Abstract：
BACKGROUND:Infantile hemangiomas (IHs) are the most common soft tissue tumors of infancy. Although spontaneous regression is expected, medical treatment is needed in approximately 10-20% of cases. AIMS:We aimed to assess the safety and efficacy of systemic propranolol for the treatment of IH. PATIENTS/METHODS:Medical records of 34 eligible patients were analyzed retrospectively. RESULTS:Treatment indications were local complications (hemorrhage, ulceration) in 38.2% of patients, cosmetic risk and face deformity in 35.3%, life-threatening organ dysfunction in 17.6%, and impending visual impairment in 8.8%. The median age at start of treatment with propranolol was 3.5 months (range, 2-65 months). The median duration of propranolol treatment was 8 months (3-12). Response was graded as excellent (>75% improvement) in 30 patients (88.2%) and good (50-75% improvement) in 3 (8.9%). Recurrence was not observed after termination of treatment. None of our patients showed severe side effects at the beginning of or during the treatment. CONCLUSIONS:Propranolol is a well-tolerated, efficacious, and safe drug for treatment of IH. It can be initiated and administered in the outpatient setting. Our report supports the excellent effect and good tolerance of this novel therapy, and we propose the use of propranolol as first-line treatment for IH.
journal_name
J Cosmet Dermatoljournal_title
Journal of cosmetic dermatologyauthors
Turhan AB,Bör Ö,Özdemir ZCdoi
10.1111/jocd.12220subject
Has Abstractpub_date
2016-09-01 00:00:00pages
296-302issue
3eissn
1473-2130issn
1473-2165journal_volume
15pub_type
杂志文章abstract：BACKGROUND:Inflammation and postinflammatory hyperpigmentation (PIH) are two adverse side effects of ablative fractional CO2 laser (ablative Fr CO2 ) treatment for both rejuvenation and acne scars. AIMS:To evaluate the efficacy of fusidic acid cream versus erythromycin ointment as postoperative therapy in patients who...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
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更新日期：2020-09-26 00:00:00
abstract：BACKGROUND:Undecylenoyl phenylalanine is a novel skin-lightening agent, probably acting as α-melanocyte-stimulating hormone (α-MSH) and beta-adrenergic receptor (β-ADR) antagonist. OBJECTIVES:The objective of this double-blind randomized comparative study was to evaluate the efficacy and safety of a preparation contai...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章,随机对照试验
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更新日期：2014-06-01 00:00:00
abstract：:The carboxylic acids include alpha-hydroxyacids (AHAs), polyhydroxy acids (PHAs), aldobionic acids (ABAs), retinoic acid, vitamin C and azelaic acid. They all have therapeutic actions. AHAs, PHAs and ABAs are organic hydroxyacids, a group of natural and physiological substances which can modulate skin keratinization a...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/j.1473-2130.2004.00059.x
更新日期：2004-04-01 00:00:00
abstract：:Intralesional injection with corticosteroid remains the mainstay of therapy for hypertrophic scars and keloids, however some lesions are unresponsive or may result in skin atrophy. Intralesional bleomycin injection is an alternative therapy that has been widely reported. In order to compare the effectiveness and safet...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章,随机对照试验
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更新日期：2015-03-01 00:00:00
abstract：BACKGROUND:Different laser systems are reported to be effective in treatment of telangiectasia and erythema, but comparative studies on 1064-nm neodymium-yttrium aluminum garnet (Nd-YAG) laser and pulsed dye laser (PDL) in treatment of erythemato-telangiectatic rosacea are lacking. Substance (P) is implicated in rosace...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/jocd.12048
更新日期：2013-09-01 00:00:00
abstract：BACKGROUND:Human hair cuticle is always exposed to various stresses and then gradually lost in daily life. There are two typical patterns of cuticle damage: type L, where the cell membrane complex, the structure located between cuticle cells, is split and the cuticle lifts up, and type E, where the fragile substructure...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/jocd.12129
更新日期：2015-03-01 00:00:00
abstract：BACKGROUND:Acne vulgaris in females may be resistant to treatment in spite of topical and systemic therapy for a sufficient period. In this condition, acne may be a manifestation of underlying endocrine conditions such as polycystic ovary syndrome (PCOS). OBJECTIVE:To evaluate the frequency of PCOS in females with res...
