当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Diversity of gut microflora is required for the generation of B cell with regulatory properties in a skin graft model.

Diversity of gut microflora is required for the generation of B cell with regulatory properties in a skin graft model.

Abstract：

:B cells have been reported to promote graft rejection through alloantibody production. However, there is growing evidence that B cells can contribute to the maintenance of tolerance. Here, we used a mouse model of MHC-class I mismatched skin transplantation to investigate the contribution of B cells to graft survival. We demonstrate that adoptive transfer of B cells prolongs skin graft survival but only when the B cells were isolated from mice housed in low sterility "conventional" (CV) facilities and not from mice housed in pathogen free facilities (SPF). However, prolongation of skin graft survival was lost when B cells were isolated from IL-10 deficient mice housed in CV facilities. The suppressive function of B cells isolated from mice housed in CV facilities correlated with an anti-inflammatory environment and with the presence of a different gut microflora compared to mice maintained in SPF facilities. Treatment of mice in the CV facility with antibiotics abrogated the regulatory capacity of B cells. Finally, we identified transitional B cells isolated from CV facilities as possessing the regulatory function. These findings demonstrate that B cells, and in particular transitional B cells, can promote prolongation of graft survival, a function dependent on licensing by gut microflora.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Alhabbab R,Blair P,Elgueta R,Stolarczyk E,Marks E,Becker PD,Ratnasothy K,Smyth L,Safinia N,Sharif-Paghaleh E,O'Connell S,Noelle RJ,Lord GM,Howard JK,Spencer J,Lechler RI,Lombardi G

doi

10.1038/srep11554

subject

Has Abstract

pub_date

2015-06-25 00:00:00

pages

11554

issn

2045-2322

pii

srep11554

journal_volume

5

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Human GPR42 is a transcribed multisite variant that exhibits copy number polymorphism and is functional when heterologously expressed.

    abstract：:FFAR3 (GPR41) is a G-protein coupled receptor for which short-chain fatty acids serve as endogenous ligands. The receptor is found on gut enteroendocrine L-cells, pancreatic β-cells, and sympathetic neurons, and is implicated in obesity, diabetes, allergic airway disease, and altered immune function. In primates, FFAR...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep12880

    authors： Puhl HL 3rd,Won YJ,Lu VB,Ikeda SR

    更新日期：2015-08-11 00:00:00

  • Deletion of CD38 and supplementation of NAD+ attenuate axon degeneration in a mouse facial nerve axotomy model.

    abstract：:Following facial nerve axotomy, nerve function is not fully restored even after reconstruction. This may be attributed to axon degeneration/neuronal death and sustained neuroinflammation. CD38 is an enzyme that catalyses the hydrolysis of nicotinamide adenine dinucleotide (NAD+) and is a candidate molecule for regulat...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-73984-3

    authors： Takaso Y,Noda M,Hattori T,Roboon J,Hatano M,Sugimoto H,Brenner C,Yamamoto Y,Okamoto H,Higashida H,Ito M,Yoshizaki T,Hori O

    更新日期：2020-10-20 00:00:00

  • Controlling the Polarity of the Molecular Beam Epitaxy Grown In-Bi Atomic Film on the Si(111) Surface.

    abstract：:Synchrotron radiation core-level photoemission spectroscopy, scanning tunneling microscopy (STM), and first-principles calculations have been utilized to explore the growth processes and the atomic structure of the resulting films during the two-step molecular beam epitaxy (MBE) of In and Bi on the Si(111) surface. De...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-37051-2

    authors： Lin CY,Hsu CH,Huang YZ,Hsieh SC,Chen HD,Huang L,Huang ZQ,Chuang FC,Lin DS

    更新日期：2019-01-24 00:00:00

  • Online flow cytometry reveals microbial dynamics influenced by concurrent natural and operational events in groundwater used for drinking water treatment.

