Abstract:
BACKGROUND:Pediatric hypertrophic burn scars are challenging to treat due to their widespread nature and pain associated with the treatment. Intralesional triamcinolone acetonide (TAC) injection with or without 5-fluorouracil (5FU) is considered first-line treatment for severe hypertrophic scars. The pain associated with the procedure, the uneven topography, and epidermal atrophy, all limit the application of this treatment modality. AIMS:We sought to evaluate the clinical effectiveness and safety profile of a novel thermomechanical system (Tixel, Novoxel) for transdermal delivery of a topical solution containing TAC and 5-FU in the treatment of hypertrophic scars. PATIENTS/METHODS:A retrospective study of pediatric hypertrophic burn scars treated between 2015 and 2017 was performed. Epidemiologic, treatment data, effectiveness score, and safety were reviewed. RESULTS:Four children (one male and three females, ages 3-10 years old) with hypertrophic burn scars treated with the Tixel device were evaluated. Mean scar VSS was reduced from 8.4 ± 0.8-5.2 ± 0.5 (P-value - .001) after eight treatments. The mean improvement of toughness, thickness, color, and general aesthetic impression was 3.1 ± 0.43 → 2.2 ± 0.31, 3.4 ± 0.5 → 1.9 ± 0.63, 2.7 ± 0.21 → 2.4 ± 0.25, and 3.23 ± 0.44 → 1.6 ± 0.64, respectively. Mean treatment pain VAS score was 1.74 ± 0.9. Patient's parents rated their satisfaction level as "moderate-high." No topical or systemic complications were observed. CONCLUSION:Thermomechanical decomposition of the stratum corneum, in combination with topical application of TAC and 5-FU, is a safe, relatively painless, and efficient modality for the treatment of pediatric hypertrophic burn scars.
journal_name
J Cosmet Dermatoljournal_title
Journal of cosmetic dermatologyauthors
Artzi O,Koren A,Niv R,Mehrabi JN,Mashiah J,Friedman Odoi
10.1111/jocd.13192subject
Has Abstractpub_date
2020-01-01 00:00:00pages
131-134issue
1eissn
1473-2130issn
1473-2165journal_volume
19pub_type
杂志文章abstract::The nail is the largest skin appendage. In addition to its important physiological and sensory functions, it is also of great esthetic importance. Complaints of brittle or soft nails are frequent, particularly among women. Innumerable preparations claiming to improve the nail quality are being sold; however, most have...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1473-2165.2006.00232.x
更新日期:2006-03-01 00:00:00
abstract:BACKGROUND:Dermal fillers have become an integral part of any aesthetic physician's intervention. AIMS:To assess, by means of ultrasounds, the tissue integration of the hyaluronic acid (HA) dermal filler VYC-25L in chin and jaw. METHODS:Prospective, noncomparative, open-label, and multicenter study conducted on healt...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13632
更新日期:2020-08-04 00:00:00
abstract:BACKGROUND:Age-associated volume loss is now known to play an important role in the structural changes of the aging face. In the lower face, this manifests as drooping of the corners of the mouth and jowl leading to a loss of the oval jawline of youth. Jawline reshaping by replacing volume has therefore become an indis...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.12074
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:Platelet-rich plasma is rich in growth factors that promote differentiation and growth of dermal papilla cells by various signaling pathways. Dermoscopy is handy, bedside tool that helps to improve diagnostic accuracy in various hair disorders. OBJECTIVES:To evaluate and study the role of dermoscopy in pati...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.12845
更新日期:2018-12-16 00:00:00
abstract:BACKGROUND:Doctors and healthcare workers (HCW) are at frontline in control of the pandemic caused by the novel coronavirus infection (COVID-19). The virus is transmitted by contact, droplet, and airborne transmission; hence, hand hygiene, social distancing, environmental disinfection, and use of appropriate personal p...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,评审
doi:10.1111/jocd.13736
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Transcutaneous pneumatic injection (TPI) is a minimally invasive, needle-free modality that can be used to forcefully deliver solution into soft tissues of the face and scalp. OBJECTIVE:To evaluate the effects of TPI of 5% isotonic and 20% hypertonic glucose solutions in in vivo human skin for face lifting....
