Neuropilin regulation of angiogenesis.

abstract：:A comparative approach has been used to study the role of several lipid-body-binding proteins in plants and animals. Caleosins are a newly discovered class of calcium-binding lipid-body proteins found in plants and fungi, which we now report to have separate endoplasmic reticulum- and lipid-body-associated isoforms. W...

journal_title：Biochemical Society transactions

authors： Murphy DJ,Hernendez-Pinzon I,Patel K,Hope RG,McLauchlan J

更新日期：2000-12-01 00:00:00

abstract：:Nicotinic ACh (acetylcholine) and 5-HT3 (5-hydroxytryptamine type-3) receptors are cation-selective ion channels of the Cys-loop transmitter-gated ion channel superfamily. Numerous lines of evidence indicate that the channel lining domain of such receptors is formed by the alpha-helical M2 domain (second transmembrane...

journal_title：Biochemical Society transactions

authors： Peters JA,Carland JE,Cooper MA,Livesey MR,Deeb TZ,Hales TG,Lambert JJ

更新日期：2006-11-01 00:00:00

abstract：:The network of the ER (endoplasmic reticulum) is set up by cytoskeletal control of the movement and remodelling of polygonal rings of tubules, bundles of tubules and cisternal regions. We have developed a new image analysis tool, persistency mapping, to understand the framework upon which the plant ER remodels. With t...

journal_title：Biochemical Society transactions

authors： Griffing LR

更新日期：2010-06-01 00:00:00

abstract：:Gap junctions are channels which allow electrical signals to propagate through the heart from the sinoatrial node and through the atria, conduction system and onwards to the ventricles, and hence are essential for co-ordinated cardiac contraction. Twelve connexin (Cx) proteins make up one gap junction channel, of whic...

journal_title：Biochemical Society transactions

authors： McArthur L,Chilton L,Smith GL,Nicklin SA

更新日期：2015-06-01 00:00:00

abstract：:IAPP has been postulated to have a role as a modulating factor in glucose homoeostasis and to be involved in the pathophysiology of diabetes. However, the normal physiological functions of the peptide remain obscure: exogenous IAPP acts on many experimental systems to modulate nutrient supply and metabolism but there ...

journal_title：Biochemical Society transactions

authors： Clark A,Charge SB,Badman MK,MacArthur DA,de Koning EJ

更新日期：1996-05-01 00:00:00

abstract：:14-3-3 proteins are involved in signalling processes in neuronal cells. Using isoform-specific antibodies we have examined the variation in 14-3-3 isoform neurolocation in normal and scrapie-infected murine brain and show that in defined areas of the brain there are significant changes associated with the pathology of...

journal_title：Biochemical Society transactions

authors： Baxter HC,Fraser JR,Liu WG,Forster JL,Clokie S,Steinacker P,Otto M,Bahn E,Wiltfang J,Aitken A

更新日期：2002-08-01 00:00:00

abstract：:The giant cytoskeletal kinases of the titin-like family are emerging as key mediators of stretch-sensing in muscle. It is thought that their elastic conformational deformation during muscle function regulates both their catalysis and the recruitment of regulatory proteins to signalosomes that assemble in their vicinit...

journal_title：Biochemical Society transactions

authors： Mayans O,Benian GM,Simkovic F,Rigden DJ

更新日期：2013-08-01 00:00:00

abstract：:Biophysical techniques developed during the last three decades have provided an increasingly detailed description of the internal processes associated with ligand capture and release by haem proteins. Myoglobin has long been the paradigm for these studies. More recently, cytochrome P450cam (the camphor-metabolizing cy...

journal_title：Biochemical Society transactions

authors： Lavalette D,Tétreau C,Mouawad L

更新日期：2006-11-01 00:00:00

abstract：:The structural maintenance of chromosomes hinge domain containing protein 1 (SMCHD1) is a large multidomain protein involved in epigenetic gene silencing. Variations in the SMCHD1 gene are associated with two debilitating human disorders, facioscapulohumeral muscular dystrophy (FSHD) and Bosma arhinia microphthalmia s...

journal_title：Biochemical Society transactions

authors： Gurzau AD,Blewitt ME,Czabotar PE,Murphy JM,Birkinshaw RW

更新日期：2020-08-28 00:00:00

abstract：:Although heat-shock (cell stress) proteins are commonly considered as being intracellular molecular chaperones that undertake a number of cytoprotective and cellular housekeeping functions, there is now a wealth of evidence to indicate that these proteins can be released by cells via active processes. Many molecular c...

