Abstract：
:In response to decreasing Ca2+ levels in the endoplasmic reticulum, STIM proteins couple with Orai channels in the plasma membrane, leading to Ca2+ influx into the cell. In addition to Ca2+-related endoplasmic reticulum stress, STIM proteins are emerging as general stress sensors that react to multiple stress signals to orchestrate Ca2+ signaling and homeostasis.
journal_name
Nat Chem Bioljournal_title
Nature chemical biologyauthors
Soboloff J,Madesh M,Gill DLdoi
10.1038/nchembio.619subject
Has Abstractpub_date
2011-07-18 00:00:00pages
488-92issue
8eissn
1552-4450issn
1552-4469pii
nchembio.619journal_volume
7pub_type
杂志文章abstract：:Chemistry drives many biological interactions between the microbiota and host animals, yet it is often challenging to identify the chemicals involved. This poses a problem, as such small molecules are excellent sources of potential pharmaceuticals, pretested by nature for animal compatibility. We discovered anti-HIV c...
journal_title：Nature chemical biology
pub_type： 杂志文章
doi：10.1038/nchembio.2537
更新日期：2018-02-01 00:00:00
abstract：:Although the protein synthesis inhibitor cycloheximide (CHX) has been known for decades, its precise mechanism of action remains incompletely understood. The glutarimide portion of CHX is seen in a family of structurally related natural products including migrastatin, isomigrastatin and lactimidomycin (LTM). We found ...
journal_title：Nature chemical biology
pub_type： 杂志文章
doi：10.1038/nchembio.304
更新日期：2010-03-01 00:00:00
abstract：:The lasso peptide microcin J25 is known to hijack the siderophore receptor FhuA for initiating internalization. Here, we provide what is to our knowledge the first structural evidence on the recognition mechanism, and our biochemical data show that another closely related lasso peptide cannot interact with FhuA. Our w...
journal_title：Nature chemical biology
pub_type： 杂志文章
doi：10.1038/nchembio.1499
更新日期：2014-05-01 00:00:00
abstract：:Transcription factors have diverse roles during embryonic development, combinatorially controlling cellular states in a spatially and temporally defined manner. Resolving the dynamic transcriptional profiles that underlie these patterning processes is essential for understanding embryogenesis at the molecular level. H...
journal_title：Nature chemical biology
pub_type： 杂志文章
doi：10.1038/nchembio.772
更新日期：2012-01-29 00:00:00
abstract：:Despite the remarkable versatility displayed by flavin-dependent monooxygenases (FMOs) in natural product biosynthesis, one notably missing activity is the oxidative generation of carbonate functional groups. We describe a multifunctional Baeyer-Villiger monooxygenase, CcsB, which catalyzes the formation of an in-line...
journal_title：Nature chemical biology
pub_type： 杂志文章
doi：10.1038/nchembio.1527
更新日期：2014-07-01 00:00:00
abstract：:Trafficking and sorting of membrane-anchored Ras GTPases are regulated by partitioning between distinct membrane domains. Here, in vitro experiments and microscopic molecular theory reveal membrane curvature as a new modulator of N-Ras lipid anchor and palmitoyl chain partitioning. Membrane curvature was essential for...
journal_title：Nature chemical biology
pub_type： 杂志文章
doi：10.1038/nchembio.1733
更新日期：2015-03-01 00:00:00
abstract：:We report a salvage pathway in Gram-negative bacteria that bypasses de novo biosynthesis of UDP N-acetylmuramic acid (UDP-MurNAc), the first committed peptidoglycan precursor, and thus provides a rationale for intrinsic fosfomycin resistance. The anomeric sugar kinase AmgK and the MurNAc α-1-phosphate uridylyl transfe...
journal_title：Nature chemical biology
pub_type： 杂志文章
doi：10.1038/nchembio.1289
更新日期：2013-08-01 00:00:00
abstract：:Nitrite represents a bioactive reservoir of nitric oxide (NO) that may modulate vasodilation, respiration and cytoprotection after ischemia-reperfusion injury. Although nitrite formation is thought to occur via reaction of NO with oxygen, this third-order reaction cannot compete kinetically with the reaction of NO wit...
journal_title：Nature chemical biology
pub_type： 杂志文章
doi：10.1038/nchembio813
更新日期：2006-09-01 00:00:00
abstract：:The resistance of Caenorhabditis elegans to pharmacological perturbation limits its use as a screening tool for novel small bioactive molecules. One strategy to improve the hit rate of small-molecule screens is to preselect molecules that have an increased likelihood of reaching their target in the worm. To learn whic...
