Abstract:
BACKGROUND:Although the etiopathogenesis of alopecia areata (AA) is still unclear, inflammation, oxidative stress, and subsequent DNA damage might be considered role players in disease development. AIM:We aimed at exploring the potential link between oxidative DNA damage and inflammation in AA patients through measuring 8-hydroxy deoxyguanosine (8-OHdG), high mobility group box 1 protein (HMGB1), and one of the inflammatory mediators, C-reactive protein (CRP). METHODS:A total of 79 subjects (49 AA patients in addition to 30 apparently healthy control subjects) were tested for serum levels of 8-OHdG, HMBG1, and CRP. RESULTS:Compared with the control group, serum 8-OHdG, HMBG1, and CRP levels were significantly elevated in the studied patients group (0.031, <0.001, and <0.001, respectively). Moreover, logistic regression analysis revealed that disease course, serum levels of 8-OHdG, and HMBG1 were considered independent predictors for AA severity in both uni- and multivariable analyses. CONCLUSION:Our results suggest a possible role of oxidative stress together with proinflammatory biomarkers in development of AA and their benefit in predicting a severe form of the disease.
journal_name
J Cosmet Dermatoljournal_title
Journal of cosmetic dermatologyauthors
Mustafa AI,Khashaba RA,Fawzy E,Baghdady SMA,Rezk SMdoi
10.1111/jocd.13814subject
Has Abstractpub_date
2020-10-25 00:00:00eissn
1473-2130issn
1473-2165pub_type
杂志文章abstract:BACKGROUND:Botulinum toxin (BTX) therapy is currently the most popular cosmetic procedure in the United States. However, few studies exist regarding post-procedure perceptions of the patients' BTX therapy. OBJECTIVE:The aim of this cohort study was to determine patients' responses from pre- to post-BTX treatment exper...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/j.1473-2165.2008.00359.x
更新日期:2008-03-01 00:00:00
abstract:BACKGROUND:Spitzoid melanoma is one of the rare subtypes of melanoma, whose clinical and pathological characteristics have yet to be understood. OBJECTIVE:Understanding the histopathologic features and behavior characteristics of Spitzoid cutaneous melanoma. METHODS:A total number of 11 Turkish Caucasian patients wit...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.12958
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:Reducing erythema and infiltration of inflamed, hypertrophic, and colloidal scars have been a challenge for healthcare providers. Peer-reviewed scientific data for intense pulsed light systems are lacking. OBJECTIVE:A chronicle of three patients who have participated in the treatment of inflamed, hypertroph...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/j.1473-2165.2005.00157.x
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Skin pH is an important parameter indicating the condition of the skin because imbalance can contribute to the development of skin problems and earlier aging. Individual skin pH depends on many factors such as hydration, sweating, sebum excretion, genetics, sex, and age. Additionally, it can be affected by e...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.12303
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Brittle nail syndrome is a common problem among women and refers to nails that exhibit surface roughness, raggedness, and peeling. AIM:The goal of this study was to investigate whether daily oral supplementation with collagen peptides alleviates the symptoms of brittle nails and improves nail growth rate. ...
journal_title:Journal of cosmetic dermatology
pub_type: 临床试验,杂志文章
doi:10.1111/jocd.12393
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Topical cosmetic products can cause adverse reactions in some individuals, particularly those with sensitive skin who may develop irritations or allergic contact dermatitis. Evidence suggests that the frequency of self-reported sensitive skin is increasing in the general population, placing greater importanc...
journal_title:Journal of cosmetic dermatology
pub_type: 临床试验,杂志文章
doi:10.1111/jocd.12547
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:Abobotulinum- toxin A is used extensively for the treatment of frown (glabellar) lines. AIMS:The aim of this study was to evaluate the efficacy and complications of a new injection technique and to assess the amount of satisfaction in patients with the frown lines. METHODS:This cross-sectional study was co...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.12529
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:There remains the need for more effective therapeutic options to treat acne vulgaris. Interest in light-based acne treatments has increased, but few randomized, controlled clinical trials assessing the value of photodynamic therapy (PDT) for acne have been reported. AIMS:We sought to examine the efficacy of...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1473-2165.2010.00483.x
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:Platelet-rich plasma is rich in growth factors that promote differentiation and growth of dermal papilla cells by various signaling pathways. Dermoscopy is handy, bedside tool that helps to improve diagnostic accuracy in various hair disorders. OBJECTIVES:To evaluate and study the role of dermoscopy in pati...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.12845
更新日期:2018-12-16 00:00:00
abstract:BACKGROUND:Acne vulgaris is a highly prevalent skin condition associated with considerable psychological burden. Acne and its sequelae can affect many domains of life leading to social dysfunction, psychiatric issues and educational shortcomings. Psychiatric conditions like depression is found to be more prevalent in a...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,评审
doi:10.1111/jocd.13753
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Hair plays a significant role in shaping the appearance of an individual. Loss of hair can lead to serious effects on social esteem of an individual. The most common cause of hair loss is Androgenetic Alopecia (AGA).This hereditary disorder followed a specific pattern causing progressive thinning of hair in ...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13398
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:Undecylenoyl phenylalanine is a novel skin-lightening agent, probably acting as α-melanocyte-stimulating hormone (α-MSH) and beta-adrenergic receptor (β-ADR) antagonist. OBJECTIVES:The objective of this double-blind randomized comparative study was to evaluate the efficacy and safety of a preparation contai...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,随机对照试验
doi:10.1111/jocd.12089
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:Seborrhea is linked to several medical and mental conditions. Although it is common, effective agents and the standardized sebum level for seborrhea are not elucidated. AIMS:To determine the efficacy of chitosan particles (CP) formulation on controlling sebum secretion, its extended effects on skin redness ...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13274
更新日期:2020-08-01 00:00:00
