Abstract:
BACKGROUND:Skin dryness and an accelerated fragmentation of the collagen network in the dermis are hallmarks of skin aging. Nutrition is a key factor influencing skin health and consequently its appearance. A wide range of dietary supplements is offered to improve skin health. Collagen peptides are used as a bioactive ingredient in nutricosmetic products and have been shown in preclinical studies to improve skin barrier function, to induce the synthesis of collagen and hyaluronic acid, and to promote fibroblast growth and migration. Our aim was to investigate the effect of oral supplementation with specific collagen peptides on skin hydration and the dermal collagen network in a clinical setting. METHODS:Two placebo-controlled clinical trials were run to assess the effect of a daily oral supplementation with collagen peptides on skin hydration by corneometry, on collagen density by high-resolution ultrasound and on collagen fragmentation by reflectance confocal microscopy. Human skin explants were used to study extracellular matrix components in the presence of collagen peptides ex vivo. RESULTS:Oral collagen peptide supplementation significantly increased skin hydration after 8 weeks of intake. The collagen density in the dermis significantly increased and the fragmentation of the dermal collagen network significantly decreased already after 4 weeks of supplementation. Both effects persisted after 12 weeks. Ex vivo experiments demonstrated that collagen peptides induce collagen as well as glycosaminoglycan production, offering a mechanistic explanation for the observed clinical effects. CONCLUSION:The oral supplementation with collagen peptides is efficacious to improve hallmarks of skin aging.
journal_name
J Cosmet Dermatoljournal_title
Journal of cosmetic dermatologyauthors
Asserin J,Lati E,Shioya T,Prawitt Jdoi
10.1111/jocd.12174subject
Has Abstractpub_date
2015-12-01 00:00:00pages
291-301issue
4eissn
1473-2130issn
1473-2165journal_volume
14pub_type
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journal_title:Journal of cosmetic dermatology
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pub_type: 杂志文章,随机对照试验
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更新日期:2014-12-01 00:00:00
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journal_title:Journal of cosmetic dermatology
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