Facial lipoatrophy: report of five cases after injection of synthetic filler into naso-labial folds.

Abstract:

BACKGROUND:Facial lipoatrophies are rare disfiguring syndromes, most commonly characterized by loss of buccal fat pads. AIMS:To demonstrate a relationship between facial lipoatrophy and a new synthetic filler device (Profill) used to correct naso-labial folds. METHODS:Five cases of lipoatrophy, appeared 9 months or later after Profill injections. No systematic abnormalities were found. In one case biopsy reported a destruction of adipocytes with intense fibrosis in the hypodermis. DISCUSSION:The culpability of this new biodegradable product is highlighted. To our knowledge, this is the first time this adverse reaction has been reported. CONCLUSION:Serious adverse reactions may appear months after Profill injection, skin testing is not always predictive or sufficient. Clinical studies with long-term follow-up need to be carried out before new filler devices are launched on the market.

journal_name

J Cosmet Dermatol

authors

André P,Wechsler J,Revuz J

doi

10.1046/j.1473-2165.2002.00052.x

subject

Has Abstract

pub_date

2002-10-01 00:00:00

pages

120-3

issue

3

eissn

1473-2130

issn

1473-2165

pii

JCD052

journal_volume

1

pub_type

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