Abstract:
BACKGROUND:Intradermal application of hyaluronic acid (HA) in varying chain length and cross-linking density is used routinely for hydrodynamic volume replacement of the extracellular matrix to reduce the clinical effects of aging. OBJECTIVES:In vitro data show that via receptors of the hyaladherin group hyaluronic acid has additionally direct or indirect effects on cells. In the case of native noncross-linked HA, it has been proved that the proliferative and metabolic activity of cutaneous fibroblasts can be increased. The aim of this study was to investigate whether these effects can be proved also for cross-linked HA and how these effects can be quantified for different preparations. MATERIALS AND METHODS:The effect on proliferative activity in cultures of native cutaneous fibroblasts and keratinocytes was investigated for noncross-linked HA, for noncross-linked HA with added glycerol, for HA that was stabilized in the carboxyl and hydroxyl groups per inner esterification, and for HA that was chemically cross-linked by 1,4-butanediol-diglycidylether, mixed in small particles in a biphasic compound with native HA, each in different concentrations (0.1, 1.0 and 10.0 mg/mL). RESULTS:HA that was stabilized in the carboxyl and hydroxyl groups per inner esterification induces the strongest proliferative effect on both cell types. Native noncross-linked HA and chemically cross-linked HA show a rather modest proliferative effect and on fibroblasts only, whereas noncross-linked HA with added glycerol in high concentrations provokes a rather antiproliferative effect. CONCLUSIONS:The data show that HA does induce direct effects on cells depending on type and density of the cross-linkage. The practical relevance in terms of a metabolic filler effect needs to be verified in clinical studies.
journal_name
J Cosmet Dermatoljournal_title
Journal of cosmetic dermatologyauthors
Wohlrab J,Wohlrab D,Neubert RHdoi
10.1111/jocd.12024subject
Has Abstractpub_date
2013-03-01 00:00:00pages
36-40issue
1eissn
1473-2130issn
1473-2165journal_volume
12pub_type
杂志文章abstract:BACKGROUND:Homologous autoinoculation is a novel minimally invasive procedure that treats warts by stimulating specific immune response. AIM:To evaluate the efficacy and safety of autoinoculation in treatment of multiple recalcitrant warts of different types in relation to patient's age, gender, type, number, size, an...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13831
更新日期:2020-11-11 00:00:00
abstract:BACKGROUND:Reducing erythema and infiltration of inflamed, hypertrophic, and colloidal scars have been a challenge for healthcare providers. Peer-reviewed scientific data for intense pulsed light systems are lacking. OBJECTIVE:A chronicle of three patients who have participated in the treatment of inflamed, hypertroph...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/j.1473-2165.2005.00157.x
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Type XVI collagen is a member of the fibril-associated collagens with interrupted triple helices; however, its function or regulation remain unclear. AIMS:This study is to examine the effect of ultraviolet B (UVB) or photoaging on type XVI collagen expression in various cultured cells, mouse, and human skin...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/j.1473-2165.2012.00612.x
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Facial lipoatrophies are rare, disfiguring syndromes requiring correction. Lipofilling is an 'ecological' treatment that does not carry any risk of allergy. AIM:To demonstrate efficacy of this technique in facial lipoatrophy. RESULTS:This technique was used in four patients suffering from lipoatrophy secon...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1046/j.1473-2165.2002.00044.x
更新日期:2002-07-01 00:00:00
abstract:BACKGROUND:Transcutaneous pneumatic injection (TPI) is a minimally invasive, needle-free modality that can be used to forcefully deliver solution into soft tissues of the face and scalp. OBJECTIVE:To evaluate the effects of TPI of 5% isotonic and 20% hypertonic glucose solutions in in vivo human skin for face lifting....
