Abstract：
BACKGROUND:At present, it is no longer possible to use animal testing for ingredients and cosmetic products in the Organisation for Economic Co-operation and Development (OECD) member states. However, in vitro tests are widely used to determine the safety and efficacy of ingredients and medicines. OBJECTIVE:Obviously, 3D skin models with natural human features can be used to analyze cosmetic ingredients and formulations. Skin irritation by cosmetic products is studied less than ingredients on 3D skin models. Therefore, it is necessary for us to explore using 3D skin models to detect skin irritation with resident and cleaning cosmetic products. METHODS:We used HE staining to observe the structure of reconstructed skin models, the MTT assay to analyze tissue activity, and the ELISA to detect the relative expression of IL-1α release to evaluate skin irritation with cosmetic products. RESULTS:We found that 0.3% SLS treatment and 1% Triton X-100 in 3D skin models resulted in a tissue activity of <20% and increased IL-1α release. We suggest that 0.3% SLS be used as a positive control for resident cosmetics and 1% Triton X-100 be used for cleaning products. After a comprehensive analysis of the relative expression of tissue activity and IL-1α, we found that 4 cosmetic products were skin irritants. Compared with multiple skin irritation tests using rabbit irritancy evaluation, we find that skin models can objectively respond to skin irritation with reliability. CONCLUSION:We may redefine the exposure method time for cosmetics. For resident cosmetic products, the exposure time is 18 hours. For cosmetic cleaning products, the exposure time is 1 hour, with 10% dilution. We suggest that skin irritation evaluation in 3D skin models have a tissue activity of <50% and, at the same time, have a relative expression of IL-1α that is 3-fold greater than baseline.
journal_name
J Cosmet Dermatoljournal_title
Journal of cosmetic dermatologyauthors
Ma X,Wang F,Wang Bdoi
10.1111/jocd.13789subject
Has Abstractpub_date
2020-10-14 00:00:00eissn
1473-2130issn
1473-2165pub_type
杂志文章abstract：BACKGROUND:UV filters should be determined a strict toxicological safety prior to approval. Homosalate (HMS) is one of the most widely used organic UV filter. HMS accumulates in aquatic biota ecosystems and humans through the food chain; therefore, it is important to consider the effects on health and know its mechanis...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/jocd.12973
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:Propionibacterium acnes is a major contributing factor to the inflammatory component of acne. The interaction of P. acnes with keratinocytes leads to an innate immune response via activation of toll-like receptors (TLR2, TLR4) resulting in the production and secretion of pro-inflammatory mediators. SIG1273, ...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章,随机对照试验
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abstract：:Controversy exists as to whether topical antioxidants can be effective in protecting against and reversing photodamage to the skin. Topical vitamins C and E, as well as topical selenium, protect skin against sunburn, suntan and skin cancer and also reverse the mottled pigmentation and wrinkles of photoageing. However,...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/j.1473-2130.2004.00067.x
更新日期：2004-07-01 00:00:00
abstract：:In recent years, popularity of radiofrequency (RF) has increased significantly. They are characterized by a low risk of complications and relatively high effectiveness. RF use high-frequency currents causing oscillating motion of ions resulting in temperature rise stimulating skin regeneration processes. The aim of th...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/jocd.12775
更新日期：2018-09-17 00:00:00
abstract：OBJECTIVE:To assess the effectiveness of injection of autologous keratin gel and fibroblast for neck aging as soft tissue filler. MATERIALS AND METHODS:Totally 30 volunteers received treatment of autologous keratin and fibroblast for neck wrinkles and 5 of them received hyaluronic acid (HA) treatment as control. Clini...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章,随机对照试验
doi：10.1111/jocd.12438
更新日期：2018-08-01 00:00:00
abstract：BACKGROUND:Although more and more noninvasive detection technologies have been used in assessing skin barrier integrity and functions, more accurate, intuitive, and convenient detective methods still needed to be explored and developed. AIMS:To investigate the characteristic image changes under the dermoscopy and to e...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/jocd.13643
更新日期：2020-09-06 00:00:00
abstract：BACKGROUND:Facial telangiectasia is one of the common skin vascular lesions characterized by dilated cutaneous vasculatures. The variety of diameters and difference in depths of lesional blood vessels are the major challenges for effective treatments for Facial telangiectasia. AIMS:To compare the efficacy and safety p...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/jocd.13179
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:Dermal fillers have been used safely and effectively to revolumize aging hands. We assess the effectiveness of polymethylmethacrylate (PMMA) to treat the volume loss of photoaged dorsal hands for up to 12 months. METHODS:In a 12-month prospective study, 15 subjects were treated with PMMA filler in the bilat...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/jocd.13445
更新日期：2020-09-01 00:00:00
abstract：:Recently, both doctors and patients pay particular attention to aesthetic medical services quality and efficacy of aesthetic adjustment implemented. It is essential to ensure research, analysis, and improving of botulinum toxin therapy quality and provide patients' orientation on the adjustment schedule, which include...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/jocd.13584
更新日期：2021-02-01 00:00:00
abstract：BACKGROUND:Undecylenoyl phenylalanine is a novel skin-lightening agent, probably acting as α-melanocyte-stimulating hormone (α-MSH) and beta-adrenergic receptor (β-ADR) antagonist. OBJECTIVES:The objective of this double-blind randomized comparative study was to evaluate the efficacy and safety of a preparation contai...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章,随机对照试验
doi：10.1111/jocd.12089
更新日期：2014-06-01 00:00:00
abstract：BACKGROUND:Riehl's melanosis is a chronic, refractory disorder, which can adversely affect patient's quality of life. Intense pulse light, neodymium-doped yttrium aluminum garnet laser, hydroquinone, tranexamic acid have been reported to treat this disease, but there have been few reports on the effectiveness of other ...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