    abstract：:Detailed measurements of physical, chemical and biological dynamics in groundwater are key to understanding the important processes in place and their influence on water quality - particularly when used for drinking water. Measuring temporal bacterial dynamics at high frequency is challenging due to the limitations in...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep38462

    authors： Besmer MD,Epting J,Page RM,Sigrist JA,Huggenberger P,Hammes F

    更新日期：2016-12-07 00:00:00

  • Angiotensin II synergizes with BAFF to promote atheroprotective regulatory B cells.

    abstract：:Angiotensin II (AngII) promotes hypertension, atherogenesis, vascular aneurysm and impairs post-ischemic cardiac remodeling through concerted roles on vascular cells, monocytes and T lymphocytes. However, the role of AngII in B lymphocyte responses is largely unexplored. Here, we show that chronic B cell depletion (Ba...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-04438-6

    authors： Ponnuswamy P,Joffre J,Herbin O,Esposito B,Laurans L,Binder CJ,Tedder TF,Zeboudj L,Loyer X,Giraud A,Zhang Y,Tedgui A,Mallat Z,Ait-Oufella H

    更新日期：2017-06-23 00:00:00

  • Comparison between thulium laser resection of prostate and transurethral plasmakinetic resection of prostate or transurethral resection of prostate.

    abstract：:Benign prostatic hyperplasia (BPH) is one of the most common diseases in middle-aged and elderly men. In the present study, we aimed to compare the efficacy and safety of thulium laser resection of the prostate (TMLRP) with either transurethral plasmakinetic resection of the prostate (TUPKP) or transurethral resection...

    journal_title：Scientific reports

    pub_type： 杂志文章,meta分析

    doi：10.1038/srep14542

    authors： DeCao H,Wang J,Huang Y,LiangLiu R,JunLei H,Gao L,Tang Z,YingHu C,Li X,JiuYuan H,Dong Q,Wei Q

    更新日期：2015-10-07 00:00:00

  • Caveolin 1 is Associated with Upregulated Claudin 2 in Necrotizing Enterocolitis.

    abstract：:Necrotizing enterocolitis (NEC) is a devastating gastrointestinal emergency of neonates. Epithelial tight junction (TJ) proteins, such as claudins, are essential for regulation and function of the intestinal barrier. Rho kinase (ROCK) affects cellular permeability and TJ regulation. We hypothesized that TJ protein cha...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-41442-4

    authors： Ares G,Buonpane C,Sincavage J,Yuan C,Wood DR,Hunter CJ

    更新日期：2019-03-21 00:00:00

  • Exploring the role of the Ser9Gly (rs6280) Dopamine D3 receptor polymorphism in nicotine reinforcement and cue-elicited craving.

    abstract：:Preclinical studies show that the dopamine D3 receptor (D3R) is involved in the reinstatement of drug seeking and motivation for drugs of abuse. A D3R gene variant, Ser9Gly (rs6280) has been linked to nicotine dependence, yet the mechanisms underlying its involvement in nicotine dependence is unclear. This study inves...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-60940-4

    authors： Chukwueke CC,Kowalczyk WJ,Di Ciano P,Gendy M,Taylor R,Heishman SJ,Le Foll B

    更新日期：2020-03-05 00:00:00

  • Considering tumour volume for motion corrected DWI of colorectal liver metastases increases sensitivity of ADC to detect treatment-induced changes.

    abstract：:ADC is a potential post treatment imaging biomarker in colorectal liver metastasis however measurements are affected by respiratory motion. This is compounded by increased statistical uncertainty in ADC measurement with decreasing tumour volume. In this prospective study we applied a retrospective motion correction me...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-40565-y

    authors： Pathak R,Tian J,Thacker NA,Morris DM,Ragheb H,Saunders C,Saunders M,Jackson A

    更新日期：2019-03-07 00:00:00

  • Manual, In situ, Real-Time Nanofabrication using Cracking through Indentation.

    abstract：:Nanofabrication has seen an increasing demand for applications in many fields of science and technology, but its production still requires relatively difficult, time-consuming, and expensive processes. Here we report a simple but very effective one dimensional (1D) nano-patterning technology that suggests a new nanofa...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep18892

    authors： Nam KH,Suh YD,Yeo J,Woo D

    更新日期：2016-01-04 00:00:00

  • Self-organization of network dynamics into local quantized states.

    abstract：:Self-organization and pattern formation in network-organized systems emerges from the collective activation and interaction of many interconnected units. A striking feature of these non-equilibrium structures is that they are often localized and robust: only a small subset of the nodes, or cell assembly, is activated....

