Abstract:
OBJECTIVE:Currently, the cosmetic and medical industries are paying considerable attention to solve or prevent skin damage or diseases, such as hyperpigmentation and oxidation and free radical damage. In this study, the effective compounds in Myrica rubra fruit were extracted and studied the biological effects of these M. rubra fruit extracts. METHODS:In this study, we extracted M. rubra fruit using solutions with various ratios of water to ethanol (100:0, 50:50, 5:95) and studied the anti-melanogenesis, anti-oxidation and radical scavenging effects of these M. rubra fruit extracts on two melanoma cell lines: mouse melanoma (B16-F0) and human melanoma (A2058). The cytotoxicity, melanin synthesis, mushroom and cellular tyrosinase activities, enzyme kinetics, melanogenesis-related gene expression, melanogenesis-related protein secretion, radical DPPH scavenging activity and ROS inhibition after treatment with M. rubra fruit extracts were determined. RESULTS:The results showed that the water extract of M. rubra fruit was less cytotoxic to the melanoma cell lines, effectively inhibited melanin synthesis and tyrosinase activity and down-regulated the gene expression and protein secretion of MITF and TRP-1. In addition, the M. rubra fruit extracts also showed the abilities to scavenge DPPH free radicals and suppress ROS production. Finally, the effective compounds in the water extract were Myricetin-O-deoxyhexoside, Quercetin-O-deoxyhexoside, and Kaempferol-O-hexoside determined by LC/MS/MS assay. CONCLUSION:Overall, the water extract of M. rubra fruit is a safe and effective melanin inhibitor and anti-oxidant and can be applied widely in the fields of cosmetics and medicine.
journal_name
J Cosmet Dermatoljournal_title
Journal of cosmetic dermatologyauthors
Juang LJ,Gao XY,Mai ST,Lee CH,Lee MC,Yao CLdoi
10.1111/jocd.12505subject
Has Abstractpub_date
2019-02-01 00:00:00pages
322-332issue
1eissn
1473-2130issn
1473-2165journal_volume
18pub_type
杂志文章abstract::The nail is the largest skin appendage. In addition to its important physiological and sensory functions, it is also of great esthetic importance. Complaints of brittle or soft nails are frequent, particularly among women. Innumerable preparations claiming to improve the nail quality are being sold; however, most have...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1473-2165.2006.00232.x
更新日期:2006-03-01 00:00:00
abstract:BACKGROUND:Type XVI collagen is a member of the fibril-associated collagens with interrupted triple helices; however, its function or regulation remain unclear. AIMS:This study is to examine the effect of ultraviolet B (UVB) or photoaging on type XVI collagen expression in various cultured cells, mouse, and human skin...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/j.1473-2165.2012.00612.x
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Petrolatum is often used to suppress water evaporation from the skin surface. However, its stickiness, shininess, and other factors make it inconvenient for continuous use. OBJECTIVE:To compare the effectiveness and usability between a newly developed petrolatum-based ointment (NOV® II Moisture Balm) and wh...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13300
更新日期:2020-01-28 00:00:00
abstract:BACKGROUND:Postinflammatory hyperpigmentation (PIH) is an acquired hyperpigmentation that involves areas of prior cutaneous inflammation. In addition to prevention, there are a variety of medications and procedures used to treat PIH. AIM OF THE WORK:The aim of this work was to evaluate the efficacy, tolerability, and ...
