Abstract:
OBJECTIVE:To assess whether a platelet-rich plasma (PRP) injection leads to an enhanced tendon structure and neovascularisation, measured with ultrasonographic techniques, in chronic midportion Achilles tendinopathy. DESIGN:Double-blind, randomised, placebo-controlled clinical trial. SETTING:Sports medical department of The Hague medical centre. PATIENTS:54 patients with chronic midportion Achilles tendinopathy were included. INTERVENTIONS:Patients were randomised to eccentric exercise therapy with either a PRP injection (PRP group) or a saline injection (placebo group). MAIN OUTCOME MEASUREMENTS:Tendon structure was evaluated by ultrasonographic tissue characterisation, a novel technique which quantifies tendon structure into four echo-types: echo-types I+II represent organised tendon bundles, whereas echo-types III+IV represent a disorganised tendon structure. Colour Doppler ultrasonography was used to measure the degree of neovascularisation. Follow-up was at 6, 12 and 24 weeks. RESULTS:A significant improvement in echo-types I+II was found after 24 weeks within both the PRP group (n=27) and the placebo group (n=27), but there was no significant between-group difference (95% CI -1.6 to 7.8, p=0.169). After 6 weeks, the neovascularisation score increased within the PRP group (p=0.001) and the placebo group (p=0.002), but there was no significant between-group difference in change in neovascularisation score at any point in time. CONCLUSION:Injecting PRP for the treatment of chronic midportion Achilles tendinopathy does not contribute to an increased tendon structure or alter the degree of neovascularisation, compared with placebo. FUNDING:Biomet Biologics LLC, Warsaw, Indiana.
journal_name
Br J Sports Medjournal_title
British journal of sports medicineauthors
de Vos RJ,Weir A,Tol JL,Verhaar JA,Weinans H,van Schie HTdoi
10.1136/bjsm.2010.076398subject
Has Abstractpub_date
2011-04-01 00:00:00pages
387-92issue
5eissn
0306-3674issn
1473-0480pii
bjsm.2010.076398journal_volume
45pub_type
杂志文章,随机对照试验abstract:OBJECTIVE:Functional strength deficits associated with chronic isolated posterior cruciate ligament (PCL) insufficiency have received limited attention in the literature. The purpose of this study was to determine the eccentric and concentric isokinetic moment characteristics of the quadriceps and hamstrings in a sampl...
journal_title:British journal of sports medicine
pub_type: 临床试验,杂志文章
doi:10.1136/bjsm.33.6.405
更新日期:1999-12-01 00:00:00
abstract:OBJECTIVES:(a) To review the methacholine tests performed in our laboratory up until 2008; (b) to compare them with previously reported data in 2006 and (c) to examine if the anti-doping rules are meeting the needs of asthmatic athletes who really need bronchodilator treatment. METHODS:Between April 2004 and September...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2008.056903
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journal_title:British journal of sports medicine
pub_type: 杂志文章,meta分析,评审
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更新日期:2018-05-01 00:00:00
abstract::This systematic review set out to identify randomised controlled trials and controlled intervention studies that evaluated the effectiveness of preventive strategies in adolescent sport and to draw conclusions on the strength of the evidence. A literature search in seven databases (Medline, SportDiscus, EMBASE, CINAHL...
journal_title:British journal of sports medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1136/bjsm.2007.035691
更新日期:2007-10-01 00:00:00
abstract:OBJECTIVE:Regular physical activity is associated with a reduction of cardiovascular morbidity and mortality; however, evidence of unfortunate cardiovascular events accompanying elite sport involvement continues to accumulate. To date, no information is available on possible peculiarities of the cardiovascular risk pro...
journal_title:British journal of sports medicine
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journal_title:British journal of sports medicine
pub_type: 杂志文章,评审
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journal_title:British journal of sports medicine
pub_type: 杂志文章,随机对照试验
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journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.34.4.273
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abstract:BACKGROUND:Temporomandibular dysfunction (TMD) has been reported to be a common problem in divers, with a prevalence of up to 68%. No evidence for this is available. OBJECTIVE:To investigate the prevalence of TMD in divers. METHOD:Sixty three subjects were asked to retrospectively complete a questionnaire on symptoms...
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doi:10.1136/bjsm.2003.005025
更新日期:2004-02-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2014-04-01 00:00:00
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更新日期:2006-02-01 00:00:00
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