Abstract:
BACKGROUND:Ultraviolet B (UVB) irradiation is viewed as the main factor of skin aging, associated with acceleration of elastin, collagen degradation and expression of matrix metalloproteinases (MMPs). Apples are one of the most commonly eaten fruits in the world, and isoquercitrin is the main active ingredient in new bred varieties "Green ball" apple. Therefore, we are studying the functionality of the active ingredient of apple, a natural raw material that does not have toxicity or sensitivity problems. OBJECTIVES:The aim of this study, we scrutinized the effects of isoquercitrin on skin photoaging in UVB-exposed human fibroblasts (CCD-986Sk). METHODS:To investigate the inhibition effect on photoaging factor regulation, isolated isoquercitrin were treated with UVB, which induces photoaging-related factors in CCD-986Sk fibroblast cells. Pro-inflammatory factors were measured by ELISA, Western blotting and real-time PCR. RESULTS:Isoquercitrin exhibited antioxidant activity and UVB-induced generation of photoaging-related factor inhibition without showing any toxicity. Anti-photoaging effect for protein levels using Isoquercitin was competent, of both the combate MMP-1 and MMP-9. Also, effect of COL1A2 product significantly increase, from up regulating the TIMP-1 mediated pathway in CCD-986Sk cells via the inhibition of MMPs. Isoquercitrin also downregulated the mRNA gene expression of MMPs while upregulating type I procollagen, HAS2 by modulating TIMP-1 and TGF-β in UVB-irradiated CCD-986Sk cells. CONCLUSIONS:Collectively, our results show that isoquercitrin might be useful as a functional food while being a good candidate in the development of cosmetic products and medicines for the remedy of UVB-induced skin photoaging.
journal_name
J Cosmet Dermatoljournal_title
Journal of cosmetic dermatologyauthors
Lee EH,Park HJ,Kim HH,Jung HY,Kang IK,Cho YJdoi
10.1111/jocd.13903subject
Has Abstractpub_date
2020-12-23 00:00:00eissn
1473-2130issn
1473-2165pub_type
杂志文章abstract:BACKGROUND:Hair removal practices have changed in frequency and location on the body. Previous research on hair removal injuries has focused on a specific body region, age, or gender. OBJECTIVE:This study sought to take a broader perspective of hair removal-associated injuries in the United States which sought treatme...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.12283
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Facial dermatitis can result from various conditions, some of which are of a chronic and relapsing nature. The use of topical corticosteroid therapy may lead to additional adverse effects. OBJECTIVE:To compare the efficacy of moisturizer containing 4-t-butylcyclohexanol, which acts as a sensitivity regulato...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,随机对照试验
doi:10.1111/jocd.12499
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Rosacea is a chronic skin condition that typically affects the face and it results in redness and inflammation. The main risk factors of this disease are Demodex folliculorum, living in the pilosebaceous units. AIMS:To evaluate the efficacy and safty of permethrin 2.5% in combination with tea tree oil (TTO)...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13177
更新日期:2020-06-01 00:00:00
abstract::Melasma is an acquired hypermelanosis that results in localized hyperpigmentation, commonly found on the face. This condition is much more common in women than men. There are some features of melasma in men that seem to differ from those seen in women. However, there is a paucity of data on this topic. The aim of this...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1473-2165.2012.00613.x
更新日期:2012-06-01 00:00:00
abstract::Psoriasis is a chronic, immune-mediated disease that has a major negative impact on a patient's quality of life. Although several literature reviews indicate that skin microbiota may play an important role in the development and regulation of the immune and inflammatory response of psoriasis, few clinical studies are ...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,评审
doi:10.1111/jocd.13752
更新日期:2020-09-30 00:00:00
abstract::Chemical peeling, also known as chemoexfoliation or dermapeeling, is performed to improve the skin's appearance as it reduces the wrinkles caused by aging and the features of photoaged skin. Although the best results are obtained with deep peels, the medium-depth peels allow to obtain excellent results without the dan...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/j.1473-2165.2005.40213.x
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND:Brittle nail syndrome is a common problem among women and refers to nails that exhibit surface roughness, raggedness, and peeling. AIM:The goal of this study was to investigate whether daily oral supplementation with collagen peptides alleviates the symptoms of brittle nails and improves nail growth rate. ...
