Abstract:
:Here we identify the amino acid transporter AnsP1 as the unique aspartate importer in the human pathogen Mycobacterium tuberculosis. Metabolomic analysis of a mutant with an inactive AnsP1 revealed that the transporter is essential for M. tuberculosis to assimilate nitrogen from aspartate. Virulence of the AnsP1 mutant is impaired in vivo, revealing that aspartate is a primary nitrogen source required for host colonization by the tuberculosis bacillus.
journal_name
Nat Chem Bioljournal_title
Nature chemical biologyauthors
Gouzy A,Larrouy-Maumus G,Wu TD,Peixoto A,Levillain F,Lugo-Villarino G,Guerquin-Kern JL,de Carvalho LP,Poquet Y,Neyrolles Odoi
10.1038/nchembio.1355subject
Has Abstractpub_date
2013-11-01 00:00:00pages
674-6issue
11eissn
1552-4450issn
1552-4469pii
nchembio.1355journal_volume
9pub_type
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