Abstract:
BACKGROUND:Hair transplant surgery using follicular unit extraction technique (FUE) is a common surgical procedure for the treatment of severe hair loss. Blood-derived autologous growth factors have also proved to promote hair regeneration in patients with different types of alopecia. AIMS:The aim of this study was to evaluate the safety and clinical efficacy of plasma rich in growth factors (PRGF) technology as an adjuvant therapy for FUE surgery in hair loss affected patients. METHODS:The biologic potential of PRGF was firstly in vitro evaluated over follicular germinal matrix and dermal papilla cells. Afterward, fifteen patients were subjected to routine FUE procedure while 15 patients underwent FUE+PRGF therapy. PRGF group included intradermal injections of growth factors and follicular transfer unit (FTU) preservation in an autologous fibrin clot. Postsurgical patient satisfaction and clinical improvement were evaluated, and PRGF or saline-preserved hair grafts were histomorphometrically analyzed. RESULTS:Follicular cell proliferation and migration was induced after autologous growth factors treatment. PRGF-preserved FTUs presented higher bioactivity signals and improved integrity of perifollicular structures and extracellular matrix proteins such as collagen and elastic fibers. PRGF not only reduced the postsurgical crust healing and hair fixation period, but also decreased the inflammatory pain and itching sensation. CONCLUSIONS:This preliminary data demonstrate that PRGF is able to minimize the postsurgical follicle loss and potentiate the performance of grafted hairs. The fibrin clot not only acts as a protective barrier against environmental factors, but also provides a biologically active scaffold that induces resident cell proliferation and maintains an optimal integrity of the grafted hair.
journal_name
J Cosmet Dermatoljournal_title
Journal of cosmetic dermatologyauthors
Navarro RM,Pino A,Martinez-Andres A,Molina C,Martinez AM,Martinez N,Orive G,Anitua Edoi
10.1111/jocd.12446subject
Has Abstractpub_date
2018-10-01 00:00:00pages
862-873issue
5eissn
1473-2130issn
1473-2165journal_volume
17pub_type
杂志文章abstract:AIMS:Bromhidrosis is a common problem with a severe negative impact on the patient's social and emotional life. The objective of this open-label study was to evaluate the efficacy and safety of a local product with the main active ingredient of glycine-soja sterocomplex in the treatment of local bromhidrosis. PATIENTS...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/j.1473-2165.2010.00536.x
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:Port Wine Stain (PWS) is a congenital capillary malformation. Although multiple treatments are required, the gold standard treatment for PWS is Pulsed Dye Laser (PDL). Given its anti-angiogenic effects, sirolimus can be considered as an adjuvant to PDL in PWS. AIM:To evaluate the efficacy and safety of topi...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13867
更新日期:2020-11-29 00:00:00
abstract:BACKGROUND:The intracellular form of action of retinoids requires these agents to reach deeper layers of the skin with viable cells to ensure therapeutic efficiency. However, studies on swine skin models show that some retinoids have low skin permeability. Thus, the association of innovative formulations with technolog...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13826
更新日期:2020-11-03 00:00:00
abstract:BACKGROUND:Combination therapies have reported to augment the repigmentation in vitiligo. Microneedling (Mn) facilitates drug delivery across the skin barrier. OBJECTIVE:To evaluate and compare the efficacy and safety of Mn combined with tacrolimus vs Mn alone or tacrolimus 0.1% ointment for treatment of localized and...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,随机对照试验
doi:10.1111/jocd.13304
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Acne scars are a major concerning problem to all acne patients affecting their quality of life. Platelet-rich plasma (PRP) and fractional CO2 laser are innovative treatment modalities for acne scars. Carboxytherapy can also be used to improve scar tissue through the increase in collagen deposition and reorga...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.12561
