Abstract:
:Intralesional injection with corticosteroid remains the mainstay of therapy for hypertrophic scars and keloids, however some lesions are unresponsive or may result in skin atrophy. Intralesional bleomycin injection is an alternative therapy that has been widely reported. In order to compare the effectiveness and safety of bleomycin for the treatment of keloids and hypertrophic scars in skin of color population, Fitzpatrick skin type III to V patients with keloids or hypertrophic scars were randomized into two groups. Group A was treated monthly with intralesional triamcinolone acetonide (10 mg/mL), while group B with intralesional bleomycin (1 mg/mL) for three consecutive months. Evaluation of the treatment was performed using "Patient and Observer Scar Assessment Scale" (POSAS), self-rated patient satisfaction score, photography, and ultrasonography. Two patients had their bleomycin blood levels monitored. Twenty-six patients with keloids or hypertrophic scars were recruited. The clinical improvement as assessed by the POSAS was not statistically significant. In terms of patients satisfaction score, one half of both groups reported a very good improvement. Photographic as well as ultrasonographic evaluation showed no difference between the two groups. Bleomycin was found to enter the blood circulation in a very small amount. The major side effect was hyperpigmentation. There was no skin atrophy detected in this study. Intralesional bleomycin is a safe and effective treatment for keloids and hypertrophic scars. The treatment is comparable to intralesional triamcinolone. Unfortunately, hyperpigmentation was the major side effect in darker skin type.
journal_name
J Cosmet Dermatoljournal_title
Journal of cosmetic dermatologyauthors
Payapvipapong K,Niumpradit N,Piriyanand C,Buranaphalin S,Nakakes Adoi
10.1111/jocd.12132subject
Has Abstractpub_date
2015-03-01 00:00:00pages
83-90issue
1eissn
1473-2130issn
1473-2165journal_volume
14pub_type
杂志文章,随机对照试验abstract:BACKGROUND:Acne vulgaris is the most common inflammatory sebaceous gland disorder in young adults. The resistant strains of Propionibacterium acnes (P. acnes) are of increasing concern in the treatment of acne. OBJECTIVES:To evaluate the efficacy of 0.5% topical mangosteen extract in nanoparticle loaded gel (containin...
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更新日期:2018-04-01 00:00:00
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更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Botulinum toxin is generally considered safe and has been used in constantly expanded cosmetic and therapeutic indications. However, long-term side effects such as granulomatous reactions have been associated with this drug. AIMS:We aim to evaluate a rare reaction to Botulonium toxin A injection. PATIENTS/...
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更新日期:2020-02-06 00:00:00
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更新日期:2020-10-14 00:00:00
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pub_type: 历史文章,杂志文章,评审
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更新日期:2010-12-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2019-04-01 00:00:00
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更新日期:2020-11-18 00:00:00
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journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,评审
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更新日期:2016-12-01 00:00:00
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pub_type: 杂志文章
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journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
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更新日期:2016-09-01 00:00:00
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journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
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更新日期:2020-04-01 00:00:00
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journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
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更新日期:2020-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-06-01 00:00:00
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journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/j.1473-2165.2005.40213.x
更新日期:2005-06-01 00:00:00
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journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
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更新日期:2021-02-01 00:00:00
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journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,随机对照试验
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更新日期:2013-12-01 00:00:00
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journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,随机对照试验
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更新日期:2020-04-01 00:00:00
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journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,随机对照试验
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更新日期:2016-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-12-01 00:00:00
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journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
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更新日期:2020-09-01 00:00:00
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journal_title:Journal of cosmetic dermatology
pub_type: 临床试验,杂志文章
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更新日期:2007-12-01 00:00:00
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pub_type: 信件
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更新日期:2012-09-01 00:00:00
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更新日期:2019-02-01 00:00:00
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journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,评审
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更新日期:2016-06-01 00:00:00
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journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
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更新日期:2020-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-02-01 00:00:00