Abstract:
BACKGROUND:Propionibacterium acnes is a major contributing factor to the inflammatory component of acne. The interaction of P. acnes with keratinocytes leads to an innate immune response via activation of toll-like receptors (TLR2, TLR4) resulting in the production and secretion of pro-inflammatory mediators. SIG1273, an isoprenylcysteine small molecule modulates inflammatory signaling pathways and kills P. acnes. SIG1273 represents a novel cosmetic functional ingredient that provides relief from blemishes in acne prone skin. OBJECTIVE:To assess the keratinocyte response and microbial growth of SIG1273 in vitro and evaluate the tolerability of SIG1273 gel applied topically in acne prone subjects. METHODS:For in vitro studies, human keratinocytes were exposed in culture to live P. acnes and peptidoglycan (PGN) to induce IL-8 production. P. acnes were cultured to determine minimal inhibitory concentration and minimal bactericidal concentration values. A total of 30 subjects were randomized in a double-blind controlled trial receiving 3% SIG1273 gel or vehicle for 6 weeks. Evaluation included inflammatory lesions, noninflammatory lesions, microcomedones, Sebutape scores, and P. acnes counts. RESULTS:In vitro studies demonstrate SIG1273 inhibits P. acnes-induced IL-8 production and inhibits P. acnes growth. SIG1273 gel was well tolerated with no signs of stinging, redness, or itching. Furthermore, improvement in some aspects of acne was observed in subjects applying SIG1273 gel, including inflammatory lesions, microcomedone counts and Sebutape scores. Facial scrubs taken to measure P. acnes colony-forming units showed those applying SIG1273 gel had ~1.0 Log 10 colony reduction over the length of the study, a statistically significantly improvement when compared with vehicle. No significant effects above vehicle were observed for noninflammatory lesions. CONCLUSIONS:SIG1273 represents a novel cosmetic functional ingredient that provides a safe dual modulating benefit to individuals with acne prone skin by reducing P. acnes counts and reducing inflammation.
journal_name
J Cosmet Dermatoljournal_title
Journal of cosmetic dermatologyauthors
Fernandéz JR,Rouzard K,Voronkov M,Feng X,Stock JB,Stock M,Gordon JS,Shroot B,Christensen MS,Pérez Edoi
10.1111/jocd.12002subject
Has Abstractpub_date
2012-12-01 00:00:00pages
272-8issue
4eissn
1473-2130issn
1473-2165journal_volume
11pub_type
杂志文章,随机对照试验abstract:BACKGROUND:Numerous fillers can be used for midface revolumization. While rheological data, physiochemical properties, and durability measured in clinical studies can inform selection, direct comparisons between equal volumes of different fillers are lacking. AIMS:To compare aesthetic improvement achieved with 3 cc of...
journal_title:Journal of cosmetic dermatology
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更新日期:2021-02-01 00:00:00
abstract::Recently, both doctors and patients pay particular attention to aesthetic medical services quality and efficacy of aesthetic adjustment implemented. It is essential to ensure research, analysis, and improving of botulinum toxin therapy quality and provide patients' orientation on the adjustment schedule, which include...
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journal_title:Journal of cosmetic dermatology
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abstract:BACKGROUND:Hair removal practices have changed in frequency and location on the body. Previous research on hair removal injuries has focused on a specific body region, age, or gender. OBJECTIVE:This study sought to take a broader perspective of hair removal-associated injuries in the United States which sought treatme...
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abstract:BACKGROUND:Botulinum toxin is generally considered safe and has been used in constantly expanded cosmetic and therapeutic indications. However, long-term side effects such as granulomatous reactions have been associated with this drug. AIMS:We aim to evaluate a rare reaction to Botulonium toxin A injection. PATIENTS/...
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journal_title:Journal of cosmetic dermatology
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journal_title:Journal of cosmetic dermatology
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journal_title:Journal of cosmetic dermatology
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journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
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journal_title:Journal of cosmetic dermatology
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更新日期:2020-09-06 00:00:00
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