更新日期:2019-02-01 00:00:00
abstract::The American Academy of Dermatology (AAD) has prioritized skin cancer prevention efforts in 2018, as photoprotection measures adopted by the general public remain suboptimal. A large proportion of patients lack understanding of primary prevention methods for skin cancer, and mistruths in advertising may contribute sig...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.12743
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Masseter hypertrophy is a common, prominent feature in many Asian patients, and correction procedures are often requested for esthetic reasons. Toxin masseter injections have a high efficacy and safety profile, but the risks of a variety of side effects or complications remain. OBJECTIVES:The categorization...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.12473
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:UV radiation from the sun is the most common environmental stressor to damage the skin. It is now well established that photodamaged skin manifests signs of mild but chronic inflammation, termed as "inflammaging." Thus, there is an urgent need for anti-inflammatory regimes that can limit the damage caused by...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.12421
更新日期:2018-06-01 00:00:00
abstract::Hydroquinone has been used for decades as a skin lightening agent. Since January 1, 2001, its use in cosmetics has been banned. This ban is as a result of mid-term effects such as leukoderma-en-confetti/occupational vitiligo and exogenous ochronosis. However, a recent literature search on hydroquinone as a skin lighte...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/j.1473-2165.2005.40202.x
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND:Reducing erythema and infiltration of inflamed, hypertrophic, and colloidal scars have been a challenge for healthcare providers. Peer-reviewed scientific data for intense pulsed light systems are lacking. OBJECTIVE:A chronicle of three patients who have participated in the treatment of inflamed, hypertroph...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/j.1473-2165.2005.00157.x
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVE:To provide retrospective clinical review of some uncommonly reported side effects of long-pulsed alexandrite laser treatment for hair removal. MATERIAL AND METHODS:Two hundred and fifty female patients suffering from hirsutism of the face were subjected to treatment by long pulse alexandrite laser for a maxi...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/j.1473-2165.2009.00465.x
更新日期:2009-12-01 00:00:00
abstract:OBJECTIVE:Currently, the cosmetic and medical industries are paying considerable attention to solve or prevent skin damage or diseases, such as hyperpigmentation and oxidation and free radical damage. In this study, the effective compounds in Myrica rubra fruit were extracted and studied the biological effects of these...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.12505
更新日期:2019-02-01 00:00:00
abstract::Soap is the most useful things which we use our everyday life in various cleansing and cosmetics purposes. Jatropha oil is nonedible oil which has more benefits to soap making. It has also cosmetics and medicinal properties. But the presence of toxic Phorbol esters in Jatropha oil is the main constrains to use it. So ...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,评审
doi:10.1111/jocd.12209
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Adult dermatological out patients have a 40% prevalence of psychiatric co-morbidity. If psychiatric co-morbidity is unrecognized, undetected and untreated, the consequences may be fatal. Acne is the most common skin disorder of the second and third decades of life. Acne and its treatments may cause depressio...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1473-2165.2002.00057.x
更新日期:2002-12-01 00:00:00
abstract:BACKGROUND:Excess skin and fatty tissues beneath the jaw lead to a double chin deformity. Localized fat deposits in this area are a cause of discomfort and anguish, leading patients to undergo surgical procedures such as liposuction and dermolipectomy to improve the cosmetic effect. Both procedures require anesthesia a...
