Neoadjuvant therapy for pancreas cancer: past lessons and future therapies.

abstract：AIM:To investigate serum insulin-like growth factor-binding protein 5 (IGFBP-5) levels and intestinal IGFBP-5 expression in patients with Crohn's disease (CD). METHODS:We analyzed the serum concentrations and intestinal expression of IGFBP-5 in 42 patients with CD, of whom 26 had endoscopically or radiologically prove...

journal_title：World journal of gastroenterology

authors： Adali G,Yorulmaz E,Ozkanli S,Ulasoglu C,Bayraktar B,Orhun A,Colak Y,Tuncer I

更新日期：2013-12-21 00:00:00

abstract：AIM:To investigate the effect of side-stream smoking on gut microflora composition, intestinal inflammation and expression of tight junction proteins. METHODS:C57BL/6 mice were exposed to side-stream cigarette smoking for one hour daily over eight weeks. Cecal contents were collected for microbial composition analysis...

journal_title：World journal of gastroenterology

authors： Wang H,Zhao JX,Hu N,Ren J,Du M,Zhu MJ

更新日期：2012-05-14 00:00:00

abstract：AIM:To explore the efficacy and safety of herbal medicines (HM) in the treatment of irritable bowel syndrome (IBS). METHODS:A computer-based as well as manual literature search was performed. We reviewed randomized controlled trials on the treatment of IBS with and without HM. RESULTS:A total of 22 studies with 25 HM...

journal_title：World journal of gastroenterology

authors： Shi J,Tong Y,Shen JG,Li HX

更新日期：2008-01-21 00:00:00

abstract：AIM:To study the differential protein profile in serum of hepatitis B patients. METHODS:Serum samples were obtained from patients with chronic hepatitis B who were receiving peginterferon alfa-2b. The serum samples were subjected to albumin depletion and analyzed by two-dimensional gel electrophoresis (2-DE). Differen...

journal_title：World journal of gastroenterology

authors： Kuakarn S,SomParn P,Tangkijvanich P,Mahachai V,Thongboonkerd V,Hirankarn N

更新日期：2013-08-21 00:00:00

abstract：:The nasogastric tube (NGT) has become a frequently used device to alleviate gastrointestinal symptoms. Nasogastric tube syndrome (NTS) is an uncommon but potentially life-threatening complication of an indwelling NGT. NTS is characterized by acute upper airway obstruction due to bilateral vocal cord paralysis. We repo...

journal_title：World journal of gastroenterology

authors： Sano N,Yamamoto M,Nagai K,Yamada K,Ohkohchi N

更新日期：2016-04-21 00:00:00

abstract：AIM:To detect linc00675 expression in pancreatic ductal adenocarcinoma (PDAC), to analyze the relationship between the expression level of linc00675 and the clinical pathological characteristics, to explore the biological functions of linc00675, and to determine whether linc00675 has independent prognostic value in PDA...

journal_title：World journal of gastroenterology

authors： Li DD,Fu ZQ,Lin Q,Zhou Y,Zhou QB,Li ZH,Tan LP,Chen RF,Liu YM

更新日期：2015-08-21 00:00:00

abstract：AIM:To investigate the relationship of changes in expression of marker genes in functional categories or molecular networks comprising one functional category or multiple categories in progression of hepatic fibrosis in hepatitis C (HCV) patients. METHODS:Marker genes were initially identified using DNA microarray dat...

journal_title：World journal of gastroenterology

authors： Takahara Y,Takahashi M,Zhang QW,Wagatsuma H,Mori M,Tamori A,Shiomi S,Nishiguchi S

更新日期：2008-04-07 00:00:00

abstract：AIM:To validate the Rockall scoring system for predicting outcomes of rebleeding, and the need for a surgical procedure and death. METHODS:We used data extracted from the Registry of Upper Gastrointestinal Bleeding and Endoscopy including information of 1869 patients with non-variceal upper gastrointestinal bleeding t...

journal_title：World journal of gastroenterology

authors： Enns RA,Gagnon YM,Barkun AN,Armstrong D,Gregor JC,Fedorak RN,RUGBE Investigators Group.

更新日期：2006-12-28 00:00:00

abstract：:Cytomegalovirus (CMV) infection is a common complication after liver transplantation, and it is associated with multiple direct and indirect effects. Management of CMV infection and disease has evolved over the years, and clinical guidelines have been recently updated. Universal antiviral prophylaxis and a pre-emptive...

journal_title：World journal of gastroenterology

authors： Marcelin JR,Beam E,Razonable RR

更新日期：2014-08-21 00:00:00

abstract：:AIM:To construct Hsp90 antisense RNA eukaryotic expression vector, transfect it into SGC7901 and SGC7901/VCR of MDR-type human gastric cancer cell lines, HCC7402 of human hepatic cancer and Ec109 of human esophageal cancer cell lines, and to study the cell cycle distribution of the gene transected cells and their resp...