journal_title:Journal of cosmetic dermatology
pub_type: 临床试验,杂志文章
doi:10.1111/jocd.12766
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:Adolescent and young adult melanomas show different histopathological characteristics and clinical behaviors from adult melanomas. OBJECTIVE:To describe the histopathological and clinical features pertinent to vicenarian skin melanomas and compare them with adult melanomas using a large cohort from a single...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13314
更新日期:2020-01-31 00:00:00
abstract:OBJECTIVE:To provide retrospective clinical review of some uncommonly reported side effects of long-pulsed alexandrite laser treatment for hair removal. MATERIAL AND METHODS:Two hundred and fifty female patients suffering from hirsutism of the face were subjected to treatment by long pulse alexandrite laser for a maxi...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/j.1473-2165.2009.00465.x
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:Excess skin and fatty tissues beneath the jaw lead to a double chin deformity. Localized fat deposits in this area are a cause of discomfort and anguish, leading patients to undergo surgical procedures such as liposuction and dermolipectomy to improve the cosmetic effect. Both procedures require anesthesia a...
journal_title:Journal of cosmetic dermatology
pub_type: 临床试验,杂志文章
doi:10.1111/j.1473-2165.2007.00343.x
更新日期:2007-12-01 00:00:00
abstract:INTRODUCTION:Tattooing is a very popular form of body modification among young people. However, this kind of procedure entails the risk of various health complications. The objective of the study was to evaluate the students' knowledge about contraindications, complications, and health risks that skin tattooing may cau...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,评审
doi:10.1111/jocd.12479
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Welders are normally at risk of skin cancer due to continuous contact with natural ultraviolet rays and welding radiation. Protective behaviors against the radiations are the most fundamental measures taken to prevent skin cancer in these individuals. AIMS:This research aimed to evaluate the factors affecti...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13092
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:The skin exposome refers to the constellation of external exposures that contribute to cutaneous aging, including solar radiation, air pollution, tobacco smoke, unbalanced nutrition, and cosmetic products. This review explores the skin exposome and the role of a combination hyaluronic acid and mineralized th...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,评审
doi:10.1111/jocd.12927
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Propionibacterium acnes is a major contributing factor to the inflammatory component of acne. The interaction of P. acnes with keratinocytes leads to an innate immune response via activation of toll-like receptors (TLR2, TLR4) resulting in the production and secretion of pro-inflammatory mediators. SIG1273, ...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,随机对照试验
doi:10.1111/jocd.12002
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:Childhood vitiligo is commonly encountered. Pattern and distribution of childhood vitiligo were not clearly described in past. AIMS:To study clinical characteristics of vitiligo among Egyptian children in relation to epidemiological data and compare them with those of adolescents and adults. PATIENTS AND M...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13451
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Xanthelasma palpebrarum (XP) is the most common type of cutaneous xanthoma and has been treated with intralesional injection of pingyangmycin effectively. However, bleomycin, which has the same effect in antitumor activity as pingyangmycin, has not been applied in the treatment of XP. AIMS:To explore and as...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13258
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Different laser systems are reported to be effective in treatment of telangiectasia and erythema, but comparative studies on 1064-nm neodymium-yttrium aluminum garnet (Nd-YAG) laser and pulsed dye laser (PDL) in treatment of erythemato-telangiectatic rosacea are lacking. Substance (P) is implicated in rosace...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.12048
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND:Platelet-rich plasma is highly enriched plasma that contains a large concentration of platelets that secrete various growth factors and is used in a wide variety of surgical and cosmetic procedures, including hair regrowth and skin rejuvenation. METHODS:Microneedling therapy is being combined with platelet-...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.12772
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Epidermal growth factor (EGF) is one of the important peptides in wound healing process. The effects of EGF have been increasingly studied in various types of ulcers. However, data on postablative laser resurfacing wound is still limited. OBJECTIVES:To evaluate the effects of the topical EGF ointment on wou...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,随机对照试验
