Abstract:
:Evidence from familial and genetic association studies have reported that DNA sequence variants play an important role, together with non-genetic factors, in the aetiology of both exercise-associated and occupational-associated acute and chronic musculoskeletal soft tissue injuries. The associated variants, which have been identified to date, may contribute to the interindividual variation in the structure and, by implication, mechanical properties of the collagen fibril and surrounding matrix within musculoskeletal soft tissues, as well as their response to mechanical loading and other stimuli. Future work should focus on the establishment of multidisciplinary international consortia for the identification of biologically relevant variants involved in modulating injury risk. These consortia will improve the limitations of the published hypothesis-driven genetic association studies, since they will allow resources to be pooled in recruiting large well-characterised cohorts required for whole-genome screening. Finally, clinicians and coaches need to be aware that many direct-to-consumer companies are currently marketing genetic tests directly to athletes without it being requested by an appropriately qualified healthcare professional, and without interpretation alongside other clinical indicators or lifestyle factors. These specific genetic tests are premature and are not necessarily required to evaluate susceptibility to musculoskeletal soft tissue injury. Current practice should rather consider susceptibility through known risk factors such as a positive family history of a specific injury, a history of other tendon and/or ligament injuries and participation in activities associated with the specific musculoskeletal injuries. Potential susceptible athletes may then be individually managed to reduce their risk profile.
journal_name
Br J Sports Medjournal_title
British journal of sports medicineauthors
Collins M,September AV,Posthumus Mdoi
10.1136/bjsports-2015-095180subject
Has Abstractpub_date
2015-12-01 00:00:00pages
1497-503issue
23eissn
0306-3674issn
1473-0480pii
bjsports-2015-095180journal_volume
49pub_type
杂志文章,评审abstract::It is thankfully rare for extenuating circumstances to fully test the processes and procedures enshrined in national and world antidoping authorities' rules and laws. It is also thankfully very rare that a failed drugs test can have some positive implications. Antidoping laws are undoubtedly focused on ensuring fair c...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsports-2014-093550
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVE:The influence of an exercise programme performed by healthy pregnant women on maternal glucose tolerance was studied. STUDY DESIGN:A physical activity (PA, land/aquatic activities) programme during the entire pregnancy (three sessions per week) was conducted by a qualified instructor. 83 healthy pregnant wom...
journal_title:British journal of sports medicine
pub_type: 杂志文章,随机对照试验
doi:10.1136/bjsports-2011-090009
更新日期:2012-07-01 00:00:00
abstract:OBJECTIVE:Back protectors for snowboarders were analysed with respect to their potential to prevent spinal injury. DESIGN:In 20 Swiss skiing resorts, athletes were interviewed on the slope. In addition, an online survey was conducted. The performance of 12 commercially available back protectors was investigated by mea...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2010.072728
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVE:The perception of Nigerian athletes of the use of mouth guards to prevent the stresses of sports injuries was examined using psychological, sociological, and physical stress variables. METHODS:The descriptive survey research design was used in this study. Participants (n = 333) were selected using the purpos...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2003.004838
更新日期:2004-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the efficacy of ultrasound guided dry needling and autologous blood injection for the treatment of patellar tendinosis. DESIGN:Prospective cohort study. SETTING:Hospital/clinic based. PATIENTS:47 knees in 44 patients (40 men, 7 women, mean age 34.5 years, age range 17 to 54 years) with refracto...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2006.034686
更新日期:2007-08-01 00:00:00
abstract:OBJECTIVE:To determine physical activity levels during phase IV cardiac rehabilitation in 31 male myocardial infarction patients (median age 62, range 53-77 years). METHODS:Patients recorded daily physical activity over 16 weeks in a diary. Diaries were analysed for total general physical activity (TGPA), leisure time...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2003.010983
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND:Improved oxygen uptake improves soccer performance as regards distance covered, involvements with the ball, and number of sprints. Large improvements in oxygen uptake have been shown using interval running. A similar physiological load arising from interval running could be obtained using the soccer ball in ...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2004.012526
更新日期:2005-05-01 00:00:00
abstract:BACKGROUND:Technological limitations associated with oesophageal and rectal temperature probes have previously limited match play observations of body temperature. OBJECTIVE:To investigate the application of an intestinal pill system to measure core temperature during dynamic, field based, soccer matches. METHODS:Cor...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2005.021980
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND:In professional soccer, a significant amount of training time is used to improve players' aerobic capacity. However, it is not known whether soccer specific training fulfils the criterion of effective endurance training to improve maximal oxygen uptake, namely an exercise intensity of 90-95% of maximal heart...