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep21360

    authors： Nicolaides C,Juanes R,Cueto-Felgueroso L

    更新日期：2016-02-17 00:00:00

  • Metabotropic Acetylcholine and Glutamate Receptors Mediate PI(4,5)P2 Depletion and Oscillations in Hippocampal CA1 Pyramidal Neurons in situ.

    abstract：:The sensitivity of many ion channels to phosphatidylinositol-4,5-bisphosphate (PIP2) levels in the cell membrane suggests that PIP2 fluctuations are important and general signals modulating neuronal excitability. Yet the PIP2 dynamics of central neurons in their native environment remained largely unexplored. Here, we...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-31322-8

    authors： Hackelberg S,Oliver D

    更新日期：2018-08-28 00:00:00

  • A Functional Polymorphism (rs2494752) in the AKT1 Promoter Region and Gastric Adenocarcinoma Risk in an Eastern Chinese Population.

    abstract：:AKT is an important signal transduction protein that plays a crucial role in cancer development. Therefore, we evaluated associations between single nucleotide polymorphisms (SNPs) in the AKT promoter region and gastric cancer (GCa) risk in a case-control study of 1,110 GCa patients and 1,114 matched cancer-free contr...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep20008

    authors： Wang MY,He J,Zhu ML,Teng XY,Li QX,Sun MH,Wang XF,Yang YJ,Wang JC,Jin L,Wang YN,Wei QY

    更新日期：2016-01-28 00:00:00

  • Biochemical analysis of leishmanial and human GDP-Mannose Pyrophosphorylases and selection of inhibitors as new leads.

    abstract：:Leishmaniases are an ensemble of diseases caused by the protozoan parasite of the genus Leishmania. Current antileishmanial treatments are limited and present main issues of toxicity and drug resistance emergence. Therefore, the generation of new inhibitors specifically directed against a leishmanial target is an attr...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-00848-8

    authors： Mao W,Daligaux P,Lazar N,Ha-Duong T,Cavé C,van Tilbeurgh H,Loiseau PM,Pomel S

    更新日期：2017-04-07 00:00:00

  • Author Correction: Impact of hormone receptor status and distant recurrence-free interval on survival benefits from trastuzumab in HER2-positive metastatic breast cancer.

    abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-018-32881-6

    authors： Yang HY,Ma D,Liu YR,Hu X,Zhang J,Wang ZH,Di GH,Hu XC,Shao ZM

    更新日期：2018-10-12 00:00:00

  • Differential brain mechanisms during reading human vs. machine translated fiction and news texts.

    abstract：:Few neuroimaigng studies on reading comprehension have been conducted under natural reading settings. In this study, we showed texts presented in a natural way during functional MRI (fMRI) measurements to reveal brain areas sensitive to reading comprehension. Specifically, this paradigm independently manipulated two h...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-49632-w

    authors： Lin FH,Liu YF,Lee HJ,Chang CHC,Jaaskelainen IP,Yeh JN,Kuo WJ

    更新日期：2019-09-13 00:00:00

  • Precision and safety of Multilevel Cervical Transpedicular Screw Fixation with 3D Patient-Specific Guides; A Cadaveric Study.

    abstract：:The aim is to design a patient-specific instrument (PSI) for multilevel cervical pedicle screw placement from C2 to C7, as well as verifying reliability and reproducibility. Computed tomography (CT) scans were obtained from 7 cadaveric cervical spines. Using Mimics software, semiautomatic segmentation was performed fo...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-51936-w

    authors： Sallent A,Ramírez M,Catalá J,Rodríguez-Baeza A,Bagó J,de Albert M,Vélez R

    更新日期：2019-10-30 00:00:00

  • The impact of wavelengths of LED light-therapy on endothelial cells.