journal_title：Biochemical Society transactions

authors： Pockley AG,Henderson B,Multhoff G

更新日期：2014-12-01 00:00:00

abstract：:Pantothenate (vitamin B5) is a water-soluble vitamin essential for the synthesis of CoA and ACP (acyl-carrier protein, cofactors in energy yielding reactions including carbohydrate metabolism and fatty acid synthesis. Pantothenate is synthesized de novo by plants and micro-organisms; however, animals obtain the vitami...

journal_title：Biochemical Society transactions

authors： Coxon KM,Chakauya E,Ottenhof HH,Whitney HM,Blundell TL,Abell C,Smith AG

更新日期：2005-08-01 00:00:00

abstract：:Higher eukaryotes rely on AS (alternative splicing) of pre-mRNAs (mRNA precursors) to generate more than one protein product from a single gene and to regulate mRNA stability and translational activity. An important example of the latter function involves an interplay between AS and NMD (nonsense-mediated decay), a cy...

journal_title：Biochemical Society transactions

authors： Hamid FM,Makeyev EV

更新日期：2014-08-01 00:00:00

abstract：:Escherichia coli FtsK is a septum-located DNA translocase that co-ordinates the late stages of cytokinesis and chromosome segregation. Relatives of FtsK are present in most bacteria; in Bacillus subtilis, the FtsK orthologue, SpoIIIE, transfers the majority of a chromosome into the forespore during sporulation. DNA tr...

journal_title：Biochemical Society transactions

authors： Sherratt DJ,Arciszewska LK,Crozat E,Graham JE,Grainge I

更新日期：2010-04-01 00:00:00

abstract：:Approximately 30-50% of individuals who are allergic to natural rubber latex (NRL) show an associated hypersensitivity to some plant-derived foods, especially freshly consumed fruits. This association of latex allergy and allergy to plant-derived foods is called latex-fruit syndrome. An increasing number of plant sour...

journal_title：Biochemical Society transactions

authors： Wagner S,Breiteneder H

更新日期：2002-11-01 00:00:00

abstract：:Complex biological machines arise from self-assembly on the basis of structural features programmed into sequence-specific macromolecules (i.e. polypeptides and polynucleotides) at the molecular level. As a consequence of the near-absolute control of macromolecular architecture that results from such sequence specific...

journal_title：Biochemical Society transactions

authors： Dublin S,Zimenkov Y,Conticello VP

更新日期：2009-08-01 00:00:00

abstract：:Cellular membranes communicate extensively via contact sites that form between two membranes. Such sites allow exchange of specific ions, lipids or proteins between two compartments without content mixing, thereby preserving organellar architecture during the transfer process. Even though the molecular compositions of...

journal_title：Biochemical Society transactions

authors： Raiborg C,Wenzel EM,Pedersen NM,Stenmark H

更新日期：2016-04-15 00:00:00

abstract：:The mTOR (mammalian target of rapamycin) signalling pathway functions as a nutrient sensor, both in individual cells and, more globally, in organs such as the fat body in Drosophila and the hypothalamus in the rat. The activity of placental amino acid transporters is decreased in IUGR (intrauterine growth restriction)...

journal_title：Biochemical Society transactions

authors： Roos S,Powell TL,Jansson T

更新日期：2009-02-01 00:00:00

abstract：:Mucus plays a vital role in protecting the lungs from environmental factors, but conversely, in muco-obstructive airway disease, mucus becomes pathologic. In its protective role, mucus entraps microbes and particles removing them from the lungs via the co-ordinated beating of motile cilia. This mechanism of lung defen...

journal_title：Biochemical Society transactions

authors： Ridley C,Thornton DJ

更新日期：2018-10-19 00:00:00

abstract：:Prelamin A is the precursor protein of lamin A, a major constituent of the nuclear lamina in higher eukaryotes. Increasing attention to prelamin A processing and function has been given after the discovery, from 2002 to 2004, of diseases caused by prelamin A accumulation. These diseases, belonging to the group of lami...

journal_title：Biochemical Society transactions

authors： Lattanzi G

更新日期：2011-12-01 00:00:00

abstract：:Findings from gene expression profiling studies are leading to new diagnostic and therapeutic strategies that can be applied in medical practice, especially in the field of oncology. Promising results of gene expression profiling of the peripheral blood in patients with ischaemic stroke have been obtained in recent pi...

journal_title：Biochemical Society transactions

authors： Baird AE

更新日期：2006-12-01 00:00:00

abstract：:There are eight members of the phosphoinositide family of phospholipids in eukaryotes; PI, PI3P, PI4P, PI5P, PI(4,5)P2, PI(3,4)P2, PI(3,5)P2 and PI(3,4,5)P3. Receptor activation of Class I PI3Ks stimulates the phosphorylation of PI(4,5)P2 to form PI(3,4,5)P3. PI(3,4,5)P3 is an important messenger molecule that is part...