journal_title:British journal of sports medicine
pub_type: 临床试验,杂志文章
doi:10.1136/bjsm.36.3.218
更新日期:2002-06-01 00:00:00
abstract:BACKGROUND:In adults, exercise is a powerful and natural stimulator of immune cells and adhesion molecules. Far less is known about exercise responses during childhood and adolescence and whether or not exercise in "real life" activities of healthy adolescents influences immune responses. OBJECTIVE:To determine if str...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2002.002576
更新日期:2004-04-01 00:00:00
abstract:BACKGROUND:Swimming is a widespread sporting activity generally regarded as an ideal form of exercise, which has little or no impact on the knees. However, overuse or repetitive microtrauma injuries may often affect the knee joint of young competitive swimmers. These early lesions are frequently asymptomatic for a cons...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2010.083345
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:Cell adhesion molecules are proteins expressed on the surface of a variety of cells and mediate the leucocyte response to inflammation. Some of these molecules are released to the plasma as soluble forms, whose presence indicates the degree of vascular endothelial activation or dysfunction. Increased concent...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2006.031047
更新日期:2007-02-01 00:00:00
abstract:OBJECTIVE:To assess whether a platelet-rich plasma (PRP) injection leads to an enhanced tendon structure and neovascularisation, measured with ultrasonographic techniques, in chronic midportion Achilles tendinopathy. DESIGN:Double-blind, randomised, placebo-controlled clinical trial. SETTING:Sports medical department...
journal_title:British journal of sports medicine
pub_type: 杂志文章,随机对照试验
doi:10.1136/bjsm.2010.076398
更新日期:2011-04-01 00:00:00
abstract::The question of whether altitude training can enhance subsequent sea-level performance has been well investigated over many decades. However, research on this topic has focused on athletes from individual or endurance sports, with scant number of studies on team-sport athletes. Questions that need to be answered inclu...
journal_title:British journal of sports medicine
pub_type: 杂志文章,评审
doi:10.1136/bjsports-2013-092764
更新日期:2013-12-01 00:00:00
abstract::Acclimatisation to environmental hypoxia initiates a series of metabolic and musculocardio-respiratory adaptations that influence oxygen transport and utilisation, or better still, being born and raised at altitude, is necessary to achieve optimal physical performance at altitude, scientific evidence to support the po...
journal_title:British journal of sports medicine
pub_type: 杂志文章,评审
doi:10.1136/bjsm.31.3.183
更新日期:1997-09-01 00:00:00
abstract::In Part II of the study, the British Olympic track (sprint) squad cyclists demonstrated reductions in body fat index, % body fat and endomorphy (p greater than .05), increased Hb and PCV % (p greater than .05), and lowered HR at rest and in warm-up exercise (p greater than .05), but no change in leg power. Repeated in...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.16.1.13
更新日期:1982-03-01 00:00:00
abstract::A previously well 30 year old man presented with a short history of intra-articular mechanical locking, swelling, and anteromedial joint line pain. There was localised tenderness, and McMurray's test was positive. Arthroscopy revealed a 3.6 x 2.6 x 1.5 cm firm pedicular localised pigmented villonodular synovitis origi...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.37.4.368
更新日期:2003-08-01 00:00:00
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journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.37.4.335
更新日期:2003-08-01 00:00:00
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journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsports-2011-090822
更新日期:2012-05-01 00:00:00
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journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.27.4.237
更新日期:1993-12-01 00:00:00
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journal_title:British journal of sports medicine
pub_type: 杂志文章,评审
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更新日期:2009-12-01 00:00:00
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journal_title:British journal of sports medicine
pub_type: 杂志文章,评审
doi:10.1136/bjsports-2020-102892
更新日期:2020-12-21 00:00:00
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journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2004.016527
更新日期:2005-11-01 00:00:00
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journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2003.010827
更新日期:2004-12-01 00:00:00
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journal_title:British journal of sports medicine
pub_type: 临床试验,杂志文章
doi:10.1136/bjsm.30.3.243
更新日期:1996-09-01 00:00:00
abstract::Acute mood changes occur with various forms of physical activity. Increased levels of endogenous opioids (endorphins) in response to exercise may mediate activity-induced shifts in mood state. Thirteen female and six male aerobics class participants aged 20-46 years received the opiate receptor antagonist naltrexone a...
journal_title:British journal of sports medicine
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1992-06-01 00:00:00
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journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.23.4.237
更新日期:1989-12-01 00:00:00
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journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.25.3.139
更新日期:1991-09-01 00:00:00
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journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.22.1.31
更新日期:1988-03-01 00:00:00
abstract::The second international consensus conference on the scapula was held in Lexington Kentucky. The purpose of the conference was to update, present and discuss the accumulated knowledge regarding scapular involvement in various shoulder injuries and highlight the clinical implications for the evaluation and treatment of...
journal_title:British journal of sports medicine
pub_type: 共识发展会议,杂志文章
doi:10.1136/bjsports-2013-092425
更新日期:2013-09-01 00:00:00