journal_title：World journal of gastroenterology

authors： Liu XL,Xiao B,Yu ZC,Guo JC,Zhao QC,Xu L,Shi YQ,Fan DM

更新日期：1999-06-01 00:00:00

abstract：AIM:To explore the impact of prolonged fraction dose-delivery time modeling intensity-modulated radiation therapy (IMRT) on cell killing of human hepatocellular carcinoma (HCC) HepG2 and Hep3B cell lines. METHODS:The radiobiological characteristics of human HCC HepG2 and Hep3b cell lines were studied with standard clo...

journal_title：World journal of gastroenterology

authors： Zheng XK,Chen LH,Yan X,Wang HM

更新日期：2005-03-14 00:00:00

abstract：AIM:To evaluate the efficacy of 5 compared to 10 granulocyteaphaeresis sessions in patients with active steroid-dependent ulcerative colitis. METHODS:In this pilot, prospective, multicenter randomized trial, 20 patients with moderately active steroid-dependent ulcerative colitis were randomized to 5 or 10 granulocytea...

journal_title：World journal of gastroenterology

authors： Ricart E,Esteve M,Andreu M,Casellas F,Monfort D,Sans M,Oudovenko N,Lafuente R,Panes J

更新日期：2007-04-21 00:00:00

abstract：AIM:To investigate the molecular mechanism for regulation of cholesterol metabolism by hepatitis C virus (HCV) core protein in HepG2 cells. METHODS:HCV genotype 1b core protein was cloned and expressed in HepG2 cells. The cholesterol content was determined after transfection. The expression of sterol regulatory elemen...

journal_title：World journal of gastroenterology

authors： Li M,Wang Q,Liu SA,Zhang JQ,Ju W,Quan M,Feng SH,Dong JL,Gao P,Cheng J

更新日期：2015-04-21 00:00:00

abstract：:Anorectal melanoma is a very rare tumor with poor prognosis. Rectal bleeding is the most frequent symptom and surgical treatment ranges from local excision to radical abdominoperineal resection. We report a case of a 75-years-old male patient who presented with a history of recurrent rectal bleeding, and whose histopa...

journal_title：World journal of gastroenterology

authors： Balicevic D,Tomic K,Bekavac-Beslin M,Kovacevic I,Mijic A,Belicza M,Kruslin B

更新日期：2006-06-07 00:00:00

abstract：:The intestinal microbiome is a dynamic system of interactions between the host and its microbes. Under physiological conditions, a fine balance and mutually beneficial relationship is present. Disruption of this balance is a hallmark of inflammatory bowel disease (IBD). Whether an altered microbiome is the consequence...

journal_title：World journal of gastroenterology

authors： Babickova J,Gardlik R

更新日期：2015-10-28 00:00:00

abstract：AIM:To examine an increased risk of esophageal adenocarcinoma is restricted to patients who develop Barrett's esophagus or whether esophagitis per se is a risk factor for adenocarcinoma. METHODS:A population-based cohort of patients with histological evidence of esophagitis without Barrett's esophagus was constructed ...

journal_title：World journal of gastroenterology

authors： Murphy SJ,Anderson LA,Johnston BT,Fitzpatrick DA,Watson PR,Monaghan P,Murray LJ

更新日期：2005-12-14 00:00:00

abstract：AIM:To compare two different laparotomy methods for modeling rabbit VX2 hepatocarcinoma. METHODS:Thirty New Zealand rabbits were randomly divided into two groups: A and B. Group A was assigned a traditional laparotomy method (embedding tumor fragments directly into the liver with tweezers). Group B was subjected to an...

journal_title：World journal of gastroenterology

authors： Chen Z,Kang Z,Xiao EH,Tong M,Xiao YD,Li HB

更新日期：2015-04-28 00:00:00

abstract：:P21-activated kinases (PAKs) are central players in various oncogenic signaling pathways. The six PAK family members are classified into group I (PAK1-3) and group II (PAK4-6). Focus is currently shifting from group I PAKs to group II PAKs. Group II PAKs play important roles in many fundamental cellular processes, som...

journal_title：World journal of gastroenterology

authors： Shao YG,Ning K,Li F

更新日期：2016-01-21 00:00:00

abstract：:Surgical resection offers the best opportunity for survival in patients with colorectal cancer metastatic to the liver, with five-year survival rates up to 58% in selected cases. However, only a minority are resectable at the time of diagnosis. Continuous research in this field aims at increasing the percentage of pat...

journal_title：World journal of gastroenterology

authors： Misiakos EP,Karidis NP,Kouraklis G

更新日期：2011-09-28 00:00:00

abstract：AIM:To assess whether polymorphisms in NOD2 and ATG16L1 affect cytokine responses and mycobacterium avium subspecies paratuberculosis (MAP) survival in monocytes from Crohn's disease (CD) patients. METHODS:Monocytes were isolated from peripheral blood of CD patients of known genotype for common single nucleotide polym...

journal_title：World journal of gastroenterology

authors： Glubb DM,Gearry RB,Barclay ML,Roberts RL,Pearson J,Keenan JI,McKenzie J,Bentley RW