journal_title：Nature chemical biology
pub_type： 杂志文章
doi：10.1038/nchembio.380
更新日期：2010-07-01 00:00:00
abstract：:Despite the fundamental roles of sialyl- and fucosyltransferases in mammalian physiology, there are few pharmacological tools to manipulate their function in a cellular setting. Although fluorinated analogs of the donor substrates are well-established transition state inhibitors of these enzymes, they are not membrane...
journal_title：Nature chemical biology
pub_type： 杂志文章
doi：10.1038/nchembio.999
更新日期：2012-07-01 00:00:00
abstract：:Biotin is an essential vitamin in plants and mammals, functioning as the carbon dioxide carrier within central lipid metabolism. Bacterial pimeloyl-CoA synthetase (BioW) acts as a highly specific substrate-selection gate, ensuring the integrity of the carbon chain in biotin synthesis. BioW catalyzes the condensation o...
journal_title：Nature chemical biology
pub_type： 杂志文章
doi：10.1038/nchembio.2361
更新日期：2017-06-01 00:00:00
abstract：:Receptor-mediated endocytosis is an integral part of signal transduction as it mediates signal attenuation and provides spatial and temporal dimensions to signaling events. One of the best-studied leucine-rich repeat receptor-like kinases in plants, BRASSINOSTEROID INSENSITIVE 1 (BRI1), perceives its ligand, the brass...
journal_title：Nature chemical biology
pub_type： 杂志文章
doi：10.1038/nchembio.958
更新日期：2012-05-06 00:00:00
abstract：:Enzymatic incorporation of a halogen atom is a common feature in the biosyntheses of more than 4,500 natural products. Halogenation of unactivated carbon centers in the biosyntheses of several compounds of nonribosomal peptide origin is carried out by a class of mononuclear nonheme iron enzymes that require alpha-keto...
journal_title：Nature chemical biology
pub_type： 杂志文章
doi：10.1038/nchembio856
更新日期：2007-02-01 00:00:00
abstract：:Helical membrane proteins are typically assumed to attain stable transmembrane topologies immediately upon co-translational membrane insertion. Here we show that unassembled monomers of the small multidrug resistance (SMR) family exist in a dynamic equilibrium where the N-terminal transmembrane helix flips in and out ...
journal_title：Nature chemical biology
pub_type： 杂志文章
doi：10.1038/s41589-019-0356-9
更新日期：2019-10-01 00:00:00
abstract：:Methods for imaging and tracking single molecules conjugated with fluorescent probes, called single-molecule tracking (SMT), are now providing researchers with the unprecedented ability to directly observe molecular behaviors and interactions in living cells. Current SMT methods are achieving almost the ultimate spati...
journal_title：Nature chemical biology
pub_type： 杂志文章,评审
doi：10.1038/nchembio.1558
更新日期：2014-07-01 00:00:00
abstract：:Regio- and stereospecific incorporation of a halogen atom to an unactivated sp(3) carbon in a freestanding molecule is a challenging transformation that is currently missing in the inventory of enzyme-mediated reactions. Here we report what is to our knowledge the first example of a nonheme iron enzyme (WelO5) in the ...
journal_title：Nature chemical biology
pub_type： 杂志文章
doi：10.1038/nchembio.1625
更新日期：2014-11-01 00:00:00
abstract：:Thiazole/oxazole-modified microcins (TOMMs) encompass a recently defined class of ribosomally synthesized natural products with a diverse set of biological activities. Although TOMM biosynthesis has been investigated for over a decade, the mechanism of heterocycle formation by the synthetase enzymes remains poorly und...
journal_title：Nature chemical biology
pub_type： 杂志文章
doi：10.1038/nchembio.944
更新日期：2012-04-22 00:00:00
abstract：:Naturally produced polybrominated diphenyl ethers (PBDEs) pervade the marine environment and structurally resemble toxic man-made brominated flame retardants. PBDEs bioaccumulate in marine animals and are likely transferred to the human food chain. However, the biogenic basis for PBDE production in one of their most p...
journal_title：Nature chemical biology
pub_type： 杂志文章
doi：10.1038/nchembio.2330
更新日期：2017-05-01 00:00:00
abstract：:Phenylketonuria (PKU) is characterized by phenylalanine accumulation and progressive mental retardation caused by an unknown mechanism. We demonstrate that at pathological concentrations, phenylalanine self-assembles into fibrils with amyloid-like morphology and well-ordered electron diffraction. These assemblies are ...
journal_title：Nature chemical biology
pub_type： 杂志文章
doi：10.1038/nchembio.1002
更新日期：2012-08-01 00:00:00
abstract：:The GATOR1 (SEACIT) complex consisting of Iml1-Npr2-Npr3 inhibits target of rapamycin complex 1 (TORC1) in response to amino acid insufficiency. In glucose medium, Saccharomyces cerevisiae mutants lacking the function of this complex grow poorly in the absence of amino acid supplementation, despite showing hallmarks o...
