Abstract:
BACKGROUND:Undecylenoyl phenylalanine is a novel skin-lightening agent, probably acting as α-melanocyte-stimulating hormone (α-MSH) and beta-adrenergic receptor (β-ADR) antagonist. OBJECTIVES:The objective of this double-blind randomized comparative study was to evaluate the efficacy and safety of a preparation containing undecylenoyl phenylalanine 2% in the topical treatment of melasma in females. METHODS:Forty female patients with melasma were randomly assigned to apply either the active preparation or the vehicle alone, twice daily for 12 weeks. Patients were evaluated monthly for efficacy and safety. RESULTS:In all, 37 patients completed the study. Of the 20 patients on active treatment, no one responded completely, but 17 (85%) had partial response. Of them, 11 had moderate improvement and six had marked improvement. Lightening of the lesions was evident from the first follow-up visit at 4 weeks. A statistically significant difference (P < 0.001) in efficacy between the active preparation and the vehicle was documented. Using patient assessment ratings, 80% were extremely satisfied or satisfied with the result. The reported side effects were minor and included erythema and itching or burning at the site of application. CONCLUSIONS:Undecylenoyl phenylalanine 2% achieved a significant lightening of melasma lesions with minimal side effects.
journal_name
J Cosmet Dermatoljournal_title
Journal of cosmetic dermatologyauthors
Katoulis A,Alevizou A,Soura E,Mantas N,Bozi E,Gregoriou S,Makris M,Rigopoulos Ddoi
10.1111/jocd.12089subject
Has Abstractpub_date
2014-06-01 00:00:00pages
86-90issue
2eissn
1473-2130issn
1473-2165journal_volume
13pub_type
杂志文章,随机对照试验abstract:BACKGROUND:Although more and more noninvasive detection technologies have been used in assessing skin barrier integrity and functions, more accurate, intuitive, and convenient detective methods still needed to be explored and developed. AIMS:To investigate the characteristic image changes under the dermoscopy and to e...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
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更新日期:2020-09-06 00:00:00
abstract:BACKGROUND:Spiny keratoderma shows "music box spine" keratotic papules limited to the palms and soles and these lesions do not cause any trouble besides the cosmetic impairment and the sensation of roughness of hands and soles. AIM:To present cases and review the literature on spiny keratoderma. PATIENTS/METHODS, RES...
journal_title:Journal of cosmetic dermatology
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更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Glycolic acid (GA) is an effective way of reversing the signs of age and photodamage. GA enhances desquamation of the stratum corneum and induces biological responses that can help restore skin's integrity. GA can, however, cause irritation, especially when its concentration is high, and its pH is low. Thus,...
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更新日期:2021-02-01 00:00:00
abstract:BACKGROUND:Management of periorbital hyperpigmentation (POH) is still a therapeutic challenge. Although different therapeutic modalities are available, the outcomes of most of them are unsatisfactory. OBJECTIVES:To investigate and compare the efficacy and safety of two new modalities in the treatment of POH; the plate...
journal_title:Journal of cosmetic dermatology
pub_type: 临床试验,杂志文章
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更新日期:2018-12-01 00:00:00
abstract::Chemical peeling, also known as chemoexfoliation or dermapeeling, is performed to improve the skin's appearance as it reduces the wrinkles caused by aging and the features of photoaged skin. Although the best results are obtained with deep peels, the medium-depth peels allow to obtain excellent results without the dan...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
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更新日期:2005-06-01 00:00:00
abstract:BACKGROUND:Infraorbital dark circles (DC) are defined as a symptom that presents darkness under infraorbital eyelids. The objective of this study was to evaluate the efficacy and safety of nano-microneedle-assisted phenylethyl resorcinol (PR) for the treatment of infraorbital dark circles. METHODS:Twenty female partic...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
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更新日期:2020-08-11 00:00:00
abstract:INTRODUCTION:There are no evidence-based data how to predict response to therapy in patients with alopecia areata. AIM:The assessment of the predictive value of trichoscopy for the therapeutic outcome in patients with alopecia areata. METHODS:A total of 65 patients with patchy alopecia areata were included into the s...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
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更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:Although the etiopathogenesis of alopecia areata (AA) is still unclear, inflammation, oxidative stress, and subsequent DNA damage might be considered role players in disease development. AIM:We aimed at exploring the potential link between oxidative DNA damage and inflammation in AA patients through measuri...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
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更新日期:2020-10-25 00:00:00
abstract:BACKGROUND:Skin color varies among ethnic groups on accounts of genetic background. Within an ethnic group, skin color may also vary according to geographical environments and sun exposure habits. While many reports address skin color differences between ethnic groups, few have compared skin color within as ethnic grou...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
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更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Atopic dermatitis (AD) is an inflammatory pruritic chronic dermatosis involving the alarmin thymic stromal lymphopoietin (TSLP), which is directly implicated in AD pruritus. AIMS:To evaluate the efficacy of Tambourissa trichophylla leaf extract (TTLE) titrated in polyphenols and 18β-glycyrrhetinic acid (GA)...
