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Cholesterol modulates glycolipid conformation and receptor activity.

Abstract：

:We document a new dimension of surface recognition in which communication is controlled through the collective behavior of lipids. Membrane cholesterol induces a tilt in glycolipid receptor headgroup, resulting in loss of access for ligand binding. This property appears to organize erythrocyte blood group presentation and glycolipid receptor function during the activation of sperm fertility, suggesting that lipid 'allostery' is a means to regulate membrane recognition processes.

journal_name

Nat Chem Biol

journal_title

Nature chemical biology

authors

Lingwood D,Binnington B,Róg T,Vattulainen I,Grzybek M,Coskun U,Lingwood CA,Simons K

doi

10.1038/nchembio.551

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

260-2

issue

5

eissn

1552-4450

issn

1552-4469

pii

nchembio.551

journal_volume

7

pub_type

杂志文章

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