abstract::Soap is the most useful things which we use our everyday life in various cleansing and cosmetics purposes. Jatropha oil is nonedible oil which has more benefits to soap making. It has also cosmetics and medicinal properties. But the presence of toxic Phorbol esters in Jatropha oil is the main constrains to use it. So ...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,评审
doi:10.1111/jocd.12209
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Ascorbic acid has numerous essential and beneficial functions in normal and photoaged skin. Ionisation of ascorbic acid in aqueous topical formulations leads to oxidative degradation. Ascorbic acid in an anhydrous vehicle would inherently have greater stability. OBJECTIVE:The objective of this study was to ...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/j.1473-2165.2006.00242.x
更新日期:2006-06-01 00:00:00
abstract:BACKGROUND:Welders are normally at risk of skin cancer due to continuous contact with natural ultraviolet rays and welding radiation. Protective behaviors against the radiations are the most fundamental measures taken to prevent skin cancer in these individuals. AIMS:This research aimed to evaluate the factors affecti...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13092
更新日期:2020-04-01 00:00:00
abstract::Moisturizers are used on large body surfaces to maintain the smoothness of the skin and to break the dry-skin cycle. Many healthcare professionals and patients overlook the importance of moisturizers and do not consider them to be 'active' treatments. However, evidence from clinical and experimental studies shows that...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/j.1473-2130.2004.00062.x
更新日期:2003-07-01 00:00:00
abstract:OBJECTIVE:Currently, the cosmetic and medical industries are paying considerable attention to solve or prevent skin damage or diseases, such as hyperpigmentation and oxidation and free radical damage. In this study, the effective compounds in Myrica rubra fruit were extracted and studied the biological effects of these...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.12505
更新日期:2019-02-01 00:00:00
abstract::The authors report the case of a 58-year-old woman presenting with "puffiness" in her lower eyelids persisting for approximately 5 years. While dark, puffy eyelid circles following hyaluronic acid placement periorbitally are not uncommon, what is so unusual in our case is that it was noted 5 years after treatment with...
journal_title:Journal of cosmetic dermatology
pub_type: 信件
doi:10.1111/j.1473-2165.2012.00622.x
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Homologous autoinoculation is a novel minimally invasive procedure that treats warts by stimulating specific immune response. AIM:To evaluate the efficacy and safety of autoinoculation in treatment of multiple recalcitrant warts of different types in relation to patient's age, gender, type, number, size, an...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13831
更新日期:2020-11-11 00:00:00
abstract::Cosmetic defects of the nail cover a range of changes. Some are variants of normal which are considered unattractive, others are part of the normal ageing process and some changes are manifestations of local or systemic disease. Interpretation of these changes relies on recognition of the specific characteristics in q...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1046/j.1473-2130.2001.00014.x
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:The pathophysiology of cellulite involves changes in the subcutaneous adipose layer and the extracellular matrix (ECM) that supports it together with overlying dermal layer. Cellular mechanisms governing cellulite are not fully understood. However, it is accepted that changes include enhanced lipogenesis, de...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1473-2165.2011.00594.x
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:Hair removal practices have changed in frequency and location on the body. Previous research on hair removal injuries has focused on a specific body region, age, or gender. OBJECTIVE:This study sought to take a broader perspective of hair removal-associated injuries in the United States which sought treatme...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.12283
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Synthetic hair fiber implantation first achieved widespread use in the 1970s, but in 1983, the US Federal Drug Administration banned the fibers due to its complications. Currently available synthetic fibers consist of polyamide material, which has been claimed to be effective and safe. Nevertheless, its use ...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13318
更新日期:2020-02-15 00:00:00
abstract::To review indexed literature concerning adverse ocular effects of the most common aesthetic facial procedures (light-emitting therapy, dermal fillers injection, and botulinum toxin). Literature search using three online databases - PubMed, SciELO, and Capes - selecting case reports, series of cases and reviews, with n...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,评审
doi:10.1111/jocd.12141
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Management of periorbital hyperpigmentation (POH) is still a therapeutic challenge. Although different therapeutic modalities are available, the outcomes of most of them are unsatisfactory. OBJECTIVES:To investigate and compare the efficacy and safety of two new modalities in the treatment of POH; the plate...
journal_title:Journal of cosmetic dermatology
pub_type: 临床试验,杂志文章
doi:10.1111/jocd.12478
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Ultraviolet (UV) radiation exposure is related to skin and lip tumors. Therefore, the development of photoprotective lipstick formulations is of utmost importance. AIMS:Considering the biological properties of Shea butter (Butyrospermum parkii), we assessed its potential as an adjuvant in a molded lipstick ...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13429
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Ultraviolet (UV) radiation has been implicated in photoaging and various types of skin carcinomas. Although the human skin has evolved several defense mechanisms to survive the insults of actinic damage like keratinization, melanin pigmentation, etc., it is still subjected to the harmful effects of sunlight....
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/j.1473-2165.2007.00293.x
更新日期:2007-03-01 00:00:00
abstract:BACKGROUND:The use of the injectable products for soft tissue augmentation and treatment of skin aging is an uncomfortable, invasive and related to several complications, and chronic reactions, mainly after long-term application. Efforts to develop new topically active anti-aging products with fewer adverse effects are...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13818
更新日期:2020-11-10 00:00:00
abstract:BACKGROUND:Pigmentary disorders are commonly seen in dermatology practice and can have a negative psychosocial impact on patients. OBJECTIVE:This study aims to examine the prevalence of pigmentary disorders and their level of psychological and physical impact on patients. METHODS:A prospective cohort study involved a...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/j.1473-2165.2008.00384.x
更新日期:2008-09-01 00:00:00