journal_title：Journal of cosmetic dermatology
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doi：10.1111/j.1473-2165.2010.00500.x
更新日期：2010-06-01 00:00:00
abstract：BACKGROUND:Gender-related price inequalities for over-the-counter dermatologic products such as shampoos and conditioners, razors, deodorants, and lotions remain prevalent in the marketplace. This trend has also been found to apply to topical minoxidil, a common treatment for male and female pattern hair loss. OBJECTI...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/jocd.12954
更新日期：2019-12-01 00:00:00
abstract：BACKGROUND:Bimatoprost has known adnexal activity and was observed to increase nail growth at two clinical centers. OBJECTIVES:In this randomized, double-blinded, placebo-controlled pilot study, we examine the effect of bimatoprost (Lumigan 0.01%), applied bid to the proximal nail fold on nail growth, nail brittleness...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1111/jocd.12372
更新日期：2018-04-01 00:00:00
abstract：BACKGROUND:Although more and more noninvasive detection technologies have been used in assessing skin barrier integrity and functions, more accurate, intuitive, and convenient detective methods still needed to be explored and developed. AIMS:To investigate the characteristic image changes under the dermoscopy and to e...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/jocd.13643
更新日期：2020-09-06 00:00:00
abstract：BACKGROUND:Adolescent and young adult melanomas show different histopathological characteristics and clinical behaviors from adult melanomas. OBJECTIVE:To describe the histopathological and clinical features pertinent to vicenarian skin melanomas and compare them with adult melanomas using a large cohort from a single...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/jocd.13314
更新日期：2020-01-31 00:00:00
abstract：BACKGROUND:As skin ages, a functional decrement occurs. To avoid future vulnerability to dermatologic diseases, an optimal cutaneous regeneration is mandatory. Biological therapies based on blood-derived autologous proteins are gaining attention of scientists and dermatologists. OBJECTIVES:A novel 100% autologous topi...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/jocd.13075
更新日期：2020-03-01 00:00:00
abstract：BACKGROUND:For treating irregular skin pigmentation, a hallmark of premature skin aging, safe and effective alternatives to hydroquinone and kojic acid are being researched. AIMS:Four skin-brightening actives targeting melanin formation at multiple levels, namely disodium glycerophosphate, L-leucine, phenylethyl resor...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/j.1473-2165.2011.00573.x
更新日期：2011-09-01 00:00:00
abstract：BACKGROUND:Injectable fillers are widely used in aesthetic medicine. Polylactic acid (PLA) is a semipermanent filler that needs to be diluted with sterile water before injection. PLA has been associated with an increased risk of adverse reactions, specifically nodule formation. OBJECTIVE:To describe adverse reactions ...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/j.1473-2165.2009.00417.x
更新日期：2009-03-01 00:00:00
abstract：BACKGROUND:Androgenetic alopecia (AGA) is the most common cause of alopecia in men. In the literature, although there are in vitro studies investigating the relationship between oxidative stress and AGA, any in vivo study does not exist. AIM:Our aim was to evaluate the oxidative stress status in male patients with ear...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/jocd.12300
更新日期：2017-12-01 00:00:00
abstract：OBJECTIVE:The aim of the study was to evaluate the efficacy of tattoo removal treatments using the 1064-nm Q-switched (QS) Nd:YAG laser. BACKGROUND DATA:Today, QS lasers appear to be the most common, effective, and safest methods to treat unwanted markings. MATERIAL AND METHODS:A total of 64 patients with 75 unwanted...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/jocd.12162
更新日期：2015-12-01 00:00:00
abstract：:Skin aging (intrinsic aging) and photoaging (extrinsic aging) involve a similar process that leads to the typical creased appearance of the skin, with the progressive loss of its physical and biologic properties. Photoaging is a premature skin aging caused by long-term exposure to the ultraviolet B radiations of the s...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/j.1473-2165.2005.00198.x
更新日期：2005-12-01 00:00:00
abstract：BACKGROUND:Dermal fillers have been used safely and effectively to revolumize aging hands. We assess the effectiveness of polymethylmethacrylate (PMMA) to treat the volume loss of photoaged dorsal hands for up to 12 months. METHODS:In a 12-month prospective study, 15 subjects were treated with PMMA filler in the bilat...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/jocd.13445
更新日期：2020-09-01 00:00:00
