Abstract:
BACKGROUND:Anti-aging effects of high concentrations of salicylic acid (SA) peels are commonly known. Like all acids, SA can produce somatosensory and visible irritation to the skin and as such may be unsuitable for subjects with sensitive skin. AIMS:To provide evidence that sodium salicylate (SS) obtained from neutralization of 1% SA by sodium hydroxide can deliver significant anti-aging benefits. METHODS:The effects of SS were examined using three approaches: (1) evaluating its effects on stimulating the synthesis of fibrillin and collagen-1 in vivo; (2) examining its efficacy by using Fast Optical in vivo Topometry (FOITS) in a double-blind, placebo-controlled clinical study; (3) determining its effects on both expert and naïve grader assessement of wrinkles in a double-blind, placebo-controlled study. RESULTS:In the first study SS produced significant increases of the fibrillin and collagen-1 anti-aging biomarkers compared with the untreated skin control. A commercially available retinol cream delivered similar effects to SS. In the second study using FOITS we showed that the SS formulation significantly reduced wrinkle depth (Rz) and skin roughness (Ra) after 4 and 8 weeks of daily application vs. placebo (Rz: -8.2 ± 1.40% and -11.4 ± 1.07%; Ra: -7.8 ± 1.33% and -11.9 ± 0.61%; P < 0.01). In the third study reductions in wrinkle depth were observed by expert assessment at both 4 and 8 weeks for the SS-containing formulation compared to its placebo (P < 0.05). Equally, non-expert graders recorded the SS formulation superior to its placebo. CONCLUSION:Although the mechanism of action is not completely understood, we believe the benefits of SS are derived from its intrinsic stratum corneum exfoliation effects. All three studies demonstrate the significant anti-aging effects of SS that are especially suitable for subjects with sensitive skin.
journal_name
J Cosmet Dermatoljournal_title
Journal of cosmetic dermatologyauthors
Merinville E,Byrne AJ,Rawlings AV,Muggleton AJ,Laloeuf ACdoi
10.1111/j.1473-2165.2010.00506.xsubject
Has Abstractpub_date
2010-09-01 00:00:00pages
174-84issue
3eissn
1473-2130issn
1473-2165journal_volume
9pub_type
杂志文章abstract:BACKGROUND:Childhood vitiligo is commonly encountered. Pattern and distribution of childhood vitiligo were not clearly described in past. AIMS:To study clinical characteristics of vitiligo among Egyptian children in relation to epidemiological data and compare them with those of adolescents and adults. PATIENTS AND M...
journal_title:Journal of cosmetic dermatology
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abstract:BACKGROUND:Brittle nail syndrome is a common problem among women and refers to nails that exhibit surface roughness, raggedness, and peeling. AIM:The goal of this study was to investigate whether daily oral supplementation with collagen peptides alleviates the symptoms of brittle nails and improves nail growth rate. ...
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abstract:BACKGROUND:As skin ages, a functional decrement occurs. To avoid future vulnerability to dermatologic diseases, an optimal cutaneous regeneration is mandatory. Biological therapies based on blood-derived autologous proteins are gaining attention of scientists and dermatologists. OBJECTIVES:A novel 100% autologous topi...
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abstract:BACKGROUND:Numerous oncology patients who receive targeted therapy suffer from the skin adverse effects induced. Novel agents, that is tyrosine kinase inhibitors and RAS-RAF-MEK-ERK pathway, have given good results in patient survival while decreasing the systemic toxicities in comparison to conventional cytotoxic chem...
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abstract:BACKGROUND:Treating the lower face with neuromodulators and targeting the masseter muscle can reduce masseteric hypertrophy but can also change the facial shape. A novel observation after the treatment of the masseter muscle with incobotulinumtoxin Type A was the increase in temporal volume. AIM:Objectively assess tem...
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更新日期:2020-06-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to evaluate the efficacy of tattoo removal treatments using the 1064-nm Q-switched (QS) Nd:YAG laser. BACKGROUND DATA:Today, QS lasers appear to be the most common, effective, and safest methods to treat unwanted markings. MATERIAL AND METHODS:A total of 64 patients with 75 unwanted...
journal_title:Journal of cosmetic dermatology
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journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,多中心研究,随机对照试验
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abstract:BACKGROUND:Bimatoprost has known adnexal activity and was observed to increase nail growth at two clinical centers. OBJECTIVES:In this randomized, double-blinded, placebo-controlled pilot study, we examine the effect of bimatoprost (Lumigan 0.01%), applied bid to the proximal nail fold on nail growth, nail brittleness...
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更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Petrolatum is often used to suppress water evaporation from the skin surface. However, its stickiness, shininess, and other factors make it inconvenient for continuous use. OBJECTIVE:To compare the effectiveness and usability between a newly developed petrolatum-based ointment (NOV® II Moisture Balm) and wh...
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abstract::The American Academy of Dermatology (AAD) has prioritized skin cancer prevention efforts in 2018, as photoprotection measures adopted by the general public remain suboptimal. A large proportion of patients lack understanding of primary prevention methods for skin cancer, and mistruths in advertising may contribute sig...
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journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/j.1473-2130.2004.00044.x
更新日期:2003-04-01 00:00:00
abstract:OBJECTIVE:To provide retrospective clinical review of some uncommonly reported side effects of long-pulsed alexandrite laser treatment for hair removal. MATERIAL AND METHODS:Two hundred and fifty female patients suffering from hirsutism of the face were subjected to treatment by long pulse alexandrite laser for a maxi...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/j.1473-2165.2009.00465.x
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更新日期:2018-09-17 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2010-03-01 00:00:00
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journal_title:Journal of cosmetic dermatology
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更新日期:2017-09-01 00:00:00
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journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
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更新日期:2017-06-01 00:00:00
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journal_title:Journal of cosmetic dermatology
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更新日期:2020-09-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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