Proposed mechanisms of action for retinoid derivatives in the treatment of skin aging.


:Skin aging (intrinsic aging) and photoaging (extrinsic aging) involve a similar process that leads to the typical creased appearance of the skin, with the progressive loss of its physical and biologic properties. Photoaging is a premature skin aging caused by long-term exposure to the ultraviolet B radiations of the sun, and is more frequently associated to skin cancer than intrinsic aging. Retinoids are natural and synthetic vitamin A derivatives. They are lipophilic molecules and penetrate the epidermis easily. Their biologically active forms can modulate gene expression by binding to nuclear receptors and then to specific DNA sequences. Because of their ability to modulate genes involved in cellular differentiation and proliferation, they appear as good candidates to treat and prevent photoaging. Hyaluronate and collagen, two major constituents of the dermis, are progressively decreased and altered during aging. Various retinoids were shown to increase their synthesis and concentration in the skin and reduce their rate of degradation. Furthermore, retinoids share a common chemical structure containing several conjugated double bonds that enable them to trap free radicals and absorb UV radiations from the sun, thereby protecting cellular targets such as DNA, lipid membranes, or proteins by preventing direct photochemical damage or UV-induced oxidative stress. Therefore, retinoids may be beneficial in treating skin aging and photoaging because of their biologic, chemical, and physical properties, which act at several levels.


J Cosmet Dermatol


Sorg O,Kuenzli S,Kaya G,Saurat JH




Has Abstract


2005-12-01 00:00:00














  • The efficacy and safety of permethrin 2.5% with tea tree oil gel on rosacea treatment: A double-blind, controlled clinical trial.

    abstract:BACKGROUND:Rosacea is a chronic skin condition that typically affects the face and it results in redness and inflammation. The main risk factors of this disease are Demodex folliculorum, living in the pilosebaceous units. AIMS:To evaluate the efficacy and safty of permethrin 2.5% in combination with tea tree oil (TTO)...

    journal_title:Journal of cosmetic dermatology

    pub_type: 杂志文章


    authors: Ebneyamin E,Mansouri P,Rajabi M,Qomi M,Asgharian R,Azizian Z

    更新日期:2020-06-01 00:00:00

  • Medicinal and cosmetics soap production from Jatropha oil.

    abstract::Soap is the most useful things which we use our everyday life in various cleansing and cosmetics purposes. Jatropha oil is nonedible oil which has more benefits to soap making. It has also cosmetics and medicinal properties. But the presence of toxic Phorbol esters in Jatropha oil is the main constrains to use it. So ...

    journal_title:Journal of cosmetic dermatology

    pub_type: 杂志文章,评审


    authors: Shahinuzzaman M,Yaakob Z,Moniruzzaman M

    更新日期:2016-06-01 00:00:00

  • Dual functional bioactive-peptide, AIMP1-derived peptide (AdP), for anti-aging.

    abstract:BACKGROUND:Human skin aging is caused by several factors, such as UV irradiation, stress, hormone, and pollution. Wrinkle formation and skin pigmentation are representative features of skin aging. Although EGF and arbutin are used as anti-wrinkle and skin whitening agents, respectively, they have adverse effects on ski...

    journal_title:Journal of cosmetic dermatology

    pub_type: 杂志文章


    authors: Kim J,Kang S,Kwon H,Moon H,Park MC

    更新日期:2019-02-01 00:00:00

  • Glycolic acid adjusted to pH 4 stimulates collagen production and epidermal renewal without affecting levels of proinflammatory TNF-alpha in human skin explants.

    abstract:BACKGROUND:Glycolic acid (GA) is an effective way of reversing the signs of age and photodamage. GA enhances desquamation of the stratum corneum and induces biological responses that can help restore skin's integrity. GA can, however, cause irritation, especially when its concentration is high, and its pH is low. Thus,...