更新日期：2011-06-21 00:00:00

abstract：:AIM:To study the anticarcinogenic effect and acute toxicity of liver targeting mitoxantrone nanospheres.METHODS:The anticarcinogenic effect of mitoxan-trone polybutylcyanoacrylate nanoparticles (DHAQ-PBCA-NP) was investigated by using heterotopic and orthotopic transplantation models of human hepatocellular carcinoma ...

journal_title：World journal of gastroenterology

authors： Zhang ZR,He Q,Liao GT,Bai SH

更新日期：1999-12-01 00:00:00

abstract：AIM:To investigate the mechanism of chaperone-mediated autophagy (CMA)-induced resistance to irradiation-triggered apoptosis through regulation of the p53 protein in hepatocellular carcinoma (HCC). METHODS:Firstly, we detected expression of lysosome-associated membrane protein 2a (Lamp-2a), which is the key protein of...

journal_title：World journal of gastroenterology

authors： Wu JH,Guo JP,Shi J,Wang H,Li LL,Guo B,Liu DX,Cao Q,Yuan ZY

更新日期：2017-04-07 00:00:00

abstract：AIM:To study the response to infliximab in pediatric inflammatory bowel disease (IBD), as reflected in fecal calprotectin levels. METHODS:Thirty-six pediatric patients with IBD [23 Crohn's disease (CD), 13 ulcerative colitis (UC); median age 14 years] were treated with infliximab. Fecal calprotectin was measured at ba...

journal_title：World journal of gastroenterology

authors： Hämäläinen A,Sipponen T,Kolho KL

更新日期：2011-12-21 00:00:00

abstract：AIM:To investigate the aberrant expression of nuclear matrix proteins in human gastric cancer cells before and after hexamethylene bisacetamide (HMBA) treatment. METHODS:Proteomics analysis of differential nuclear matrix proteins was performed by two dimensional electrophoresis polyacrylamide gel electrophoresis and m...

journal_title：World journal of gastroenterology

authors： Jing GJ,Xu DH,Shi SL,Li QF,Wang SY,Wu FY,Kong HY

更新日期：2010-05-07 00:00:00

abstract：:In order to have an adequate view of the whole small intestine during capsule endoscopy, the preparation recommended consists of a clear liquid diet and an overnight fast. However, visualization of the small bowel during video capsule endoscopy can be impaired by intestinal contents. To improve mucosal visualization, ...

journal_title：World journal of gastroenterology

authors： Pons Beltrán V,Carretero C,Gonzalez-Suárez B,Fernandez-Urien I,Muñoz-Navas M

更新日期：2008-10-07 00:00:00

abstract：AIM:To investigate the role of neoadjuvant chemoradiotherapy in prognosis and surgery for esophageal carcinoma by a meta-analysis. METHODS:PubMed and manual searches were done to identify all published randomized controlled trials (RCTs) that compared neoadjuvant chemoradiotherapy plus surgery (CRTS) with surgery alon...

journal_title：World journal of gastroenterology

authors： Lv J,Cao XF,Zhu B,Ji L,Tao L,Wang DD

更新日期：2009-10-21 00:00:00

abstract：AIM:To compare the outcome of upper gastrointestinal bleeding (UGIB) between patients receiving restrictive and liberal transfusion. METHODS:PubMed, EMBASE, and Cochrane Library databases were employed to identify all relevant randomized controlled trials regarding the outcome of UGIB after restrictive or liberal tran...

journal_title：World journal of gastroenterology

authors： Wang J,Bao YX,Bai M,Zhang YG,Xu WD,Qi XS

更新日期：2013-10-28 00:00:00

abstract：AIM:To investigate the reactivity of a panel of 8 mouse anti-hepatitis B surface antigen (HBsAg) monoclonal antibodies (mAbs) using a collection of 9 recombinant HBsAg mutants with a variety of amino acid substitutions mostly located within the "a" region. METHODS:The entire HBs genes previously cloned into a mammalia...

journal_title：World journal of gastroenterology

authors： Roohi A,Yazdani Y,Khoshnoodi J,Jazayeri SM,Carman WF,Chamankhah M,Rashedan M,Shokri F

更新日期：2006-09-07 00:00:00

abstract：:To review the underlying pathophysiology and currently available treatments for pruritis associated with jaundice. English language literature was reviewed using MEDLINE, PubMed, EMBASE and clinicaltrials.gov for papers and trails addressing the pathophysiology and potential treatments for pruritis associated with jau...

journal_title：World journal of gastroenterology

authors： Bassari R,Koea JB

更新日期：2015-02-07 00:00:00

abstract：AIM:To investigate the changes that occur in E-cadherin expression during the process of metastasis in colorectal cancer. METHODS:E-cadherin expression was detected by immunohistochemistry and two indices of expression were calculated which reflected the level of expression and the locations (membrane and cytoplasm). ...

journal_title：World journal of gastroenterology

authors： Elzagheid A,Algars A,Bendardaf R,Lamlum H,Ristamaki R,Collan Y,Syrjanen K,Pyrhonen S

更新日期：2006-07-21 00:00:00