abstract：BACKGROUND:Activation of the WNT/β-catenin pathway has emerged as a potential therapeutic target in androgenetic alopecia (AGA). Methyl vanillate (MV) - a safe plant-derived ingredient - has been recently shown to activate the WNT/β-catenin signaling. Objectives Two distinct substudies were conducted. First, we designe...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
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更新日期：2016-12-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Topical aminophylline, caffeine, yohimbe, l-carnitine, and gotu kola (Centella asiatica) may aid in reducing body fat. Lipoxyderm™ contains these ingredients and was used to test if fat loss of the thigh, in conjunction with a low intensity exercise program and restricted calorie intake, was en...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章,随机对照试验
doi：10.1111/jocd.12801
更新日期：2019-08-01 00:00:00
abstract：OBJECTIVE:Striae gravidarum is a form of scarring on the skin observed during pregnancy and can cause serious cosmetic problems. Striae gravidarum may be influenced by hormonal changes, although the etiology is not clear. The aim of this study was to investigate whether body mass index (BMI) and serum collagenase-2 lev...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/jocd.12269
更新日期：2017-09-01 00:00:00
abstract：BACKGROUND:Riehl's melanosis is a chronic, refractory disorder, which can adversely affect patient's quality of life. Intense pulse light, neodymium-doped yttrium aluminum garnet laser, hydroquinone, tranexamic acid have been reported to treat this disease, but there have been few reports on the effectiveness of other ...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/jocd.13153
更新日期：2020-06-01 00:00:00
abstract：OBJECTIVES:Para rubber (Hevea brasiliensis (Willd. ex A. Juss.) Müll. Arg.)) is the important crop of the word. It has been vastly used in biomedical products. However, its pharmacologically application besides the latex is sparely to be explored especially the seed. Cellular biological activities of the standardized p...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/jocd.13843
更新日期：2020-11-13 00:00:00
abstract：OBJECTIVE:To explore the influence of hyperbaric oxygen on scar formation in rabbit ears. METHODS:A total of 20 New Zealand rabbits were selected to establish the hypertrophic scar model on the ears. The rabbits were randomly divided into control group and experimental group (7d, 14d, 21d, and 28d group according to d...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/jocd.12468
更新日期：2018-12-01 00:00:00
abstract：INTRODUCTION:The addition of hydrophobically modified polymers (HMPs) to cleansers that contain surfactants can create polymer-surfactant complexes that are less irritating to the skin than commercially available mild cleansers. Our objective was to compare the tolerability and efficacy of a test foaming liquid facial ...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章,随机对照试验
doi：10.1111/jocd.12061
更新日期：2013-12-01 00:00:00
abstract：BACKGROUND:Some moisturizing formulations can help restore and maintain the barrier function of the skin. OBJECTIVES:This study was designed to assess the hydration potential of three lamellar moisturizers relative to a control (nonlamellar) moisturizer. METHODS:Healthy adults aged 18 to 65 years with self-reported s...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/jocd.13361
更新日期：2020-11-01 00:00:00
abstract：:In recent years, popularity of radiofrequency (RF) has increased significantly. They are characterized by a low risk of complications and relatively high effectiveness. RF use high-frequency currents causing oscillating motion of ions resulting in temperature rise stimulating skin regeneration processes. The aim of th...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/jocd.12775
更新日期：2018-09-17 00:00:00
abstract：BACKGROUND:Although the etiopathogenesis of alopecia areata (AA) is still unclear, inflammation, oxidative stress, and subsequent DNA damage might be considered role players in disease development. AIM:We aimed at exploring the potential link between oxidative DNA damage and inflammation in AA patients through measuri...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/jocd.13814
更新日期：2020-10-25 00:00:00
abstract：:Psoriasis is a chronic, immune-mediated disease that has a major negative impact on a patient's quality of life. Although several literature reviews indicate that skin microbiota may play an important role in the development and regulation of the immune and inflammatory response of psoriasis, few clinical studies are ...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章,评审
doi：10.1111/jocd.13752
更新日期：2020-09-30 00:00:00
abstract：BACKGROUND:The intracellular form of action of retinoids requires these agents to reach deeper layers of the skin with viable cells to ensure therapeutic efficiency. However, studies on swine skin models show that some retinoids have low skin permeability. Thus, the association of innovative formulations with technolog...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/jocd.13826
更新日期：2020-11-03 00:00:00
