当前位置： SCI文献检索 > Journal of Cosmetic Dermatology期刊下所有文献 > Effect of cosmetic ingredients as anticellulite agents: synergistic action of actives with in vitro and in vivo efficacy.

Effect of cosmetic ingredients as anticellulite agents: synergistic action of actives with in vitro and in vivo efficacy.

Abstract：

BACKGROUND:The pathophysiology of cellulite involves changes in the subcutaneous adipose layer and the extracellular matrix (ECM) that supports it together with overlying dermal layer. Cellular mechanisms governing cellulite are not fully understood. However, it is accepted that changes include enhanced lipogenesis, decreased lipolysis, and increased lipid storage within the adipocytes as well as changes in the dermal architecture. AIM:In our studies the ability of cosmetic agents Furcellaria lumbricalis, Fucus vesiculosus, retinoid, conjugated linoleic acid (CLA), and a glaucine mixture to stimulate in vitro 1) lipolysis in human adipocytes and 2) production of pro-collagen I by fibroblasts was investigated in vitro. The ability of these ingredients to improve cellulite condition in vivo was also determined. PATIENTS/METHODS:Mature adipocytes and 'aged' fibroblasts were used for in vitro studies. The assessment of cellulite in vivo was performed by dermatological grading and ultrasound measurements. RESULTS:Mature adipocytes treated with combined actives resulted in a significant synergistic increase in free glycerol release. On "aged" fibroblasts, combined treatment of F. vesiculosus and F. lumbricalis stimulated pro-collagen I production. CLA increased pro-collagen I production, but the glaucine mixture had no effect. The clinical study demonstrated a significant improvement in cellulite grading by a dermatologist after 8 and 12 weeks vs. vehicle, and ultrasound imaging showed a significant decrease in fat thickness compared with placebo after 12 weeks. CONCLUSIONS:Our studies revealed a potent cocktail of ingredients that when combined together can act in vitro to markedly improve lipolysis mechanisms and by way of stimulating pro-collagen I can also have an effect on the surrounding extracellular matrix. The in vitro actions of the ingredients were translated in vivo, where a clinical improvement of cellulite condition was observed.

journal_name

J Cosmet Dermatol

journal_title

Journal of cosmetic dermatology

authors

Al-Bader T,Byrne A,Gillbro J,Mitarotonda A,Metois A,Vial F,Rawlings AV,Laloeuf A

doi

10.1111/j.1473-2165.2011.00594.x

subject

Has Abstract

pub_date

2012-03-01 00:00:00

pages

17-26

issue

eissn

1473-2130

issn

1473-2165

journal_volume

pub_type

杂志文章,随机对照试验

在线工具

Effect of cosmetic ingredients as anticellulite agents: synergistic action of actives with in vitro and in vivo efficacy.