Arabidopsis ERF109 mediates cross-talk between jasmonic acid and auxin biosynthesis during lateral root formation.

abstract：:The environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes hepatic toxicity associated with prominent lipid accumulation in humans. Here, the authors report that the lysosomal copper transporter SLC46A3 is induced by TCDD and underlies the hepatic lipid accumulation in mice, potentially via effect...

journal_title：Nature communications

authors： Kim JH,Matsubara T,Lee J,Fenollar-Ferrer C,Han K,Kim D,Jia S,Chang CJ,Yang H,Nagano T,Krausz KW,Yim SH,Gonzalez FJ

更新日期：2021-01-12 00:00:00

abstract：:Crosstalk between liver and skeletal muscle is vital for glucose homeostasis. Hepatokines, liver-derived proteins that play an important role in regulating muscle metabolism, are important to this communication. Here we identify apolipoprotein J (ApoJ) as a novel hepatokine targeting muscle glucose metabolism and insu...

journal_title：Nature communications

authors： Seo JA,Kang MC,Yang WM,Hwang WM,Kim SS,Hong SH,Heo JI,Vijyakumar A,Pereira de Moura L,Uner A,Huang H,Lee SH,Lima IS,Park KS,Kim MS,Dagon Y,Willnow TE,Aroda V,Ciaraldi TP,Henry RR,Kim YB

更新日期：2020-04-24 00:00:00

abstract：:Accurate prediction of an individual's phenotype from their DNA sequence is one of the great promises of genomics and precision medicine. We extend a powerful individual-level data Bayesian multiple regression model (BayesR) to one that utilises summary statistics from genome-wide association studies (GWAS), SBayesR. ...

journal_title：Nature communications

authors： Lloyd-Jones LR,Zeng J,Sidorenko J,Yengo L,Moser G,Kemper KE,Wang H,Zheng Z,Magi R,Esko T,Metspalu A,Wray NR,Goddard ME,Yang J,Visscher PM

更新日期：2019-11-08 00:00:00

abstract：:Microbial population growth is typically measured when cells can be directly observed, or when death is rare. However, neither of these conditions hold for the mammalian gut microbiota, and, therefore, standard approaches cannot accurately measure the growth dynamics of this community. Here we introduce a new method (...

journal_title：Nature communications

authors： Myhrvold C,Kotula JW,Hicks WM,Conway NJ,Silver PA

更新日期：2015-11-30 00:00:00

abstract：:Achieving control over the directionality of active colloids is essential for their use in practical applications such as cargo carriers in microfluidic devices. So far, guidance of spherical Janus colloids was mainly realized using specially engineered magnetic multilayer coatings combined with external magnetic fiel...

journal_title：Nature communications

authors： Simmchen J,Katuri J,Uspal WE,Popescu MN,Tasinkevych M,Sánchez S

更新日期：2016-02-09 00:00:00

abstract：:Parkinson's disease-associated kinase LRRK2 has been linked to IFN type II (IFN-γ) response in infections and to dopaminergic neuronal loss. However, whether and how LRRK2 synergizes with IFN-γ remains unclear. In this study, we employed dopaminergic neurons and microglia differentiated from patient-derived induced pl...

journal_title：Nature communications

authors： Panagiotakopoulou V,Ivanyuk D,De Cicco S,Haq W,Arsić A,Yu C,Messelodi D,Oldrati M,Schöndorf DC,Perez MJ,Cassatella RP,Jakobi M,Schneiderhan-Marra N,Gasser T,Nikić-Spiegel I,Deleidi M

更新日期：2020-10-14 00:00:00

abstract：:A transcriptional programme initiated by the proneural factors Neurog2 and Ascl1 controls successive steps of neurogenesis in the embryonic cerebral cortex. Previous work has shown that proneural factors also confer a migratory behaviour to cortical neurons by inducing the expression of the small GTP-binding proteins ...

journal_title：Nature communications

authors： Azzarelli R,Pacary E,Garg R,Garcez P,van den Berg D,Riou P,Ridley AJ,Friedel RH,Parsons M,Guillemot F