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更新日期：2020-06-01 00:00:00
abstract：:Cosmetic defects of the nail cover a range of changes. Some are variants of normal which are considered unattractive, others are part of the normal ageing process and some changes are manifestations of local or systemic disease. Interpretation of these changes relies on recognition of the specific characteristics in q...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1046/j.1473-2130.2001.00014.x
更新日期：2002-01-01 00:00:00
abstract：BACKGROUND:Hair plays a significant role in shaping the appearance of an individual. Loss of hair can lead to serious effects on social esteem of an individual. The most common cause of hair loss is Androgenetic Alopecia (AGA).This hereditary disorder followed a specific pattern causing progressive thinning of hair in ...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/jocd.13398
更新日期：2020-11-01 00:00:00
abstract：BACKGROUND:To investigate the effectiveness of the posterior temporal supraSMAS minimally invasive lifting technique and compared it to experiments performed in fresh human body donors by applying skin vector displacement measurement technology. MATERIALS AND METHODS:A total of 15 patients (14 females/1 male) with a m...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/jocd.12722
更新日期：2018-08-01 00:00:00
abstract：:Chronic headaches are common and can have a significant effect on quality of life. Approved treatment options are vast and include the use botulinum toxin injections. The objective of this study is to evaluate the effects of purely cosmetic onabotulinumtoxinA (BOTOX) injections on the frequency and severity of chronic...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/jocd.12098
更新日期：2014-09-01 00:00:00
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journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/jocd.12772
更新日期：2019-06-01 00:00:00
abstract：BACKGROUND:The increase in the pigmentation of skin grafts during the healing process is a cosmetic problem. There are a variety of medical and surgical treatment options for skin graft darkening. AIMS:The aim of this study was to investigate the effects of topical hydroquinone, tretinoin, and betamethasone applicatio...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/jocd.13315
更新日期：2020-02-06 00:00:00
abstract：BACKGROUND:Rosacea is a chronic skin condition that typically affects the face and it results in redness and inflammation. The main risk factors of this disease are Demodex folliculorum, living in the pilosebaceous units. AIMS:To evaluate the efficacy and safty of permethrin 2.5% in combination with tea tree oil (TTO)...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/jocd.13177
更新日期：2020-06-01 00:00:00
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journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章,评审
doi：10.1111/jocd.13736
更新日期：2020-12-01 00:00:00
abstract：:Many cosmetic companies utilize in vitro gene array studies to display significant stimulation or inhibition of various human skin biomarkers to validate in vivo actions that are reported to enhance dermal health. This follows the central dogma of DNA-to-RNA results in protein expression; however, gene and protein exp...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/jocd.12362
更新日期：2018-04-01 00:00:00
abstract：OBJECTIVE:To explore the influence of hyperbaric oxygen on scar formation in rabbit ears. METHODS:A total of 20 New Zealand rabbits were selected to establish the hypertrophic scar model on the ears. The rabbits were randomly divided into control group and experimental group (7d, 14d, 21d, and 28d group according to d...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/jocd.12468
更新日期：2018-12-01 00:00:00
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journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/jocd.12153
更新日期：2015-09-01 00:00:00
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journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/jocd.13818
更新日期：2020-11-10 00:00:00
abstract：BACKGROUND:Seborrhea is linked to several medical and mental conditions. Although it is common, effective agents and the standardized sebum level for seborrhea are not elucidated. AIMS:To determine the efficacy of chitosan particles (CP) formulation on controlling sebum secretion, its extended effects on skin redness ...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/jocd.13274
更新日期：2020-08-01 00:00:00
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journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章,评审
doi：10.1111/jocd.13549
更新日期：2020-08-01 00:00:00
abstract：BACKGROUND:Palmar hyperhidrosis (PH) can produce social and occupational difficulties and reduce the quality of life of those who suffer from this kind of problem. When dealing with focal hyperhidrosis, the patients' attitudes and their subjective approaches regarding the process may influence the objective evaluation ...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/j.1473-2165.2005.00304.x
更新日期：2005-09-01 00:00:00
abstract：BACKGROUND:Cutaneous hyperchromias are disorders of skin pigmentation involving an increase of melanin production and its irregular accumulation in skin cells. It is known that the use of sunscreens helps to prevent changes in the skin pigmentation pattern, but the structural and morphological alterations that occur in...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/jocd.12307
更新日期：2017-09-01 00:00:00
abstract：BACKGROUND:Many methods have been performed to achieve a satisfying outcome in acne scars but some of them were high cost and also were associated with low results and some complications. OBJECTIVES:To evaluate and compare the efficacy and safety therapy of glycolic acid (GA) peel, microneedling with dermapen and a co...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章
doi：10.1111/jocd.12827
更新日期：2019-02-01 00:00:00
abstract：:Hydroquinone (HQ) has been used since the 1950s in commercially available over-the-counter skin lightener products and since the 1960s as a commercially available medical product. It is also used in cosmetic products such as hair dyes and products for coating finger nails. Beginning in 2001, HQ is no longer authorized...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章,评审
doi：10.1111/j.1473-2165.2006.00253.x
更新日期：2006-09-01 00:00:00
abstract：BACKGROUND:Skin care influences skin barrier function during the first postnatal weeks. Although the use of natural oils in preterms has been investigated, there are currently no data comparing the effect of sunflower oil to an emollient on barrier development in healthy term newborns. METHODS:In a prospective, random...
journal_title：Journal of cosmetic dermatology
pub_type： 杂志文章,随机对照试验
doi：10.1111/jocd.12302
更新日期：2017-12-01 00:00:00