journal_title:Journal of cosmetic dermatology
pub_type: 临床试验,杂志文章
doi:10.1111/jocd.12766
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:Recent studies have reported that the incidence of acne combined with rosacea is increasing. However, the clinical feature and inducing factor of these two diseases co-occurrence is remain unclear. AIMS:This study aims to investigate the classification and severity of female patients combining with acne and...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13762
更新日期:2020-10-06 00:00:00
abstract:BACKGROUND:Anecdotal data suggest that combed natural African hair reaches a length steady state. Easier grooming and anticipated long hair have made relaxers popular. OBJECTIVES:These hypotheses were tested in a cross-sectional survey of 1042 school children using a piloted questionnaire and hair length measurements ...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/j.1473-2165.2007.00326.x
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND:Petrolatum is often used to suppress water evaporation from the skin surface. However, its stickiness, shininess, and other factors make it inconvenient for continuous use. OBJECTIVE:To compare the effectiveness and usability between a newly developed petrolatum-based ointment (NOV® II Moisture Balm) and wh...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13300
更新日期:2020-01-28 00:00:00
abstract::Recently, both doctors and patients pay particular attention to aesthetic medical services quality and efficacy of aesthetic adjustment implemented. It is essential to ensure research, analysis, and improving of botulinum toxin therapy quality and provide patients' orientation on the adjustment schedule, which include...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13584
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND:Skin dryness and an accelerated fragmentation of the collagen network in the dermis are hallmarks of skin aging. Nutrition is a key factor influencing skin health and consequently its appearance. A wide range of dietary supplements is offered to improve skin health. Collagen peptides are used as a bioactive ...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,随机对照试验
doi:10.1111/jocd.12174
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:As skin ages, a functional decrement occurs. To avoid future vulnerability to dermatologic diseases, an optimal cutaneous regeneration is mandatory. Biological therapies based on blood-derived autologous proteins are gaining attention of scientists and dermatologists. OBJECTIVES:A novel 100% autologous topi...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13075
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:Facial lipoatrophies are rare disfiguring syndromes, most commonly characterized by loss of buccal fat pads. AIMS:To demonstrate a relationship between facial lipoatrophy and a new synthetic filler device (Profill) used to correct naso-labial folds. METHODS:Five cases of lipoatrophy, appeared 9 months or l...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1046/j.1473-2165.2002.00052.x
更新日期:2002-10-01 00:00:00
abstract:BACKGROUND:Argyria results from silver accumulation in the skin. It is a stressful condition for patients due to skin discoloration. In the past, no effective treatments were available. However, it has been recently reported laser treatments showed promising results. AIM:To review and summarize all reported laser trea...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,评审
doi:10.1111/jocd.13549
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Platelet-rich plasma is rich in growth factors that promote differentiation and growth of dermal papilla cells by various signaling pathways. Dermoscopy is handy, bedside tool that helps to improve diagnostic accuracy in various hair disorders. OBJECTIVES:To evaluate and study the role of dermoscopy in pati...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.12845
更新日期:2018-12-16 00:00:00
abstract:BACKGROUND:Facial telangiectasia is one of the common skin vascular lesions characterized by dilated cutaneous vasculatures. The variety of diameters and difference in depths of lesional blood vessels are the major challenges for effective treatments for Facial telangiectasia. AIMS:To compare the efficacy and safety p...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13179
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Spasmodic senile entropion (SE) is characterized by the inward turning of the eyelid. SE typically occurs spontaneously, but sometimes after ocular surgery. As of today, it is still lacking a gold standard technique. AIMS:To report the results of 11 cases of involutional entropion of the lower lid successfu...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,评审
doi:10.1111/jocd.12210
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Acne vulgaris is a highly prevalent skin condition associated with considerable psychological burden. Acne and its sequelae can affect many domains of life leading to social dysfunction, psychiatric issues and educational shortcomings. Psychiatric conditions like depression is found to be more prevalent in a...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,评审
doi:10.1111/jocd.13753