更新日期：2014-02-27 00:00:00

abstract：:We lack an understanding of how the full range of genetic variants that occur in individuals can interact. To address this shortcoming, here we combine diverse mutations between genes in a model regulatory network, the galactose (GAL) switch of budding yeast. The effects of thousands of pairs of mutations fall into a ...

journal_title：Nature communications

authors： New AM,Lehner B

更新日期：2019-08-14 00:00:00

abstract：:The extent to which the impact of regulatory genetic variants may depend on other factors, such as the expression levels of upstream transcription factors, remains poorly understood. Here we report a framework in which regulatory variants are first aggregated into sets, and using these as estimates of the total cis-ge...

journal_title：Nature communications

authors： Wragg D,Liu Q,Lin Z,Riggio V,Pugh CA,Beveridge AJ,Brown H,Hume DA,Harris SE,Deary IJ,Tenesa A,Prendergast JGD

更新日期：2020-01-17 00:00:00

abstract：:SCRaMbLE (Synthetic Chromosome Rearrangement and Modification by LoxP-mediated Evolution) is a genome restructuring technique that can be used in synthetic genomes such as that of Sc2.0, the synthetic yeast genome, which contains hundreds to thousands of strategically positioned loxPsym sites. SCRaMbLE has been used t...

journal_title：Nature communications

authors： Shen MJ,Wu Y,Yang K,Li Y,Xu H,Zhang H,Li BZ,Li X,Xiao WH,Zhou X,Mitchell LA,Bader JS,Yuan Y,Boeke JD

更新日期：2018-05-22 00:00:00

abstract：:Climate change is impacting fisheries worldwide with uncertain outcomes for food and nutritional security. Using management strategy evaluations for key US fisheries in the eastern Bering Sea we find that Ecosystem Based Fisheries Management (EBFM) measures forestall future declines under climate change over non-EBFM ...

journal_title：Nature communications

authors： Holsman KK,Haynie AC,Hollowed AB,Reum JCP,Aydin K,Hermann AJ,Cheng W,Faig A,Ianelli JN,Kearney KA,Punt AE

更新日期：2020-09-11 00:00:00

abstract：:Successive cold winters of severely low temperatures in recent years have had critical social and economic impacts on the mid-latitude continents in the Northern Hemisphere. Although these cold winters are thought to be partly driven by dramatic losses of Arctic sea-ice, the mechanism that links sea-ice loss to cold w...

journal_title：Nature communications

authors： Kim BM,Son SW,Min SK,Jeong JH,Kim SJ,Zhang X,Shim T,Yoon JH

更新日期：2014-09-02 00:00:00

abstract：:Tenuazonic acid (TeA) is a well-known mycotoxin produced by various plant pathogenic fungi. However, its biosynthetic gene has been unknown to date. Here we identify the TeA biosynthetic gene from Magnaporthe oryzae by finding two TeA-inducing conditions of a low-producing strain. We demonstrate that TeA is synthesize...

journal_title：Nature communications

authors： Yun CS,Motoyama T,Osada H

更新日期：2015-10-27 00:00:00

abstract：:The control of the magnetization of a material with an electric field would make the design and the integration of novel electronic devices possible. This explains the renewed interest in multiferroic materials. Progress in this field is currently hampered by the scarcity of the materials available and the smallness o...

journal_title：Nature communications

authors： Halley D,Najjari N,Majjad H,Joly L,Ohresser P,Scheurer F,Ulhaq-Bouillet C,Berciaud S,Doudin B,Henry Y

更新日期：2014-01-01 00:00:00

abstract：:It is well known that a topologically protected gapless state appears at an interface between a topological insulator and an ordinary insulator; however, the physics of the interface between a topological insulator and a metal has largely been left unexplored. Here we report a novel phenomenon termed topological proxi...