    journal_title:Journal of cosmetic dermatology

    pub_type: 杂志文章


    authors: Narda M,Trullas C,Brown A,Piquero-Casals J,Granger C,Fabbrocini G

    更新日期:2021-02-01 00:00:00

  • Medium-depth and deep chemical peels.

    abstract::Chemical peeling, also known as chemoexfoliation or dermapeeling, is performed to improve the skin's appearance as it reduces the wrinkles caused by aging and the features of photoaged skin. Although the best results are obtained with deep peels, the medium-depth peels allow to obtain excellent results without the dan...

    journal_title:Journal of cosmetic dermatology

    pub_type: 杂志文章


    authors: Camacho FM

    更新日期:2005-06-01 00:00:00

  • Tattoo: Ancient art and current problems.

    abstract::The popularity of tattoos in the today's society brings with it a significant increase of the incidence of associated cutaneous reactions. Among the several complications that may occur after a tattooing procedure, allergic and photo-allergic reactions, infections, and Koebner phenomenon are the most common ones obser...

    journal_title:Journal of cosmetic dermatology

    pub_type: 杂志文章


    authors: Gualdi G,Fabiano A,Moro R,Venturuzzo A,Monari P,Calzavara-Pinton P,Amerio P

    更新日期:2021-02-01 00:00:00

  • Sunscreen remanence on the skin: a noninvasive real time in vivo spectral analysis assessing the quenching of specular ultraviolet A light reflectance.

    abstract:BACKGROUND:Under specific light illumination, particularly ultraviolet radiation (UVR), the skin produces both specular light reflectance and, possibly, specific fluorescent emission. A quenching effect of fluorescence is observed following the application of sunscreens active against UVA radiations. AIMS:To assess no...

    journal_title:Journal of cosmetic dermatology

    pub_type: 杂志文章


    authors: Piérard GE,Khazaka D,Khazaka G

    更新日期:2016-03-01 00:00:00

  • Efficacy of a novel hydroquinone-free skin-brightening cream in patients with melasma.

    abstract:BACKGROUND:For treating irregular skin pigmentation, a hallmark of premature skin aging, safe and effective alternatives to hydroquinone and kojic acid are being researched. AIMS:Four skin-brightening actives targeting melanin formation at multiple levels, namely disodium glycerophosphate, L-leucine, phenylethyl resor...

    journal_title:Journal of cosmetic dermatology

    pub_type: 杂志文章


    authors: Gold MH,Biron J

    更新日期:2011-09-01 00:00:00

  • Established treatments of skin hypermelanoses.

    abstract::Cutaneous hypermelanoses are frequently encountered conditions that can have severe adverse psychosocial and emotional effects on affected patients. Melasma, postinflammatory hyperpigmentation, drug-induced pigmentation, and erythema dischromicum perstans are among the most common cutaneous disorders leading to acquir...

    journal_title:Journal of cosmetic dermatology

    pub_type: 杂志文章,评审


    authors: Nikolaou V,Stratigos AJ,Katsambas AD

    更新日期:2006-12-01 00:00:00

  • Comparison of noncross-linked and cross-linked hyaluronic acid with regard to efficacy of the proliferative activity of cutaneous fibroblasts and keratinocytes in vitro.

    abstract:BACKGROUND:Intradermal application of hyaluronic acid (HA) in varying chain length and cross-linking density is used routinely for hydrodynamic volume replacement of the extracellular matrix to reduce the clinical effects of aging. OBJECTIVES:In vitro data show that via receptors of the hyaladherin group hyaluronic ac...

    journal_title:Journal of cosmetic dermatology

    pub_type: 杂志文章


    authors: Wohlrab J,Wohlrab D,Neubert RH

    更新日期:2013-03-01 00:00:00

  • Clinical efficacy of 0.5% topical mangosteen extract in nanoparticle loaded gel in treatment of mild-to-moderate acne vulgaris: A 12-week, split-face, double-blinded, randomized, controlled trial.