journal_title:Journal of cosmetic dermatology
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更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Acne vulgaris is a common cosmetic problem that is frequently associated with psychosocial disturbances as well as increased oxidative stress. However, oxidative stress and psychological aspects have been studied separately in acne. OBJECTIVE:To evaluate the relationships between oxidative stress, anxiety, ...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.12366
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Acne vulgaris is an inflammatory disorder with a profound heterogenous aetio-pathophysiology. ACE gene I/D polymorphism affects angiotensin-converting enzyme activities that play a role in inflammation. However, there are no molecular genetic studies investigating the contribution of ACE gene insertion/delet...
journal_title:Journal of cosmetic dermatology
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更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:The sebaceous gland and the follicular bulge region have important role in biology of the hair. They initiate destruction of the hair follicle both in human and animal models in certain conditions. The morphometric feature of the sebaceous gland is not well understood so as the distribution of the bulge stem...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
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更新日期:2015-09-01 00:00:00
abstract::Soap is the most useful things which we use our everyday life in various cleansing and cosmetics purposes. Jatropha oil is nonedible oil which has more benefits to soap making. It has also cosmetics and medicinal properties. But the presence of toxic Phorbol esters in Jatropha oil is the main constrains to use it. So ...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,评审
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更新日期:2016-06-01 00:00:00
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journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章,评审
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更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Topical anesthetics are widely used in dermatology and cosmetology to alleviate the pain from nonsurgical cosmetic procedures, while the transdermal drug delivery is limited by the skin barrier. Cold atmospheric plasma (CAP) is a potential approach used for skin pretreatment to enhance transdermal delivery o...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13581
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND:Welders are normally at risk of skin cancer due to continuous contact with natural ultraviolet rays and welding radiation. Protective behaviors against the radiations are the most fundamental measures taken to prevent skin cancer in these individuals. AIMS:This research aimed to evaluate the factors affecti...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
doi:10.1111/jocd.13092
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Cutaneous hyperchromias are disorders of skin pigmentation involving an increase of melanin production and its irregular accumulation in skin cells. It is known that the use of sunscreens helps to prevent changes in the skin pigmentation pattern, but the structural and morphological alterations that occur in...
journal_title:Journal of cosmetic dermatology
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doi:10.1111/jocd.12307
更新日期:2017-09-01 00:00:00
abstract::Facial expressions convey emotions that form the foundation of interpersonal relationships, and many of these emotions promote and regulate our social linkages. Hence, the facial aging symptomatological analysis and the treatment plan must of necessity include knowledge of the facial dynamics and the emotional express...
journal_title:Journal of cosmetic dermatology
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更新日期:2015-03-01 00:00:00
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journal_title:Journal of cosmetic dermatology
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更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:Application of radiofrequency (RF) energy with microneedles to facial skin shown to promote skin renewal. AIM:To evaluate the safety and efficacy of the VoluDerm technology with 100 ultra-thin electrodes gen100 tip for improvement of skin texture and wrinkles. METHODS:A prospective, open-label, intra-indiv...
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journal_title:Journal of cosmetic dermatology
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pub_type: 杂志文章,随机对照试验
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更新日期:2012-03-01 00:00:00
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更新日期:2020-05-01 00:00:00
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journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
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更新日期:2020-06-01 00:00:00
abstract:CONTEXT:Subcision is a simple surgical method that can be effective in treatment of acne scars. AIMS:This study was conducted to evaluate and compare the two methods of Nokor needle and blunt blade (BB) subcision in treatment of acne scars. SETTINGS AND DESIGN:This clinical trial study was conducted on 28 patients wi...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
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更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:Ultraviolet B (UVB) irradiation is viewed as the main factor of skin aging, associated with acceleration of elastin, collagen degradation and expression of matrix metalloproteinases (MMPs). Apples are one of the most commonly eaten fruits in the world, and isoquercitrin is the main active ingredient in new b...
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journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
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更新日期:2002-10-01 00:00:00
abstract:BACKGROUND:Phenolic and flavonoid compounds found in plants alleviate the photo-damaging skin conditions by playing a major role in skin rejuvenation. AIMS:The aim of the study was to explore the cosmeceutical effects of Cinnamomum tamala extract. OBJECTIVE:Recent research was aimed to quantify phenols and flavonoids...
journal_title:Journal of cosmetic dermatology
pub_type: 杂志文章
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更新日期:2020-07-01 00:00:00
abstract::Skin resurfacing has been a part of cosmetic dermatology for more than two decades now, and most of it has been ablative with traditional aggressive lasers including the CO(2) and erbium. The last few years have seen a revolutionary change with the invention of nonablative lasers for skin tightening. Fractional resurf...
journal_title:Journal of cosmetic dermatology
pub_type: 历史文章,杂志文章,评审
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