journal_title：Nature communications

authors： Shoman T,Takayama A,Sato T,Souma S,Takahashi T,Oguchi T,Segawa K,Ando Y

更新日期：2015-03-12 00:00:00

abstract：:Pompe disease, a rare lysosomal storage disease caused by deficiency of the lysosomal acid α-glucosidase (GAA), is characterized by glycogen accumulation, triggering severe secondary cellular damage and resulting in progressive motor handicap and premature death. Numerous disease-causing mutations in the gaa gene have...

journal_title：Nature communications

authors： Roig-Zamboni V,Cobucci-Ponzano B,Iacono R,Ferrara MC,Germany S,Bourne Y,Parenti G,Moracci M,Sulzenbacher G

更新日期：2017-10-24 00:00:00

abstract：:Hyperpolarization via dynamic nuclear polarization (DNP) is pivotal for boosting magnetic resonance imaging (MRI) sensitivity and dissolution DNP can be used to perform in vivo real-time 13C MRI. The type of applications is however limited by the relatively fast decay time of the hyperpolarized spin state together wit...

journal_title：Nature communications

authors： Capozzi A,Cheng T,Boero G,Roussel C,Comment A

更新日期：2017-06-01 00:00:00

abstract：:Bright solitons are non-dispersive wave solutions, arising in a diverse range of nonlinear, one-dimensional systems, including atomic Bose-Einstein condensates with attractive interactions. In reality, cold-atom experiments can only approach the idealized one-dimensional limit necessary for the realization of true sol...

journal_title：Nature communications

authors： Marchant AL,Billam TP,Wiles TP,Yu MM,Gardiner SA,Cornish SL

更新日期：2013-01-01 00:00:00

abstract：:How sleep influences brain plasticity is not known. In particular, why certain electroencephalographic (EEG) rhythms are linked to memory consolidation is poorly understood. Calcium activity in dendrites is known to be necessary for structural plasticity changes, but this has never been carefully examined during sleep...

journal_title：Nature communications

authors： Seibt J,Richard CJ,Sigl-Glöckner J,Takahashi N,Kaplan DI,Doron G,de Limoges D,Bocklisch C,Larkum ME

更新日期：2017-09-25 00:00:00

abstract：:Cell-to-cell variability (noise) is an important feature of gene expression that impacts cell fitness and development. The regulatory mechanism of this variability is not fully understood. Here we investigate the effect on gene expression noise in divergent gene pairs (DGPs). We generated reporters driven by divergent...

journal_title：Nature communications

authors： Yan C,Wu S,Pocetti C,Bai L

更新日期：2016-03-24 00:00:00

abstract：:Essential components of animal behaviour are modulated by dopaminergic (DA) and noradrenergic circuitry. In this study, we reveal at cellular resolution the complete set of projections ('projectome') of every single type of DA and noradrenergio neurons in the central nervous system of zebrafish larvae. The most extens...

journal_title：Nature communications

authors： Tay TL,Ronneberger O,Ryu S,Nitschke R,Driever W

更新日期：2011-01-25 00:00:00

abstract：:Stimulation of TNFR1 by TNFα can promote three distinct alternative mechanisms of cell death: necroptosis, RIPK1-independent and -dependent apoptosis. How cells decide which way to die is unclear. Here, we report that TNFα-induced phosphorylation of RIPK1 in the intermediate domain by TAK1 plays a key role in regulati...

journal_title：Nature communications

authors： Geng J,Ito Y,Shi L,Amin P,Chu J,Ouchida AT,Mookhtiar AK,Zhao H,Xu D,Shan B,Najafov A,Gao G,Akira S,Yuan J

更新日期：2017-08-25 00:00:00

abstract：:The molecular mechanisms underlying vascular inflammation and associated inflammatory vascular diseases are not well defined. Here we show that endothelial intracellular adenosine and its key regulator adenosine kinase (ADK) play important roles in vascular inflammation. Pro-inflammatory stimuli lead to endothelial in...

journal_title：Nature communications

authors： Xu Y,Wang Y,Yan S,Yang Q,Zhou Y,Zeng X,Liu Z,An X,Toque HA,Dong Z,Jiang X,Fulton DJ,Weintraub NL,Li Q,Bagi Z,Hong M,Boison D,Wu C,Huo Y

