 15 (T2) and 30 (T3) they underwent measurement of maximal oxygen uptake (VO2 max), submaximal VO2 and submaximal plasma lactate concentration during cycle ergometry. No ...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章


    authors: Rumley AG,Taylor R,Grant S,Pettigrew AR,Findlay I,Dargie H

    更新日期:1988-03-01 00:00:00

  • Microwave hyperthermia treatment increases heat shock proteins in human skeletal muscle.

    abstract:OBJECTIVE:To test the hypothesis that microwave hyperthermia treatment (MHT) increases heat shock proteins (HSPs) in the human vastus lateralis muscle. METHODS:Four untrained healthy male volunteers participated in this study. The lateral side of the thigh of one leg (heated leg) was heated with a microwave generator ...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章


    authors: Ogura Y,Naito H,Tsurukawa T,Ichinoseki-Sekine N,Saga N,Sugiura T,Katamoto S

    更新日期:2007-07-01 00:00:00

  • What interventions can improve quality of life or psychosocial factors of individuals with knee osteoarthritis? A systematic review with meta-analysis of primary outcomes from randomised controlled trials.

    abstract:OBJECTIVE:To systematically review evidence of primary outcomes from randomised controlled trials (RCTs) examining the effect of treatment strategies on quality of life (QoL) or psychosocial factors in individuals with knee osteoarthritis (OA). DESIGN:Systematic review with meta-analysis. DATA SOURCES:Medline, Embase...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章,meta分析,评审


    authors: Briani RV,Ferreira AS,Pazzinatto MF,Pappas E,De Oliveira Silva D,Azevedo FM

    更新日期:2018-08-01 00:00:00

  • Comparison of four Fitbit and Jawbone activity monitors with a research-grade ActiGraph accelerometer for estimating physical activity and energy expenditure.

    abstract:BACKGROUND/AIM:Consumer-based physical activity (PA) monitors have become popular tools to track PA behaviours. Currently, little is known about the validity of the measurements provided by consumer monitors. We aimed to compare measures of steps, energy expenditure (EE) and active minutes of four consumer monitors wit...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章


    authors: Imboden MT,Nelson MB,Kaminsky LA,Montoye AH

    更新日期:2018-07-01 00:00:00

  • Does MRI add value in general practice for patients with traumatic knee complaints? A 1-year randomised controlled trial.

    abstract:OBJECTIVE:To determine whether referral to MRI by the general practitioner (GP) is non-inferior to usual care (no access to MRI by GPs) in patients with traumatic knee complaints regarding knee-related daily function. METHODS:This was a multicentre, non-inferiority randomised controlled trial with 1-year follow-up. GP...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章,多中心研究


    authors: Swart NM,van Oudenaarde K,Bierma-Zeinstra SM,Bloem HJ,van den Hout WB,Algra PR,Bindels PJ,Koes BW,Nelissen RG,Verhaar JA,Reijnierse M,Luijsterburg PA

    更新日期:2019-10-01 00:00:00

  • Inferior capsular shift operation for multidirectional instability of the shoulder in players of contact sports.

    abstract:OBJECTIVES:To assess the results of inferior capsular shift for multidirectional instability of the shoulder in athletes. METHODS:Multidirectional instability was surgically corrected in 53 shoulders in 47 athletes who engaged in contact sports. A history of major trauma was found in eight patients, the others having ...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章


    authors: Choi CH,Ogilvie-Harris DJ

    更新日期:2002-08-01 00:00:00

  • Effects of short-term treatment strategies over 4 weeks in Achilles tendinopathy.

    abstract:BACKGROUND:The therapeutic efficacy of non-surgical treatment strategies in Achilles tendinopathy (AT) has not been well clarified. Time-consuming and costly combinations of treatment for pain, physiotherapy and biomechanical procedures are often applied. OBJECTIVE:To analyse the efficacy of single therapeutic regimen...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章,随机对照试验


    authors: Mayer F,Hirschmüller A,Müller S,Schuberth M,Baur H

    更新日期:2007-07-01 00:00:00

  • Logical limitations to the "catastrophe" models of fatigue during exercise in humans.