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Masseter hypertrophy is a common, prominent feature in many Asian patients, and correction procedures are often requested for esthetic reasons. Toxin masseter injections have a high efficacy and safety profile, but the risks of a variety of side effects or complications remain. OBJECTIVES:The categorization...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.12473
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:UV filters should be determined a strict toxicological safety prior to approval. Homosalate (HMS) is one of the most widely used organic UV filter. HMS accumulates in aquatic biota ecosystems and humans through the food chain; therefore, it is important to consider the effects on health and know its mechanis...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.12973
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Scalp psoriasis is reported to occur in 50-80% of psoriasis sufferers. Treatment of scalp psoriasis requires special consideration of product esthetics and staining potential due to the presence of hair. AIM:To evaluate the potential of a new, marketed liquor carbonis distillate (LCD; coal tar) solution to ...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/j.1473-2165.2009.00453.x
更新日期:2009-09-01 00:00:00
abstract::Chemical peeling, also known as chemoexfoliation or dermapeeling, is performed to improve the skin's appearance as it reduces the wrinkles caused by aging and the features of photoaged skin. Although the best results are obtained with deep peels, the medium-depth peels allow to obtain excellent results without the dan...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/j.1473-2165.2005.40213.x
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND:Vitiligo is one of the commonest pigmentary disorders characterized by destruction of melanocytes. AIM:To evaluate the efficacy of topical bimatoprost ophthalmic solution in stable facial vitiligo. MATERIAL AND METHODS:Eight cases of stable facial vitiligo were treated with bimatoprost 0.03% ophthalmic sol...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.12443
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:A variety of energy-based devices have been used to treat acne. However, all studies have been subjective and have not involved double-blind and randomized controlled studies. AIMS:We undertook a randomized controlled study evaluating the use of a 650 usec 1064 nm Nd:YAG laser compared with a sham in the tr...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13480
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Infantile hemangiomas (IHs) are the most common soft tissue tumors of infancy. Although spontaneous regression is expected, medical treatment is needed in approximately 10-20% of cases. AIMS:We aimed to assess the safety and efficacy of systemic propranolol for the treatment of IH. PATIENTS/METHODS:Medical...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.12220
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Atopic dermatitis (AD) is an inflammatory pruritic chronic dermatosis involving the alarmin thymic stromal lymphopoietin (TSLP), which is directly implicated in AD pruritus. AIMS:To evaluate the efficacy of Tambourissa trichophylla leaf extract (TTLE) titrated in polyphenols and 18β-glycyrrhetinic acid (GA)...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13515
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Androgenetic alopecia is a common cosmetic hair disorder, resulting from interplay of genetic, endocrine, and aging factors leading to a patterned follicular miniaturization. Microinflammation seems to be a potential active player in this process. AIMS:To study the histopathological and ultrastructural chan...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/j.1473-2165.2009.00439.x
更新日期:2009-06-01 00:00:00
abstract:OBJECTIVE:To provide retrospective clinical review of some uncommonly reported side effects of long-pulsed alexandrite laser treatment for hair removal. MATERIAL AND METHODS:Two hundred and fifty female patients suffering from hirsutism of the face were subjected to treatment by long pulse alexandrite laser for a maxi...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/j.1473-2165.2009.00465.x
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:Dermal fillers have been used safely and effectively to revolumize aging hands. We assess the effectiveness of polymethylmethacrylate (PMMA) to treat the volume loss of photoaged dorsal hands for up to 12 months. METHODS:In a 12-month prospective study, 15 subjects were treated with PMMA filler in the bilat...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13445
更新日期:2020-09-01 00:00:00
abstract::In recent years, popularity of radiofrequency (RF) has increased significantly. They are characterized by a low risk of complications and relatively high effectiveness. RF use high-frequency currents causing oscillating motion of ions resulting in temperature rise stimulating skin regeneration processes. The aim of th...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.12775
更新日期:2018-09-17 00:00:00
abstract::We report the case of a woman who presented with several facial scars following a road accident. Treatment was carried out using combined laser treatment with pulsed dye laser (PDL) and Q-switched neodymium:yttrium-aluminum-garnet laser (QS Nd:YAG laser). No side effects or complications from treatment were noted or r...
journal_title:Journal of cosmetic dermatology
pub_type: 信件
doi:10.1111/j.1473-2165.2008.00394.x
更新日期:2008-09-01 00:00:00