journal_title:Journal of cosmetic dermatology
pub_type: 临床试验,杂志文章
doi:10.1111/j.1473-2165.2007.00343.x
更新日期:2007-12-01 00:00:00
abstract:BACKGROUND:Atopic dermatitis (AD) is an inflammatory pruritic chronic dermatosis involving the alarmin thymic stromal lymphopoietin (TSLP), which is directly implicated in AD pruritus. AIMS:To evaluate the efficacy of Tambourissa trichophylla leaf extract (TTLE) titrated in polyphenols and 18β-glycyrrhetinic acid (GA)...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13515
更新日期:2020-08-01 00:00:00
abstract::The popularity of tattoos in the today's society brings with it a significant increase of the incidence of associated cutaneous reactions. Among the several complications that may occur after a tattooing procedure, allergic and photo-allergic reactions, infections, and Koebner phenomenon are the most common ones obser...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13548
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND:Activation of the WNT/β-catenin pathway has emerged as a potential therapeutic target in androgenetic alopecia (AGA). Methyl vanillate (MV) - a safe plant-derived ingredient - has been recently shown to activate the WNT/β-catenin signaling. Objectives Two distinct substudies were conducted. First, we designe...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.12225
更新日期:2016-12-01 00:00:00
abstract::Forced air cooling is a well-established technique that protects the epidermis during laser heating of deeper structures, thereby allowing for increased laser fluences. The goal of this prospective study was to identify whether an elevation in ambient room temperature influences the efficacy of forced air cooling. Ski...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/j.1473-2165.2007.00327.x
更新日期:2007-09-01 00:00:00
abstract::To review indexed literature concerning adverse ocular effects of the most common aesthetic facial procedures (light-emitting therapy, dermal fillers injection, and botulinum toxin). Literature search using three online databases - PubMed, SciELO, and Capes - selecting case reports, series of cases and reviews, with n...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,评审
doi:10.1111/jocd.12141
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:New treatments and techniques were being added over the last few years to treat atrophic scars with variable results and adverse effects. AIM OF THE WORK:The aim of this study was to evaluate and compare the therapeutic efficacy and safety of microneedling, autologous platelet-rich plasma, and combination o...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,随机对照试验
doi:10.1111/jocd.12356
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:Different laser systems are reported to be effective in treatment of telangiectasia and erythema, but comparative studies on 1064-nm neodymium-yttrium aluminum garnet (Nd-YAG) laser and pulsed dye laser (PDL) in treatment of erythemato-telangiectatic rosacea are lacking. Substance (P) is implicated in rosace...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.12048
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND:Anecdotal data suggest that combed natural African hair reaches a length steady state. Easier grooming and anticipated long hair have made relaxers popular. OBJECTIVES:These hypotheses were tested in a cross-sectional survey of 1042 school children using a piloted questionnaire and hair length measurements ...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/j.1473-2165.2007.00326.x
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND:Hair plays a significant role in shaping the appearance of an individual. Loss of hair can lead to serious effects on social esteem of an individual. The most common cause of hair loss is Androgenetic Alopecia (AGA).This hereditary disorder followed a specific pattern causing progressive thinning of hair in ...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13398
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVE:To evaluate the efficacy and safety associated with use of a 589-nm solid-state laser for treatment of facial erythema. METHODS:A prospective, IRB-approved study was conducted. Participants who were interested in treatment for facial erythema were recruited. They received four monthly treatments with the 589...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.12742
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Botulinum toxin (BTX) therapy is currently the most popular cosmetic procedure in the United States. However, few studies exist regarding post-procedure perceptions of the patients' BTX therapy. OBJECTIVE:The aim of this cohort study was to determine patients' responses from pre- to post-BTX treatment exper...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/j.1473-2165.2008.00359.x
更新日期:2008-03-01 00:00:00
abstract:BACKGROUND:At present, it is no longer possible to use animal testing for ingredients and cosmetic products in the Organisation for Economic Co-operation and Development (OECD) member states. However, in vitro tests are widely used to determine the safety and efficacy of ingredients and medicines. OBJECTIVE:Obviously,...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13789
更新日期:2020-10-14 00:00:00
abstract:BACKGROUND:Acne vulgaris is a highly prevalent skin condition associated with considerable psychological burden. Acne and its sequelae can affect many domains of life leading to social dysfunction, psychiatric issues and educational shortcomings. Psychiatric conditions like depression is found to be more prevalent in a...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,评审
doi:10.1111/jocd.13753
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Rosacea is a chronic skin condition that typically affects the face and it results in redness and inflammation. The main risk factors of this disease are Demodex folliculorum, living in the pilosebaceous units. AIMS:To evaluate the efficacy and safty of permethrin 2.5% in combination with tea tree oil (TTO)...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13177
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Doctors and healthcare workers (HCW) are at frontline in control of the pandemic caused by the novel coronavirus infection (COVID-19). The virus is transmitted by contact, droplet, and airborne transmission; hence, hand hygiene, social distancing, environmental disinfection, and use of appropriate personal p...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,评审
doi:10.1111/jocd.13736
更新日期:2020-12-01 00:00:00