    abstract:BACKGROUND:Acne vulgaris is the most common inflammatory sebaceous gland disorder in young adults. The resistant strains of Propionibacterium acnes (P. acnes) are of increasing concern in the treatment of acne. OBJECTIVES:To evaluate the efficacy of 0.5% topical mangosteen extract in nanoparticle loaded gel (containin...

    journal_title:Journal of cosmetic dermatology

    pub_type: 杂志文章


    authors: Lueangarun S,Sriviriyakul K,Tempark T,Managit C,Sithisarn P

    更新日期:2019-01-27 00:00:00

  • Hair removal-related injuries in the United States, 1991-2014.

    abstract:BACKGROUND:Hair removal practices have changed in frequency and location on the body. Previous research on hair removal injuries has focused on a specific body region, age, or gender. OBJECTIVE:This study sought to take a broader perspective of hair removal-associated injuries in the United States which sought treatme...

    journal_title:Journal of cosmetic dermatology

    pub_type: 杂志文章


    authors: Swain TA,Tully AS,Redford T,McGwin G

    更新日期:2016-12-01 00:00:00

  • Treatment with propranolol for infantile hemangiomas: single-center experience.

    abstract:BACKGROUND:Infantile hemangiomas (IHs) are the most common soft tissue tumors of infancy. Although spontaneous regression is expected, medical treatment is needed in approximately 10-20% of cases. AIMS:We aimed to assess the safety and efficacy of systemic propranolol for the treatment of IH. PATIENTS/METHODS:Medical...

    journal_title:Journal of cosmetic dermatology

    pub_type: 杂志文章


    authors: Turhan AB,Bör Ö,Özdemir ZC

    更新日期:2016-09-01 00:00:00

  • Facial lipoatrophy: report of five cases after injection of synthetic filler into naso-labial folds.

    abstract:BACKGROUND:Facial lipoatrophies are rare disfiguring syndromes, most commonly characterized by loss of buccal fat pads. AIMS:To demonstrate a relationship between facial lipoatrophy and a new synthetic filler device (Profill) used to correct naso-labial folds. METHODS:Five cases of lipoatrophy, appeared 9 months or l...

    journal_title:Journal of cosmetic dermatology

    pub_type: 杂志文章


    authors: André P,Wechsler J,Revuz J

    更新日期:2002-10-01 00:00:00

  • An observational study of a 24 mg/mL hyaluronic acid with pre-incorporated lidocaine for lip definition and enhancement.

    abstract:BACKGROUND:Lip enhancement using fillers improves appearance by increasing fullness, enhancing lip definition, and reducing fine lines and wrinkles around the lips. AIMS:To investigate a 24 mg/mL hyaluronic acid (HA) with pre-incorporated lidocaine gel for lip definition and enhancement, medium-deep lines, and oral co...

    journal_title:Journal of cosmetic dermatology

    pub_type: 杂志文章


    authors: Lanigan S

    更新日期:2011-03-01 00:00:00

  • Treatment of Nevus lipomatosus cutaneous superficialis with CO2 laser.

    abstract::Nevus lipomatosus cutaneous superficialis (NLCS) is an uncommon lesion characterized by ectopic adipose tissue in the dermis and can be generalized or localized. It presents as a soft skin colored to yellowish papules or cerebriform plaques occurring usually on the buttock or thigh in a segment distribution. We report...

    journal_title:Journal of cosmetic dermatology

    pub_type: 杂志文章


    authors: Sardana K,Bansal S,Garg VK,Khurana N

    更新日期:2017-09-01 00:00:00

  • Microneedling by dermapen and glycolic acid peel for the treatment of acne scars: Comparative study.

    abstract:BACKGROUND:Many methods have been performed to achieve a satisfying outcome in acne scars but some of them were high cost and also were associated with low results and some complications. OBJECTIVES:To evaluate and compare the efficacy and safety therapy of glycolic acid (GA) peel, microneedling with dermapen and a co...

