Abstract:
:Regio- and stereospecific incorporation of a halogen atom to an unactivated sp(3) carbon in a freestanding molecule is a challenging transformation that is currently missing in the inventory of enzyme-mediated reactions. Here we report what is to our knowledge the first example of a nonheme iron enzyme (WelO5) in the welwitindolinone biosynthetic pathway that can monochlorinate an aliphatic carbon in 12-epi-fischerindole U and 12-epi-hapalindole C, substrates that are free from peptidyl or acyl carrier protein.
journal_name
Nat Chem Bioljournal_title
Nature chemical biologyauthors
Hillwig ML,Liu Xdoi
10.1038/nchembio.1625subject
Has Abstractpub_date
2014-11-01 00:00:00pages
921-3issue
11eissn
1552-4450issn
1552-4469pii
nchembio.1625journal_volume
10pub_type
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