journal_title:Journal of cosmetic dermatology
pub_type: 临床试验,杂志文章
doi:10.1111/jocd.12393
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Skin dryness and an accelerated fragmentation of the collagen network in the dermis are hallmarks of skin aging. Nutrition is a key factor influencing skin health and consequently its appearance. A wide range of dietary supplements is offered to improve skin health. Collagen peptides are used as a bioactive ...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,随机对照试验
doi:10.1111/jocd.12174
更新日期:2015-12-01 00:00:00
abstract:AIMS:Bromhidrosis is a common problem with a severe negative impact on the patient's social and emotional life. The objective of this open-label study was to evaluate the efficacy and safety of a local product with the main active ingredient of glycine-soja sterocomplex in the treatment of local bromhidrosis. PATIENTS...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/j.1473-2165.2010.00536.x
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:Platelet-rich plasma is rich in growth factors that promote differentiation and growth of dermal papilla cells by various signaling pathways. Dermoscopy is handy, bedside tool that helps to improve diagnostic accuracy in various hair disorders. OBJECTIVES:To evaluate and study the role of dermoscopy in pati...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.12845
更新日期:2018-12-16 00:00:00
abstract:BACKGROUND:Gender-related price inequalities for over-the-counter dermatologic products such as shampoos and conditioners, razors, deodorants, and lotions remain prevalent in the marketplace. This trend has also been found to apply to topical minoxidil, a common treatment for male and female pattern hair loss. OBJECTI...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.12954
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:New treatments and techniques were being added over the last few years to treat atrophic scars with variable results and adverse effects. AIM OF THE WORK:The aim of this study was to evaluate and compare the therapeutic efficacy and safety of microneedling, autologous platelet-rich plasma, and combination o...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,随机对照试验
doi:10.1111/jocd.12356
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:Under specific light illumination, particularly ultraviolet radiation (UVR), the skin produces both specular light reflectance and, possibly, specific fluorescent emission. A quenching effect of fluorescence is observed following the application of sunscreens active against UVA radiations. AIMS:To assess no...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.12169
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:UV radiation from the sun is the most common environmental stressor to damage the skin. It is now well established that photodamaged skin manifests signs of mild but chronic inflammation, termed as "inflammaging." Thus, there is an urgent need for anti-inflammatory regimes that can limit the damage caused by...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.12421
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Xanthelasma palpebrarum (XP) is the most common type of cutaneous xanthoma and has been treated with intralesional injection of pingyangmycin effectively. However, bleomycin, which has the same effect in antitumor activity as pingyangmycin, has not been applied in the treatment of XP. AIMS:To explore and as...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13258
更新日期:2020-08-01 00:00:00
abstract::Today, most do not go a day without practicing or hearing about new hair removal methods. However, little is discussed about the history of hair removal and the development of most hair removal methods since the period of cavemen. Avoiding decapitation and fitting in with society are two of many reasons for the develo...