    journal_title:Journal of cosmetic dermatology

    pub_type: 杂志文章


    authors: Saadawi AN,Esawy AM,Kandeel AH,El-Sayed W

    更新日期:2019-02-01 00:00:00

  • A novel LCD (coal tar) solution for psoriasis does not discolor naturally light or color-processed hair in an exaggerated exposure test model.

    abstract:BACKGROUND:Scalp psoriasis is reported to occur in 50-80% of psoriasis sufferers. Treatment of scalp psoriasis requires special consideration of product esthetics and staining potential due to the presence of hair. AIM:To evaluate the potential of a new, marketed liquor carbonis distillate (LCD; coal tar) solution to ...

    journal_title:Journal of cosmetic dermatology

    pub_type: 杂志文章


    authors: Johnson C,Edison B,Brouda I,Green B

    更新日期:2009-09-01 00:00:00

  • Role of KLF2: New insight in inflammatory acne pathogenesis.

    abstract:BACKGROUND:Acne is an inflammatory skin condition of pilosebaceous unit. Its pathogenesis is multifactorial with a central role of inflammatory and pro-inflammatory cytokines mediators. Downregulated Kruppel-like factor 2 (KLF2) leads to rapid secretion of many cytokines that are involved in acne pathogenesis. AIMS:Th...

    journal_title:Journal of cosmetic dermatology

    pub_type: 杂志文章


    authors: Ibrahim MA,Mohammed SA,Elhabak DM

    更新日期:2020-07-05 00:00:00

  • Tocotrienol-rich fraction attenuates UV-induced inflammaging: A bench to bedside study.

    abstract:BACKGROUND:UV radiation from the sun is the most common environmental stressor to damage the skin. It is now well established that photodamaged skin manifests signs of mild but chronic inflammation, termed as "inflammaging." Thus, there is an urgent need for anti-inflammatory regimes that can limit the damage caused by...

    journal_title:Journal of cosmetic dermatology

    pub_type: 杂志文章


    authors: Yap WN

    更新日期:2018-06-01 00:00:00

  • Isolated isoquercitrin from Green ball apple peel inhibits photoaging in CCD-986Sk fibroblasts cells via modulation of the MMPs signaling.

    abstract:BACKGROUND:Ultraviolet B (UVB) irradiation is viewed as the main factor of skin aging, associated with acceleration of elastin, collagen degradation and expression of matrix metalloproteinases (MMPs). Apples are one of the most commonly eaten fruits in the world, and isoquercitrin is the main active ingredient in new b...

    journal_title:Journal of cosmetic dermatology

    pub_type: 杂志文章


    authors: Lee EH,Park HJ,Kim HH,Jung HY,Kang IK,Cho YJ

    更新日期:2020-12-23 00:00:00

  • Hydroquinone and its analogues in dermatology - a risk-benefit viewpoint.

    abstract::Hydroquinone (HQ) has been used since the 1950s in commercially available over-the-counter skin lightener products and since the 1960s as a commercially available medical product. It is also used in cosmetic products such as hair dyes and products for coating finger nails. Beginning in 2001, HQ is no longer authorized...

    journal_title:Journal of cosmetic dermatology

    pub_type: 杂志文章,评审


    authors: O'Donoghue JL

    更新日期:2006-09-01 00:00:00

  • Literature review of the adverse events associated with botulinum toxin injection for the masseter muscle hypertrophy.

    abstract:BACKGROUND:Masseteric hypertrophy is a benign condition characterized by the enlargement of the masseter muscles. A square-shaped jawline due to masseter muscle prominence or hypertrophy is one of the general characteristics of the Asian face, making it a frequent target for esthetic treatment requests. While the appli...

    journal_title:Journal of cosmetic dermatology

    pub_type: 杂志文章,评审


    authors: Yeh YT,Peng JH,Peng HP

    更新日期:2018-10-01 00:00:00

  • New trends in face rejuvenation by hyaluronic acid injections.