journal_title:Journal of cosmetic dermatology
pub_type: 临床试验,杂志文章
doi:10.1111/jocd.12301
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:Facial lipoatrophies are rare, disfiguring syndromes requiring correction. Lipofilling is an 'ecological' treatment that does not carry any risk of allergy. AIM:To demonstrate efficacy of this technique in facial lipoatrophy. RESULTS:This technique was used in four patients suffering from lipoatrophy secon...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1046/j.1473-2165.2002.00044.x
更新日期:2002-07-01 00:00:00
abstract:BACKGROUND:Botulinum toxin (BTX) therapy is currently the most popular cosmetic procedure in the United States. However, few studies exist regarding post-procedure perceptions of the patients' BTX therapy. OBJECTIVE:The aim of this cohort study was to determine patients' responses from pre- to post-BTX treatment exper...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/j.1473-2165.2008.00359.x
更新日期:2008-03-01 00:00:00
abstract:BACKGROUND:Hair transplant procedure is a surgical procedure which affects the sensitivity of the scalp. OBJECTIVES:To compare scalp two-point discrimination (2PD) values in healthy controls and patients who had hair transplant surgery. PATIENTS/METHODS:The comparative study was conducted in 25 healthy individuals an...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13326
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:Acne vulgaris in females may be resistant to treatment in spite of topical and systemic therapy for a sufficient period. In this condition, acne may be a manifestation of underlying endocrine conditions such as polycystic ovary syndrome (PCOS). OBJECTIVE:To evaluate the frequency of PCOS in females with res...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/j.1473-2165.2010.00500.x
更新日期:2010-06-01 00:00:00
abstract::Facial expressions convey emotions that form the foundation of interpersonal relationships, and many of these emotions promote and regulate our social linkages. Hence, the facial aging symptomatological analysis and the treatment plan must of necessity include knowledge of the facial dynamics and the emotional express...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.12128
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Current in vitro SPF screening method for plant oil body (oleosome)-based SPF products possesses significant inconsistency and low reliability in the SPF rating. OBJECTIVES:The primary objective of this study was to evaluate the reliability and reproducibility of spectrophotometrically determined sun protec...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.12390
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Dietary or supplementary intake of nutrients and other ingredients positively affects skin appearance. AIMS:Evaluate a multicomponent nutritional supplement on photoaged skin. PATIENTS/METHODS:This multicenter, double-blind, placebo-controlled trial randomized healthy 35- to 65-year-old women with Fitzpatr...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/jocd.12290
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:A growing patient demand for a favorable body shape has led to the development of many new treatment modalities. Noninvasive devices were developed to improve body contour without physical intervention or scarring and with reduced downtime compared to surgical options such as liposuction. AIMS:This study ex...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13533
更新日期:2020-09-01 00:00:00
abstract::In contrast to the female breast the male breast has gained much less attention by aesthetic surgery and cosmetic dermatology. In this review a focus on minimally invasive procedures to correct aesthetic problems of male breast are discussed. The major indications are gynecomastia, breast asymmetry, and body sculpturi...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1473-2165.2011.00548.x
更新日期:2011-06-01 00:00:00
abstract::Psoriasis is a chronic, immune-mediated disease that has a major negative impact on a patient's quality of life. Although several literature reviews indicate that skin microbiota may play an important role in the development and regulation of the immune and inflammatory response of psoriasis, few clinical studies are ...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,评审
doi:10.1111/jocd.13752
更新日期:2020-09-30 00:00:00
abstract:BACKGROUND:Acne vulgaris is one of the most common dermatological diseases, and it is known that various factors are related to triggering this condition in a patient. In particular, although the use of cosmetics is thought to be associated with the onset of a patient developing acne, there are few studies that have be...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13853
更新日期:2020-11-18 00:00:00
abstract:OBJECTIVE:Striae gravidarum is a form of scarring on the skin observed during pregnancy and can cause serious cosmetic problems. Striae gravidarum may be influenced by hormonal changes, although the etiology is not clear. The aim of this study was to investigate whether body mass index (BMI) and serum collagenase-2 lev...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.12269
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:The application of ingredients from marine and maritime origins is increasingly common in skin care products, driven by consumer expectations for natural ingredients. However, these ingredients are typically studied for a few isolated in vitro activities. OBJECTIVES:The purpose of this study was to carry ou...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.12528