doi:10.1111/jocd.12691
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:At present, it is no longer possible to use animal testing for ingredients and cosmetic products in the Organisation for Economic Co-operation and Development (OECD) member states. However, in vitro tests are widely used to determine the safety and efficacy of ingredients and medicines. OBJECTIVE:Obviously,...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13789
更新日期:2020-10-14 00:00:00
abstract::Psoriasis is a chronic, immune-mediated disease that has a major negative impact on a patient's quality of life. Although several literature reviews indicate that skin microbiota may play an important role in the development and regulation of the immune and inflammatory response of psoriasis, few clinical studies are ...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,评审
doi:10.1111/jocd.13752
更新日期:2020-09-30 00:00:00
abstract:BACKGROUND:Human hair cuticle is always exposed to various stresses and then gradually lost in daily life. There are two typical patterns of cuticle damage: type L, where the cell membrane complex, the structure located between cuticle cells, is split and the cuticle lifts up, and type E, where the fragile substructure...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.12129
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Energy-based devices are increasingly used for noninvasive body contouring. Our aim was to investigate the clinical efficacy of combined radiofrequency and ultrasound device for reduction in body circumference in various body parts. AIMS:The aim of our study was to investigate the clinical efficacy of combi...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13896
更新日期:2020-12-19 00:00:00
abstract:BACKGROUND:Skin care influences skin barrier function during the first postnatal weeks. Although the use of natural oils in preterms has been investigated, there are currently no data comparing the effect of sunflower oil to an emollient on barrier development in healthy term newborns. METHODS:In a prospective, random...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,随机对照试验
doi:10.1111/jocd.12302
更新日期:2017-12-01 00:00:00
abstract:INTRODUCTION:The ideal filler should be long-lasting, biocompatible, chemically inert, soft and easy to use, and have a long history of safety. This review focuses on the evolution and development of the PMMA-collagen gel, Bellafill, and the 10 years of postmarketing experience of Bellafill since it received premarket ...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,评审
doi:10.1111/jocd.12539
更新日期:2018-06-01 00:00:00
abstract::Facial expressions convey emotions that form the foundation of interpersonal relationships, and many of these emotions promote and regulate our social linkages. Hence, the facial aging symptomatological analysis and the treatment plan must of necessity include knowledge of the facial dynamics and the emotional express...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.12128
更新日期:2015-03-01 00:00:00
abstract::Intralesional injection with corticosteroid remains the mainstay of therapy for hypertrophic scars and keloids, however some lesions are unresponsive or may result in skin atrophy. Intralesional bleomycin injection is an alternative therapy that has been widely reported. In order to compare the effectiveness and safet...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,随机对照试验
doi:10.1111/jocd.12132
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:A growing patient demand for a favorable body shape has led to the development of many new treatment modalities. Noninvasive devices were developed to improve body contour without physical intervention or scarring and with reduced downtime compared to surgical options such as liposuction. AIMS:This study ex...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13533
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Dietary or supplementary intake of nutrients and other ingredients positively affects skin appearance. AIMS:Evaluate a multicomponent nutritional supplement on photoaged skin. PATIENTS/METHODS:This multicenter, double-blind, placebo-controlled trial randomized healthy 35- to 65-year-old women with Fitzpatr...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/jocd.12290
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:Hair plays a significant role in shaping the appearance of an individual. Loss of hair can lead to serious effects on social esteem of an individual. The most common cause of hair loss is Androgenetic Alopecia (AGA).This hereditary disorder followed a specific pattern causing progressive thinning of hair in ...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13398
更新日期:2020-11-01 00:00:00
abstract::Twin studies, especially those involving monozygotic (MZ) twins, facilitate the analysis of factors affecting skin aging while controlling for age, gender, and genetic susceptibility. The purpose of this study was to objectively assess various features of facial skin and analyze the effects of environmental factors on...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.12081
更新日期:2014-06-01 00:00:00