    abstract：:Low level light therapy receives increasing interest in the fields of tissue regeneration and wound healing. Several in vivo studies demonstrated the positive effects of LLLT on angiogenesis. This study aimed to investigate the underlying properties in vitro by comparing the effects of light therapy by light emitting ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-11061-y

    authors： Rohringer S,Holnthoner W,Chaudary S,Slezak P,Priglinger E,Strassl M,Pill K,Mühleder S,Redl H,Dungel P

    更新日期：2017-09-06 00:00:00

  • Modelling of psychosocial and lifestyle predictors of peripartum depressive symptoms associated with distinct risk trajectories: a prospective cohort study.

    abstract：:Perinatal depression involves interplay between individual chronic and acute disease burdens, biological and psychosocial environmental and behavioural factors. Here we explored the predictive potential of specific psycho-socio-demographic characteristics for antenatal and postpartum depression symptoms and contributi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-30874-z

    authors： English S,Steele A,Williams A,Blacklay J,Sorinola O,Wernisch L,Grammatopoulos DK

    更新日期：2018-08-24 00:00:00

  • Ammonia-induced miRNA expression changes in cultured rat astrocytes.

    abstract：:Hepatic encephalopathy is a neuropsychiatric syndrome evolving from cerebral osmotic disturbances and oxidative/nitrosative stress. Ammonia, the main toxin of hepatic encephalopathy, triggers astrocyte senescence in an oxidative stress-dependent way. As miRNAs are critically involved in cell cycle regulation and their...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep18493

    authors： Oenarto J,Karababa A,Castoldi M,Bidmon HJ,Görg B,Häussinger D

    更新日期：2016-01-12 00:00:00

  • Mutational profile of Brazilian lung adenocarcinoma unveils association of EGFR mutations with high Asian ancestry and independent prognostic role of KRAS mutations.

    abstract：:Lung cancer is the deadliest cancer worldwide. The mutational frequency of EGFR and KRAS genes in lung adenocarcinoma varies worldwide per ethnicity and smoking. The impact of EGFR and KRAS mutations in Brazilian lung cancer remains poorly explored. Thus, we investigated the frequency of EGFR and KRAS mutations in a l...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-39965-x

    authors： Leal LF,de Paula FE,De Marchi P,de Souza Viana L,Pinto GDJ,Carlos CD,Berardinelli GN,Miziara JE,da Silva CM,Silva ECA,Pereira R,de Oliveira MA,Scapulatempo-Neto C,Reis RM

    更新日期：2019-03-01 00:00:00

  • Rapid and transient oxygen consumption increase following acute HDAC/KDAC inhibition in Drosophila tissue.

    abstract：:Epigenetic deregulation, such as the reduction of histone acetylation levels, is thought to be causally linked to various maladies associated with aging. Consequently, histone deacetylase inhibitors are suggested to serve as epigenetic therapy by increasing histone acetylation. However, previous work suggests that man...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-22674-2

    authors： Becker L,Nogueira MS,Klima C,de Angelis MH,Peleg S

    更新日期：2018-03-08 00:00:00

  • Chocolate for breakfast prevents circadian desynchrony in experimental models of jet-lag and shift-work.

    abstract：:Night-workers, transcontinental travelers and individuals that regularly shift their sleep timing, suffer from circadian desynchrony and are at risk to develop metabolic disease, cancer, and mood disorders, among others. Experimental and clinical studies provide evidence that food intake restricted to the normal activ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-63227-w

    authors： Escobar C,Espitia-Bautista E,Guzmán-Ruiz MA,Guerrero-Vargas NN,Hernández-Navarrete MÁ,Ángeles-Castellanos M,Morales-Pérez B,Buijs RM

    更新日期：2020-04-10 00:00:00

  • Oman coral δ18O seawater record suggests that Western Indian Ocean upwelling uncouples from the Indian Ocean Dipole during the global-warming hiatus.

