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Suppressors of superoxide production from mitochondrial complex III.

Abstract：

:Mitochondrial electron transport drives ATP synthesis but also generates reactive oxygen species, which are both cellular signals and damaging oxidants. Superoxide production by respiratory complex III is implicated in diverse signaling events and pathologies, but its role remains controversial. Using high-throughput screening, we identified compounds that selectively eliminate superoxide production by complex III without altering oxidative phosphorylation; they modulate retrograde signaling including cellular responses to hypoxic and oxidative stress.

journal_name

Nat Chem Biol

journal_title

Nature chemical biology

authors

Orr AL,Vargas L,Turk CN,Baaten JE,Matzen JT,Dardov VJ,Attle SJ,Li J,Quackenbush DC,Goncalves RL,Perevoshchikova IV,Petrassi HM,Meeusen SL,Ainscow EK,Brand MD

doi

10.1038/nchembio.1910

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

834-6

issue

11

eissn

1552-4450

issn

1552-4469

pii

nchembio.1910

journal_volume

11

pub_type

杂志文章

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