    abstract:BACKGROUND:Injection techniques are growing, thanks to safer and more suitable filling agents. Hyaluronic acid (HA), a biodegradable product, has become the "gold standard" for fillers. With its wide range, it not only improves wrinkles but also restores volume. METHODS:Since 1996, many patients have been injected for...

    journal_title:Journal of cosmetic dermatology

    pub_type: 杂志文章,评审


    authors: Andre P

    更新日期:2008-12-01 00:00:00

  • Skin infections by Mycobacterium chelonae following mesotherapy: A report of two cases and review of the literature.

    abstract::Mesotherapy is sometimes responsible for dermal and subcutaneous infections caused by nontuberculous mycobacteria. Mycobacterium chelonae, M abscessus, and M fortuitum are usually involved. We present two cases of deep skin infections caused by M chelonae following mesotherapy. A review of the literature is included. ...

    journal_title:Journal of cosmetic dermatology

    pub_type: 杂志文章


    authors: Veraldi S,Spigariolo CB,Cusini M,Nazzaro G,Gianotti R

    更新日期:2020-08-01 00:00:00

  • New soft tissue filler derived from autologous keratin and fibroblast for neck wrinkles.

    abstract:OBJECTIVE:To assess the effectiveness of injection of autologous keratin gel and fibroblast for neck aging as soft tissue filler. MATERIALS AND METHODS:Totally 30 volunteers received treatment of autologous keratin and fibroblast for neck wrinkles and 5 of them received hyaluronic acid (HA) treatment as control. Clini...

    journal_title:Journal of cosmetic dermatology

    pub_type: 杂志文章,随机对照试验


    authors: Wang Y,Wang B,Zhang Q,Ma J

    更新日期:2018-08-01 00:00:00

  • Spiny keratoderma: Report of three cases.

    abstract:BACKGROUND:Spiny keratoderma shows "music box spine" keratotic papules limited to the palms and soles and these lesions do not cause any trouble besides the cosmetic impairment and the sensation of roughness of hands and soles. AIM:To present cases and review the literature on spiny keratoderma. PATIENTS/METHODS, RES...

    journal_title:Journal of cosmetic dermatology

    pub_type: 杂志文章


    authors: de Azevedo TP,Sodré CT,Santangelo CL,Quintella DC,Cuzzi T,Ramos-E-Silva M

    更新日期:2020-08-01 00:00:00

  • Combination therapy with salicylic acid chemical peels, glycyrrhizin compound, and vitamin C for Riehl's melanosis.

    abstract:BACKGROUND:Riehl's melanosis is a chronic, refractory disorder, which can adversely affect patient's quality of life. Intense pulse light, neodymium-doped yttrium aluminum garnet laser, hydroquinone, tranexamic acid have been reported to treat this disease, but there have been few reports on the effectiveness of other ...

    journal_title:Journal of cosmetic dermatology

    pub_type: 杂志文章


    authors: Wang L,Wen X,Hao D,Li Y,Du D,Jiang X

    更新日期:2020-06-01 00:00:00

  • African hair length in a school population: a clue to disease pathogenesis?

    abstract:BACKGROUND:Anecdotal data suggest that combed natural African hair reaches a length steady state. Easier grooming and anticipated long hair have made relaxers popular. OBJECTIVES:These hypotheses were tested in a cross-sectional survey of 1042 school children using a piloted questionnaire and hair length measurements ...

    journal_title:Journal of cosmetic dermatology

    pub_type: 杂志文章


    authors: Khumalo NP,Gumedze F

    更新日期:2007-09-01 00:00:00

  • Facial dynamics and emotional expressions in facial aging treatments.

    abstract::Facial expressions convey emotions that form the foundation of interpersonal relationships, and many of these emotions promote and regulate our social linkages. Hence, the facial aging symptomatological analysis and the treatment plan must of necessity include knowledge of the facial dynamics and the emotional express...

    journal_title:Journal of cosmetic dermatology

    pub_type: 杂志文章


    authors: Michaud T,Gassia V,Belhaouari L

    更新日期:2015-03-01 00:00:00