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:Subjects seeking facial rejuvenation want the results to appear natural. Currently, however, there is no consensus definition of, or assessment scale for, "naturalness." AIMS:This open-label pilot study explored evaluation techniques and criteria to assess naturalness of facial movement and expression follo...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.12961
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Homologous autoinoculation is a novel minimally invasive procedure that treats warts by stimulating specific immune response. AIM:To evaluate the efficacy and safety of autoinoculation in treatment of multiple recalcitrant warts of different types in relation to patient's age, gender, type, number, size, an...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13831
更新日期:2020-11-11 00:00:00
abstract:BACKGROUND:Activation of the WNT/β-catenin pathway has emerged as a potential therapeutic target in androgenetic alopecia (AGA). Methyl vanillate (MV) - a safe plant-derived ingredient - has been recently shown to activate the WNT/β-catenin signaling. Objectives Two distinct substudies were conducted. First, we designe...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.12225
更新日期:2016-12-01 00:00:00
abstract::A 23-year-old left-handed white male was referred with a complaint of brown discolouration of the fingernails of his left hand. He had been applying 4% hydroquinone cream to facial melasma. The discolouration began in winter and worsened in March and April. It resolved within 2 months of cessation of hydroquinone. The...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/j.1473-2130.2004.00085.x
更新日期:2003-07-01 00:00:00
abstract::Controversy exists as to whether topical antioxidants can be effective in protecting against and reversing photodamage to the skin. Topical vitamins C and E, as well as topical selenium, protect skin against sunburn, suntan and skin cancer and also reverse the mottled pigmentation and wrinkles of photoageing. However,...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/j.1473-2130.2004.00067.x
更新日期:2004-07-01 00:00:00
abstract:INTRODUCTION:There are no evidence-based data how to predict response to therapy in patients with alopecia areata. AIM:The assessment of the predictive value of trichoscopy for the therapeutic outcome in patients with alopecia areata. METHODS:A total of 65 patients with patchy alopecia areata were included into the s...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13064
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:Propionibacterium acnes is a major contributing factor to the inflammatory component of acne. The interaction of P. acnes with keratinocytes leads to an innate immune response via activation of toll-like receptors (TLR2, TLR4) resulting in the production and secretion of pro-inflammatory mediators. SIG1273, ...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,随机对照试验
doi:10.1111/jocd.12002
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:Ultraviolet B (UVB) irradiation is viewed as the main factor of skin aging, associated with acceleration of elastin, collagen degradation and expression of matrix metalloproteinases (MMPs). Apples are one of the most commonly eaten fruits in the world, and isoquercitrin is the main active ingredient in new b...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13903
更新日期:2020-12-23 00:00:00
abstract:BACKGROUND:Platelet-rich plasma is highly enriched plasma that contains a large concentration of platelets that secrete various growth factors and is used in a wide variety of surgical and cosmetic procedures, including hair regrowth and skin rejuvenation. METHODS:Microneedling therapy is being combined with platelet-...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.12772
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Age-associated volume loss is now known to play an important role in the structural changes of the aging face. In the lower face, this manifests as drooping of the corners of the mouth and jowl leading to a loss of the oval jawline of youth. Jawline reshaping by replacing volume has therefore become an indis...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.12074
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:Epidermal growth factor (EGF) is one of the important peptides in wound healing process. The effects of EGF have been increasingly studied in various types of ulcers. However, data on postablative laser resurfacing wound is still limited. OBJECTIVES:To evaluate the effects of the topical EGF ointment on wou...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,随机对照试验
doi:10.1111/jocd.12691
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Adult dermatological out patients have a 40% prevalence of psychiatric co-morbidity. If psychiatric co-morbidity is unrecognized, undetected and untreated, the consequences may be fatal. Acne is the most common skin disorder of the second and third decades of life. Acne and its treatments may cause depressio...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1473-2165.2002.00057.x
更新日期:2002-12-01 00:00:00
abstract:BACKGROUND:Microdermabrasion is a nonchemical superficial resurfacing procedure that removes the stratum corneum. Because it is a somewhat subtle procedure, it may be difficult to demonstrate its cosmetic benefit. OBJECTIVES:To assess the efficacy of microdermabrasion in treatment of melasma, postacne scarring, striae...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.12252
更新日期:2016-12-01 00:00:00