journal_title：Nature chemical biology
pub_type： 杂志文章
doi：10.1038/nchembio.2478
更新日期：2017-11-01 00:00:00
abstract：:Nontranslational functions of vertebrate aminoacyl tRNA synthetases (aaRSs), which catalyze the production of aminoacyl-tRNAs for protein synthesis, have recently been discovered. Although these new functions were thought to be 'moonlighting activities', many are as critical for cellular homeostasis as their activity ...
journal_title：Nature chemical biology
pub_type： 杂志文章,评审
doi：10.1038/nchembio.1158
更新日期：2013-03-01 00:00:00
abstract：:A 2.4-Å-resolution X-ray crystal structure of the carrier-protein-independent halogenase WelO5 in complex with its welwitindolinone precursor substrate, 12-epi-fischerindole U, reveals that the C13 chlorination target is proximal to the anticipated site of the oxo group in a presumptive cis-halo-oxo-iron(IV) (haloferr...
journal_title：Nature chemical biology
pub_type： 杂志文章
doi：10.1038/nchembio.2112
更新日期：2016-08-01 00:00:00
abstract：:We document a new dimension of surface recognition in which communication is controlled through the collective behavior of lipids. Membrane cholesterol induces a tilt in glycolipid receptor headgroup, resulting in loss of access for ligand binding. This property appears to organize erythrocyte blood group presentation...
journal_title：Nature chemical biology
pub_type： 杂志文章
doi：10.1038/nchembio.551
更新日期：2011-05-01 00:00:00
abstract：:Targeted protein degradation via small-molecule modulation of cereblon offers vast potential for the development of new therapeutics. Cereblon-binding therapeutics carry the safety risks of thalidomide, which caused an epidemic of severe birth defects characterized by forelimb shortening or phocomelia. Here we show th...
journal_title：Nature chemical biology
pub_type： 杂志文章
doi：10.1038/s41589-018-0129-x
更新日期：2018-10-01 00:00:00
abstract：:We describe a new technology for recruiting specific proteins to RNA through selective recognition of heteroduplexes formed with chemically modified antisense oligonucleotides (ASOs). Typically, ASOs function by hybridizing to their RNA targets and blocking the binding of single-stranded RNA-binding proteins. Unexpect...
journal_title：Nature chemical biology
pub_type： 杂志文章
doi：10.1038/nchembio.939
更新日期：2012-04-15 00:00:00
abstract：:Gentamicin B (GB), a valuable starting material for the preparation of the semisynthetic aminoglycoside antibiotic isepamicin, is produced in trace amounts by the wild-type Micromonospora echinospora. Though the biosynthetic pathway to GB has remained obscure for decades, we have now identified three hidden pathways t...
journal_title：Nature chemical biology
pub_type： 杂志文章
doi：10.1038/s41589-018-0203-4
更新日期：2019-03-01 00:00:00
abstract：:The N-end rule pathway senses the N-terminal destabilizing residues of degradation substrates for the ubiquitin-proteasome system, whose integrity shields against various human syndromes including cancer and cardiovascular diseases. GID4, a subunit of the ubiquitin ligase GID complex, has been recently identified as t...
journal_title：Nature chemical biology
pub_type： 杂志文章
doi：10.1038/s41589-018-0036-1
更新日期：2018-05-01 00:00:00
abstract：:More than 30 years ago, a calcium-dependent enzyme activity was described that generates N-acyl phosphatidylethanolamines (NAPEs), which are precursors for N-acyl ethanolamine (NAE) lipid transmitters, including the endocannabinoid anandamide. The identity of this calcium-dependent N-acyltransferase (Ca-NAT) has remai...
journal_title：Nature chemical biology
pub_type： 杂志文章
doi：10.1038/nchembio.2127
更新日期：2016-09-01 00:00:00
abstract：:Identification of endogenous glycan-binding ligands for cell-surface receptors has been difficult. Incorporation of a photoactive sialic acid analog into B-cell surface glycoproteins suggests that CD22 molecules may cluster by binding carbohydrate antigens on neighboring CD22 molecules. ...
journal_title：Nature chemical biology
pub_type： 评论,新闻
doi：10.1038/nchembio0705-69
更新日期：2005-07-01 00:00:00
abstract：:The sea lamprey is an ancient, parasitic fish that invaded the Great Lakes a century ago, where it triggered the collapse of many fisheries. Like many fishes, this species relies on chemical cues to mediate key aspects of its life, including migration and reproduction. Here we report the discovery of a multicomponent ...
journal_title：Nature chemical biology
pub_type： 杂志文章
doi：10.1038/nchembio739
更新日期：2005-11-01 00:00:00
