Granuloma annulare after Botulonium toxin A injection: A rare association.

Abstract:

BACKGROUND:Botulinum toxin is generally considered safe and has been used in constantly expanded cosmetic and therapeutic indications. However, long-term side effects such as granulomatous reactions have been associated with this drug. AIMS:We aim to evaluate a rare reaction to Botulonium toxin A injection. PATIENTS/METHODS:A 44-year-old woman, developed annular plaques eleven months after botulinum toxin A injection for the correction treatment of wrinklesglabellar rhytides. RESULTS:Histopathological examination revealed granuloma annulare formation. Clinical and biological investigations were negative, ruling out the hypothesis of systemic sarcoidosis. Triamcinolone acetonide injection was followed by a regression of the plaques. CONCLUSION:There are previous reports in the literature of sarcoidal and foreign body granuloma at the sites of injection of botulinum toxin A injection. To our knowledge this is the first report of granuloma annulare occurrence after botulinum toxin A injection.

journal_name

J Cosmet Dermatol

authors

Balighi K,Kamyab K,Azizpour A

doi

10.1111/jocd.13310

subject

Has Abstract

pub_date

2020-02-06 00:00:00

eissn

1473-2130

issn

1473-2165

pub_type

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