Abstract:
BACKGROUND:The application of ingredients from marine and maritime origins is increasingly common in skin care products, driven by consumer expectations for natural ingredients. However, these ingredients are typically studied for a few isolated in vitro activities. OBJECTIVES:The purpose of this study was to carry out a comprehensive evaluation of the activity on the skin of an association of ingredients from marine and maritime origins using label-free quantitative proteomic analysis, in order to predict the clinical benefits if used in a skin care product. METHODS:An aqueous gel containing 6.1% of ingredients from marine and maritime origins (amino acid-enriched giant kelp extract, trace element-enriched seawater, dedifferentiated sea fennel cells) was topically applied on human skin explants. The skin explants' proteome was analyzed in a label-free manner by high-performance liquid nano-chromatography coupled with tandem mass spectrometry. A specific data processing pipeline (CORAVALID) providing an objective and comprehensive interpretation of the statistically relevant biological activities processed the results. RESULTS:Compared to untreated skin explants, 64 proteins were significantly regulated by the gel treatment (q-value ≤ 0.05). Computer data processing revealed an activity of the ingredients on the epidermis and the dermis. These significantly regulated proteins are involved in gene expression, cell survival and metabolism, inflammatory processes, dermal extracellular matrix synthesis, melanogenesis and keratinocyte proliferation, migration, and differentiation. CONCLUSIONS:These results suggest that the tested ingredients could help to preserve a healthy epidermis and dermis, and possibly to prevent the visible signs of skin aging.
journal_name
J Cosmet Dermatoljournal_title
Journal of cosmetic dermatologyauthors
Hameury S,Borderie L,Monneuse JM,Skorski G,Pradines Ddoi
10.1111/jocd.12528subject
Has Abstractpub_date
2019-02-01 00:00:00pages
355-370issue
1eissn
1473-2130issn
1473-2165journal_volume
18pub_type
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abstract:BACKGROUND:Although the etiopathogenesis of alopecia areata (AA) is still unclear, inflammation, oxidative stress, and subsequent DNA damage might be considered role players in disease development. AIM:We aimed at exploring the potential link between oxidative DNA damage and inflammation in AA patients through measuri...
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journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,随机对照试验
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journal_title:Journal of cosmetic dermatology
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pub_type: 临床试验,杂志文章
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journal_title:Journal of cosmetic dermatology
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journal_title:Journal of cosmetic dermatology
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更新日期:2006-09-01 00:00:00
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journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/j.1473-2165.2008.00359.x
更新日期:2008-03-01 00:00:00
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journal_title:Journal of cosmetic dermatology
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journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
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更新日期:2014-06-01 00:00:00
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