journal_title：Biochemical Society transactions

authors： Hawkins PT,Stephens LR

更新日期：2016-02-01 00:00:00

abstract：:RNase A (1 mM) was incubated with glucose (0.4 M) at 37 degrees C for up to 14 days in phosphate buffer (0.2 M, pH 7.4), digested with trypsin and analysed by LC-MS. The major sites of fructoselysine formation were Lys(1), Lys(7), Lys(37) and Lys(41). Three of these sites (Lys(7), Lys(37) and Lys(41)) were also the ma...

journal_title：Biochemical Society transactions

authors： Cotham WE,Hinton DJ,Metz TO,Brock JW,Thorpe SR,Baynes JW,Ames JM

更新日期：2003-12-01 00:00:00

abstract：:NO (nitric oxide) is a signal molecule involved in diverse physiological processes in cells which can become very toxic under certain conditions determined by its rate of production and diffusion. Several studies have clearly shown the production of NO in early stages of rhizobia-legume symbiosis and in mature nodules...

journal_title：Biochemical Society transactions

authors： Sánchez C,Cabrera JJ,Gates AJ,Bedmar EJ,Richardson DJ,Delgado MJ

更新日期：2011-01-01 00:00:00

abstract：:Intracellular cross-talk or synergism between receptors coupled negatively to adenylate cyclase via PTX-sensitive Gi-protein(s) and receptors coupled to phospholipase C via PTX-insensitive G-proteins is prevalent in a variety of cell types (see above) and may represent a universal mechanism for the modulation of phosp...

journal_title：Biochemical Society transactions

authors： Dickenson JM,Hill SJ

更新日期：1993-11-01 00:00:00

abstract：:Mammalian peroxisomes degrade fatty carboxylates via two pathways, beta-oxidation and, as shown more recently, alpha-oxidation. The latter process consists of an activation step, followed by a hydroxylation at position 2 and cleavage of the 2-hydroxyacyl-CoA, generating formyl-CoA (precursor of formate/CO(2)) and, in ...

journal_title：Biochemical Society transactions

authors： Van Veldhoven PP,Casteels M,Mannaerts GP,Baes M

更新日期：2001-05-01 00:00:00

abstract：:Metabolic and epidemiologic studies support the idea that the type of dietary fat is more important than the total amount of fat with respect to the development of atherosclerosis and the risk of cardiovascular heart disease. Dietary fat is carried in CMs (chylomicrons), which can be taken up by macrophages without ne...

journal_title：Biochemical Society transactions

authors： Cabello-Moruno R,Perona JS,Ruiz-Gutierrez V

更新日期：2007-06-01 00:00:00

abstract：:Bioprocess monitoring is used to track the progress of a cell culture and ensure that the product quality is maintained. Current schemes for monitoring metabolism rely on offline measurements of samples of the extracellular medium. However, in the era of synthetic biology, it is now possible to design and implement bi...

journal_title：Biochemical Society transactions

authors： Constantinou A,Polizzi KM

更新日期：2013-10-01 00:00:00

abstract：:The identification of nitric oxide-bound leghaemoglobin within soya bean nodules has led to the question of how Bradyrhizobium japonicum bacteroids overcome the toxicity of this nitric oxide. It has previously been shown that one candidate for nitric oxide detoxification, the respiratory nitric oxide reductase, is exp...

journal_title：Biochemical Society transactions

authors： Meakin GE,Jepson BJ,Richardson DJ,Bedmar EJ,Delgado MJ

更新日期：2006-02-01 00:00:00

abstract：:c-Type cytochromes are characterized by covalent attachment of haem to protein through thioether bonds between the vinyl groups of the haem and the thiols of a Cys-Xaa-Xaa-Cys-His motif. Proteins of this type play crucial roles in the biochemistry of the nitrogen cycle. Many Gram-negative bacteria use the Ccm (cytochr...

journal_title：Biochemical Society transactions

authors： Allen JW,Ferguson SJ

更新日期：2006-02-01 00:00:00

abstract：:Cystic fibrosis, one of the major human inherited diseases, is caused by defects in the CFTR (cystic fibrosis transmembrane conductance regulator), a cell-membrane protein. CFTR acts as a chloride channel which can be opened by ATP. Low-resolution structural studies of purified recombinant human CFTR are described in ...

journal_title：Biochemical Society transactions

authors： Awayn NH,Rosenberg MF,Kamis AB,Aleksandrov LA,Riordan JR,Ford RC

更新日期：2005-11-01 00:00:00