    abstract：:The Indian Ocean Dipole (IOD) is an interannual mode of climate variability in the Indian Ocean that has intensified with 20th century global-warming. However, instrumental data shows a global-warming hiatus between the late-1990s and 2015. It is presently not clear how the global-warming hiatus affects modes of clima...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-38429-y

    authors： Watanabe TK,Watanabe T,Yamazaki A,Pfeiffer M,Claereboudt MR

    更新日期：2019-02-13 00:00:00

  • Synthesis and tumour cell uptake studies of gadolinium(III)-phosphonium complexes.

    abstract：:The synthesis of a new series of Gd(III)-arylphosphonium complexes is described and the solution stability of selected compounds is reported. Their lipophilicity and uptake in human glial (SVG p12) and human glioblastoma multiforme (T98G) cell lines are presented. The in vitro cytotoxicity of all complexes was determi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-79893-9

    authors： Hall AJ,Robertson AG,Hill LR,Rendina LM

    更新日期：2021-01-12 00:00:00

  • Real-time and ultrahigh accuracy image synthesis algorithm for full field of view imaging system.

    abstract：:In this paper, we propose a real time, ultrahigh accuracy and full-field-of-view (RUF) algorithm for full field of view (FOV) imaging system. The proposed algorithm combines rough matching and precise matching method to stitch multiple images with the whole FOV in short time and high imaging quality. In order to verif...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-69353-9

    authors： Liu SB,Wang JH,Yuan RY,Zhao WX,Li L,Wang QH

    更新日期：2020-07-24 00:00:00

  • Annexin-A1 enhances breast cancer growth and migration by promoting alternative macrophage polarization in the tumour microenvironment.

    abstract：:Macrophages are potent immune cells with well-established roles in the response to stress, injury, infection and inflammation. The classically activated macrophages (M1) are induced by lipopolysaccharide (LPS) and express a wide range of pro-inflammatory genes. M2 macrophages are induced by T helper type 2 cytokines s...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-17622-5

    authors： Moraes LA,Kar S,Foo SL,Gu T,Toh YQ,Ampomah PB,Sachaphibulkij K,Yap G,Zharkova O,Lukman HM,Fairhurst AM,Kumar AP,Lim LHK

    更新日期：2017-12-20 00:00:00

  • Ectopic expression of Snord115 in choroid plexus interferes with editing but not splicing of 5-Ht2c receptor pre-mRNA in mice.

    abstract：:Serotonin 5-HT2C receptor is a G-protein coupled excitatory receptor that regulates several biochemical pathways and has been implicated in obesity, mental state, sleep cycles, autism, neuropsychiatric disorders and neurodegenerative diseases. The activity of 5-HT2CR is regulated via alternative splicing and A to I ed...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-39940-6

    authors： Raabe CA,Voss R,Kummerfeld DM,Brosius J,Galiveti CR,Wolters A,Seggewiss J,Huge A,Skryabin BV,Rozhdestvensky TS

    更新日期：2019-03-12 00:00:00

  • Preserved immune functionality and high CMV-specific T-cell responses in HIV-infected individuals with poor CD4+ T-cell immune recovery.

    abstract：:Poor CD4+ T-cell recovery after cART has been associated with skewed T-cell maturation, inflammation and immunosenescence; however, T-cell functionality in those individuals has not been fully characterized. In the present study, we assessed T-cell function by assessing cytokine production after polyclonal, CMV and HI...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-12013-2

    authors： Gómez-Mora E,García E,Urrea V,Massanella M,Puig J,Negredo E,Clotet B,Blanco J,Cabrera C

    更新日期：2017-09-15 00:00:00

  • A five-year longitudinal observational study in morbidity and mortality of negative appendectomy in Sulaimani teaching Hospital/Kurdistan Region/Iraq.

    abstract：:The most common surgical emergency is suspected acute appendicitis, the lifetime risk of acute appendicitis is estimated to be 8.6% for men and 6.7% for women, with a male to female ratio of 1.4:1; correct diagnosis can be made in 70-80% of patients after the operations about 32% of appendectomies revealed normal appe...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-58847-1

    authors： Ahmed HO,Muhedin R,Boujan A,Aziz AHS,Abdulla AM,Hardi RA,Abdulla AA,Sidiq TA

    更新日期：2020-02-06 00:00:00