Abstract:
:5-Formylcytosine (5fC) is a rare base found in mammalian DNA and thought to be involved in active DNA demethylation. Here, we show that developmental dynamics of 5fC levels in mouse DNA differ from those of 5-hydroxymethylcytosine (5hmC), and using stable isotope labeling in vivo, we show that 5fC can be a stable DNA modification. These results suggest that 5fC has functional roles in DNA that go beyond being a demethylation intermediate.
journal_name
Nat Chem Bioljournal_title
Nature chemical biologyauthors
Bachman M,Uribe-Lewis S,Yang X,Burgess HE,Iurlaro M,Reik W,Murrell A,Balasubramanian Sdoi
10.1038/nchembio.1848subject
Has Abstractpub_date
2015-08-01 00:00:00pages
555-7issue
8eissn
1552-4450issn
1552-4469pii
nchembio.1848journal_volume
11pub_type
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