Abstract：
:R 61,837, a new antirhinovirus compound, was able to protect several susceptible rhinoviruses against inactivation by mild acidification or heat. This observation strengthens the hypothesis that the drug exerts antiviral activity by a direct interaction with the viral protein capsid to stabilize the particle. However, the minimal concentrations necessary to inhibit either acetate or citrate or heat inactivation were different for each of five tested serotypes and we therefore conclude that stabilization and inhibition of replication are not causally linked but parallel events, both independently resulting from the binding of the drug to the viral capsid. Studies using drug resistant mutants of HRV51 and HRV9 confirmed this lack of quantitative correlation. The mutants were also shown to be cross resistant to a panel of seven different reference antirhinoviral drugs including SDS, WIN51711, chalcone, dichloroflavan and MDL20,610. This indicates that all these compounds bind to the same site corresponding to the hydrophobic pocket within the viral protein VP 1 beta-barrel structure of HRV14.
journal_name
Arch Viroljournal_title
Archives of virologyauthors
Andries K,Dewindt B,Snoeks J,Willebrords Rdoi
10.1007/BF01311037subject
Has Abstractpub_date
1989-01-01 00:00:00pages
51-61issue
1-2eissn
0304-8608issn
1432-8798journal_volume
106pub_type
杂志文章abstract：:Entry processes were compared between dengue-2 (DEN-2) virus and a DEN-2 neutralisation escape mutant virus in baby hamster kidney (BHK) cells. The mutant virus (mu6B2) was resistant to neutralisation by a monoclonal antibody, MAb 6B2. Infection of BHK cells by the wild-type DEN-2 virus resulted in direct penetration ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s007050050561
更新日期：1999-01-01 00:00:00
abstract：:Infectious laryngotracheitis (ILT), caused by infectious laryngotracheitis virus (ILTV), is an Office International des Epizooties (OIE) notifiable disease. However, we have not clearly understood the dynamic distribution, tissue tropism, pathogenesis, and replication of ILTV in chickens. In this report, we investigat...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-012-1414-8
更新日期：2013-03-01 00:00:00
abstract：:Rice black-streaked dwarf virus (RBSDV) is an economically important virus that causes maize rough dwarf disease and rice black-streaked dwarf disease in East Asia. To study RBSDV variation and recombination, we examined the segment 9 (S9) sequences of 49 RBSDV isolates from maize and rice in China. Three S9 recombina...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-014-2291-0
更新日期：2015-04-01 00:00:00
abstract：:Human polymorphonuclear leukocytes (PMNL) incubated with influenza virus, A/USSR/90/77 (H1N1) or its hemagglutinin produced a significant increase in their PKC activity when compared with untreated PMNL. The activated kinase translocated from cytosol to cellular membrane. The calcium-dependent enzyme activity was inhi...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s007050050439
更新日期：1998-01-01 00:00:00
abstract：:The adsorption and retention properties of native (unfixed) and glutaraldehyde-fixed alfalfa mosaic virus (AMV) antigens to the polystyrene of ELISA plates were studied using [35S]-labelled virus preparations. It was shown that adsorption was a temperature-dependent, relatively slow process which varied between differ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01310767
更新日期：1991-01-01 00:00:00
abstract：:Chikungunya fever is self-limiting. However, neurological and hemorrhagic complications have been seen in recent outbreaks. The clinical manifestations of this disease are similar to those of dengue virus infection, indicating the need for differential diagnosis in areas such as India, which are endemic for both virus...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-016-2829-4
更新日期：2016-06-01 00:00:00
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journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-002-0838-y
更新日期：2002-08-01 00:00:00
abstract：:A rice protein homologous to eukaryotic translation elongation factor 1A (eEF-1A) was found to interact with the Pns6 of rice ragged stunt virus (RRSV), the type member of the genus Oryzavirus, family Reoviridae, in yeast two-hybrid screening. The interaction between the rice protein, designated OseEF-1A, and RRSV Pns...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-013-1703-x
更新日期：2013-10-01 00:00:00
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journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF02175596
更新日期：1975-01-01 00:00:00
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journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01317004
更新日期：1985-01-01 00:00:00
abstract：:The complete genome of a novel mycovirus, Puccinia striiformis mitovirus 1 (PsMV1), derived from the wheat stripe rust fungus Puccinia striiformis strain SCSN-10, was sequenced and analyzed. The full-length cDNA sequence is 2496 bp in length with a predicted AU content of 57.65% in the genomic RNA. Sequence analysis i...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-018-04134-4
更新日期：2019-03-01 00:00:00
abstract：:African swine fever virus (ASFV) was detected in wild boar in eastern Poland in early 2014. So far, 65 cases of ASFV infection in wild boar have been recognised. The methods used for ASFV detection included highly specific real-time PCR with a universal probe library (UPL), enzyme-linked immunosorbent assay (ELISA), a...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-015-2650-5
更新日期：2016-01-01 00:00:00
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journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01314606
更新日期：1981-01-01 00:00:00
abstract：:In this work, we describe the complete sequence and genome organization of a novel tobamovirus detected in a prickly pear plant (Opuntia sp.) by high-throughput sequencing, tentatively named "opuntia virus 2". The full genome of opuntia virus 2 is 6,453 nucleotides in length and contains four open reading frames (ORFs...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-020-04528-3
更新日期：2020-03-01 00:00:00