    abstract::A central debate in the exercise sciences is the cause of the fatigue that develops especially during high intensity exercise of short duration. The most popular theory holds that this form of exercise is limited by a peripherally based, metabolite induced failure of skeletal muscle contractile function, independent o...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章


    authors: Noakes TD,St Clair Gibson A

    更新日期:2004-10-01 00:00:00

  • Does physical activity reduce seniors' need for healthcare?: a study of 24 281 Canadians.

    abstract:OBJECTIVES:Physical inactivity has been associated with significant increases in disease morbidity and mortality. This study assessed the association between physical activity and (1) health resource use and (2) health resource use costs. DESIGN AND PARTICIPANTS:The responses from 24 281 respondents >65 years to the C...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章


    authors: Woolcott JC,Ashe MC,Miller WC,Shi P,Marra CA,PACC Research Team.

    更新日期:2010-09-01 00:00:00

  • Injury risk factors, screening tests and preventative strategies: a systematic review of the evidence that underpins the perceptions and practices of 44 football (soccer) teams from various premier leagues.

    abstract:PURPOSE:To systematically review the scientific level of evidence for the 'Top 3' risk factors, screening tests and preventative exercises identified by a previously published survey of 44 premier league football (soccer) teams. Also, to provide an overall scientific level of evidence and graded recommendation based on...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章,评审


    authors: McCall A,Carling C,Davison M,Nedelec M,Le Gall F,Berthoin S,Dupont G

    更新日期:2015-05-01 00:00:00

  • Injuries and musculoskeletal complaints in referees and assistant referees selected for the 2006 FIFA World Cup: retrospective and prospective survey.

    abstract:BACKGROUND:There is a considerable amount of scientific literature on football, but few studies have focused on referees, despite their key role in this sport. Existing studies focus on the physiological demands and training of referees. PURPOSE:To analyse injuries and musculoskeletal complaints in referees and assist...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章,多中心研究


    authors: Bizzini M,Junge A,Bahr R,Helsen W,Dvorak J

    更新日期:2009-07-01 00:00:00

  • Contribution of house and garden work to the association between physical activity and well-being in young, mid-aged and older women.

    abstract:OBJECTIVE:Although physical activity occurs in leisure, transport, occupational and domestic domains of life, the contribution of house and garden work (HGW) to the association between total physical activity and well-being is not clear. The aim was to describe the contribution of HGW to total physical activity (TPA) i...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章


    authors: Peeters G,van Gellecum YR,van Uffelen JG,Burton NW,Brown WJ

    更新日期:2014-06-01 00:00:00

  • Cervical disc herniation in a football player.

    abstract::A case of cervical disc herniation occurring in close association with playing football is reported. The handling of neck injuries in football players is outlined. ...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章


    authors: Tysvaer AT

    更新日期:1985-03-01 00:00:00

  • Upper limb fractures in rugby in Huddersfield 1986-1990.

    abstract::Most injuries sustained by rugby players affect the soft tissues, and fracture is relatively uncommon. Whereas the lower limb is most affected in footballers, the upper limb tends to be injured in rugby players. Thirty consecutive fractures and ten dislocations affecting the upper limb, sustained by 35 rugby players, ...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章


    authors: Eyres KS,Abdel-Salam A,Cleary J

    更新日期:1991-09-01 00:00:00

  • Effects and dose-response relationships of resistance training on physical performance in youth athletes: a systematic review and meta-analysis.

    abstract:OBJECTIVES:To quantify age, sex, sport and training type-specific effects of resistance training on physical performance, and to characterise dose-response relationships of resistance training parameters that could maximise gains in physical performance in youth athletes. DESIGN:Systematic review and meta-analysis of ...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章,meta分析,评审


    authors: Lesinski M,Prieske O,Granacher U

    更新日期:2016-07-01 00:00:00