journal_title:Journal of cosmetic dermatology
pub_type: 历史文章,杂志文章
doi:10.1111/jocd.12021
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:Cutaneous hyperchromias are disorders of skin pigmentation involving an increase of melanin production and its irregular accumulation in skin cells. It is known that the use of sunscreens helps to prevent changes in the skin pigmentation pattern, but the structural and morphological alterations that occur in...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.12307
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:Reducing erythema and infiltration of inflamed, hypertrophic, and colloidal scars have been a challenge for healthcare providers. Peer-reviewed scientific data for intense pulsed light systems are lacking. OBJECTIVE:A chronicle of three patients who have participated in the treatment of inflamed, hypertroph...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/j.1473-2165.2005.00157.x
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Psoriasis is an inflammatory disease that is mostly immune-derived. It causes proliferation of skin cells, forming plaques. Psoriasis etiology is unknown. It might be multifactorial. AIMS:This work aimed to study Smad7 expression in psoriasis vulgaris patients in comparison with normal skin. PATIENTS/METHO...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13425
更新日期:2020-12-01 00:00:00
abstract::Twin studies, especially those involving monozygotic (MZ) twins, facilitate the analysis of factors affecting skin aging while controlling for age, gender, and genetic susceptibility. The purpose of this study was to objectively assess various features of facial skin and analyze the effects of environmental factors on...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.12081
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:Application of radiofrequency (RF) energy with microneedles to facial skin shown to promote skin renewal. AIM:To evaluate the safety and efficacy of the VoluDerm technology with 100 ultra-thin electrodes gen100 tip for improvement of skin texture and wrinkles. METHODS:A prospective, open-label, intra-indiv...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13239
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Scalp psoriasis is reported to occur in 50-80% of psoriasis sufferers. Treatment of scalp psoriasis requires special consideration of product esthetics and staining potential due to the presence of hair. AIM:To evaluate the potential of a new, marketed liquor carbonis distillate (LCD; coal tar) solution to ...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/j.1473-2165.2009.00453.x
更新日期:2009-09-01 00:00:00
abstract:BACKGROUND:Topical anesthetics are widely used in dermatology and cosmetology to alleviate the pain from nonsurgical cosmetic procedures, while the transdermal drug delivery is limited by the skin barrier. Cold atmospheric plasma (CAP) is a potential approach used for skin pretreatment to enhance transdermal delivery o...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13581
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND:Anti-aging effects of high concentrations of salicylic acid (SA) peels are commonly known. Like all acids, SA can produce somatosensory and visible irritation to the skin and as such may be unsuitable for subjects with sensitive skin. AIMS:To provide evidence that sodium salicylate (SS) obtained from neutra...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/j.1473-2165.2010.00506.x
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:Type XVI collagen is a member of the fibril-associated collagens with interrupted triple helices; however, its function or regulation remain unclear. AIMS:This study is to examine the effect of ultraviolet B (UVB) or photoaging on type XVI collagen expression in various cultured cells, mouse, and human skin...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/j.1473-2165.2012.00612.x
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Seborrhea is linked to several medical and mental conditions. Although it is common, effective agents and the standardized sebum level for seborrhea are not elucidated. AIMS:To determine the efficacy of chitosan particles (CP) formulation on controlling sebum secretion, its extended effects on skin redness ...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13274
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Masseteric hypertrophy is a benign condition characterized by the enlargement of the masseter muscles. A square-shaped jawline due to masseter muscle prominence or hypertrophy is one of the general characteristics of the Asian face, making it a frequent target for esthetic treatment requests. While the appli...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,评审
doi:10.1111/jocd.12721
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Although more and more noninvasive detection technologies have been used in assessing skin barrier integrity and functions, more accurate, intuitive, and convenient detective methods still needed to be explored and developed. AIMS:To investigate the characteristic image changes under the dermoscopy and to e...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13643
更新日期:2020-09-06 00:00:00
abstract:BACKGROUND:Glycolic acid (GA) is an effective way of reversing the signs of age and photodamage. GA enhances desquamation of the stratum corneum and induces biological responses that can help restore skin's integrity. GA can, however, cause irritation, especially when its concentration is high, and its pH is low. Thus,...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13570
更新日期:2021-02-01 00:00:00
abstract::A 23-year-old left-handed white male was referred with a complaint of brown discolouration of the fingernails of his left hand. He had been applying 4% hydroquinone cream to facial melasma. The discolouration began in winter and worsened in March and April. It resolved within 2 months of cessation of hydroquinone. The...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/j.1473-2130.2004.00085.x
更新日期:2003-07-01 00:00:00