abstract：:The effects of human alpha-, beta-, or gamma-interferon (IFN) on the replication and production of human T-lymphotrophic virus type-I (HTLV-I) were investigated in a human T-cell line, MT-2. Virus transmission and production estimated by syncytium formation and HTLV-I-associated reverse transcriptase (RT) activity wer...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01310623
更新日期：1990-01-01 00:00:00
abstract：:Strains of an influenza H10N4 virus have been isolated during an outbreak of a respiratory disease in mink on the south-east coast of Sweden. This was the first example of a disease in mammals caused by the H10 subtype. We compared the A/mink/Sweden/84 strain with two recent avian H10N4 isolates, one from fowl and ano...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01318353
更新日期：1990-01-01 00:00:00
abstract：:An outbreak of a canine influenza virus (CIV) H3N2 reassortant derived from pandemic (pdm) H1N1 and CIV H3N2 in companion animals has underscored the urgent need to monitor CIV infections for potential zoonotic transmission of influenza viruses to humans. In this study, we assessed the virulence of a novel CIV H3N2 re...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-016-2868-x
更新日期：2016-07-01 00:00:00
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journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01310484
更新日期：1991-01-01 00:00:00
abstract：:The effect of the local anaesthetic drug procaine on the adsorption of two enveloped viruses was studied. Physiological concentrations of the drug (7 X 10(-3)--7 X 10(-2) M) strongly inhibited the adsorption of both West-Nile and herpes viruses as determined by plaque assay and the infective center assay. ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01317291
更新日期：1978-01-01 00:00:00
abstract：:The present study reports the first complete genome sequence analysis of West Nile virus (WNV) strains isolated from brain samples from raptors. The results prove the circulation of closely related WNV lineage II strains in central Europe and genetic analysis revealed seven amino acid substitutions in structural (PrM3...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-018-4056-7
更新日期：2019-01-01 00:00:00
abstract：:Conditions for ELISA by using IgG linked with horseradish peroxidase have been developed for the detection of 6 arenaviruses (Machupo, Junin, Tacaribe, Amapari, LCM and Tamiami). This method allows the detection of arenavirus antigens in various materials; organs and blood in affected animals and infected cell culture...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01314603
更新日期：1981-01-01 00:00:00
abstract：:Pigeon circovirus (PiCV) is taxonomically classified as a member of the Circovirus genus, family Circoviridae. The virus contains a single stranded DNA genome of approximately 2 kb, with minor length variations among different isolates. The occurrence of PiCV infections in pigeons (Columba livia) has been documented w...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-018-3990-8
更新日期：2018-11-01 00:00:00
abstract：:The complete genome sequence of the T4-related low-temperature Escherichia coli bacteriophage vB_EcoM-VR7 was determined. The genome sequence is 169,285 bp long, with a G+C content of 40.3%. Overall, 95% of the phage genome is coding. It encodes 293 putative protein-encoding open reading frames (ORFs) and tRNA(Met). M...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-011-1084-y
更新日期：2011-10-01 00:00:00
abstract：:The complete genome sequences of isolates of two new bipartite begomoviruses (genus Begomovirus, family Geminiviridae) found infecting common bean in Venezuela are provided. The names proposed for each of these viruses are "bean yellow chlorosis virus" (BYCV) and "bean white chlorosis mosaic virus" (BWCMV). Phylogenet...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-012-1545-y
更新日期：2013-03-01 00:00:00
abstract：:Some of the properties of three continuous cell lines derived from BK virus-induced hamster tumors were examined. The cell lines had in vitro growth characteristics of transformed cells. Morphologically most of the cells were fibroblastic, but multinucleated giant cells were also common. Ultrastructurally all three ce...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01318002
更新日期：1976-01-01 00:00:00
abstract：:Molecular analyses of viruses infecting Chinese scallion (Allium chinense G. Don) showed that the plants did not contain any of the poty-, carla- or allexiviruses that are common in garlic plants in China. The complete sequences of a potyvirus and a potexvirus were determined and these were shown to represent differen...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s007050200018
更新日期：2002-04-01 00:00:00
abstract：:Triple gene block 1 (TGB1) and coat protein (CP) sequences of 30 hosta virus X (HVX) isolates from Tennessee (TN), USA, were determined and compared with available sequences in GenBank. The CPs of all known HVX isolates, including those from TN, shared 98.3-100% and 98.2-100% nucleotide and amino acid sequence identit...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-009-0522-6
更新日期：2009-01-01 00:00:00
abstract：:The four CC chemokine-like proteins (Fpv060, Fpv061, Fpv116 and Fpv121) of fowlpox virus (FWPV) were over-expressed as His-tagged versions from a T7 promoter/EMCV IRES construct in vitro, by coupled transcription/translation, or in cell culture, by co-infection with two recombinant FWPVs (one expressing the chemokine-...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-005-0560-7
更新日期：2005-09-01 00:00:00
abstract：:Echovirus 33 (E33) has been infrequently detected and is less frequently associated with clinical diseases when compared with other types of enteroviruses (EVs) in China. An outbreak of E33 was identified in four schools in Hunan Province, China, in June 2013. For laboratory diagnosis, throat swabs and/or serum specim...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-014-2059-6
更新日期：2014-09-01 00:00:00
abstract：:Grapevine Pinot gris virus (GPGV), a member of the genus Trichovirus in the family Betaflexiviridae, was recently discovered in Italy and subsequently in other European countries and in Korea. In this study, we assessed the occurrence of GPGV in 441 samples from Western and Eastern Europe collected over the period 200...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-015-2718-2
更新日期：2016-03-01 00:00:00