更新日期：2017-10-16 00:00:00

abstract：:Quantum technology promises revolutionizing applications in information processing, communications, sensing and modelling. However, efficient on-demand cooling of the functional quantum degrees of freedom remains challenging in many solid-state implementations, such as superconducting circuits. Here we demonstrate dir...

journal_title：Nature communications

authors： Tan KY,Partanen M,Lake RE,Govenius J,Masuda S,Möttönen M

更新日期：2017-05-08 00:00:00

abstract：:Many volcanoes erupt compositionally homogeneous magmas over timescales ranging from decades to millennia. This monotonous activity is thought to reflect a high degree of chemical homogeneity in their magmatic systems, leading to predictable eruptive behaviour. We combine petrological analyses of erupted crystals with...

journal_title：Nature communications

authors： Stock MJ,Geist D,Neave DA,Gleeson MLM,Bernard B,Howard KA,Buisman I,Maclennan J

更新日期：2020-07-28 00:00:00

abstract：:Ultrafast photoinduced electron transfer preceding energy equilibration still poses many experimental and conceptual challenges to the optimization of photoconversion since an atomic-scale description has so far been beyond reach. Here we combine femtosecond transient optical absorption spectroscopy with ultrafast X-r...

journal_title：Nature communications

authors： Canton SE,Kjær KS,Vankó G,van Driel TB,Adachi S,Bordage A,Bressler C,Chabera P,Christensen M,Dohn AO,Galler A,Gawelda W,Gosztola D,Haldrup K,Harlang T,Liu Y,Møller KB,Németh Z,Nozawa S,Pápai M,Sato T,Sato T,Su

更新日期：2015-03-02 00:00:00

abstract：:As children grow, they gradually learn how to make decisions independently. However, decisions like choosing healthy but less-tasty foods can be challenging for children whose self-regulation and executive cognitive functions are still maturing. We propose a computational decision-making process in which children esti...

journal_title：Nature communications

authors： Lim SL,Cherry JB,Davis AM,Balakrishnan SN,Ha OR,Bruce JM,Bruce AS

更新日期：2016-05-24 00:00:00

abstract：:We previously demonstrated that beta II protein kinase C (βIIPKC) activity is elevated in failing hearts and contributes to this pathology. Here we report that βIIPKC accumulates on the mitochondrial outer membrane and phosphorylates mitofusin 1 (Mfn1) at serine 86. Mfn1 phosphorylation results in partial loss of its ...

journal_title：Nature communications

authors： Ferreira JCB,Campos JC,Qvit N,Qi X,Bozi LHM,Bechara LRG,Lima VM,Queliconi BB,Disatnik MH,Dourado PMM,Kowaltowski AJ,Mochly-Rosen D

更新日期：2019-01-18 00:00:00

abstract：:Reversible acetylation of α-tubulin is an evolutionarily conserved modification in microtubule networks. Despite its prevalence, the physiological function and regulation of microtubule acetylation remain poorly understood. Here we report that macrophages challenged by bacterial lipopolysaccharides (LPS) undergo exten...

journal_title：Nature communications

authors： Wang B,Rao YH,Inoue M,Hao R,Lai CH,Chen D,McDonald SL,Choi MC,Wang Q,Shinohara ML,Yao TP

更新日期：2014-03-17 00:00:00

abstract：:Covalent organic frameworks (COFs) have emerged as a promising light-harvesting module for artificial photosynthesis and photovoltaics. For efficient generation of free charge carriers, the donor-acceptor (D-A) conjugation has been adopted for two-dimensional (2D) COFs recently. In the 2D D-A COFs, photoexcitation wou...

journal_title：Nature communications

authors： Kim TW,Jun S,Ha Y,Yadav RK,Kumar A,Yoo CY,Oh I,Lim HK,Shin JW,Ryoo R,Kim H,Kim J,Baeg JO,Ihee H

更新日期：2019-04-23 00:00:00